44results about How to "Increase the effective amount" patented technology

The present invention is directed to a pharmaceutical composition that includes a combination of about 2-5 milligrams of a non-steroidal anti-inflammatory drug and from about 2-30 milligrams of an opioid analgesic in a single pharmaceutical dosage unit that can provide effective pain management with the added benefit of reduced side effects such as withdrawal and gastrointestinal disorders. The non-steroidal anti-inflammatory drug may be piroxicam and the opioid analgesic may be buprenorphine. The present invention also provides for a method of managing pain in a patient that includes administering the pharmaceutical composition previously described. The pharmaceutical composition previously described may be administered in a single or multiple dosage regimen.

Renewable energy sources provide electricity without consuming fossil fuels and contributing to emissions that impact the global environment. Unlike wind and water methods solar photovoltaic generators provide this renewable energy without geographic or meteorological limitations. However, today electricity generation from solar using photovoltaics is more expensive than fossil fuel sources and is generally limited to deployments with large planar photovoltaic panels. According to embodiments of the invention concentrator based azimuth-altitude tracking solar power generators are provided offering reduced electricity generation costs, reduced installation costs, increased flexibility in deployment and locations of deployment, and initial system costs. The optical assembly comprises a concentrating lens and a reflector to couple the solar radiation to the photovoltaic cell. The concentrating lens is offset out of the plane parallel to the photovoltaic cell whilst the reflector and the reflector may be disposed angularly offset to an axis perpendicular to the photovoltaic cell.

The invention provides conditioning powder suitable of being eaten by a diabetic patient. The conditioning powder comprises 6-12 parts of water-soluble dietary fiber extractive, 0.1-1 part of wheat germ extractive, 0.1-1.5 parts of soybean protein isolate, 1-3 parts of secalin, 0.5-2 part of vegetable fat powder, 0.2-1.5 parts of Chinese yam extractive, 0.2-1 part of sealwort extractive, 0.2-1 part of mulberry leaf extractive, 0.2-1 part of polygonatum odoratum extractive, 0.1-1 part of medlar extractive, 0.1-0.3 part of flaxseed gum, 0.5-2 parts of L-arabinose, 0.09-0.3 part of yeast and 0.001-0.006 part of zinc gluconate. The conditioning powder is low in carbohydrate content, has abundant nutrients, is particularly suitable for serving as food of the diabetic patent, has the remarkable hypoglycemic effect and the conditioning function, has the prevention and treatment functions on various diabetic complications, and particularly has the good conditioning effect on a diabetes type nephropathy patient. The nutrients of the conditioning powder are easy to digest and absorb. The conditioning powder is convenient to eat and good in taste.

A rotor includes a rotor core having a plurality of pairs of magnet-receiving holes and a plurality of magnets respectively received in the magnet-receiving holes. Each pair of the magnet-receiving holes is arranged in a substantially V-shape that opens toward a stator side. The rotor core has, for each of the magnet-receiving holes, a magnetic flux barrier that is formed, at a magnetic pole centerline-side end of a stator-side wall surface of the magnet-receiving hole, so as to protrude from the stator-side wall surface toward the stator side. The protruding height H of the magnetic flux barrier from the stator-side wall surface is set to be in the following range: 0.12×R≦H 0.29×R, where R is the minimum distance from an intersection P1, which is between the magnetic pole centerline and a rotor-side circumferential surface of the stator, to the stator-side wall surface of the magnet receiving hole.

