50 results about "Transcranial alternating current stimulation" patented technology

The invention provides a closed-loop nerve regulation method and device, a medium and a program product, and relates to the technical field of nerve regulation. The method comprises the steps that an electroencephalogram collection module collects electroencephalogram signals in real time and provides real-time feedback data for nerve regulation and control; the magnetic resonance imaging module provides high-precision brain structure and function positioning information; the three different stimulation modules (transcranial alternating current stimulation, low-field magnetic field stimulation and transcranial magnetic stimulation) can stimulate brain regions with different depths and ranges; the multi-mode navigation module carries out accurate positioning based on the magnetic resonance image; the electroencephalogram detection module analyzes the collected signals; and the central control module coordinates the work of each module. According to the multi-module cooperative working mode, accurate stimulation of different areas and different depths of the brain is achieved, meanwhile, the stimulation effect is ensured through real-time monitoring, and therefore the accuracy and effectiveness of nerve regulation and control are improved.

The invention discloses a closed-loop transcranial alternating current stimulation system based on phase-amplitude coupling stimulation, and the system comprises an alternating current stimulation current source which is used for generating a current signal with a fixed frequency; the stimulation and collection integrated electrode is connected with the alternating current stimulation current source and used for being worn on the head, conducting electric stimulation on a target scalp area and collecting electric signals of the target scalp area; the electroencephalogram acquisition front end is connected with the stimulation and acquisition integrated electrode and is used for acquiring electroencephalogram data according to the acquired electric signals; and the DSP processor is connected with the electroencephalogram acquisition front end and is used for executing a control algorithm according to the electroencephalogram data and adjusting parameters of the alternating current stimulation current source so as to control the stimulation and acquisition integrated electrode to perform closed-loop regulation and control on the brain. Based on the real-time electroencephalogram feedback technology, a set of closed-loop transcranial alternating current stimulation technology is constructed, phase-coupling regulation and control of the cortex are achieved, and the application range of the transcranial alternating current stimulation technology in the aspect of cognitive ability regulation and control is widened.

The invention discloses a multi-target transcranial electrical stimulation device based on cross-regional phase-locked stimulation, and the device comprises a light electroencephalogram cap which is integrated with at least one pair of electroencephalogram signal collection electrodes located in a first brain region and used for monitoring specific neural oscillation, and is provided with electrode holes used for placing stimulation electrodes in a second brain region; a plurality of stimulating electrodes; a controller, a multi-channel stimulation module, an electroencephalogram signal processing and feedback regulation and control module and a communication module are arranged in the control box; the electroencephalogram signal module is configured to detect the phase of specific neural oscillation of a first brain region in real time; the controller is configured to accurately control the time or phase of stimulation (such as transcranial alternating current stimulation or pulse stimulation) output by the multi-channel stimulation module in the second brain region based on the detected real-time phase information, and cross-region phase-locked stimulation is achieved. The device is suitable for personalized nerve regulation and control application in a family environment while remarkably simplifying user operation, reducing cost and improving comfort and portability.

The invention relates to a closed-loop feedback transcranial alternating current stimulation system and method. The closed-loop feedback transcranial alternating current stimulation system comprises a phase stimulation system used for generating a plurality of electrical stimulation signals and stimulating different brain areas in the brain based on the electrical stimulation signals; a preset phase difference exists between the electrical stimulation signals; the electroencephalogram acquisition system is used for acquiring electroencephalogram signals of the brain after the phase stimulation system stimulates the brain for a preset time; and the evaluation feedback system is connected with the phase stimulation system and the electroencephalogram acquisition system and is used for evaluating the electroencephalogram signals acquired by the electroencephalogram acquisition system and adjusting the electrical stimulation signals based on an evaluation result. According to the closed-loop feedback transcranial alternating current stimulation system, the waveform signal can be flexibly adjusted based on the real-time oscillation signal of the brain, and the problems that in the prior art, the shock wave form is single, individual differences cannot be accurately matched, and dynamic brain network state changes cannot be adapted are solved.

