56results about How to "Synthesis is simple and controllable" patented technology

The invention relates to an H-grade wire coating enamel that has good salt water pinhole performance and can be directly welded at low temperature, containing hydroxyl component, sealed isocyanate component and solvent, where its hydroxyl component has an acid value less than 2, a hydroxyl value of 150-300, and number-average molecular weight of 1500-5000, and as synthesized, the raw materials has at least m-phthalic acid, p-phthalic acid, adilic acid, glycerin and a kind of dibasic alcohol in the weight ratio of 1 to (0.2-2) to (0.2-0.5) to (0.5-3) to (0.5-1.5); and its sealed isocyanate component is partially added of MDI by mixed polyalcohol that at least has a dibasic alcohol and a tribasic alcohol; in the paint base, the equivalent ratio of isocyanate base to OH is (0.9-1.2) : 1, and it reaches H-grade and has good salt water pinhole property of paint film, tin daubing temperature less than or equal to 375 deg.C.

The invention provides a method for preparing a nanocrystal with a core-shell structure. The method comprises the following steps of: (1) mixing a glycol solution containing Au ions and a glycol solution of polyvinylpyrrolidone, heating the mixed solution by microwave radiation, adding ethanol after the solution is cooled, and centrifuging to obtain a gold crystal seed precipitate; and (2) mixing N,N-dimethyl formamide containing Ag ions and N,N-dimethyl formamide of polyvinylpyrrolidone, adding the gold crystal seed precipitate into the mixed solution, heating till boiled, centrifuging to collect precipitate, and cleaning. The invention also provides the nanocrystal prepared with the method. The equipment and the process of the preparation method are simple, safe and universal and have strong operability; and scale production can be realized. Therefore, under the conventional experimental condition, the crystal with a regular crystalline form and a gold-core silver-shell nano-structure can be synthesized in high yield.

The invention provides a composite nano-grade novel material based on cancer early-stage integrated detection, diagnoses, and treatment, and a preparation method thereof. According to the invention, gold nano-cage (gold nano-box) and nano-grade iron oxide are assembled, such that gold nano-cage (box) / nano-grade iron oxide composite particles are synthesized. With an assembling method from the inside to the outside, the gold nano-cage (box) is first prepared; iron oxide is nucleated and grown in the gold nano-cage (box); with a surfactant (such as glucan or the like), mono-dispersed iron oxide is obtained; the iron oxide is packaged by using biological molecules, such that the gold nano-cage (box) / nano-grade iron oxide composite particles are obtained; surface modification is carried out by using biological targeting molecules (antibodies or DNA molecules). The material is used in tumor magnetic resonance imaging, fluorescence imaging, dark field imaging, specific targeting multifunctional diagnosis, and photothermal therapy. The material can also be used as a targeting medicine carrier.

The invention belongs to the field of biological nano-materials, and specifically relates to a preparation method of biological nano-ferrous sulfide. The preparation method comprises the specific steps: firstly, a phosphate-ferric sustained release system is constructed; secondly, shewanella oneidensis MR-1 is inoculated into an LB culture medium, subjected to activation culture, and then inoculated into the phosphate-ferric sustained release system under aseptic and anaerobic conditions, and when the OD600 value of the final concentration of the shewanella oneidensis MR-1 in the system is 0.1-2, inoculation with the shewanella oneidensis MR-1 stops; and then sodium thiosulfate mother liquor is added, and the biological nano ferrous sulfide is obtained by culturing, centrifuging and washing. The novel phosphate-ferric sustained release system is constructed to realize the quantitative control of ferric iron. A series of nano-ferrous sulfide with different catalytic properties can be controllably bio-synthesized by adjusting the adding amount of the sulfur source in synthesis, the catalytic performance is effectively regulated, and a new way is opened up for regulation of the catalytic performance of the bio-synthesized nano-material.

