Embodiments of the disclosure provide ophthalmic compositions and methods of use thereof. The embodiments disclose ophthalmic compositions including devices such as a
punctal plug. Some embodiments are directed to a method of preparing and using such devices. One embodiment provides a method of dissolving a hydrophilic
polymer and an active pharmaceutical ingredient (API) in
alcohol to form a hydrophilic
polymer / API solution, where the API includes
tacrolimus,
spray drying the hydrophilic
polymer / API solution to form a hydrophilic polymer / API mixture, mixing the hydrophilic polymer / API mixture with a binder to form an API paste, and curing the API paste to form a
punctal plug, where the
punctal plug is configured to release an effective amount of the API for a
treatment period of 30 days to one year.