The invention provides a transcranial alternating current stimulation method and system with an automatic adjustment function, and relates to the technical field of transcranial alternating current stimulation, and the method comprises the steps: obtaining, compressing and sampling a multi-channel electroencephalogram signal, carrying out the multi-channel reconstruction through the physiological priori and the related information of adjacent brain regions, extracting the feature parameters of target brain waves, and carrying out the reconstruction of the target brain waves. Based on the parameters, dual-stage transcranial alternating current signals of prior stimulation and post stimulation are output; by introducing an adjacent matrix or a graph Laplacian operator in a compressed sensing acquisition and reconstruction link, high-fidelity recovery of cross-brain region oscillation can be maintained under the conditions of low sampling rate and noise; performing layered screening and dynamic fine tuning on characteristic frequency bands of different brain regions by combining general and individualized prior; the target brain wave phase is locked in advance in the first stimulation stage, and the stimulation intensity of each brain region is independently or cooperatively adjusted in the later stimulation stage, so that the requirement of coupling regulation and control of multiple brain regions is met, and the closed-loop intervention effect on nerve states such as insomnia and anxiety is improved.

The invention relates to the technical field of neuroscience and medical treatment, in particular to an individual head model dynamic optimization method and system based on transcranial alternating current stimulation. According to the method, the three-dimensional initial individual head model is partitioned, the parameters are set, the real-time electrical stimulation parameters and the real-time electroencephalogram information of the individual head under the stimulation effect are synchronously obtained, and then the parameters of the initial head model are adjusted according to the real-time data; then, according to the obtained data, simulating and calculating electrophysiological change data of the three-dimensional initial individual head model under the action of initial transcranial alternating current stimulation, and based on a focusing index value and a uniformity index value calculated through the electrophysiological change data, optimizing dynamically-adjusted head model parameters, and finally, calculating a focus index value and a uniformity index value of the three-dimensional initial individual head model under the action of initial transcranial alternating current stimulation. The information entropy difference value obtained through calculation of the optimized head model parameters and the real-time electroencephalogram information is compared with a preset difference threshold value, a clear termination condition is provided for optimization of the head model parameters, and therefore dynamic optimization of the individual head model is achieved.

The invention provides a transcranial deep electrical stimulation closed-loop regulation and control system and method based on fNIRS dynamic guidance. The method comprises the steps that a transcranial alternating current electrical stimulation module applies an electrical signal to a target deep brain region according to preset parameters to carry out electrical stimulation regulation and control; the synchronous triggering module is used for realizing millisecond-level synchronization of a stimulation task and near-infrared brain function data acquisition; the brain function monitoring module analyzes the concentration change of cortex oxyhemoglobin in real time through the multi-channel head cap; the electrical stimulation-response coupling mapping module positions a significant activation channel by adopting statistical test, and establishes an oxyhemoglobin concentration variable and electrical stimulation current amplitude quantitative model; and the dynamic parameter adjusting module optimizes the output current in real time. Personalized closed-loop regulation and control of non-invasive deep brain stimulation can be achieved, cerebral cortex blood oxygen signals are monitored in real time through near-infrared brain function imaging, stimulation parameters are dynamically adjusted, and the accuracy and individualization level of deep brain stimulation are remarkably improved.

The invention discloses a transcranial alternating current stimulation system and a transcranial alternating current stimulation method based on event-related potential double-component alignment. The system comprises an individualized feature extraction module, a dynamic phase mapping module, a real-time synchronous triggering module and a closed-loop feedback module, wherein the individualized feature extraction module extracts an ERP component latency period and a dominant oscillation frequency based on task state electroencephalogram data; the dynamic phase mapping module establishes phase alignment of an ERP component time window and a tACS waveform to realize a brain oscillation control process; the real-time synchronous triggering module calculates an evoked potential incubation period and a visual presentation incubation period of a corresponding task item, accurately matches a peak value of the evoked potential with a corresponding peak value of a tACS waveform, reads a current phase of the tACS waveform in advance, performs prospective prediction, adjusts the starting time of each stimulation, and realizes millisecond-level stimulation synchronization; the closed-loop feedback module monitors the brain state on line and dynamically corrects alignment parameters to ensure that the stimulation effect is stable; according to the method, accurate phase alignment of tACS and brain endogenous ERP components is realized, neural activities in a specific cognitive process can be effectively enhanced or inhibited, and the accuracy and individualization level of neural regulation and control are improved.