The invention relates to a FeNiCo oxygenated chemical nanosheet with adjustable metal proportion as well as a preparation method and application thereof. The preparation method comprises the followingsteps that S1, a metal organic framework ZIF-67 is prepared by adopting a normal-temperature standing precipitation method; S2, FeSO4*7H2O and NiSO4*6H2O are weighed according to a certain ratio andare fully dissolved in deionized water so as to obtain liquid A, and a proper amount of metal organic framework ZIF-67 powder obtained in the step S1 is taken and and is fully dispersed in absolute ethyl alcohol so as to obtain liquid B; S3, the liquid B is rapidly poured into the liquid A, and stirring is carried out; and S4, a product obtained in the step S3 is washed, and a centrifuged productis subjected to freeze drying so as to obtain the FeNiCo oxygenated chemical nanosheet with uniform morphology. The FeNiCo oxygenated chemical nanosheet as well as the preparation method and application thereof have the beneficial effects that the FeNiCo oxygenated chemical nanosheet serves as an anode for electrocatalytic water decomposition, and the oxygen evolution catalytic performance is excellent; and the material is simple in synthetic process, low in cost, environmentally-friendly and extremely high in repeatability.

The invention relates to a polycarboxylic acid water reducing agent suitable for high-strength self-compacting concrete and a preparation method of the polycarboxylic acid water reducing agent. The agent is characterized by comprising 70-90wt% of a isopentene group polyoxyethylene ether monomer a, 5-25wt% of binary unsaturated carboxylic acid and a derivative monomer b of the binary unsaturated carboxylic acid and 1-10wt% of unitary unsaturated carboxylic acid and a derivative monomer c, wherein a+b+c=10wt%, under the action of an initiator and a chain transfer agent, an inductive copolymerization assistant agent monomer d is subjected to copolymerization for 1-3.5h in a water solution at the temperature of 60-80 DEG C, then alkali is added, and neutralization is conducted to obtain the polycarboxylic acid water reducing agent. The water reducing agent is not only can be compounded into an addition agent and used in ordinary concrete and also can be used in the C70-C100 high-strength self-compacting concrete, high mobility and low viscosity are provided, and the requirement (the performance grade can reach SR2) for segregation resistance in engineering construction is met, the performance is excellent, and the construction application requirement is met; and the cost is low, and the agent is convenient to popularize.

The invention discloses a preparation method for a titanium dioxide nanotube array electrode decorated with a cobalt and nickel double-layer hydroxide and application of photoelectron-chemistry hydrolysis hydrogen production. Through an electrochemical deposition method, the tube walls of titanium dioxide nanotubes are rapidly and controllably decorated with the cobalt and nickel double-layer hydroxide. The reaction process is rapid and efficient, and the covering density of CoNi-LHDs on the surfaces of the titanium dioxide nanotubes is controllable. The decoration of the CoNi-LHDs remarkably improves the ultraviolet light absorption efficiency of the titanium dioxide nanotubes and prolongs the service life of photo-generated electrons, separation between the photo-generated electrons and holes is accelerated, and the clean contact interfaces between the photo-generated electrons and the holes are also beneficial for transmission of the photo-generated electrons. By the adoption of the new method for compounding the titanium dioxide heterogeneous nanotube array electrode decorated with the cobalt and nickel double-layer hydroxide rapidly and controllably, operation is easy, industrialization is easy, and the new method has important application value.

The invention provides a preparation method of molybdenum boride powder. In the preparation steps, the molybdenum boride powder which completely accords with material design phase compositions can be controlled to be prepared by means of a high-temperature and high-pressure synthesis mode according to setting of the B / Mo mole ratio n (n=0.5, 1, 2, 2.5, 4) before synthesis, controllable synthesis of target molybdenum boride material phase compositions is achieved, and the synthesized molybdenum boride powder is uniform in particle size, complete in grain crystallization and excellent in property. The method is controllable in technological process, short in technological route, high in targeted property, convenient to operate, efficient, economical in energy, safe and good in reliability. The finished molybdenum boride powder is uniform in particle size distribution and complete in grain crystallization, the chemical purity is higher than or equal to 99.8%, and the product quality stability is good, the properties are obviously improved compared with a molybdenum boride material synthesized through a conventional method, and therefore the produced molybdenum boride material shows excellent physical and chemical properties in industrial application.

