16 results about "Punctal plug" patented technology

The present invention discloses a sustained-release levofloxacin punctal plug and a preparation method thereof. The sustained-release levofloxacin punctal plug prepared by cross-linking levofloxacin, polyglycolide, chitosan, and polylysine and then plasma-treating the plug can reduce the frequency of antibiotic use or eliminate the need for antibiotics. The plug has good patient compliance, comfort, biocompatibility, short-term degradation, minimal side effects, good water swelling properties, and is not easily dislodged.

The present disclosure provides devices and methods for the treatment of ophthalmological conditions such as dry eye. Among the devices provided are punctal plugs and devices for inserting punctal plugs. The punctal plugs may be shaped for insertion in the punctum and / or the canaliculus. They may also be coated with a bioadhesive. Methods for inserting the punctal plugs are provided, as well as methods for preparing bioadhesive-coated punctal plugs. A method is also provided to treat dry-eye using a bioadhesive without use of a punctal plug.

Embodiments of the disclosure provide ophthalmic compositions and methods of use thereof. The embodiments disclose ophthalmic compositions including devices such as a punctal plug. Some embodiments are directed to a method of preparing and using such devices. One embodiment provides a method of dissolving a hydrophilic polymer and an active pharmaceutical ingredient (API) in alcohol to form a hydrophilic polymer / API solution, where the API includes tacrolimus, spray drying the hydrophilic polymer / API solution to form a hydrophilic polymer / API mixture, mixing the hydrophilic polymer / API mixture with a binder to form an API paste, and curing the API paste to form a punctal plug, where the punctal plug is configured to release an effective amount of the API for a treatment period of 30 days to one year.

The punctal plug insertion device of the present invention comprises: a catheter hub having a channel formed to contain a punctal plug; and a main body coupled to the catheter hub and including an external force application unit for applying an external force to the punctal plug contained in the catheter hub.

A punctum plug or lacrimal insert is constructed of a monolithic material, such that the punctum plug is configured to turn approximately 90 degrees upon insertion into a canaliculus of an eye. The punctum plug or lacrimal insert may include high-molecular-weight polysaccharide and added plasticizers.

The invention belongs to the field of medical instruments, and particularly relates to a degradable tracing punctum plug and a preparation method and application thereof. The preparation method comprises the steps that polylactic acid and a coloring agent are mixed to obtain colored polylactic acid; mixing the colored polylactic acid with an alkaline inorganic filler to obtain a mixture; carrying out segmented temperature control injection molding treatment on the mixture to obtain an injection molding product; the injection molding product is treated for 5-120 s under the conditions of 25-40 DEG C and 20-50 Mpa, and a punctal plug precursor is obtained; and carrying out heat preservation treatment on the punctum plug precursor to obtain the degradable tracing punctum plug. According to the preparation method, raw materials are easy to obtain, the process is simple, the alkaline inorganic filler regulates and controls the degradation rate and inhibits inflammation caused by an acidic product generated by degradation of polylactic acid in the use process of the punctal plug, intraoperative visual tracing and positioning are achieved through the coloring agent, and the crystallinity of the material is improved through the low-temperature pressure maintaining process; the problems of brittle fracture and uncontrollable degradation rate of the degradable punctum plug are solved, and the degradable punctum plug has a wide prospect in minimally invasive treatment of xerophthalmia.

The present disclosure provides devices and methods for the treatment of ophthalmological conditions such as dry eye. Among the devices provided are punctal plugs and devices for inserting punctal plugs. The punctal plugs may be shaped for insertion in the punctum and / or the canaliculus. They may also be coated with a bioadhesive. Methods for inserting the punctal plugs are provided, as well as methods for preparing bioadhesive-coated punctal plugs. A method is also provided to treat dry-eye using a bioadhesive without use of a punctal plug.

The invention discloses a polyvinyl alcohol hydrogel punctal plug and a preparation method thereof. The two ends of the punctum plug are provided with a cap structure and an anchor structure respectively, the middle of the punctum plug is provided with a conical shaft structure with round ribs, and no central blind hole is formed. As the punctal plug is small in volume, the punctal plug is prepared by a method of combining injection molding, double crosslinking of physical crosslinking and chemical crosslinking, an excipient gradient soaking and shaping process and the like, the obtained punctal plug is uniform in crosslinking and stable in form, and can be quickly expanded after being implanted, and the risks of separation and bacterial infection are reduced.