The invention discloses an integrated multi-mode transcranial electrical stimulation and high-intensity deep brain stimulation device, and belongs to the field of neuromedical treatment, in the device, a main control module is used for receiving data sent by a serial port display screen communication module and processing and analyzing the data, and then a signal source module is driven to output a target signal; the signal source module selectively outputs a transcranial alternating current stimulation waveform, a time intervention electrical stimulation waveform, a high-current phase modulation time intervention electrical stimulation waveform, a transcranial pulse electrical stimulation waveform and a transcranial direct current stimulation waveform based on a plurality of waveform generators and digital potentiometers; and the signal amplification and constant current output module is used for amplifying the waveform voltage signal output by the signal source module, converting the waveform voltage signal into a constant current signal and outputting the constant current signal to the output module. According to the invention, the electric field intensity generated by the stimulation current at the deep brain target spot is improved, so that the deep brain region is effectively stimulated, and a more remarkable stimulation intervention effect is achieved.

The invention relates to a system for activating nerve cells in the human eye and brain for enhancing the residual vision in existing visual-field defects, for reducing or correcting other visual disturbances or cognitive deficits by means of neurostimulation, in particular non-invasive application of microcurrent to the head, more particularly non-invasive transcranial alternating current stimulation (tACS), the system consisting of: a non-invasive applicator for guiding a flow of energy to the eye and brain and for stimulating the blood flow and activation of nerve cells, in particular retinal ganglion cells and brain cells; an impulse generator for generating electrical or magnetic stimulation signals; and a data-processing and control unit for providing patient-specific stimulation signal sequences; wherein the applicator comprises for example at least two electrodes, which can be brought into contact with the head of the test subject and in this respect stimulation electrodes, in particular replaceable stimulation electrodes, are fixed on the applicator such that they rest or make contact on the right and left of the eye in the region of the temple of the patient's head; wherein the stimulation signal sequences are provided repeatedly for application until a demonstrable reduction in an existing vascular dysregulation in the eyes and in the brain is determined.

The invention relates to the technical field of transcranial alternating current waveform control, and discloses a current waveform control method and system based on transcranial alternating current stimulation, and the method comprises the steps: carrying out the time-frequency analysis of an electroencephalogram signal through short-time Fourier transform; generating an initialized current waveform according to individual neural oscillation characteristics; different stimulation modes are selected according to task requirements to adjust the current waveform; and frequency deviation and phase deviation are calculated through real-time feedback, and the current waveform is dynamically compensated and adjusted. The technical problems that in the prior art, a stimulation method with fixed frequency and amplitude is usually adopted, and particularly under the condition of large individual difference, accurate individualized current waveform control is difficult to achieve, so that the stimulation effect is unstable and poor are solved. Due to the fact that the frequency and the phase of the current waveform can be accurately adjusted according to the actual neural oscillation state of the brain through real-time feedback and the dynamic frequency, the synchronism of stimulation and brain neural oscillation is improved.

The detection system of individual transcranial alternating current stimulation current amplitude threshold and frequency band range relates to the technical field of data identification, recording and processing in medical instrument and meter technology. It comprises: an upper computer which sends stimulation parameters to a stimulator, receives and stores detection information sent by the stimulator; a control keyboard which obtains stimulation sensitivity of an individual under current stimulation and transmits to the stimulator; and the stimulator which adjusts alternating stimulation current parameters, obtains a frequency band range supplement interval in a frequency adjustment stage, adjusts stimulation current amplitude value based on a fuzzy control algorithm according to a frequency band range proportion and stimulation sensitivity in an amplitude adjustment stage, and repeatedly and alternately carries out the frequency adjustment stage and the amplitude adjustment stage until the current amplitude threshold of the individual is detected or the upper limit of test time is reached. The present application is suitable for threshold detection under different frequency bands, and the current amplitude change is improved in two aspects of direction and size, which will improve the practicability and accuracy of the detection system.