The invention relates to the technical field of preparation of nano powder materials, and discloses a high-flux preparation method of monodisperse silicon dioxide microspheres, the silicon dioxide microspheres are prepared based on a microfluidic reactor, the microfluidic reactor comprises a reaction chamber, the reaction chamber is internally provided with a multi-channel spiral tube comprising at least one spiral tube, The preparation method comprises the following steps: 1) dispersing a silicon source in a solvent to obtain a first solution; 2) dispersing a catalyst in deionized water to obtain a second solution; 3) simultaneously inputting the first solution and the second solution from an inlet channel of the reaction chamber, and mixing to obtain a mixed solution; and 4) reacting the mixed solution in each spiral tube of a multi-channel spiral tube, and separating and purifying to obtain the silicon dioxide with different particle sizes. According to the invention, a multi-flux microfluidic reaction system is adopted, so that the particle size distribution of the synthesized silicon dioxide is uniform, the production capacity of different particle sizes is greatly increased, and the production efficiency is improved.

The invention relates to an indenofluorene-based conjugated polymer laser gain material, a method for preparing the same and application of the indenofluorene-based conjugated polymer laser gain material. Indenofluorene structures are used as frameworks for the indenofluorene-based conjugated polymer laser gain material, different receptor structures are selected, copolymerization is carried out to obtain trapezoidal block copolymers, a general structural formula of the trapezoidal block copolymers is shown, an R in the general formula I represents one of alkyl, alkoxy, alkyl phenyl and alkoxy phenyl of C1-C30, and an A represents electron receptor structure modification units. The indenofluorene-based conjugated polymer laser gain material, the method and the application have the advantages that the indenofluorene-based conjugated polymer laser gain material is low in cost, high in yield and good in solubility, and synthesis is simple and controllable; the indenofluorene-based conjugated polymer laser gain material is good in heat stability, reversible in oxidation-reduction characteristic and excellent in film-forming properties, and film devices can be prepared by the aid of simple solution film-forming modes; the indenofluorene-based conjugated polymer laser gain material is high in brightness and excellent in luminescence efficiency when used as an active luminescence layer in organic electroluminescent devices, is low in laser threshold and high in gain when applied to organic laser devices and is a luminescent material system with important application prospect.

The invention discloses a method for synthetizing a fused cast by combustion of MgAl2O4 ceramic, relates to a method for synthetizing the fused cast by combustion of the MgAl2O4 ceramic, and aims at solving the technical problems of high cost, complicated process and environmental pollution of the traditional MgAl2O4 ceramic. Reactants in the method disclosed by the invention are Al and nitrate; diluents are Al2O3 and MgO; the materials are ignited to react through combustion and heat release of the Al and the nitrate; the experimental process is fast; the reaction time is less than 10 minutes. Thus, the method is short in preparation cycle, low in cost, high in purity of obtained product, simple in experimental process, and easy to control and operate. The temperature and the pressure of a system can be controlled by controlling the content of the diluents; each ingredient is controlled to meet the required ratio when the safety of the experiment is ensured; an external heat source is not needed; the system is heated by the heat release of reaction. Thus, the cost is low; no toxic gas is generated; the method can be applied to the field of preparation of the MgAl2O4 ceramic.

The invention provides a preparation method of ionic liquid for selectively separating a water-ethanol azeotropic system. The preparation method is characterized in that cationic groups in the synthetic ionic liquid have hydroxyl. The preparation method comprises the following steps: reacting N-methylimidazole with 2-bromoethanol under the condition of constant-temperature ultrasonic reflux to prepare bromo-1-methyl-3-(2-hydroxylethyl) imidazole; then, purifying bromo-1-methyl-3-(2-hydroxylethyl) imidazole to obtain the ionic liquid of bromo-1-methyl-3-(2-hydroxylethyl) imidazole. The preparation method has the advantages that the synthesis process is simple, and the prepared ionic liquid is non-volatile, good in stability, friendly to the environment and obvious in 'salt effect'; groups in the ionic liquid are capable of selectively bonding component water in the water-ethanol azeotropic system to generate a solvation reaction under the actions of chemical affinity, hydrogen bond force and electrostatic attraction of ions to produce a nonvolatile ionic liquid-water associated complex so that water vapor pressure is lowered, the volatility of water is reduced, steam phase partial pressure and relative volatility of ethanol are increased and the 'salting out' phenomenon appears and thus the water-ethanol azeotropic system is separated.

