56results about How to "Synthesis is simple and controllable" patented technology

The invention provides a method for preparing a nanocrystal with a core-shell structure. The method comprises the following steps of: (1) mixing a glycol solution containing Au ions and a glycol solution of polyvinylpyrrolidone, heating the mixed solution by microwave radiation, adding ethanol after the solution is cooled, and centrifuging to obtain a gold crystal seed precipitate; and (2) mixing N,N-dimethyl formamide containing Ag ions and N,N-dimethyl formamide of polyvinylpyrrolidone, adding the gold crystal seed precipitate into the mixed solution, heating till boiled, centrifuging to collect precipitate, and cleaning. The invention also provides the nanocrystal prepared with the method. The equipment and the process of the preparation method are simple, safe and universal and have strong operability; and scale production can be realized. Therefore, under the conventional experimental condition, the crystal with a regular crystalline form and a gold-core silver-shell nano-structure can be synthesized in high yield.

The invention provides a composite nano-grade novel material based on cancer early-stage integrated detection, diagnoses, and treatment, and a preparation method thereof. According to the invention, gold nano-cage (gold nano-box) and nano-grade iron oxide are assembled, such that gold nano-cage (box)/nano-grade iron oxide composite particles are synthesized. With an assembling method from the inside to the outside, the gold nano-cage (box) is first prepared; iron oxide is nucleated and grown in the gold nano-cage (box); with a surfactant (such as glucan or the like), mono-dispersed iron oxide is obtained; the iron oxide is packaged by using biological molecules, such that the gold nano-cage (box)/nano-grade iron oxide composite particles are obtained; surface modification is carried out by using biological targeting molecules (antibodies or DNA molecules). The material is used in tumor magnetic resonance imaging, fluorescence imaging, dark field imaging, specific targeting multifunctional diagnosis, and photothermal therapy. The material can also be used as a targeting medicine carrier.

The invention belongs to the field of biological nano-materials, and specifically relates to a preparation method of biological nano-ferrous sulfide. The preparation method comprises the specific steps: firstly, a phosphate-ferric sustained release system is constructed; secondly, shewanella oneidensis MR-1 is inoculated into an LB culture medium, subjected to activation culture, and then inoculated into the phosphate-ferric sustained release system under aseptic and anaerobic conditions, and when the OD600 value of the final concentration of the shewanella oneidensis MR-1 in the system is 0.1-2, inoculation with the shewanella oneidensis MR-1 stops; and then sodium thiosulfate mother liquor is added, and the biological nano ferrous sulfide is obtained by culturing, centrifuging and washing. The novel phosphate-ferric sustained release system is constructed to realize the quantitative control of ferric iron. A series of nano-ferrous sulfide with different catalytic properties can be controllably bio-synthesized by adjusting the adding amount of the sulfur source in synthesis, the catalytic performance is effectively regulated, and a new way is opened up for regulation of the catalytic performance of the bio-synthesized nano-material.

The invention discloses a preparation method for a titanium dioxide nanotube array electrode decorated with a cobalt and nickel double-layer hydroxide and application of photoelectron-chemistry hydrolysis hydrogen production. Through an electrochemical deposition method, the tube walls of titanium dioxide nanotubes are rapidly and controllably decorated with the cobalt and nickel double-layer hydroxide. The reaction process is rapid and efficient, and the covering density of CoNi-LHDs on the surfaces of the titanium dioxide nanotubes is controllable. The decoration of the CoNi-LHDs remarkably improves the ultraviolet light absorption efficiency of the titanium dioxide nanotubes and prolongs the service life of photo-generated electrons, separation between the photo-generated electrons and holes is accelerated, and the clean contact interfaces between the photo-generated electrons and the holes are also beneficial for transmission of the photo-generated electrons. By the adoption of the new method for compounding the titanium dioxide heterogeneous nanotube array electrode decorated with the cobalt and nickel double-layer hydroxide rapidly and controllably, operation is easy, industrialization is easy, and the new method has important application value.

