74 results about "Articular disease" patented technology

A method of predicting bone or articular disease in a subject includes determining one or more micro-structural parameters, one or more macroanatomical parameters or biomechanical parameters of a joint in the subject and combining at least two of the parameters to predict the risk of bone or articular disease.

Methods of predicting bone or joint disease in a subject are presented. The method may include determining one or more micro-structural parameters, one or more macroanatomical parameters or biomechanical parameters of a joint in the subject. At least two of the parameters are combined to predict the risk of bone or articular disease. Additionally, methods of determining the effect of a candidate agent on any subject's risk of developing bone or joint disease are presented.

The present invention relates to hovel fused azolepyrimidine derivatives, processes for preparing them and pharmaceutical preparations containing them. The fused azolepyrimidine derivatives of the present invention exhibit enhanced potency for phosphotidylinositol-3-kinase (PI3K) inhibition, especially for PI3K-γ inhibition and can be used for the prophylaxis and treatment of diseases associated with PI3K and particularly with PI3K-γ activity. More specifically, the azole derivatives of the present invention are useful for treatment and prophylaxis of diseases as follows: inflammatory and immunoregulatory disorders, such as asthma, atopic dermatitis, rhinitis, allergic diseases, chronic obstructive pulmonary disease (COPD), septic shock, joint diseases, autoixnmune pathologies such as rheumatoid arthritis, and Graves' disease, cancer, myocardial contractility disorders, heart failure, thromboembolism, ischemia, and atherosclerosis. The compounds of the present invention are also useful for pulmonary hypertension, renal failure, cardiac hypertrophy, as well as neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease, diabetes and focal ischemia, since the diseases also relate to PI3K activity in a human or animal subject.

The present invention provides a method of determining, in a sample, the proportion of a total amount of a molecule that is derived from catabolism due to the presence of age-related molecular alterations on the molecule, comprising: a) determining the total amount of the molecule in the sample; b) determining the amount of the molecule in the sample that contains D-aspartate; and c) calculating the proportion of the amount of the molecule of step (b) relative to the total amount of the molecule as determined in step (a), thereby determining the proportion of the total amount of the molecule that is derived from catabolism due to the presence of age-related molecular alterations in the molecule. Further provided is a method of diagnosing a musculoskeletal, arthritic or joint disorder in a subject and / or identifying a subject at risk for developing such a disorder, comprising: a) measuring an amount of D-aspartate and / or an advanced glycation end product in a sample of the subject; and b) comparing the amount of D-aspartate and / or advanced glycation end product in the sample of (a) with an amount of D-aspartate and / or advanced glycation end product in a sample of a control subject, whereby an increased amount of D-aspartate and / or advanced glycation end product in the sample of the subject as compared to the amount of D-aspartate and / or advanced glycation end product in the sample of the control subject is diagnostic of a musculoskeletal, arthritic or joint disorder in the subject and / or identifies a subject at risk of developing such a disorder.

A method of predicting bone or articular disease in a subject includes determining one or more micro-structural parameters, one or more macroanatomical parameters or biomechanical parameters of a joint in the subject and combining at least two of the parameters to predict the risk of bone or articular disease.

Disclosed are methods and compositions for treating articular diseases such as osteoarthritis and rheumatoid arthritis, or articular dysfunction in mammals. Also disclosed are self-complimentary AAV vectors useful in gene therapy and delivery of therapeutic constructs to mammalian cells, and in particular, articular joints, cartilage, ligaments, tendons, and surrounding tissues.

This invention provides a compound represented by the formula (I): wherein R1 is a hydrogen atom, a halogen atom, hydroxy, nitro, optionally halogenated alkyl, alkoxy optionally having substituents, acyl or amino optionally having substituents; R2 is pyridyl, furyl, thienyl, pyrrolyl, quinolyl, pyrazinyl, pyrimidinyl, pyridazinyl, indolyl, tetrahydroquinolyl or thiazolyl, each of which may have substituents; n is 1 or 2; or a salt. And this invention provides a safe pharmaceutical comprising the compound of the formula (I), which has an excellent apoptosis inhibitory effect and MIF binding effect, for preventing and / or treating heart disease, nervous degenerative disease, cerebrovascular disease, central nervous infectious disease, traumatorathy, demyelinating disease, bone and articular disease, kidney disease, liver disease, osteomyelodysplasia, AIDS, cancer, and the like.

Methods and compositions for preventing and / or treating degenerative joint diseases including osteoarthritis as well as inflammation of the joints and for diminishing associated pain are provided. The formulation includes glucosamine, conjugated linoleic acid and ascorbic acid. Methods of treatment are also provided. The compositions and methods can be provided as an over-the-counter drug, a nutritional supplement, a prescription medication or component thereof, or a functional or medical food or component thereof.

