12 results about "Articular disease" patented technology

An object is to provide a joint function-improving composition which is useful for prevention or treatment of various arthropathies such as osteoarthritis including knee osteoarthritis as a typical example and rheumatoid arthritis because the composition has an action of promoting growth of chondrocytes and an action of suppressing the production of an inflammation factor, a cartilage matrix degradation factor, a pain factor or a neuronal outgrowth factor by synoviocytes and to provide a joint function-improving product containing the composition such as a food or a drink, feed and a medicine. A joint function-improving composition containing bacterial cells and / or a culture of a bacterium belonging to genera Lactobacillus, Lactococcus, Streptococcus or Bifidobacterium and a joint function-improving agent, a joint function-improving food or drink, a joint function-improving nutritional composition, joint function-improving feed or a joint function-improving pharmaceutical agent which is characterized by containing the joint function-improving composition.

The invention provides immortalized adipose-derived mesenchymal stem cells as well as a preparation method and application thereof, and belongs to the technical field of cells, the preparation method comprises the following steps: separating adipose tissues, constructing cells to be screened by the obtained adipose-derived mesenchymal stem cells, and screening to obtain the immortalized adipose-derived mesenchymal stem cells; the immortalized adipose-derived mesenchymal stem cells are used for treating neurological diseases, respiratory system diseases, cardiovascular diseases, osteoarticular diseases, urinary system diseases, digestive system diseases, skin diseases or autoimmune diseases. According to the invention, by preparing the immortalized canine adipose-derived mesenchymal stem cells and utilizing an intranasal administration mode, the nervous system degenerative diseases can be safely and effectively relieved.

The present invention provides an external brace, an orthosis, for treating disorders of joints in dogs and cats. The most relevant veterinary indication is a hock joint brace to treat cranial cruciate disease in dogs.

The present disclosure relates generally to joint health supplement compositions derived from a xenogeneic cartilaginous tissue source, methods of making such compositions, as well as methods of using such compositions, for example, to treat joint pain or other joint ailments due to arthritis in human and animal populations both at risk and actively presenting with such joint pain or other joint ailments. One aspect of the present disclosure can include a nutritional joint health supplement composition including a cartilaginous tissue material harvested from a xenogeneic tissue source and at least a trace amount of a detergent, wherein the nutritional joint health supplement composition has a beneficial component profile and reduced cellular and DNA content.

The invention discloses a traditional Chinese medicine composition for treating joint diseases and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 25 to 45 parts of radix angelicae pubescentis, 25 to 45 parts of cortex phellodendri, 20 to 40 parts of rhizoma smilacis glabrae, 20 to 40 parts of rhizoma dioscoreae septemlobae, 20 to 40 parts of rhizoma chuanxiong, 20 to 40 parts of semen coicis, 20 to 40 parts of radix cyathulae, 20 to 40 parts of herba artemisiae scopariae, 20 to 40 parts of herba lycopodii, 20 to 40 parts of rhizoma polygoni cuspidati, 20 to 40 parts of radix dipsaci, 20 to 40 parts of rhizoma atractylodis, 20 to 40 parts of semen plantaginis and 10 to 25 parts of liquorice root. The traditional Chinese medicine composition has a relatively good treatment effect on gout, rheumatic arthritis and rheumatoid arthritis, can treat both symptoms and root causes, and is relatively small in side effect and relatively small in harm to a human body.

Provided herein are joint deliverable oligonucleotide modulators and the use thereof in the treatment of joint diseases, such as rheumatoid arthritis (RA). The intra-articular (IA) deliverable oligonucleotide agents comprise: a double-stranded oligonucleotide capable of modulating the expression of a selected gene associated to a joint disease, and one or more delivery moieties conjugating to the double-stranded oligonucleotide for delivery of the oligonucleotide to cells in the joint. Also provided are products comprising the same, methods for delivering the same to cells in the joint, and methods for the treatment of joint diseases using the same.

The present disclosure is directed to peptide-polymer conjugates, and to their use in treating intra-articular diseases or disorders.

Compositions and methods of treatment are disclosed using compositions of extracts from the fruit of the Synsepalum dulcificum tree, which when applied topically in mammals, can provide benefit for dermatological and joint conditions. The extracts also contain anti-inflammatory, antimicrobial and spermicidal activity in vitro.

Water-soluble hydroxybisphosphonic derivatives of meloxicam may be used as a drug, especially for the treatment of inflammatory joint diseases. Pharmaceutical compositions include such water-soluble hydroxybisphosphonic derivatives of meloxicam and at least one excipient. Methods are used to synthesize such hydroxybisphosphonic derivatives of meloxicam.

The present invention relates to new hyaluronic acid binding proteins. The invention refers to new engineered fusion proteins for use in treating disorders of the eye or the joints. The fusion proteins comprise a subunit that specifically binds to hyaluronic acid. In addition to the hyaluronic acid binding protein, the new fusion proteins comprise a protein therapeutically effective in diseases of the eye or of joints. The fusion proteins are particularly well-suited for medical applications that require extended half-life of eye specific therapeutic proteins.

The present invention provides a second use of mitochondria, which can cure a tendon injury-related disease and prevent a disease caused by a tendon injury. Specifically, the mitochondria disclosed in the present invention have the effect of repairing injured tendon cells and accelerating the healing of the tendon cells. Therefore, by administering a predetermined amount of mitochondria or a composition containing a predetermined amount of mitochondria to a part with a tendon injury, wound healing of the part with the tendon injury can be promoted, thus achieving the effect of repairing the injured tendon and further preventing a joint disease caused by the tendon injury or inflammation.

The invention belongs to the technical field of medicines, particularly relates to application of eupatilin in treatment of synovial arthropathy (such as rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis and the like) and other joint diseases characterized by synovial pathology hyperplasia, and provides novel application of eupatilin in preparation of medicines for resisting synovial arthropathy. Particularly, the compound has a good inhibition effect on abnormal behaviors such as proliferation and invasion of synovial fibroblasts; eupatilin is provided as an effective medicine component for treating joint deformation, and the main action mechanism is that clinical symptoms are relieved by inhibiting proliferation and invasion of RA-FLS; the innovation of the invention lies in providing a therapy based on eupatilin, and through application of a specific dosage, joint inflammation of patients can be effectively relieved and joint functions can be improved.