The invention provides a preparation method of molybdenum boride powder. In the preparation steps, the molybdenum boride powder which completely accords with material design phase compositions can be controlled to be prepared by means of a high-temperature and high-pressure synthesis mode according to setting of the B/Mo mole ratio n (n=0.5, 1, 2, 2.5, 4) before synthesis, controllable synthesis of target molybdenum boride material phase compositions is achieved, and the synthesized molybdenum boride powder is uniform in particle size, complete in grain crystallization and excellent in property. The method is controllable in technological process, short in technological route, high in targeted property, convenient to operate, efficient, economical in energy, safe and good in reliability. The finished molybdenum boride powder is uniform in particle size distribution and complete in grain crystallization, the chemical purity is higher than or equal to 99.8%, and the product quality stability is good, the properties are obviously improved compared with a molybdenum boride material synthesized through a conventional method, and therefore the produced molybdenum boride material shows excellent physical and chemical properties in industrial application.

The invention relates to the technical field of preparation of nano powder materials, and discloses a high-flux preparation method of monodisperse silicon dioxide microspheres, the silicon dioxide microspheres are prepared based on a microfluidic reactor, the microfluidic reactor comprises a reaction chamber, the reaction chamber is internally provided with a multi-channel spiral tube comprising at least one spiral tube, The preparation method comprises the following steps: 1) dispersing a silicon source in a solvent to obtain a first solution; 2) dispersing a catalyst in deionized water to obtain a second solution; 3) simultaneously inputting the first solution and the second solution from an inlet channel of the reaction chamber, and mixing to obtain a mixed solution; and 4) reacting the mixed solution in each spiral tube of a multi-channel spiral tube, and separating and purifying to obtain the silicon dioxide with different particle sizes. According to the invention, a multi-flux microfluidic reaction system is adopted, so that the particle size distribution of the synthesized silicon dioxide is uniform, the production capacity of different particle sizes is greatly increased, and the production efficiency is improved.

The invention relates to a specific fluorescence labeling method of food-borne probiotics. The method includes following steps: (a), preparing a Cr3+doped gallium zinc germanate long-afterglow fluorescent nano probe having near infrared fluorescence and ultralong-afterglow properties through a solvothermal-high-temperature calcining process; (b), realizing specific fluorescence labeling of the nano probe to target probiotics through antibody surface functionalizing. The method has the advantages that the nano probe prepared by the method has ultrastrong near infrared luminescence, ultralong afterglow life, excellent biocompatibility and structural stability, high grain size uniformity and low toxicity; near infrared fluorescence labeling probiotics in-vivo biological imaging technology developed by the invention can realize nondestructive tracing of distribution of probiotics after entering organisms, and the method is of important significance in developing functional sites of innovative food-borne probiotics and nutriology research concepts.

The invention discloses a branched polyetherimide material containing a ketone thioacetal bond, as well as a preparation method and application thereof. The preparation method comprises the followingsteps: (1) stirring acetone and acid containing thiol to react at room temperature; (2) adding polyetherimide and an activator after the reaction is finished, dissolving in an organic reagent, stirring to react, bonding chlorin e6 and carboxyl polyethylene glycol through an amidation reaction to obtain the reactive oxygen sensitive branched polyetherimide material containing the ketone thioacetalbond. The branched polyetherimide material has excellent biocompatibility and degradability, is entrapped with siRNA, and forms nano-particles by self-assembly, can generate a great number of reactiveoxygen under excitation of a light source with specific wavelength to destroy the structure of endosome, the reactive oxygen sensitive ketone thioacetal bond is broken, particles are disintegrated, and endosome escape and release of intracellular siRNA can be accelerated. The branched polyetherimide material containing a ketone thioacetal bond has a huge clinical application potential in the field of tumor treatment.