Method for the treatment of articular diseases or articular pain, or for the treatment of skin, which comprises the infiltration or the application of a compound that comprises at least one blood-derived substance, which is preferably a blood plasma in general, and in particular a platelet-rich plasma (PRP), and preferably a plasma rich in growth factors (PRGF), and / or a supernatant of any of the aforementioned plasmas. The inventive method enables the significant relief and even regeneration of the treated areas. Optionally, the blood-derived substance may be mixed with hyaluronic acid (HA) and / or an HA-derived compound, thereby achieving even more beneficial effects.

The invention provides a process for preparing low molecular weight glycosaminoglycan collagen compound comprising the following steps, choosing material and cleaning, disintegrating, homogenating, cracking proteolytic enzyme through catalytic decomposition, sterilizing and disinfecting, filtering for entrapment, concentrating, drying and packaging. The obtained compound can be used for treating joint diseases such as cervical vertebra disease and gonarthritis.

The invention discloses new application of melatonin, fills the technical blanks in the prior art, and discloses the application of the melatonin in the preparation of drugs for promoting mesenchymal stem cell chondrogenic differentiation, the application of the melatonin in the preparation of drugs for treatment of joint diseases, and the application of the melatonin in the preparation of drugs for treatment of cartilage diseases. The application introduces two representative proinflammatory cytokines including IL-1 beta (Interleukin-1 beta) and TNF-alpha (tumor necrosis factor-alpha), creates two in-vitro arthritis cell models for studying to determine mesenchymal stem cell in-vitro chondrogenic differentiation promoted by the melatonin and a mechanism thereof, and establishes a foundation for further application of the melatonin in the preparation of the drugs for promoting the mesenchymal stem cell chondrogenic differentiation, in the preparation of the drugs for treatment of the joint diseases, and in the preparation of the drugs for treatment of the cartilage diseases.

The invention belongs to an external medicine, in particular to a medicine for treating osteoarthrosis, which is prepared from the following raw materials by weight: 20 to 80 parts of caulis spatholobi, 5 to 30 parts of flos carthami, 10 to 40 parts of radix angelicae pubescentis, 5 to 30 parts of radix aconiti preparata, 15 to 40 part of rhizoma drynariae, 10 to 50 parts of radix achyranthis bidentatae, 10 to 30 parts of pericarpium citri reticulatae viride and 10 to 30 parts of spina gleditsiae; and according to the conventional process, the medicine is added or not added with the conventional adjuvants to prepare into external powder, a paste, an emulsifier or a cataplasm. The medicine provided by the invention has the effects on removing blood stasis, expelling cold and dehumidifying, dredging the channels and collaterals to relieve pain and tonifying kidney and strengthening bones, so that the external medicine is utilized to treat osteoproliferation, cervical spondylosis, lumbar spondylosis, lumbar disc herniation, scapulohumeral periarthritis, lumbocrural pain and spur etc., and extensively treat femoral head necrosis, rheumatism and rheumatoid and the like; and the external medicine has the advantages of being convenient to use, quick to relieve the pain, definite in efficacy, low in cost, high in cure rate, free from side effects and being capable of4 directly focusing the efficacy on the affected parts and the like.

The present invention provides, among other things, a method of intra-articular delivery of messenger RNA (mRNA), comprising administering into a joint of a subject in need of delivery a composition comprising an mRNA encoding a protein, such that the administering of the composition results in expression of the protein encoded by the mRNA in the joint.

There is disclosed novel fused thiophene derivatives as prophylactic and therapeutic drugs for bone or articular diseases, industrially advantageous processes for production thereof, and novel production intermediates. Said fused thiophene derivatives are represented by the general formula (I): wherein R1 is an optionally substituted hydrocarbon, heterocyclic, sulfinyl, sulfonyl, hydroxyl, thiol or amino group,; R2 is cyano, formyl, thioformyl, etc.; ring A is any of (wherein R3 is hydrogen or an optionally substituted hydrocarbon, heterocyclic, hydroxyl, amino, sulfonyl or acyl; R14 is hydrogen, halogen, optionally subsituted hydrocarbon group, optionally subsituted heterocyclic group etc.; and ring B represents an optionally substituted 5- to 7-membered hydrocarbon ring.

Disclosed is a medicament for treating osteoarthrosis, which comprises dutchmanspipe root, camphor, seed of nuxvomica, arisaema tuber, pinellia tuber, Inula cappa, centipede, Shushalian, dysosmapleiantha woods, Baofu lotus, and Swertia heterantha.

The invention discloses a formula for treating rheumatism and rheumatoid articular diseases. The formula is obtained by scientifically combining 22 Chinese medicinal herbs, the years of the wide application of the formula in folk shows that the formula can cure rheumatism and rheumatoid articular diseases in a short time with no relapse after being cured, the formula has the functions of convenient use and improving human immunity, can greatly relieve the pains and economic burden of patients, which is a formula for eradicating rheumatism and rheumatoid articular diseases.