The invention relates to a specific fluorescence labeling method of food-borne probiotics. The method includes following steps: (a), preparing a Cr3+doped gallium zinc germanate long-afterglow fluorescent nano probe having near infrared fluorescence and ultralong-afterglow properties through a solvothermal-high-temperature calcining process; (b), realizing specific fluorescence labeling of the nano probe to target probiotics through antibody surface functionalizing. The method has the advantages that the nano probe prepared by the method has ultrastrong near infrared luminescence, ultralong afterglow life, excellent biocompatibility and structural stability, high grain size uniformity and low toxicity; near infrared fluorescence labeling probiotics in-vivo biological imaging technology developed by the invention can realize nondestructive tracing of distribution of probiotics after entering organisms, and the method is of important significance in developing functional sites of innovative food-borne probiotics and nutriology research concepts.

The invention discloses a branched polyetherimide material containing a ketone thioacetal bond, as well as a preparation method and application thereof. The preparation method comprises the followingsteps: (1) stirring acetone and acid containing thiol to react at room temperature; (2) adding polyetherimide and an activator after the reaction is finished, dissolving in an organic reagent, stirring to react, bonding chlorin e6 and carboxyl polyethylene glycol through an amidation reaction to obtain the reactive oxygen sensitive branched polyetherimide material containing the ketone thioacetalbond. The branched polyetherimide material has excellent biocompatibility and degradability, is entrapped with siRNA, and forms nano-particles by self-assembly, can generate a great number of reactiveoxygen under excitation of a light source with specific wavelength to destroy the structure of endosome, the reactive oxygen sensitive ketone thioacetal bond is broken, particles are disintegrated, and endosome escape and release of intracellular siRNA can be accelerated. The branched polyetherimide material containing a ketone thioacetal bond has a huge clinical application potential in the field of tumor treatment.

The invention provides multi-arm high-molecular pressure sensitive paint for aerospace and a preparation method thereof, the multi-arm high-molecular pressure sensitive paint is high in sensitivity and fast in response speed, can be widely applied to pressure tests of aerospace industry aircraft surfaces and various parts. In the testing process, the surface of a tested model is not damaged, the surface shape of the model is not limited, and the application range is wide; pressure information which is continuously distributed can be obtained, the measurement precision is high, and the test period is short.

The invention relates to an H-grade wire coating enamel that has good salt water pinhole performance and can be directly welded at low temperature, containing hydroxyl component, sealed isocyanate component and solvent, where its hydroxyl component has an acid value less than 2, a hydroxyl value of 150-300, and number-average molecular weight of 1500-5000, and as synthesized, the raw materials has at least m-phthalic acid, p-phthalic acid, adilic acid, glycerin and a kind of dibasic alcohol in the weight ratio of 1 to (0.2-2) to (0.2-0.5) to (0.5-3) to (0.5-1.5); and its sealed isocyanate component is partially added of MDI by mixed polyalcohol that at least has a dibasic alcohol and a tribasic alcohol; in the paint base, the equivalent ratio of isocyanate base to OH is (0.9-1.2) : 1, and it reaches H-grade and has good salt water pinhole property of paint film, tin daubing temperature less than or equal to 375 deg.C.