An antimicrobial nano-particle preparation method using a metal-organic framework as a biocarrier for packing a medicine comprises the following steps: S1, correspondingly mixing ferric chloridehexahydrate andterephthalic acid with N, N-dimethylformamide,and arranging into an inner tank of a Teflon reaction kettle; S2, arranging the inner tank of the reaction kettle into an oven,increasing the temperature,and then cooling; S3, centrifuging the substance cooled in step 2,collecting the precipitate,then performing washing and suction filtration on the product,drying in vacuum,and grinding to obtain metal-organic framework nano-particles; S4, mixing the metal-organic framework nano-particles and vancomycin,dissolving the mixture in deionized water,and then absorbing and loading medicine; and S5, filtering the substance obtained in step S5,washing,performing suction filtration,and drying in vacuum to obtain the medicine-packed metal-organic frameworknano-particle composite. The method has the advantages of being capable of absorbing various different macromolecular and micromolecular medicines to form a double-functional metal-organic framework medicine loading system, and being simple in preparation process, green and environment-friendly.

The invention belongs to the technical field of fine chemical engineering, and relates to a preparation method and application of a binuclear Ir (III) metal-organic supramolecular cage compound. According to the preparation method, aliphatic diamine A is used as a connecting body; L1 and L2 are used as pre-assembled metal-based ligand Ir (III) complexes, then sodium borohydride is added to reduceSchiff base -C=N- double bonds in the obtained cage structure into -CH-NH-, finally, the compound with the metal-organic cage structure is prepared, and the synthetic route of the compound is: A+L1 toA-L1 or A+L2 to A-L2. The preparation process is simple, the design idea is novel, the yield of the target compound is high, the obtained functional material is stable in chemical property, and the pre-assembled body is easy to modify. The compound A-L1 or A-L2 is used in oxidation of 1-oxo-2,3-dihydro-1-indene-2-methyl formate to generate 2-hydroxy-1-oxo-2,3-dihydro-1-indene-2-methyl carboxyl ate, the yield is as high as 83%, and the compound A-L1 or A-L2 is easier to put into practical application.

The invention relates to a double-silicon-source-oriented hollow-sandwich-hollow silicon dioxide mesoporous material and a synthesizing method thereof. The synthesizing method includes the steps that ethyl alcohol serves as a solvent, and under the base catalysis effect of ammonium hydroxide, 3-(2-aminoethyl)-aminopropyl trimethoxy silane (TSD) and tetraethoxysilane (TEOS) are subjected to hydrolytic polymerization to obtain solid hybridization silicon dioxide spheres; the spheres are converted into the hollow or solid sandwich-hollow silicon dioxide mesoporous material under the etching effect of hydrofluoric acid (HF), wherein in the process of preparing the solid hybridization silicon dioxide spheres, the silicon dioxide mesoporous material of different structures can be obtained by simply adjusting the volume ratio of the two silicon sources. According to the hollow silicon dioxide mesoporous material obtained with the method, the particle size ranges from 350 nm to 420 nm, the shell thickness ranges from 30 nm to 50 nm, and the hole diameter ranges from 3 nm to 4 nm; according to the obtained sandwich-hollow silicon dioxide mesoporous material, the particle size ranges from 350 nm to 420 nm, silicon dioxide solid spheres with the particle size of 100 nm to 160 nm serve as cores, the shell thickness ranges from 30 nm to 50 nm, and the hole diameter ranges from 3 nm to 4 nm. According to the silicon dioxide mesoporous material obtained with the method, a certain amount of amino exists for modification, and the application in the fields of catalysis, biological medicine and the like is greatly expanded.

The invention discloses a method for preparing an SSZ-13 molecular sieve membrane through steam-assisted conversion. The method comprises the following steps: (1) preparing a SSZ-13 molecular sieve seed crystal; (2) pretreating a porous support, namely coating a porous support with a crystal seed layerhaving a density of 1-300 [ mu ] g/cm<2> ; and (3) preparing a SSZ-13 molecular sieve membrane, namely adding a small amount of synthetic sol without contacting with the pretreated support, heating the sol, vaporizing and transferring heat, and matching with a small amount of structure directing agent and water to pre-coat the sol to perform crystallization, thereby forming the molecular sieve membrane. According to the invention, more than 90% of synthetic sol can be saved through steam-assisted conversion, the synthesis operation process is safe, and the discharge of reaction waste liquid is reduced. The method is economical, safe and environment-friendly, and the prepared membrane is excellent in performance and can be applied to industrial preparation of the molecular sieve membrane.

