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Super-lubricating serum albumin punctal plug and preparation method thereof

A technology of serum albumin and punctal plug, which is applied in the field of medical devices, can solve the problems of not being able to reach the eyes with tears, blockage of lacrimal ducts, and outflow of tears, so as to relieve pain, reduce injuries and prevent complications

Inactive Publication Date: 2016-08-24
HANGZHOU YAHUI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

First, the tear duct of the lacrimal gland may become blocked or may malfunction so that a sufficient amount of tears cannot reach the eye
Second, although the lacrimal glands and tear ducts can deliver adequate quantities of tears to the eyes, the tears can flow out of the eyes too quickly, resulting in a dry eye condition
Since it is sometimes difficult to determine whether dry eye is caused by excessive outflow or by too little tear production, this approach can be unnecessarily traumatic for the patient, as epiphora

Method used

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  • Super-lubricating serum albumin punctal plug and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Prepare a solution system for dissolving serum albumin: take each component according to volume percentage, 0.1M ammonia water 10%, 1% mercaptoethanol, and the rest is trifluoroethanol, stir to make it fully mixed; dissolve serum albumin in the above solution, Contain 25% (w / v) serum albumin in the final serum albumin solution, gently stir with a magnetic bar for 30 minutes, use a vacuum pump to pump air for 30 minutes to eliminate the bubbles; leave the serum albumin solution at room temperature, after 48h, pour Remove the upper layer of liquid, add the lower layer of serum albumin solution with higher viscosity into the mold, and dry it overnight in the air at room temperature; open the mold, take it out, soak it in the succinimide propionate-based polyethylene glycol solution, The concentration is 10% (w / v), washed with deionized water to pH = 7.0, and dried at 25° C. to prepare super-lubricating serum albumin punctal plugs.

Embodiment 2

[0029] Prepare a solution system for dissolving serum albumin: take each component according to volume percentage, 0.1M ammonia water 10%, 1% mercaptoethanol, and the rest is trifluoroethanol, stir to make it fully mixed; dissolve serum albumin in the above solution, Contain 35% (w / v) serum albumin in the final serum albumin solution, gently stir with a magnetic bar for 30 minutes, and use a vacuum pump to pump air for 30 minutes to eliminate the bubbles; leave the serum albumin solution at room temperature, after 48 hours, pour Remove the upper layer of liquid, add the lower layer of serum albumin solution with higher viscosity into the mold, and dry it overnight in the air at room temperature; open the mold, take it out, soak it in the succinimide propionate-based polyethylene glycol solution, The concentration was 10% (w / v), washed with deionized water to pH = 7.0, and dried at 37° C. to prepare super-lubricating serum albumin punctal plugs.

Embodiment 3

[0031] Prepare a solution system for dissolving serum albumin: take each component according to volume percentage, 0.1M ammonia water 10%, 1% mercaptoethanol, and the rest is trifluoroethanol, stir to make it fully mixed; dissolve serum albumin in the above solution, The final serum albumin solution contains 45% (w / v) serum albumin, stirred gently with a magnetic bar for 30 minutes, and evacuated with a vacuum pump for 30 minutes to eliminate the bubbles; the serum albumin solution was allowed to stand at room temperature, and after 48 hours, poured Remove the upper layer of liquid, add the lower layer of serum albumin solution with higher viscosity into the mold, and dry it in the air at room temperature overnight; open the mold, take it out, soak it in the succinimide succinate-based polyethylene glycol solution, The concentration was 10% (w / v), washed with deionized water to pH = 7.0, and dried at 37° C. to prepare super-lubricating serum albumin punctal plugs.

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Abstract

The invention discloses a super lubricating serum albumin punctal plug. The punctal plug of the present invention has a main body (2), a first segment (1), a second segment (3) and a super lubricating coating (4). The surface of the serum albumin punctal plug is soaked in a hydrophilic polymer solution to form a hydrophilic polymer coating through a chemical reaction. When in contact with water, the hydrophilic group of the water-soluble polymer combines with water to swell rapidly , has excellent lubricating properties, can reduce the damage to soft tissue when the punctal plug is implanted, relieve pain, and prevent complications, so it is more suitable for clinical application.

Description

technical field [0001] The invention belongs to the field of medical devices, and in particular relates to a superlubricating serum albumin punctal plug and a preparation method thereof. Background technique [0002] The tear film has a complex structure that protects the surface of the eye. The tear film consists of three basic layers: an outer lipid layer, an inner mucin layer, and an aqueous layer between the lipid and mucin layers. Each layer has a specific function. The lipid layer prevents tear fluid from evaporating from the surface of the eye. The aquifer supplies oxygen to the cornea and contains other chemical components that are important for healthy eyes. The mucin layer maintains the interaction between the lipid layer and the aqueous layer and prevents tear beads from beading on the cornea. [0003] "Dry eye" is a condition that suffers from insufficient corneal wetting due to disturbances in the normal tear film. The condition encompasses a wide variety o...

Claims

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Application Information

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IPC IPC(8): A61L31/04A61L31/10A61L31/14A61F9/007
CPCA61F9/00772A61L31/047A61L31/10A61L31/14
Inventor 汪伟李丹何铭锋朱家喜俞益雷李绿巍许利利朱明华
Owner HANGZHOU YAHUI BIOTECH CO LTD
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