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Compound chlorhexidine acetate spray

A technology of chlorhexidine acetate and compound acetic acid, which is applied in the field of secondary infection, can solve the problems of contact dermatitis, small range of indications, inconvenient use, etc., and achieves the effects of increasing absorption function, wide indications, and convenient storage.

Inactive Publication Date: 2004-12-29
BEIJING KANGBIDE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compound chlorhexidine dusting powder and other antipruritic powder products for external use are easy to gather together with inflammatory exudate or sweat, causing irritation to the skin, and the dusting type products are inconvenient to use, and are easy to scatter on clothes and pollution in the surrounding environment
Rubber plaster products are prone to folliculitis and contact dermatitis at the site of application. They are not suitable for long-term use. They can cause local skin atrophy and telangiectasia, and are not suitable for use in hot and humid seasons or environments.
Antipruritic and anti-inflammatory water and other topical solutions are mainly aimed at skin pruritus caused by summer dermatitis or prickly heat, with a small range of indications, slow effect and high recurrence frequency

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0035] This example is the antibacterial test of compound chlorhexidine acetate spray. The compound chlorhexidine acetate liquid spray was provided by Beijing Keer Pharmaceutical Co., Ltd.

[0036] This test is to use ATCC standard strains and clinical screening strains to carry out antibacterial test on compound chlorhexidine acetate spray. The result is as follows:

[0037] 1. Materials and methods

[0038] (1) Source of strain: ATCC standard strain provided by China Institute for the Control of Pharmaceutical and Biological Products:

[0039] 32209 A-hemolytic streptococcus (streptococci)

[0040] 29106 Neisseria gonorrhoeae (standard strain)

[0041] 44113 Escherichia coli (Escherichia coli)

[0042] 26112 Staphylococcus aureus (S. aureus)

[0043] 10211 Pseudomonas aeruginosa (Pseudomonas aeruginosa)

[0044] Clinical isolates were identified and confirmed:

[0045] Neisseria gonorrhoeae (isolate)

[0046] Staphylococcus epidermidis (S. epidermidis)

[0047] (2)...

example 2

[0070] (1) Weigh 10g each of borneol and menthol, grind and dissolve in a mortar, and then add 100ml of 95% ethanol to dilute.

[0071] (2) Chlorhexidine acetate 1g, add 20ml 95% ethanol to dissolve it, dilute it with 380ml ethanol and mix it with the diluent in step 1, add essence, then add distilled water 500ml, mix to obtain a concentration of chlorhexidine containing acetic acid Hexidine 0.1% compound chlorhexidine acetate solution.

[0072] (3) The solution that step (2) is obtained is poured in the bottle that nozzle is arranged, and tightening nozzle is the required compound chlorhexidine acetate spray.

example 3

[0074] (1) Weigh 3g each of borneol and menthol, grind and dissolve in a mortar, and then add 100ml of 95% ethanol to dilute.

[0075] (2) Chlorhexidine acetate 0.5g, add 20ml 95% ethanol to dissolve it, dilute it with 380ml ethanol and then mix it with the diluent in step 1, add essence, then add distilled water 500ml, mix to obtain the concentration of acetic acid Chlorhexidine 0.05% compound chlorhexidine acetate solution.

[0076] (3) The solution that step (2) is obtained is poured in the bottle that nozzle is arranged, and tightening nozzle is the required compound chlorhexidine acetate spray.

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PUM

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Abstract

The compound Chlorhexidinum acetate spray is prepared with Chlorhexidinum acetate, borneol, menthol, ethanol, essence and distilled water as material. Daily use and clinical observation shows that the spray may be used widely in treating various skin pruritus caused by different causes, including insect bite, irritability, eczema, etc. The present invention is one kind of safe, reliable, externally applied medicine with determined treating effect and low cost.

Description

technical field [0001] The present invention relates to external medicine for treating skin diseases, more specifically, compound chlorhexidine acetate spray is applied to skin pruritus caused by various reasons, skin redness and swelling caused by mosquito bites, prickly heat and secondary infection caused by prickly heat . Background technique [0002] Pruritus is a common skin disease. At present, the common antipruritic drugs for external use on the market mainly include compound chlorhexidine powder, compound thymol powder, frost prickly heat powder, prickly heat powder, camphor eucalyptus fluoride easy plaster, antipruritic and anti-inflammatory water, big maple oil, etc. Variety. Compound chlorhexidine dusting powder and other antipruritic powder products for external use are easy to gather together with inflammatory exudate or sweat, causing irritation to the skin, and the dusting type products are inconvenient to use, and are easy to scatter on clothes and Pollut...

Claims

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Application Information

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IPC IPC(8): A61K9/12A61K31/155A61P17/04
Inventor 刘丽平韩妍妍宋志刚
Owner BEIJING KANGBIDE PHARMA
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