Gardenia polysaccharide and preparation method and application thereof

A kind of gardenia polysaccharide, gardenia technology, applied in pharmaceutical formulations, medical preparations containing active ingredients, digestive system and other directions, can solve the problem of limited research and development, no liver protection ingredients, can not fully represent the gardenia jaundice and liver protection, etc. question
CN111138557AActive Publication Date: 2020-05-12SHANGHAI UNIV OF T C M
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGHAI UNIV OF T C M
Publication Date
2020-05-12

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Abstract

The invention discloses gardenia polysaccharide and an extraction method thereof. The gardenia polysaccharide is prepared from the following raw materials (by mass): 41 to 56 percent of total sugar, 34 to 45 percent of uronic acid and 7 to 10 percent of protein. The preparation method of the gardenia polysaccharide comprises the following steps: crushing a gardenia medicinal material, degreasing,adding water, extracting, precipitating with ethanol, repeatedly freeze-thawing to remove protein, dialyzing, and freeze-drying. The gardenia polysaccharide prepared by the method can improve cholestatic liver injury induced by alpha-naphthalene isothiocyanate (ANIT) and 3, 5-diethoxycarbonyl-1, 4-dihydro-2, 4, 6-trimethylpyridine (DDC), and reduce fibrosis induced by carbon tetrachloride (CCL4).And the liver protection effect of the gardenia polysaccharide is not reported in literatures, which indicates that the gardenia polysaccharide has obvious application prospects in the preparation ofliver protection drugs, especially in the preparation of anti-cholestatic liver injury and anti-hepatic fibrosis drugs.
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Description

technical field

[0001] The invention relates to a gardenia polysaccharide and its preparation method and application, belonging to the technical field of traditional Chinese medicine. Background technique

[0002] A variety of chronic liver diseases such as liver cirrhosis of various causes, primary sclerosing cholangitis, primary biliary cirrhosis, alcoholic hepatitis, drug-induced liver disease, viral hepatitis, autoimmune hepatitis, liver tumors, etc., often Accompanied by intrahepatic cholestasis (IHC), that is, the formation, secretion and excretion of bile flow are impaired, and the bile flow cannot flow into the duodenum normally, but stays in the liver and enters the blood circulation. These liver diseases are also called Cholestatic liver disease / liver injury. As the disease progresses, intrahepatic cholestasis can aggravate liver damage and liver fibrosis / cirrhosis, which can lead to liver failure or even death in severe cases. For intrahepatic cholestatic liver ...

Claims

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