Prostheses, methods and related instrumentation for treating disorders of the knee by displacing a connective tissue acting on the patella to alter the location, angle or magnitude of forces exerted by the tissue on the patella so as to achieve a therapeutic effect in patellofemoral compartment of the knee.

The invention provides a neck and shoulder osteoarthropathy therapeutic apparatus, belonging to medical instrumentation. The therapeutic apparatus comprises a head copying therapeutic box, a neck copying therapeutic box, a back copying therapeutic box, a two-front-shoulder copying therapeutic box and a two-rear-shoulder copying therapeutic box; by means of active connection among the therapeutic boxes, the therapeutic boxes can be applied to the corresponding position of body; by adopting a sliding rail mechanism between the two-rear-shoulder therapeutic box and the back therapeutic box and a torsional spring adjusting and locking mechanism between the two-front-shoulder therapeutic box and the two-rear-shoulder therapeutic box, the therapeutic boxes can be applied to effective positions of people in different shapes as far as possible; by adopting a magnetic-pulse component and a flaky permanent magnet fixed by a pressure spring in the event that the therapeutic boxes are applied to one side of the human body, the therapeutic boxes can be applied to the effective positions; and the two-front-shoulder copying therapeutic box and the two-rear-shoulder copying therapeutic box are provided with heating sheets, temperature control sensors and far infrared ceramic powder coatings for outer surface coating for treating positions of the human body, thus achieving accurate acupoint treatment, improving effective utilization ratio, and realizing standard and normative healthcare and treatment.

The present invention provides a pharmaceutical composition comprising mesenchymal stem cells, a hyaluronan and a pharmaceutically acceptable carrier. The pharmaceutical composition is used for the treatment of the joint disease. The mesenchymal stem cells in the composition are at least one selected from the group consisting of infra-patellar fat pad stromal cells, bone marrow stem cells, Wharton's jelly stem cells and adipose derived stem cells. The concentration of the hyaluronan is in a range from 25% (v / v) to 75% (v / v). The present invention further provides a method for treating a joint disease, comprising a step of administrating a composition containing mesenchymal stem cells, a hyaluronan and a pharmaceutically acceptable carrier to an injured joint tissue of a subject.

The invention discloses a traditional Chinese medicinal ointment for treating osteoarticular diseases and bone fractures. The traditional Chinese medicinal ointment is an external preparation prepared from multibanded krait, spatholobus stem, chicken bone, notopterygium roots, pubescent angelica roots, aconite, radix cyathulae, peach kernels, papaya, common clubmoss herb, flos carthami, olibanum, myrrh, panax notoginseng, szechuan lovage rhizome, salvia chinensis, borneo camphor and the like, can effectively treat the osteoarticular diseases and the bone fractures, and is high in cure rate and free of relapse and adverse and side effects.

A Chinese medicine for treating rheumatic and rheumatoid arthritis, hyperosteogeny, spondylitis, and ischemic femur head necrosis is prepared from 26 Chinese-medicinal materials including Sichuam aconite root, donkey-hide gelatin, phellodendron bark, Chuan-xiong rhizome, etc. Its preparing process is also disclosed.

The invention relates to a traditional Chinese medicine for treating osteoarticular diseases, and a preparation method thereof. The traditional Chinese medicine for treating osteoarticular diseases is prepared through using the following raw medicines, by weight, 20-45 parts of Sevenlobed Yam Rhizome, 20-40 parts of Atractylodes lancea, 20-40 parts of white peony root, 20-40 parts of Chinese angelica, 20-40 parts of pawpaw, 20-40 parts of Millettia dielsiana, 20-40 parts of Himalayan Teasel Root, 20-40 parts of Rhizoma Corydalis, 20-40 parts of dried Rehmannia glutinosa Libosch, 20-40 parts of Chinese Taxillus Twig, 20-40 parts of Rhizoma Drynariae, 20-40 parts of Divaricate Saposhnikovia Root, 20-40 parts of Radix Stephaniae Tetrandrae, 20-40 parts of Eucommia ulmoides, 20-40 parts of Fructus Liquidambaris, 20-40 parts of Rhizoma Cibotii, 10-30 parts of Boswellia carteri, 10-30 parts of myrrh, 10-30 parts of Radix Clematidis, 5-25 parts of prepared Aconitum kusnezoffii, 5-25 parts of prepared Radix Aconiti, 10-30 parts of Ligusticum wallichii, 20-40 parts of dahurian angelica root, 20-40 parts of centipede and 20-40 parts of pangolin. The traditional Chinese medicine a beneficial effect that the traditional Chinese medicine has good treatment effects on the osteoarticular diseases, especially hydrarthrosis pains comprising pains in muscles and bones, ankylosing spondylitis, femur head necrosis and the like through the screening and the scientific matching of muscle and bone strengthening, swelling diminishing and pain relieving medicines.