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Colloid brain parenchyma preparing method and physical brain model

A physical model and brain parenchyma technology, applied in the field of medical models, can solve problems such as poor repeatability of experiments, difficulty in analyzing the process and characteristics of temperature changes, complex and dangerous operations, etc., and achieve the effect of stable performance and repeatable experiments

Active Publication Date: 2015-12-30
ZHEJIANG UNIV
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the complex structure of the brain, it is very difficult to analyze the process and characteristics of temperature changes from a theoretical point of view, and direct research on the brain in vivo requires a craniotomy experiment, which is complicated and dangerous to operate, and the repeatability of the experiment is poor due to individual differences in the human body.

Method used

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  • Colloid brain parenchyma preparing method and physical brain model

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Embodiment

[0028] Embodiment: the preparation process of a kind of colloidal brain parenchyma of the present embodiment, comprises the following steps:

[0029] 1) Preparation of 1 liter of TBS buffer solution: The function of TBS buffer solution is to keep the pH in the colloid stable for a long time and avoid the growth of bacteria. Mix 24.2 grams of Tris base and 80 grams of NaCl, add deionized water to make a solution to 1L, use a certain concentration of hydrochloric acid solution to adjust the pH value of the mixed solution to about 7.6, and then seal the solution and put it in a sterilizer at 120°C Sterilize at high temperature for 10-20 minutes, take it out after cooling and use it. When not in use, it must be stored at low temperature.

[0030] 2) Configuration of 2% agar powder solution: Use a measuring cup to measure 100ml of TBS buffer solution and 900ml of deionized water (volume ratio is 1:9) and mix them, weigh 20.0 grams of agar powder with an electronic scale and add to...

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PUM

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Abstract

The invention discloses a colloid brain parenchyma preparing method and a physical brain model. The physical brain model comprises a scalp part, a skull part, colloid brain parenchyma, a power control module, a data collecting module and a blood circulation simulating module. The scalp part is attached to the outer surface of the skull part. The interior of the skull part is poured with the colloid brain parenchyma. A heating nickel wire, a plurality of temperature sensors and a plurality of capillary copper tubes are distributed in the colloid brain parenchyma. The heating nickel wire is electrically connected with the power control module. The temperature sensors are electrically connected with the data collecting module. The capillary copper tubes are intersected with two thick copper tubes. The thick copper tubes penetrate through a foramen magnum to be connected to the blood circulation simulating system. The blood circulation simulating system cyclically inputs liquid with the temperature the same as that of blood into the capillary copper tubes. The heating nickel wire emits heat under the control of the power control module. The temperature sensors detect the temperature of all the portions of the brain and transmit the temperature to the data collecting module. The scheme is suitable for researching and testing changes of the temperature in the brain.

Description

technical field [0001] The invention relates to the field of medical models, in particular to a method for preparing colloidal brain parenchyma and a physical model of the brain based on real shape and thermodynamic characteristics. Background technique [0002] Temperature has a major impact on the treatment of brain injuries. Studies have shown that temperature has an important impact on many factors such as blood perfusion rate and intracranial pressure after brain injury, and reducing the temperature of the brain can effectively improve the therapeutic effect. From the perspective of neurobiology, the hypothermia treatment of the brain is to reduce the activity of cells by physical means, thereby reducing the oxygen demand and metabolic rate of the brain, and protecting brain cells. Other studies have shown that low temperature can also inhibit the harmful biochemical reactions to the brain after brain injury, inhibit the inflammation caused by the injury, and thus achi...

Claims

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Application Information

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IPC IPC(8): G01N25/20
Inventor 张武明王颖哲熊先胤邓鸿超
Owner ZHEJIANG UNIV
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