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Medicinal composition for preventing and curing intracranial hypertension

A technology for increased intracranial pressure and intracranial pressure, applied in the field of application of piracetam in the preparation of drugs for preventing and preventing increased intracranial pressure

Inactive Publication Date: 2003-06-18
ZHUHAI HEFAN MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is used as the main component to prepare a pharmaceutical composition for preventing and treating increased intracranial pressure, and there is no record in domestic and foreign patent documents.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Example 1 Preparation of piracetam injection with piracetam as active ingredient

[0014] Take: Piracetam 200g

[0015] Sodium chloride 9g

[0016] Add water for injection to 1000ml

[0017] Preparation method: Dissolve piracetam and sodium chloride with 2 / 3 prescription amount of water for injection, stir evenly, add water for injection to dilute to the full amount, add activated carbon for decolorization for 30 minutes, filter to remove carbon, measure the content of semi-finished products, and adjust the pH value After passing the test, fine filter to obtain a clear medicinal solution, potting, steam sterilization at 100°C for 30 minutes, and the finished product.

Embodiment 2

[0018] Example 2 Preparation of compound piracetam injection with piracetam and mannitol as main components

[0019] Take: Piracetam 160g

[0020] Sodium chloride 9g

[0021] Mannitol 40g

[0022] Add water for injection to 1000ml

[0023] Preparation method: Dissolve piracetam, sodium chloride and mannitol with 2 / 3 prescription amount of water for injection, stir evenly, add water for injection to dilute to the full amount, add activated carbon for decolorization for 30 minutes, filter to remove carbon, measure the content of the semi-finished product, After the PH value is adjusted to pass, it is finely filtered to obtain a clear medicinal solution, which is potted and steam sterilized at 100°C for 30 minutes to become a finished product.

Embodiment 3

[0024] Example 3 Preparation of compound piracetam injection with piracetam and β-escin sodium as main components

[0025] Take: Piracetam 160g

[0026] Sodium chloride 9g

[0027] β-Aescin Sodium 10mg

[0028] Add water for injection to 1000ml

[0029] Preparation method: Dissolve piracetam, sodium chloride and β-escin sodium in 2 / 3 prescription water for injection, stir evenly, add water for injection to dilute to the full amount, add activated carbon for decolorization for 30 minutes, filter to remove carbon, Measure the content of the semi-finished product, adjust the PH value to pass the fine filtration, obtain a clear liquid medicine, potting, steam sterilization at 100°C for 30 minutes, and become the finished product.

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PUM

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Abstract

This invention relates to the medicinal composition for prevention and cure of intracranial hypertension, which contains piracetam (1-acetamido-2ketone-pyrrolidine) and the carrier tolerable to pharmaceutics. It can further contain osmotic diuretic such as mannitol,etc.; or anti-tissue exuedative medicine such as esculin sodium; or the medicine such as nitroglycerin, sodium nitroprusside, etc. used for resulting in controllable hypotension.

Description

(1) Technical field [0001] The present invention relates to the application of the compound "1-acetamido-2-keto-pyrrolidine" in the manufacture of medicines. (2) Background technology [0002] After traumatic brain injury, cerebral hemorrhage, cerebral infarction, meningitis, brain tumor and other injuries, as well as brain surgery, patients have different degrees of increased intracranial pressure due to brain parenchymal edema or space-occupying lesions. The degree and duration of increased intracranial pressure have a significant impact on the outcome and prognosis of the disease, and should be treated promptly and effectively. The drugs currently used to treat increased intracranial pressure are mainly osmotic diuretics such as mannitol. This kind of medicine is not only used in a large amount and requires rapid intravenous drip, but also increases the heart load due to the increase in circulating blood volume, which is extremely unfavorable to patients with poor heart ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/40A61P9/12
Inventor 许绍衡
Owner ZHUHAI HEFAN MEDICINE
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