Multifunctional coordination copolymer nanometer material as well preparation method and application thereof

A technology of coordination polymers and nanomaterials, which is applied in the field of medical materials, can solve the problems of coordination characteristics research and undisclosed preparation methods, and achieve the effects of uniform particle size, low price and mild reaction

Inactive Publication Date: 2013-07-24
SHANGHAI NORMAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Ferrocene carboxylic acid compounds have been synthesized a long time ago, but their coordination characteristics are rarely studied
[0004] After searching, domestic and foreign patents and publications do not disclose the same preparation method as the present invention

Method used

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  • Multifunctional coordination copolymer nanometer material as well preparation method and application thereof
  • Multifunctional coordination copolymer nanometer material as well preparation method and application thereof
  • Multifunctional coordination copolymer nanometer material as well preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment

[0034] (1) Preparation of 1,1’-ferrocenedicarboxylic acid-gadolinium nanoparticles:

[0035]Weigh 13.7mg of 1,1'-ferrocenedicarboxylic acid (0.05mmol), dissolve it in 20mL of absolute ethanol; weigh 20.3mg of gadolinium acetate tetrahydrate (0.05mmol), dissolve it in 10 mL of water; then the two solutions were mixed, stirred at room temperature for 8 hours, centrifuged, and the separated precipitate was washed with absolute ethanol to obtain 1,1'-ferrocenedicarboxylic acid-gadolinium nanoparticles. Specific as figure 1 shown, from figure 1 It can be seen that the synthesized 1,1'-ferrocenedicarboxylic acid-gadolinium nanoparticles have good monodispersity in ethanol, and the average particle size is about 80nm and the uniform spherical shape.

[0036] (2) Preparation of silica-coated 1,1’-ferrocenedicarboxylic acid-gadolinium nanoparticles:

[0037] Dissolve the 1,1'-ferrocenedicarboxylate-gadolinium nanoparticles prepared in step (1) in absolute ethanol to prepare an ethan...

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Abstract

The invention belongs to the field of medicine materials, and particularly relates to a coordination copolymer nanometer material as well a preparation method and application thereof. The coordination copolymer nanometer material is characterized in that 1,1'-ferrocene dicarboxylic acid-gadolinium nanoparticles are taken as a core, silicon dioxide is taken as a shell, and the surface of the shell is modified by a functional material. The preparation method comprises the following steps of: preparing the 1,1'-ferrocene dicarboxylic acid-gadolinium nanoparticles by a direct precipitation method, then coating the silicon dioxide on the surface of the magnetic nanoparticles so that the surfaces of the 1, 1'-ferrocene dicarboxylic acid-gadolinium nanoparticles carry a quantity of amidogens while the 1,1'-ferrocene dicarboxylic acid-gadolinium nanoparticles have water solubility, connecting to the surface of the 1,1'-ferrocene dicarboxylic acid-gadolinium nanoparticles through rhodamine isothiocyanate B and an amidogen effect, and finally connecting arginine glycine aspartic acid tripeptide through the amidogens. The coordination copolymer nanometer material is uniform in particle size and has good dispersity, a very good magnetic resonance imaging effect of T1 and T2, luminescent property and a target function; the synthetic process is simple; raw materials are easily available; and environmental pollution is avoided.

Description

technical field [0001] The invention belongs to the field of medical materials, in particular to a coordination polymer with 1,1'-ferrocenedicarboxylic acid-gadolinium nanoparticles as the core, silica as the shell, and functional materials modified on the shell surface Nanomaterials and their preparation methods and applications. Background technique [0002] Metal-organic frameworks (Metal-Organic Frameworks) refer to coordination polymers formed by self-assembly of multi-dentate organic ligands containing oxygen and nitrogen (mostly aromatic polyacids and polybasics) and transition metal ions. Materials can be used in optics, catalysis, biosensing, drug delivery, bioimaging, gas recognition, gas storage, etc. Among them, metal-organic framework compounds composed of carboxylic acid organic bridges have strong and stable structures, and have been valued by many researchers. Ferrocene carboxylic acid compounds have been synthesized a long time ago, but there are few studi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/14A61K49/08A61K49/00
Inventor 杨红秦长圆杨仕平卢阳薛峰峰
Owner SHANGHAI NORMAL UNIVERSITY
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