The invention provides a superparamagnetic nanoparticle Fe3O4@SiO2@PSA modified by the PSA and a preparing method and application of the superparamagnetic nanoparticle Fe3O4@SiO2@PSA modified by the PSA. According to the superparamagnetic nanoparticle Fe3O4@SiO2@PSA modified by the PSA and the preparing method and application of the superparamagnetic nanoparticle Fe3O4@SiO2@PSA modified by the PSA, silylanization is conducted on the surface of superparamagnetic nanoparticle Fe3O4, a silylating reagent with a PSA structure is bonded, and thus a PSA group is introduced. The superparamagnetic nanoparticle Fe3O4@SiO2@PSA modified by the PSA and the preparing method of the superparamagnetic nanoparticle Fe3O4@SiO2@PSA modified by the PSA can be applied to the magnetic solid-phase extraction (M-SPE) field, and the superparamagnetic nanoparticle Fe3O4@SiO2@PSA modified by the PSA can serve as an adsorbent which is frequently used for magnetic solid-phase extraction, be applied to various pesticides such as carbamic acid ester, the organophosphorus pesticide and the herbicide and be used for absorption and extraction of target objects such as sulfonamides, organic acid and saccharides; meanwhile, the functional group of the PSA is a good binary ligand, in this way, the PSA is a good chelation material, can be used for extraction of metal ions and has high practical value and broad application prospect in the aspect of analytical investigation.

A method for enhancing glycemic control and/or insulin sensitivity in a human subject having diabetic nephropathy and/or metabolic syndrome comprises administering to the subject a selective endothelin A (ET_A) receptor antagonist in a glycemic control and/or insulin sensitivity enhancing effective amount. A method for treating a complex of comorbidities in an elderly diabetic human subject comprises administering to the subject a selective ET_A receptor antagonist in combination or as adjunctive therapy with at least one additional agent that is (i) other than a selective ET_A receptor antagonist and (ii) effective in treatment of diabetes and/or at least one of said comorbidities other than hypertension. A therapeutic combination useful in such a method comprises a selective ET_A receptor antagonist and at least one antidiabetic, anti-obesity or antidyslipidemic agent other than a selective ET_A receptor antagonist.

Oligomers of L-arginine may be used to provide prophylactic or therapeutic cosmetic or other enhancements to keratinous tissues such as skin, hair, lips and gums through vasodilation. Topical compositions preferably comprise (a) an enhancing effective amount of an oligomer having from 7 to 15 subunits, each subunit consisting of a member of the group selected from L-arginine and physiologically acceptable salts of L-arginine that enhance vasodilation through production of nitric oxide, and (b) a cosmetically or dermatologically acceptable vehicle.

Described herein are aminopyrazole compounds of formula I:

wherein R¹, R², L and Ar are as defined in the specification. Such compounds are capable of modulating the activity of a checkpoint kinase and methods for utilizing such modulation to treat cell proliferative disorders. Also described are pharmaceutical compositions containing such compounds. Also described are the therapeutic or prophylactic use of such compounds and compositions, and methods of treating cancer as well as other diseases associated with unwanted cellular proliferation, by administering effective amounts of such compounds in combination with anti-neoplastic agents.

The invention discloses a construction method and a sequencing method of a genetic typing sequencing library. The construction method comprises the following steps: S1, bonding sample label sequences at the two ends of a first enzyme digestion fragment while a gene group DNA is subjected to enzyme digestion for the first time to produce the first enzyme digestion fragment so as to obtain a first enzyme digestion fragment with a label; S2, performing PCR amplification on the first enzyme digestion fragment by utilizing an amplification primer with a library label sequence to obtain the gene typing sequencing library. According to the construction method, the sample label sequences are directly bonded at the two ends of the first enzyme digestion fragment while the gene group DNA is subjected to enzyme digestion for the first time to produce the first enzyme digestion fragment, so that the constructed library can directly get into the next step of reading a target enzyme digestion fragment sequence after the sample label information is read during sequencing by a computer, and the reading length of the target enzyme digestion fragment sequence is increased, the invalid data volume is reduced, and the effective quantity of sequencing data is increased.

