Application method of natural plant pepper extract

A technology of prickly ash extract and natural plant, applied in the field of skin anti-allergy and antipruritic active ingredients, can solve problems such as damage to the gastrointestinal digestive system, inability to fundamentally improve allergic physique, etc., and achieve the effect of less side effects

Active Publication Date: 2009-12-30
晟薇药业(上海)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the currently synthesized antihistamines have side effects such as drowsiness, thirst, and damage to the gastrointestinal digestive system in clinical use, and there are

Method used

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  • Application method of natural plant pepper extract
  • Application method of natural plant pepper extract
  • Application method of natural plant pepper extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Get 100g of Zanthoxylum bungeanum, extract solvent A as pure water, configure eluent B: deionized water, C: 70% methanol aqueous solution (V / V), select non-polar resin: HPD100, original drug: extract solvent: resin: wash Eluent B: Eluent C=1:10:3:9:12.

[0027] Crush Zanthoxylum bungeanum, extract with extraction solvent A at 30°C for 72 hours, concentrate to a medicinal solution with a crude drug concentration of about 1mg / ml, absorb by HPD100, elute with B, discard the eluent, and collect eluent C for elution part. Concentrate to an extract to obtain pepper extract.

Embodiment 2

[0029] Get 100g of Zanthoxylum bungeanum, extract solvent A as pure water, configure eluent B: deionized water, C: 70% methanol aqueous solution (V / V), select non-polar resin: HPD100, original drug: extract solvent: resin: wash Eluent B: Eluent C=1:10:3:12:9.

[0030] Crush Zanthoxylum bungeanum, extract with extraction solvent A at 50°C for 5 hours, concentrate to a medicinal solution with a crude drug concentration of about 1 mg / ml, absorb by HPD100, elute with B, discard eluent B, collect eluent C and wash Disjointed. Concentrate to an extract to obtain pepper extract.

Embodiment 3

[0032] Get Zanthoxylum bungeanum 100g, extraction solvent A is pure water, configure eluent B: deionized water, C: 70% ethanol aqueous solution (V / V), select non-polar resin: HPD100, former medicine: extraction solvent: resin: wash Eluent B: Eluent C=1:8:2:9:12.

[0033] Crush Zanthoxylum bungeanum and extract three times with extraction solvent A at 80°C, each time for 2 hours, concentrate to a medicinal solution with a crude drug concentration of about 1 mg / ml, absorb by HPD100, elute with B, discard eluent B, collect and wash Deagent C elution section. Concentrate to an extract to obtain pepper extract.

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Abstract

The invention relates to an application method of a natural plant pepper extract. In the application method, the natural plant pepper extract is applied to medicines, cosmetics and health-care foods for suppressing histamine release. The invention adopts a test model suppressing the histamine release of mass cells and validates the irritability-resisting and itching-relieving effects of the natural plant pepper extract.

Description

technical field [0001] The invention relates to an effective active ingredient for anti-allergic and antipruritic skin, the active ingredient is a natural plant Zanthoxylum bungeanum extract, in particular to an application method of the natural plant Zanthoxylum bungeanum extract. Background technique [0002] Epidemiological surveys in recent years have shown that allergic diseases have an increasing trend year by year, especially allergic reactions caused by environmental factors and anti-hereditary atopic dermatitis, which have become a social phenomenon that cannot be ignored. The emergence of its problems is not only due to the increase of allergens, air pollution, abuse of food and cosmetic additives, but also due to changes in people's eating habits in recent years. The treatment of allergic diseases is usually based on the elimination of allergens, and then selective drug treatment is carried out according to the degree, cause and pathogenesis of clinical symptoms. ...

Claims

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Application Information

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IPC IPC(8): A61K36/758A61K8/97A61Q19/00A23L1/30A61P37/08A61P17/04A23L33/105
Inventor 李成亮
Owner 晟薇药业(上海)有限公司
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