The invention discloses a novel silicon-carbon composite negative electrode material and a preparation method thereof. The preparation method comprises the following steps: firstly, growing a layer ofmetal organic framework (MOF) on surfaces of SiO2 microspheres; and then carrying out metal thermal reduction, acid pickling and drying to obtain the novel silicon-carbon composite negative electrodematerial which is a carbon-coated porous silicon composite negative electrode material. The synthesis method has characteristics of novelty, uniqueness, easy operation and low cost, and the preparedmaterial has characteristics of a high capacity and a long cycle life, and can be used as a lithium ion negative electrode material of various high-capacity devices.

The invention relates to a method for preparing nickel-based battery material and belongs to the field of battery material preparation. The method is characterized by including: mixing CeO2, NiO and SnO2 powder into binder, preparing into a circular piece after wet grinding, and sintering; hanging the sintered piece on an iron-chromium-aluminum wire to serve as a cathode, and wrapping the periphery of the sintered piece with the iron-chromium-aluminum wire; slowly heating CaCl2 in a muffle furnace; placing into an alumina crucible after cooling, and placing at the bottom of a reactor; suspending the cathode and a graphite carbon bar above molten salt for preheating during the heating process of an electrolytic furnace, and feeding argon at the same time; inserting the cathode and the graphite carbon bar into the molten salt, and applying direct currents to start electrolysis; taking out a cathode product after the electrolysis is completed, washing with distilled water, and drying under normal temperature. The method for preparing the nickel-based battery material has the advantages that the process is improved, a method which directly electrolyzes metal oxide in the molten salt to prepare metal or alloy is used, process simpleness is achieved, and the method is easy in synthesizing control, low in production cost and free of pollution.

The invention discloses a preparation method of a nano-palladium catalyst with controllable morphology and size, and relates to the technical field of nano-palladium catalyst preparation. The preparation method comprises the following steps: S1, adding a palladium source into a solvent, and uniformly stirring to prepare a palladium precursor solution; S2, adding a dispersing agent and a reducing agent into the palladium precursor solution, preparing a mixed solution, performing a reduction reaction, and preparing a colloidal solution; S3, adding ethanol into the colloidal solution for induced aggregation, performing centrifugation and washing, preparing a washed centrifugal product, adding dichloromethane into the washed centrifugal product, and preparing the nano-palladium catalyst with the controllable morphology and size. According to the preparation method provided by the invention, one-step synthesis is adopted, in an organic solvent system, under the protection of oleic acid or oleylamine, an active silicon-hydrogen compound is used as a reducing agent to reduce a palladium precursor, and palladium nanoparticles with various particle sizes and morphologies can be controllably synthesized.

The invention provides a preparation method of a rhodamine bispyrazole acetate organic laser material. The rhodamine bispyrazole acetate organic laser material provided by the invention has the advantages of low preparation cost, simple and controllable synthesis, high yield and good solubility; meanwhile, the rhodamine bispyrazole acetate organic laser material has relatively good thermal stability. The material provided by the invention has excellent thermal stability, film forming stability and low threshold value property in application of organic laser devices and has low water-oxygen sensitivity and high luminous intensity. The rhodamine bispyrazole acetate organic laser material has high luminous efficiency and mobility, so that the rhodamine bispyrazole acetate organic laser material has potential application value in the aspects of electric pumping organic semiconductor laser, organic electroluminescence and organic field effect transistors.

The invention relates to a preparation method of a gold-silver core-shell nanoparticle electrochemical biosensor synthesized by adopting a pressure change type micro-fluidic chip, and belongs to the field of micro-fluidic synthesis and electrochemical sensors. The gold and silver core-shell nanoparticles synthesized by adopting the pressure change type micro-fluidic chip have the characteristics of controllable morphology, adjustable core-shell thickness and large specific surface area. The gold-silver core-shell nanoparticles are used as the substrate of the electrochemical biosensor, are used for detecting procalcitonin, and have the advantages of high sensitivity and favorable specificity.