The invention relates to the use of cyclic Prolyl Glycine (“cyclic PG” or “cPG”) and analogs and mimetics thereof, as neuroprotective agents for the treatment and or prevention of neurological disorders including but not limited to cerebral ischemia or cerebral infarction resulting from a range of phenomena, such as thromboembolic or hemorrhagic stroke, cerebral basospasms, hypoglycemia, cardiac arrest, status epilepticus, perinatal asphyxia, anoxia such as from drowning, pulmonary surgery, and cerebral trauma, as well as to the treatment and prevention of chronic neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, and as anticonvulsants.

The present disclosure provides systems and methods that combine direct capture of one or more moieties from a gaseous mixture with one or both of calcium oxide production and power production. The systems and methods can utilize combinations of a capture unit, a regeneration unit, a calcination unit, a slaking unit, a heat exchange unit, a separation unit, and a power production unit. The present disclosure provides the ability to remove carbon dioxide and other moieties from air or other gaseous mixtures in a truly carbon negative manner by utilizing electricity from a power production unit that is operated in a carbon neutral or carbon negative manner and simultaneously provide useful products, such as calcium oxide and calcium hydroxide.

A means for increasing the amount of an effective component retained in a composition for a pump foamer is provided. The present invention provides a composition for external use containing: 1) an N-alkyl-2-pyrrolidone and/or a diester carbonate; and 2) a surfactant; which composition is in a foam state upon use.

One exemplary embodiment can be a process for facilitating adding a promoter metal to at least one catalyst particle in situ in a catalytic naphtha reforming unit. The process can include introducing a compound comprising the promoter metal to the catalyst naphtha reforming unit and adding an effective amount of the promoter metal from the compound comprising the promoter metal to the catalyst particle under conditions to effect such addition and improve a conversion of a hydrocarbon feed.

The invention discloses a method for jointly gasifying coal and heavy oil for preparing synthesis gas. The method includes steps of firstly, storing and delivering the heavy oil and preparing and delivering coal slurry; secondly, gasifying the coal and the heavy oil at the high temperatures; thirdly, cooling high-temperature crude synthesis gas and molten ash residues; fourthly, purifying the crude synthesis gas; fifthly, collecting and discharging crude residues; sixthly, treating ash water. The method has the advantages that the method includes the simple steps and is reasonable in design and convenient to implement, and good use effects can be realized; reaction is carried out on the heavy oil and the coal slurry in a gasification reactor for preparing the synthesis gas, accordingly, the effective synthesis gas yield and the utilization rate can be increased, the energy efficiency can be improved, and energy consumption and the production cost can be reduced; the heavy oil can be efficiently and economically utilized, the problem of high raw material consumption due to the fact that existing synthesis gas is prepared from pure coal by means of gasification can be solved by the aid of the method, and the method is high in practicality.

The invention discloses pueraria lobata feed as well as a preparation method and an application thereof. The pueraria lobata feed is prepared from 55%-70% by weight of pueraria lobata, 20%-30% by weight of fermentation additives and 10%-15% by weight of mixed microorganisms through anaerobic fermentation, wherein the fermentation additives comprise spirulina extract, ginkgo biloba extract, fructuslycii extract, bran, 5%-10% calcium chloride, manganese sulfate and ferrous chloride; the mixed microorganisms comprise cellulose decomposition bacteria, flavobacterium, bacillus subtilis and lactobacillus plantarum. The pueraria lobata feed has the advantages as follows: the obtained pueraria lobata feed not only has acid fragrance, but also has low requirement for storage, feed palatability isimproved, appetite of animals is stimulated, and feed intake is increased.