The present invention relates to: a punctal plug comprising a shape memory polymer; and a manufacturing method thereof. More specifically, the present invention relates to: a punctal plug made of a shape memory polymer, which includes a copolymer of lactone and glycidyl methacrylate, and located in a punctal opening of a lacrimal duct to prevent lacrimal fluid from flowing in the lacrimal duct; and a manufacturing method thereof. The punctal plug according to the present invention is made of a material having biocompatibility and shape memory properties, and thus has the advantages of being easy to insert and simple to fix, and being easy to remove by a head formed at the top of an insert. In addition, the copolymer of lactone and glycidyl methacrylate is appropriately blended, and thus the punctal plug can be applied to the lacrimal duct without causing a foreign body sensation. Moreover, the punctal plug can block the punctum without becoming dislodged even under everyday pressure generated by sneezing and the like, and thus can be effectively used in punctal occlusion procedures.

A punctum plug or lacrimal insert is constructed of a monolithic material, such that the punctum plug is configured to turn approximately 90 degrees upon insertion into a canaliculus of an eye. The punctum plug or lacrimal insert may include high-molecular-weight polysaccharide and added plasticizers.

A medical device may comprise a body including a mixture of polyvinylpyrrolidone (“PVP”) and mitomycin. The medical device may be in any size or shape such that the medical device may be inserted into living tissue, including, but not limited to, a lacrimal punctal plug and a stent. The mixture of PVP and mitomycin may be coated on a portion of the medical device, contained within a cavity on the medical device, disposed on the surface of the medical device or configured as part of the medical device such that the mixture of PVP and mitomycin can be delivered to tissue.

The utility model provides a lacrimal point plug implanter without expanding a lacrimal point, which belongs to the technical field of ophthalmology treatment and comprises a lacrimal point plug, a release component is arranged at the tail of the lacrimal point plug, and an implanter main body component is slidably connected into the release component. The problems that an existing lacrimal point plug implanting device is relatively large in clinical operation difficulty, lacrimal point expansion is not in place, a lacrimal point plug is difficult to implant, the operation time is prolonged, the pain of a patient is increased, the lacrimal point plug can fall off in the expansion process, the size of the lacrimal point plug is extremely small, the lacrimal point plug cannot be found after falling off, and the practicability of the device is reduced are solved.

The utility model discloses a punctum plug extractor, which relates to the technical field of medical instruments and comprises an expander and an implanter, the implanter and the expander are detachably connected into an integral structure, an expansion tip and an implantation column are respectively arranged at the ends of the expander and the implanter far away from the butt joint, a through air passage is arranged in the middle of the expander, and a through hole is formed in the middle of the implanter. The air channel is provided with an air inlet at the dilation tip, and the other end is provided with a negative pressure connecting end. The device further comprises a negative pressure generator, and after the dilator and the implanter are separated, the negative pressure generator can be connected to the negative pressure connecting end, negative pressure is formed in the airway, and the negative pressure is used for adsorbing a punctum plug in punctum tissue. The negative pressure is formed in the lacrimal plug, the lacrimal plug is adsorbed and taken out from the lacrimal tissue, the lacrimal plug does not need to be taken out in a saline water washing mode, discomfort when the lacrimal plug is taken out can be relieved, and meanwhile the taking-out efficiency of the lacrimal plug can be improved.

The utility model discloses a punctum plug, which relates to the technical field of medical machinery and comprises a middle shaft, a conical head is arranged at one end of the middle shaft, an arc top is arranged at the other end of the middle shaft, a concave hollow groove is arranged between the conical head and the middle shaft, and a lower cambered surface with a slope-shaped cross section is arranged on one side of the conical head, which is positioned on the hollow groove. A spherical groove with a circular cross section is formed in the root of the hollow groove; a concave upper cambered surface is arranged on one side, corresponding to the conical head, of the arc top. The thickened lower cambered surface is arranged in the hollow groove, the spherical groove is formed in the bottom of the hollow groove, the supporting strength of the side portion of the conical head can be effectively improved, deformation of the conical head is avoided, the risk of cracking of the conical head is reduced, and the lacrimal point plug can be conveniently placed into the lacrimal passage. The upper portion of the conical head and the lower portion of the arc top can be tightly clamped and attached to the lacrimal passage tissue, and the risk that the punctum plug falls off can be reduced.

The embodiment of the invention provides an implantable detection device for a tear disease marker, and the device is characterized in that a flexible rollable substrate for bearing a wireless transmission module and an electrochemical sensing module is attached to the surface of a punctum plug; the wireless transmission module comprises an antenna coil, the electrochemical sensing module comprises a working electrode, and the surface of the working electrode is modified with an organic probe; after the device is implanted into a lacrimal ductule of a patient, the antenna coil converts radio frequency field energy sent by terminal equipment into an electric signal and sends the electric signal to the working electrode; after the working electrode receives the electric signal, when the organic probe is combined with a target disease marker in tear, the working electrode sends detection information to the antenna coil, and the antenna coil sends the detection information to terminal equipment. The device can detect the disease marker in real time, avoids sampling and component extraction processes, improves the detection efficiency, and reduces the labor cost of sampling; the device is low in equipment cost and easy to process and produce in batches; the device is implanted in a non-invasive mode, and harm to the human body can be avoided.