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Submicroemulsion antifungal drug spray preparation

An antifungal drug and submicron emulsion technology, applied in the field of medicine, can solve the problems of inability to eradicate patients, achieve the effects of improving killing effect, increasing transdermal absorption, and enhancing drug efficacy

Inactive Publication Date: 2014-11-19
XIAN LIBANG ZHAOXIN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the current clinically used beriberi medicines cannot penetrate the cuticle of the skin and reach the lesion, so they cannot eradicate the disease.

Method used

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  • Submicroemulsion antifungal drug spray preparation
  • Submicroemulsion antifungal drug spray preparation
  • Submicroemulsion antifungal drug spray preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Example 1: Preparation of submicron emulsion products with different antifungal drug dosages

[0052] In Example 1, the dosage range of the listed chemically synthesized antifungal drugs in the prescription was verified. In this embodiment, only the nitrate of miconazole is taken as an example, but the dosage range is suitable for all the drugs listed in the claims. Under the technique and condition of the present invention, except that the consumption of lecithin consumption and miconazole nitrate are correspondingly adjusted in submicron emulsion prescription, other components and consumption remain constant, and the consumption of chemically synthesized medicine miconazole nitrate is by weight volume Any amount within the range of 0.005-1.2% is guaranteed to produce a stable final product. Although in principle miconazole nitrate can be made into a stable submicroemulsion liquid with a weight-to-volume ratio of less than 0.005%, its liquid concentration cannot reach...

Embodiment 11

[0053] Embodiment 1.1: Contain 0.005% miconazole nitrate by weight volume ratio in the submicron emulsion product

[0054] Submicroemulsion prescription (200mL submicroemulsion drug solution):

[0055]

[0056]

[0057] Add the prescribed amount of miconazole nitrate, lecithin, soybean oil, oleic acid, azone, vitamin E and peppermint oil into 20ml of ethanol, heat to 45°C and stir to dissolve completely. Take another 180ml of purified water and add glycerin. Under the condition of nitrogen protection, slowly add the ethanol drug solution into the aqueous glycerol solution stirred by a shearer at high speed (3000r / min), and continue stirring for 30min under the condition of nitrogen protection to obtain the colostrum solution. Homogenize 7-8 times with a high-pressure homogenizer, the pressure is 100MPa, until the particle size ranges from 180nm to 300nm, and the submicroemulsion drug solution is diluted with pure water to the final drug solution concentration to obtain ...

Embodiment 12

[0058] Embodiment 1.2: Contain 1.2% miconazole nitrate by weight volume ratio in the submicron emulsion product

[0059] Submicroemulsion prescription (200mL submicroemulsion drug solution):

[0060]

[0061] Add the prescribed amount of miconazole nitrate, lecithin, soybean oil, oleic acid, azone, vitamin E and peppermint oil into 40ml of ethanol, heat and stir until completely dissolved. Take another 160ml of purified water and add glycerin. Under the condition of nitrogen protection, slowly add the ethanol drug solution into the aqueous glycerol solution stirred by a shearer at high speed (3000r / min), and continue stirring for 30min under the condition of nitrogen protection to obtain the colostrum solution. Homogenize 7-8 times with a high-pressure homogenizer, the pressure is 100MPa, until the particle size ranges from 180nm to 300nm, and the submicroemulsion drug solution is diluted with pure water to the final drug solution concentration to obtain the final product....

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Abstract

The invention relates to a submicroemulsion antifungal drug spray preparation. The preparation mainly comprises the following components: an antifungal chemical synthetic drug, lecithin serving as an emulsifier, a transdermal absorption penetration enhancer and a skin protectant, soybean oil or other essential oils serving as an oil soluble diluent, glycerin serving as an isoosmotic adjusting agent, oleic acid serving as a co-emulsifier and a transdermal absorption penetration enhancer, azone serving as a transdermal absorption penetration enhancer, vitamin E serving as an antioxidant and a skin protectant, ethyl alcohol serving as a transdermal absorption penetration enhancer, natural essential oil serving as a transdermal absorption penetration enhancer, an antibacterial natural drug and essence. The submicroemulsion antifungal drug spray preparation has the advantages that the solubility and the uniformity of oil soluble antifungal drugs in water are increased, the transdermal absorption of the drugs is enhanced, the drugs are fed into dermis, and the absorption and utilization ratios of the drugs are increased, so that the effects of the antifungal drugs are increased; in the meantime, a cosolvent with side effects is avoided from being used, so that toxic and side effects caused by drugs entering whole body blood circulation systems and the stimulation to the skin are reduced, and the efficacies of protecting the skin and improving the looks are provided.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to an antifungal medicine spray preparation, in particular to a submicron emulsion antifungal medicine spray preparation. Background technique [0002] Athlete's foot, also known as Hong Kong's foot. The traditional Chinese medical science thinks that this disease is main symptom with foot chamber numbness, ache, weakness. According to its symptoms, it is mainly divided into dry beriberi, wet beriberi and beriberi rushing to the heart. At the beginning, dizziness and fatigue, fatigue and anorexia, pinpricks or ants crawling on the feet, distributed in a sock-like distribution, followed by muscle soreness, muscle weakness, skin dullness, muscle relaxation, contraction, and foot edema. In severe cases, palpitations, shortness of breath, tachycardia, enlarged heart, swelling and pain in the lower limbs, when the swelling and pain extend from the knee to the thigh, confusion, wheezing and vomiti...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K9/12A61K45/00A61P31/10
Inventor 惠民权刘红陈涛程薇薇杨晓莉
Owner XIAN LIBANG ZHAOXIN BIOTECH CO LTD
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