Bimetallic organic framework antibacterial nanoparticles with photothermal effect, and preparation method and application thereof

An organic framework and nanoparticle technology, applied in the field of nanomaterials, can solve the problems of unstable thermal stability and chemical stability of antibacterial nanoparticles, no ion slow-release antibacterial effect, no photothermal effect, etc., so as to promote wound repair and healing. , promote destruction, enhance the effect of photothermal performance

Active Publication Date: 2018-03-23
HUBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The existing antibacterial nano-ions do not have a good photothermal effect, and there is no long-term antibacterial effect of sustained release of ions. At the same time, the thermal and chemical stability of antibacterial nanoparticles is unstable, highly toxic, and poor in biocompatibility, which cannot meet people's expectations. its needs

Method used

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  • Bimetallic organic framework antibacterial nanoparticles with photothermal effect, and preparation method and application thereof
  • Bimetallic organic framework antibacterial nanoparticles with photothermal effect, and preparation method and application thereof
  • Bimetallic organic framework antibacterial nanoparticles with photothermal effect, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] S1. Dissolve 263.4 mg (0.8 mmol) of potassium ferricyanide in 40 mL of deionized water and magnetically stir for 10 min to form a solution, and dissolve 109.04 mg (0.8 mmol) of anhydrous zinc chloride in 40 mL of deionized water and magnetically stir for 5 min to form Solution B, and solution A was added dropwise to solution B, mixed and stirred for 20 minutes, and set aside;

[0033] S2. Add 6 g of polyvinylpyrrolidone to the solution obtained in step S1 and stir for 30 minutes to make it evenly mixed, then add 0.01 M, 80 mL of hydrochloric acid, stir for 15 minutes to fully dissolve it, and leave it standing at 80° C. for aging and precipitation for 32 hours;

[0034] S3. Centrifuge the product obtained in step S2 at 12,000 rpm for 10 min, separate the product solution to obtain a blue precipitate, and centrifuge and wash with ethanol and deionized water for 3 times, respectively, to obtain the precipitate product;

[0035] S4. Place the product obtained in step S3 in...

Embodiment 2

[0037] S1. Dissolve 263.4 mg (0.8 mmol) of potassium ferricyanide in 40 mL of deionized water and magnetically stir for 13 minutes to form A solution, and dissolve 81.78 mg (0.6 mmol) of anhydrous zinc chloride in 40 mL of deionized water and magnetically stir for 8 minutes to form Solution B, and solution A was added dropwise to solution B, mixed and stirred for 25 minutes, and set aside;

[0038] S2. Add 6 g of polyvinylpyrrolidone to the solution obtained in step S1 and stir for 40 minutes. After mixing evenly, add 0.01 M, 80 mL of hydrochloric acid, stir for 10 minutes to fully dissolve, and leave it at 82° C. for aging and precipitation for 30 hours;

[0039] S3. Centrifuge the product obtained in step S2 at 10,000 rpm for 15 minutes, separate the product solution to obtain a blue precipitate, and centrifuge and wash with ethanol and deionized water for 3 times, respectively, to obtain the precipitated product;

[0040] S4. Place the product obtained in step S3 in a freez...

Embodiment 3

[0042] S1. Dissolve 263.4mg (0.8mmol) of potassium ferricyanide in 40mL of deionized water and magnetically stir for 11min to form A solution, and dissolve 54.526mg (0.4mmol) of anhydrous zinc chloride in 40mL of deionized water and magnetically stir for 3min to form Solution B, and solution A was added dropwise to solution B, mixed and stirred for 35 minutes, and set aside;

[0043] S2. Add 6 g of polyvinylpyrrolidone to the solution obtained in step S1 and stir for 50 minutes. After mixing evenly, add 0.01 M, 80 mL of hydrochloric acid, stir for 14 minutes to fully dissolve, and leave it at 84° C. for aging and precipitation for 28 hours;

[0044] S3. Centrifuge the product obtained in step S2 at 12,000 rpm for 10 min, separate the product solution to obtain a blue precipitate, and centrifuge and wash with ethanol and deionized water for 3 times, respectively, to obtain the precipitate product;

[0045] S4. Place the product obtained in step S3 in a freezer for 7 hours to fr...

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Abstract

A preparation method of bimetallic organic framework antibacterial nanoparticles with a photothermal effect comprises the following steps: S1, respectively mixing potassium ferricyanide and anhydrouszinc chloride with deionized water, obtaining a solution A and a solution B respectively, and then mixing and stirring evenly the solution A and the solution B for standby application; S2, adding polyvinylpyrrolidone into the solution obtained in the step S1, stirring evenly, then adding hydrochloric acid, stirring evenly to make fully dissolved, and then carrying out static aging precipitation; S3, centrifuging the substance obtained in the step S2, separating a product solution to obtain a blue precipitate, and centrifuging and washing with ethanol and deionized water respectively, to obtaina precipitate product; and S4, placing the product obtained in the step S3 in a freezer, and freeze-drying. The method has the advantages that the precipitation aging method is used for controlling the stirring time in the synthetic process, and the nano cubic particles with uniform particle size can be controllably synthesized. Trace zinc ions can effectively promote cell proliferation and differentiation and promote wound repairing and healing, and the method is green and environmentally friendly.

Description

technical field [0001] The invention relates to the technical field of nanomaterials, in particular to a bimetallic organic framework antibacterial nanoparticle with photothermal effect and its preparation method and application. Background technique [0002] The existing antibacterial nano-ions do not have a good photothermal effect, and there is no long-term antibacterial effect of sustained release of ions. At the same time, the thermal and chemical stability of antibacterial nanoparticles is unstable, highly toxic, and poor in biocompatibility, which cannot meet people's expectations. its needs. Contents of the invention [0003] In order to solve the above-mentioned technical defects, the present invention provides a bimetallic organic framework antibacterial nanoparticle with photothermal effect and its preparation method and application, specifically, doping with an iron-containing metal organic framework has antibacterial properties and can heal skin wounds at the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/30A61K41/00A61K9/19A61K47/32A61K47/04A61P17/02A61P31/04A61P29/00A61K33/26
CPCA61K9/0004A61K9/0009A61K9/19A61K33/26A61K33/30A61K41/0052A61K47/02A61K47/32A61K2300/00
Inventor 吴水林林沙刘想梅崔振铎杨贤金
Owner HUBEI UNIV
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