An antimicrobial nano-particle preparation method using a metal-organic framework as a biocarrier for packing a medicine comprises the following steps: S1, correspondingly mixing ferric chloridehexahydrate andterephthalic acid with N, N-dimethylformamide,and arranging into an inner tank of a Teflon reaction kettle; S2, arranging the inner tank of the reaction kettle into an oven,increasing the temperature,and then cooling; S3, centrifuging the substance cooled in step 2,collecting the precipitate,then performing washing and suction filtration on the product,drying in vacuum,and grinding to obtain metal-organic framework nano-particles; S4, mixing the metal-organic framework nano-particles and vancomycin,dissolving the mixture in deionized water,and then absorbing and loading medicine; and S5, filtering the substance obtained in step S5,washing,performing suction filtration,and drying in vacuum to obtain the medicine-packed metal-organic frameworknano-particle composite. The method has the advantages of being capable of absorbing various different macromolecular and micromolecular medicines to form a double-functional metal-organic framework medicine loading system, and being simple in preparation process, green and environment-friendly.

The invention belongs to the technical field of fine chemical engineering, and relates to a preparation method and application of a binuclear Ir (III) metal-organic supramolecular cage compound. According to the preparation method, aliphatic diamine A is used as a connecting body; L1 and L2 are used as pre-assembled metal-based ligand Ir (III) complexes, then sodium borohydride is added to reduceSchiff base -C=N- double bonds in the obtained cage structure into -CH-NH-, finally, the compound with the metal-organic cage structure is prepared, and the synthetic route of the compound is: A+L1 toA-L1 or A+L2 to A-L2. The preparation process is simple, the design idea is novel, the yield of the target compound is high, the obtained functional material is stable in chemical property, and the pre-assembled body is easy to modify. The compound A-L1 or A-L2 is used in oxidation of 1-oxo-2,3-dihydro-1-indene-2-methyl formate to generate 2-hydroxy-1-oxo-2,3-dihydro-1-indene-2-methyl carboxyl ate, the yield is as high as 83%, and the compound A-L1 or A-L2 is easier to put into practical application.

The invention relates to a double-silicon-source-oriented hollow-sandwich-hollow silicon dioxide mesoporous material and a synthesizing method thereof. The synthesizing method includes the steps that ethyl alcohol serves as a solvent, and under the base catalysis effect of ammonium hydroxide, 3-(2-aminoethyl)-aminopropyl trimethoxy silane (TSD) and tetraethoxysilane (TEOS) are subjected to hydrolytic polymerization to obtain solid hybridization silicon dioxide spheres; the spheres are converted into the hollow or solid sandwich-hollow silicon dioxide mesoporous material under the etching effect of hydrofluoric acid (HF), wherein in the process of preparing the solid hybridization silicon dioxide spheres, the silicon dioxide mesoporous material of different structures can be obtained by simply adjusting the volume ratio of the two silicon sources. According to the hollow silicon dioxide mesoporous material obtained with the method, the particle size ranges from 350 nm to 420 nm, the shell thickness ranges from 30 nm to 50 nm, and the hole diameter ranges from 3 nm to 4 nm; according to the obtained sandwich-hollow silicon dioxide mesoporous material, the particle size ranges from 350 nm to 420 nm, silicon dioxide solid spheres with the particle size of 100 nm to 160 nm serve as cores, the shell thickness ranges from 30 nm to 50 nm, and the hole diameter ranges from 3 nm to 4 nm. According to the silicon dioxide mesoporous material obtained with the method, a certain amount of amino exists for modification, and the application in the fields of catalysis, biological medicine and the like is greatly expanded.

A preparation method of bimetallic organic framework antibacterial nanoparticles with a photothermal effect comprises the following steps: S1, respectively mixing potassium ferricyanide and anhydrouszinc chloride with deionized water, obtaining a solution A and a solution B respectively, and then mixing and stirring evenly the solution A and the solution B for standby application; S2, adding polyvinylpyrrolidone into the solution obtained in the step S1, stirring evenly, then adding hydrochloric acid, stirring evenly to make fully dissolved, and then carrying out static aging precipitation; S3, centrifuging the substance obtained in the step S2, separating a product solution to obtain a blue precipitate, and centrifuging and washing with ethanol and deionized water respectively, to obtaina precipitate product; and S4, placing the product obtained in the step S3 in a freezer, and freeze-drying. The method has the advantages that the precipitation aging method is used for controlling the stirring time in the synthetic process, and the nano cubic particles with uniform particle size can be controllably synthesized. Trace zinc ions can effectively promote cell proliferation and differentiation and promote wound repairing and healing, and the method is green and environmentally friendly.

