Blood-glucose-lowering ganoderma lucidum instant micro-encapsulated preparation and preparation method thereof

A hypoglycemic and microencapsulation technology, which is applied in the direction of microcapsules, capsule delivery, and pharmaceutical formulations, can solve problems such as incomplete extraction, and achieve the effects of improving resource utilization, improving taste, and excellent water dispersion and instant solubility

Active Publication Date: 2016-10-12
RIZHAO POLYTECHNIC
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] In order to achieve the above object, the present invention first uses Monascus to carry out fermentation cooperative extraction in the water system, and with the help of the complex enzyme system produced in the fermentation process of Monascus, on the one hand, the structure of fruiting body cells is destroyed, and the extraction efficiency is improved. On the other hand, the complex enzyme system produced can convert some low-polar components to improve their solubility in aqueous solution, so that more functional components can be leached out. Third, comprehensively use the bidirectional fermentation theory , make the efficacy of Monascus and Ganoderma lucidum synergistic, and give full play to the

Method used

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  • Blood-glucose-lowering ganoderma lucidum instant micro-encapsulated preparation and preparation method thereof
  • Blood-glucose-lowering ganoderma lucidum instant micro-encapsulated preparation and preparation method thereof
  • Blood-glucose-lowering ganoderma lucidum instant micro-encapsulated preparation and preparation method thereof

Examples

Experimental program
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Example Embodiment

[0052] Example 1

[0053] (1) Raw materials: Ganoderma lucidum fruiting bodies and spore powder for lowering blood sugar;

[0054] (2) Raw material pretreatment: pulverize the blood sugar-lowering Ganoderma lucidum fruit body into powder with a particle size of about 40 meshes, and perform wall-breaking treatment on the blood sugar-lowering Ganoderma lucidum spore powder, and detect that the wall-breaking rate is about 86%. Spore powder

[0055] (3) Fermentation and water extraction: Weigh 1kg of the hypoglycemic Ganoderma lucidum fruit body powder obtained in step (2), place it in a sterilized extraction tank, sterilize it by ultraviolet radiation; then add the equivalent to the extraction tank Sterilized citric acid aqueous solution (0.5%, w / v) with 10 times the mass of the powder of Ganoderma lucidum fruiting body for lowering blood sugar, and stir evenly to make the fermentation base; the activated red monascus rubber (Monascusrubber) bacterial liquid is 10% The inoculum was in...

Example Embodiment

[0061] Example 2

[0062] (1) Raw materials: Ganoderma lucidum fruiting bodies and spore powder for lowering blood sugar;

[0063] (2) Raw material pretreatment: pulverize the blood sugar-lowering Ganoderma lucidum fruit body into powder with a particle size of about 30 meshes, and perform wall-breaking treatment on the blood-sugar-lowering Ganoderma lucidum spore powder, and detect that the wall-breaking rate is about 82%. Spore powder

[0064] (3) Fermentation and water extraction: Weigh 1kg of the hypoglycemic Ganoderma lucidum fruit body powder obtained in step (2), put it in a sterilized extraction tank, sterilize it by using ozone sterilization; then add equivalent to the extraction tank Sterilized citric acid aqueous solution (0.4%, w / v) with 6 times the mass of Ganoderma lucidum fruit body powder for lowering blood sugar, and stir it evenly to make the fermentation base; the activated Monascus pilosus (Monascus pilosus) bacterial solution is 10% The inoculum was inoculated ...

Example Embodiment

[0070] Example 3

[0071] (1) Raw materials: Ganoderma lucidum fruiting bodies and spore powder for lowering blood sugar;

[0072] (2) Raw material pretreatment: pulverize the blood sugar-lowering Ganoderma lucidum fruiting bodies into powder with a particle size of about 20 meshes, and perform wall-breaking treatment on the blood-sugar-lowering Ganoderma lucidum spore powder, and detect that the wall-breaking rate is about 91%. Spore powder

[0073] (3) Fermentation and water extraction: Weigh 50kg of the hypoglycemic Ganoderma lucidum fruit body powder obtained in step (2), place it in a sterilized extraction tank, sterilize it by ultraviolet radiation; then add the equivalent to the extraction tank Sterilized citric acid aqueous solution (0.8%, w / v) with 15 times the mass of the powder of Ganoderma lucidum fruiting body for lowering blood sugar, and stir it evenly to make the fermentation base; the activated purple Monascus purpureus (Monascus purpureus) bacterial liquid is 15% ...

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Abstract

The invention discloses a blood-glucose-lowering ganoderma lucidum instant micro-encapsulated preparation and a preparation method thereof. The method includes the specific steps of conducting monascus fermentation, water extraction, alcohol extraction, multi-stage micro-encapsulation, spray drying and granulating processes with blood-glucose-lowering ganoderma lucidum sporocarp and conidial powder as raw materials to prepare the blood-glucose-lowering ganoderma lucidum instant micro-encapsulated preparation. The blood-glucose-lowering ganoderma lucidum instant micro-encapsulated preparation prepared through the method brings the medicinal value of monascus and ganoderma lucidum into full play, functional components in blood-glucose-lowering ganoderma lucidum are efficiently enriched, the preparation process is green and mild, industrial production is easy, the obtained product has good water dispersity, storage stability and blood glucose lowering function, the use convenience of the product and the bioavailability in human bodies are effectively improved, guarantees are provided for development, application and consumption of the blood-glucose-lowering ganoderma lucidum product, and the preparation has great significance in promoting the development of the blood-glucose-lowering ganoderma lucidum industry and promoting the national health.

Description

technical field [0001] The invention belongs to the field of preparation of hypoglycemic ganoderma preparations, and specifically relates to a preparation method of a hypoglycemic ganoderma instant microencapsulated preparation, that is, a blood sugar-lowering ganoderma is used as a raw material, which is subjected to water extraction, alcohol extraction, multi-stage microencapsulation and co-fermentation A method for preparing hypoglycemic Ganoderma lucidum instant microencapsulated preparation by dry granulation. Background technique [0002] With the continuous improvement of people's living standards, the number of patients with hyperglycemia is increasing day by day. Diabetic complications and cardiovascular diseases caused by hyperglycemia seriously endanger human health. chronic non-communicable diseases. According to the World Health Organization and the International Diabetes Federation, by 2030, the total number of diabetic patients in the world will reach 366 mil...

Claims

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Application Information

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IPC IPC(8): A61K36/074A61K9/50A61P3/10
CPCA61K9/50A61K36/074A61K47/36A61K47/40A61K47/42A61K2236/19A61K2236/333A61K2236/39A61K2236/51A61K2236/53
Inventor 周庆新林范亮周瑾若
Owner RIZHAO POLYTECHNIC
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