68 results about "Articular disease" patented technology

A method of predicting bone or articular disease in a subject includes determining one or more micro-structural parameters, one or more macroanatomical parameters or biomechanical parameters of a joint in the subject and combining at least two of the parameters to predict the risk of bone or articular disease.

Methods of predicting bone or joint disease in a subject are presented. The method may include determining one or more micro-structural parameters, one or more macroanatomical parameters or biomechanical parameters of a joint in the subject. At least two of the parameters are combined to predict the risk of bone or articular disease. Additionally, methods of determining the effect of a candidate agent on any subject's risk of developing bone or joint disease are presented.

The present invention relates to hovel fused azolepyrimidine derivatives, processes for preparing them and pharmaceutical preparations containing them. The fused azolepyrimidine derivatives of the present invention exhibit enhanced potency for phosphotidylinositol-3-kinase (PI3K) inhibition, especially for PI3K-γ inhibition and can be used for the prophylaxis and treatment of diseases associated with PI3K and particularly with PI3K-γ activity. More specifically, the azole derivatives of the present invention are useful for treatment and prophylaxis of diseases as follows: inflammatory and immunoregulatory disorders, such as asthma, atopic dermatitis, rhinitis, allergic diseases, chronic obstructive pulmonary disease (COPD), septic shock, joint diseases, autoixnmune pathologies such as rheumatoid arthritis, and Graves' disease, cancer, myocardial contractility disorders, heart failure, thromboembolism, ischemia, and atherosclerosis. The compounds of the present invention are also useful for pulmonary hypertension, renal failure, cardiac hypertrophy, as well as neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease, diabetes and focal ischemia, since the diseases also relate to PI3K activity in a human or animal subject.

Disclosed are methods and compositions for treating articular diseases such as osteoarthritis and rheumatoid arthritis, or articular dysfunction in mammals. Also disclosed are self-complimentary AAV vectors useful in gene therapy and delivery of therapeutic constructs to mammalian cells, and in particular, articular joints, cartilage, ligaments, tendons, and surrounding tissues.

This invention provides a compound represented by the formula (I):

wherein R¹ is a hydrogen atom, a halogen atom, hydroxy, nitro, optionally halogenated alkyl, alkoxy optionally having substituents, acyl or amino optionally having substituents;

• R² is pyridyl, furyl, thienyl, pyrrolyl, quinolyl, pyrazinyl, pyrimidinyl, pyridazinyl, indolyl, tetrahydroquinolyl or thiazolyl, each of which may have substituents; n is 1 or 2; or a salt. And this invention provides a safe pharmaceutical comprising the compound of the formula (I), which has an excellent apoptosis inhibitory effect and MIF binding effect, for preventing and/or treating heart disease, nervous degenerative disease, cerebrovascular disease, central nervous infectious disease, traumatorathy, demyelinating disease, bone and articular disease, kidney disease, liver disease, osteomyelodysplasia, AIDS, cancer, and the like.

Method for the treatment of articular diseases or articular pain, or for the treatment of skin, which comprises the infiltration or the application of a compound that comprises at least one blood-derived substance, which is preferably a blood plasma in general, and in particular a platelet-rich plasma (PRP), and preferably a plasma rich in growth factors (PRGF), and/or a supernatant of any of the aforementioned plasmas. The inventive method enables the significant relief and even regeneration of the treated areas. Optionally, the blood-derived substance may be mixed with hyaluronic acid (HA) and/or an HA-derived compound, thereby achieving even more beneficial effects.

The invention discloses a pharmaceutical composition for treating orthopaedic diseases, especially the injection of the pharmaceutical composition and its preparation, the medicament is prepared from bone extract of pig's limbs and sweet melon seeds extract through conventional methods for injection preparation.

The invention discloses new application of melatonin, fills the technical blanks in the prior art, and discloses the application of the melatonin in the preparation of drugs for promoting mesenchymal stem cell chondrogenic differentiation, the application of the melatonin in the preparation of drugs for treatment of joint diseases, and the application of the melatonin in the preparation of drugs for treatment of cartilage diseases. The application introduces two representative proinflammatory cytokines including IL-1 beta (Interleukin-1 beta) and TNF-alpha (tumor necrosis factor-alpha), creates two in-vitro arthritis cell models for studying to determine mesenchymal stem cell in-vitro chondrogenic differentiation promoted by the melatonin and a mechanism thereof, and establishes a foundation for further application of the melatonin in the preparation of the drugs for promoting the mesenchymal stem cell chondrogenic differentiation, in the preparation of the drugs for treatment of the joint diseases, and in the preparation of the drugs for treatment of the cartilage diseases.