The invention discloses a method for preparing an SSZ-13 molecular sieve membrane through steam-assisted conversion. The method comprises the following steps: (1) preparing a SSZ-13 molecular sieve seed crystal; (2) pretreating a porous support, namely coating a porous support with a crystal seed layerhaving a density of 1-300 [ mu ] g / cm<2> ; and (3) preparing a SSZ-13 molecular sieve membrane, namely adding a small amount of synthetic sol without contacting with the pretreated support, heating the sol, vaporizing and transferring heat, and matching with a small amount of structure directing agent and water to pre-coat the sol to perform crystallization, thereby forming the molecular sieve membrane. According to the invention, more than 90% of synthetic sol can be saved through steam-assisted conversion, the synthesis operation process is safe, and the discharge of reaction waste liquid is reduced. The method is economical, safe and environment-friendly, and the prepared membrane is excellent in performance and can be applied to industrial preparation of the molecular sieve membrane.

The invention discloses a perovskite CsPbX3 nanocrystal as well as a preparation method and application thereof. The preparation method comprises the following steps: in an inert atmosphere, heating a metal halide APbX3 precursor solution with an equivalent stoichiometric ratio, where A is H and / or DMA ions, and X is one or more halogens; and adding the cesium precursor solution into the mixed solution, reacting and rapidly cooling to obtain the CsPbX3 nanocrystal. In the method, the APbX3 compound which is easy to prepare and store is adopted as a lead and halogen source, so that the synthesized CsPbX3 nanocrystal has few defects, the situation that a perovskite structure is degraded due to the influence of light, heat, oxygen and water due to halogen defects is avoided, excellent physical and chemical stability is shown, and the luminous efficiency of the nanocrystal is further improved. Besides, the raw materials are cheap and easy to obtain, preparation is simple, the obtained nanocrystals are more stable, experimental reproducibility is good, and the method is suitable for industrial popularization and preparation.

The invention discloses a method for synthesizing dichloroether and 2-chloroethoxyethanol, and belongs to the field of organic synthesis. The method comprises the steps: adding diethylene glycol and acatalyst at a molar ratio of (0.8-1.5):0.3 into a two-necked flask, and connecting the two bottle mouths of the two-necked flask to a separating funnel and a condenser pipe separately; adding mixed acids dropwise to the two-necked flask by using the separating funnel, performing a reaction at 130-170 DEG C, collecting a condensate by using the condenser pipe during the reaction, performing distillation on the condensate so as to obtain dichloroether, and performing suction filtration on the remaining liquid in the two-necked flask so as to obtain 2-chloroethoxyethanol, wherein the mixed acidsinclude concentrated hydrochloric acid and concentrated sulfuric acid at a mass ratio of (25-35):1. Through the synthesis method, not only can dichloroether and 2-chloroethoxyethanol be synthesized simultaneously, but also the method can have a simple and controllable reaction, mild reaction conditions and safe and easily available raw materials, so that synthesis of the two is safer and more controllable, and the cost is lower.

The invention discloses a novel silicon-carbon composite negative electrode material and a preparation method thereof. The preparation method comprises the following steps: firstly, growing a layer ofmetal organic framework (MOF) on surfaces of SiO2 microspheres; and then carrying out metal thermal reduction, acid pickling and drying to obtain the novel silicon-carbon composite negative electrodematerial which is a carbon-coated porous silicon composite negative electrode material. The synthesis method has characteristics of novelty, uniqueness, easy operation and low cost, and the preparedmaterial has characteristics of a high capacity and a long cycle life, and can be used as a lithium ion negative electrode material of various high-capacity devices.

