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Application of wolfberry red

A technology of Lycium barbarum and hepatitis B, which is applied in the direction of digestive system, metabolic diseases, antiviral agents, etc.

Active Publication Date: 2017-04-26
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are no reports showing that Lycium barbarum has the effect of treating non-alcoholic steatohepatitis and / or hepatitis B

Method used

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  • Application of wolfberry red
  • Application of wolfberry red
  • Application of wolfberry red

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Experimental program
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Embodiment

[0060] Mice were randomly divided into 8 groups, 10 in each group. The treatments of mice in each group are shown in Table 1.

[0061] Among them, HBV transgenic mice (developed by PLA 458 Hospital);

[0062] MCD diet is an internationally recognized food model for inducing NASH, especially for simulating the situation of lean people suffering from NASH. The invention induces non-alcoholic fatty liver by feeding methionine and choline-deficient (MCD) rations, and establishes hepatitis B complicated non-alcoholic fatty liver mouse model.

[0063] Lycium barbarum (ZD) was dissolved in PBS solution containing 5% Tween-80, and administered to mice by intragastric administration (the treatment concentration of each mouse was 2 mg / kg).

[0064] Table 1 Experimental grouping design

[0065]

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PUM

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Abstract

The invention relates to the technical field of medicine, special medical and edible products, and health-care foods, in particular to application of wolfberry red. Experiments indicate that the wolfberry red may treat hepatitis B complicated by non-alcoholic fatty liver disease by: improving liver tissue lipid droplet accumulation, inflammatory cell infiltration and hepatic fibrosis, improving liver damage or abnormality of four times of blood lipid test, promoting SREBP-1c expression, inhibiting ATGL (adipose triglyceride lipase) expression and inhibiting HBV (hepatitis B virus) and HBsAg (hepatitis B surface antigen).

Description

technical field [0001] The invention relates to the technical fields of medicine, food for special medical treatment and health food, in particular to the application of wolfberry red pigment. Background technique [0002] Hepatitis B is a disease caused by hepatitis B virus (HBV), mainly characterized by liver inflammatory lesions, and can cause multiple organ damage. Hepatitis B has become a worldwide disease that seriously threatens human health, and it is also one of the most widespread and most harmful diseases in China. Non-alcoholic steatohepatitis (NASH) is a complication of typical metabolic disorders and an advanced form of non-alcoholic fatty liver disease (that is, not only fat accumulation in the liver, but also severe inflammation) . NASH is clinically closely related to obesity, hypertension and diabetes. The traditional view is that obese people are the main force of NASH, but now some studies have found that not only obese people, but also many thin peopl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/23A61P1/16A61P31/20A61P29/00A61P3/06A61P3/00
CPCA61K31/23
Inventor 肖佳苏国辉高昊李静静朱星谕
Owner JINAN UNIVERSITY
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