The present invention provides, among other things, a method of intra-articular delivery of messenger RNA (mRNA), comprising administering into a joint of a subject in need of delivery a composition comprising an mRNA encoding a protein, such that the administering of the composition results in expression of the protein encoded by the mRNA in the joint.

Disclosed is a medicament for treating osteoarthrosis, which comprises dutchmanspipe root, camphor, seed of nuxvomica, arisaema tuber, pinellia tuber, Inula cappa, centipede, Shushalian, dysosmapleiantha woods, Baofu lotus, and Swertia heterantha.

The invention discloses a formula for treating rheumatism and rheumatoid articular diseases. The formula is obtained by scientifically combining 22 Chinese medicinal herbs, the years of the wide application of the formula in folk shows that the formula can cure rheumatism and rheumatoid articular diseases in a short time with no relapse after being cured, the formula has the functions of convenient use and improving human immunity, can greatly relieve the pains and economic burden of patients, which is a formula for eradicating rheumatism and rheumatoid articular diseases.

Prostheses, methods and related instrumentation for treating disorders of the knee by displacing a connective tissue acting on the patella to alter the location, angle or magnitude of forces exerted by the tissue on the patella so as to achieve a therapeutic effect in patellofemoral compartment of the knee.

A Chinese medicine for treating rheumatic and rheumatoid arthritis, hyperosteogeny, spondylitis, and ischemic femur head necrosis is prepared from 26 Chinese-medicinal materials including Sichuam aconite root, donkey-hide gelatin, phellodendron bark, Chuan-xiong rhizome, etc. Its preparing process is also disclosed.

The invention relates to a traditional Chinese medicine for treating osteoarticular diseases, and a preparation method thereof. The traditional Chinese medicine for treating osteoarticular diseases is prepared through using the following raw medicines, by weight, 20-45 parts of Sevenlobed Yam Rhizome, 20-40 parts of Atractylodes lancea, 20-40 parts of white peony root, 20-40 parts of Chinese angelica, 20-40 parts of pawpaw, 20-40 parts of Millettia dielsiana, 20-40 parts of Himalayan Teasel Root, 20-40 parts of Rhizoma Corydalis, 20-40 parts of dried Rehmannia glutinosa Libosch, 20-40 parts of Chinese Taxillus Twig, 20-40 parts of Rhizoma Drynariae, 20-40 parts of Divaricate Saposhnikovia Root, 20-40 parts of Radix Stephaniae Tetrandrae, 20-40 parts of Eucommia ulmoides, 20-40 parts of Fructus Liquidambaris, 20-40 parts of Rhizoma Cibotii, 10-30 parts of Boswellia carteri, 10-30 parts of myrrh, 10-30 parts of Radix Clematidis, 5-25 parts of prepared Aconitum kusnezoffii, 5-25 parts of prepared Radix Aconiti, 10-30 parts of Ligusticum wallichii, 20-40 parts of dahurian angelica root, 20-40 parts of centipede and 20-40 parts of pangolin. The traditional Chinese medicine a beneficial effect that the traditional Chinese medicine has good treatment effects on the osteoarticular diseases, especially hydrarthrosis pains comprising pains in muscles and bones, ankylosing spondylitis, femur head necrosis and the like through the screening and the scientific matching of muscle and bone strengthening, swelling diminishing and pain relieving medicines.

The compositions and methods of the invention provide compositions and methods for preferential targeting of tissues to delivery therapeutic or diagnostic agents. For example, such compounds are useful in the treatment of joint disorders those affecting articulating joints, e.g., injury-induced osteoarthritis as well as autoimmune diseases affecting joint tissue such as rheumatoid arthritis.

The invention provides a chondroitin sulfate synthesis promoter useful for the treatment of diseases such as articular disease and discopathy. The chondroitin sulfate synthesis promoter contains, as an active ingredient, chondroitin sulfate glucuronyltransferase protein and/or chondroitin sulfate N-acetylgalactosaminyltransferase-1 protein, or a gene encoding the enzyme protein(s).