The invention relates to a method for preparing nickel-based battery material and belongs to the field of battery material preparation. The method is characterized by including: mixing CeO2, NiO and SnO2 powder into binder, preparing into a circular piece after wet grinding, and sintering; hanging the sintered piece on an iron-chromium-aluminum wire to serve as a cathode, and wrapping the periphery of the sintered piece with the iron-chromium-aluminum wire; slowly heating CaCl2 in a muffle furnace; placing into an alumina crucible after cooling, and placing at the bottom of a reactor; suspending the cathode and a graphite carbon bar above molten salt for preheating during the heating process of an electrolytic furnace, and feeding argon at the same time; inserting the cathode and the graphite carbon bar into the molten salt, and applying direct currents to start electrolysis; taking out a cathode product after the electrolysis is completed, washing with distilled water, and drying under normal temperature. The method for preparing the nickel-based battery material has the advantages that the process is improved, a method which directly electrolyzes metal oxide in the molten salt to prepare metal or alloy is used, process simpleness is achieved, and the method is easy in synthesizing control, low in production cost and free of pollution.

The invention discloses a preparation method of a nano-palladium catalyst with controllable morphology and size, and relates to the technical field of nano-palladium catalyst preparation. The preparation method comprises the following steps: S1, adding a palladium source into a solvent, and uniformly stirring to prepare a palladium precursor solution; S2, adding a dispersing agent and a reducing agent into the palladium precursor solution, preparing a mixed solution, performing a reduction reaction, and preparing a colloidal solution; S3, adding ethanol into the colloidal solution for induced aggregation, performing centrifugation and washing, preparing a washed centrifugal product, adding dichloromethane into the washed centrifugal product, and preparing the nano-palladium catalyst with the controllable morphology and size. According to the preparation method provided by the invention, one-step synthesis is adopted, in an organic solvent system, under the protection of oleic acid or oleylamine, an active silicon-hydrogen compound is used as a reducing agent to reduce a palladium precursor, and palladium nanoparticles with various particle sizes and morphologies can be controllably synthesized.

The present invention discloses a method for synthesizing and purifying a tulathromycin impurity E. In an epoxidation process, by adjusting raw materials and reaction temperatures, an epoxide isomer is obtained. Steps of protecting group removing, amination, etc. are conducted to obtain needed tulathromycin E. The method solves problems that in the prior art, the tulathromycin impurity E is low inpurity, operation is complicated, synthesis processes are not easy to control, single preparation is low in yield, and research conditions on structure and properties cannot be met. The method for synthesizing and purifying the tulathromycin impurity E adjusts the raw materials and reaction temperatures. Trimethylsulfoxonium iodide is added in DMSO to promote a sulfur ylide reaction, so that thegenerated epoxide is mainly composed of upright bonds. The method promotes conversion efficiency of the tulathromycin impurity E, thus generates a large amount of the tulathromycin impurity E and at the same time improves the purity of the tulathromycin impurity E.

The invention provides a preparation method of a rhodamine bispyrazole acetate organic laser material. The rhodamine bispyrazole acetate organic laser material provided by the invention has the advantages of low preparation cost, simple and controllable synthesis, high yield and good solubility; meanwhile, the rhodamine bispyrazole acetate organic laser material has relatively good thermal stability. The material provided by the invention has excellent thermal stability, film forming stability and low threshold value property in application of organic laser devices and has low water-oxygen sensitivity and high luminous intensity. The rhodamine bispyrazole acetate organic laser material has high luminous efficiency and mobility, so that the rhodamine bispyrazole acetate organic laser material has potential application value in the aspects of electric pumping organic semiconductor laser, organic electroluminescence and organic field effect transistors.

The invention relates to a preparation method of a gold-silver core-shell nanoparticle electrochemical biosensor synthesized by adopting a pressure change type micro-fluidic chip, and belongs to the field of micro-fluidic synthesis and electrochemical sensors. The gold and silver core-shell nanoparticles synthesized by adopting the pressure change type micro-fluidic chip have the characteristics of controllable morphology, adjustable core-shell thickness and large specific surface area. The gold-silver core-shell nanoparticles are used as the substrate of the electrochemical biosensor, are used for detecting procalcitonin, and have the advantages of high sensitivity and favorable specificity.