The invention discloses a power distribution cabinet. The power distribution cabinet comprises a power distribution cabinet body, wherein a lower portion of the power distribution cabinet body is provided with a supporting frame, the power distribution cabinet body is equipped with a fixed column through the supporting frame, the fixed column is horizontally and uniformly provided with multiple lower wiring plates, an upper portion of one side of the fixed column is provided with a hydraulic cylinder, one side of the hydraulic cylinder is provided with a sliding rod, a middle portion of the sliding rod is provided with upper wiring plates in matching the lower wiring plates, and a top end of the hydraulic cylinder is provided with a first wiring column. According to the power distribution cabinet, the lower wiring plates on the fixed column and the upper wiring plates on the sliding rod are in matching, change of wiring of a cable in the power distribution cabinet or on and off control of a power source of the power distribution cabinet can be conveniently and rapidly realized, through combination of an air inlet channel and an annular metal mesh, heat radiation performance of the power distribution cabinet is reinforced, a rotation shaft is controlled through a servo motor for rotation, the position of wiring seats is changed, the effective number of the wiring seats is improved for each space unit, and convenient maintenance is realized.

The invention discloses compound feed for improving the estrus rate of s Sanyuan replacement gilt. The compound feed comprises the following ingredients in parts by weight: 55-65 parts of corns, 7-10parts of soybean meal, 10-15 parts of fiber compounds, 1-2 parts of soybean oils, 1-2 parts of corn starches, 0.5-1 part of table salt, 1-2 parts of mountain flour, 1-2 parts of c calcium hydrogen phosphate, 0.3-0.5 part of lysine, 0.4-0.8 part of threonine, 1-2 parts of Chinese herbal medicine fermentation products, 0.1 part of choline chloride, 0.02 part of antioxidant, 0.05 part of mildew-proofagent and 3-4 parts of gilt compound premix materials. In the compound feed disclosed by the invention, key raw materials are subjected to fermentation and enzymolysis, nutrition is comprehensive, and the normal growth of the reproductive system of the Sanyuan replacement gilt can be guaranteed. Since the corn flour and the soybean oils are added, a ratio of energy from the starch and fat in feedenergy can be guaranteed, and triglyceride and total cholesterol concentrations in gilt blood can be improved so as to be favorable for puberty startup. Since a fiber compound is used for replacing bran, the secretion of insulin is accelerated so as to be favorable for the sex hormone secretion of the replacement gilt, the replacement gilt is accelerated to enter the estrus, the intestinal floraof the replacement gilt can be regulated, and the intestinal health of the replacement gilt can be maintained.

This invention discloses the use of snake venom FV polypeptides in methods and compositions for preventing or reducing blood loss or bleeding during bleeding episodes.

The invention discloses an isolated antibody that selectively binds to the C-terminal part of Abeta and is humanized or fully human. The antibody of the invention is capable of preventing oligomerisation of Abeta. Furthermore, a method of diagnosis comprising the steps of: (i) Labelling an antibody; (ii) Administering an effective dose of said antibody intranasally or systemically to a subject; and (iii) Detecting the concentration and/or presence of the labelled antibody in body parts of the subject is disclosed.

The invention relates to a selenium-rich ganoderma lucidum spore powder capsule and a preparation method thereof, and belongs to the technical field of health-care food, and the selenium-rich ganoderma lucidum spore powder capsule comprises the following components in parts by weight: 20-70 parts of wall-broken ganoderma lucidum spore powder, 4-20 parts of rhodiola rosea extract and 1-5 parts of selenium-rich yeast. The preparation method comprises the following steps: firstly, carrying out wet granulation on wall-broken ganoderma lucidum spore powder according to the properties of materials and the characteristics of formula dosage, and then uniformly mixing the selenium-enriched yeast and the rhodiola rosea extract to obtain mixed powder; uniformly mixing the dry particles with mixed powder of selenium-enriched yeast and a rhodiola rosea extract to obtain mixed particles; and finally, uniformly mixing the mixed particles with magnesium stearate to obtain total mixed particles, and filling the total mixed particles into capsules and the like to obtain the product. According to the invention, the sporoderm-broken ganoderma lucidum spore powder, the rhodiola rosea extract and the selenium-enriched yeast are used as main raw materials, and the health-care function of enhancing immunity can be effectively exerted through scientific raw material compatibility and dosage.