The invention relates to a transcranial electrical stimulation system and a storage medium, and the system comprises a neural signal sensing module which is configured to be used for collecting neural activity signals of the brain of a subject in real time; a transcranial alternating current stimulation module configured to apply transcranial alternating current stimulation to a target area of the brain of the subject; the real-time signal processing and control module is configured to be in communication connection with the neural signal sensing module and the transcranial alternating current stimulation module at the same time; the real-time signal processing and control module is configured to: receive a neural activity signal; extracting features of neural oscillation in a preset target frequency band from the neural activity signal in real time, wherein the features at least comprise an instantaneous phase; predicting a future phase of the neural oscillation based on the instantaneous phase, and generating a stimulation parameter in an anti-phase relationship with the future phase; and based on the stimulation parameters, controlling the transcranial alternating current stimulation module to apply adaptive transcranial alternating current stimulation to the target area of the brain of the patient.

1. Name of the product in this design: Transcranial AC Stimulator. 2. Purpose of this design: For the treatment of insomnia and anxiety. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

This invention relates to the field of transcranial alternating current waveform control technology, and discloses a method and system for controlling current waveforms based on transcranial alternating current stimulation. The method includes: performing time-frequency analysis of electroencephalogram (EEG) signals using short-time Fourier transform; generating an initial current waveform based on individual neural oscillation characteristics; selecting different stimulation modes to adjust the current waveform according to task requirements; and calculating and dynamically compensating for frequency and phase shifts through real-time feedback. Compared to existing stimulation methods that typically use fixed frequencies and amplitudes, especially under conditions of significant individual differences, it is difficult to achieve precise individualized current waveform control, leading to unstable and poor stimulation effects. This application, through real-time feedback and dynamic frequency, can precisely adjust the frequency and phase of the current waveform according to the actual neural oscillation state of the brain, improving the synchronization between stimulation and brain neural oscillations.

The invention discloses a cerebral apoplexy exercise rehabilitation system and method based on cortical hippocampus network neural oscillation regulation and control, electronic equipment and a storage medium, and the system comprises a cerebral apoplexy patient comprehensive evaluation module which is used for carrying out the comprehensive and systematic evaluation of a cerebral apoplexy patient; the individualized model building module is used for customizing an individualized model for a set patient; the transcranial alternating current stimulation accurate intervention module is used for accurately intervening transcranial alternating current stimulation; and the multi-modal joint evaluation and dynamic monitoring module is used for carrying out multi-modal joint evaluation and dynamic monitoring. According to the cerebral apoplexy exercise rehabilitation system and method based on cortical hippocampus network neural oscillation regulation and control, the electronic equipment and the storage medium, exercise function recovery can be promoted.

The invention discloses a non-invasive deep coupling electrical stimulation method, device and equipment and a storage medium, the non-invasive deep coupling electrical stimulation method combines cross-frequency coupling electrical stimulation and time interference electrical stimulation (TIS-CFC-tACS) technology, the time interference cross-frequency coupling transcranial alternating current electrical stimulation (TIS-CFC-tACS) is provided, and the non-invasive deep coupling electrical stimulation method has the advantages that the time interference cross-frequency coupling transcranial alternating current electrical stimulation (TIS-CFC-tACS) is combined with the time interference electrical stimulation (TIS-CFC-tACS); according to the technology, a deep brain region is precisely regulated and controlled by using high spatial specificity and deep selectivity of TIS, and meanwhile, another path of tACS stimulation is generated to form cross-frequency coupling with TIS stimulation, so that the defects of conventional CFC-tACS in stimulation depth and spatial specificity are hopefully overcome, and the efficiency and precision of cross-frequency coupling electrical stimulation are improved. The invention relates to a nerve regulation technology.

The present invention discloses a simulation system and a simulation method for measuring the effect of transcranial alternating current stimulation. The simulation system includes: a processor, on which a human-machine interactive operation interface is provided to select a stimulation electrode mode for performing alternating current stimulation simulation, in which the sum of the current amplitudes of each electrode in the stimulation electrode mode is zero at any time, including a first stimulation mode; the first stimulation mode is configured such that the number of positive stimulation electrodes or negative stimulation electrodes is 1; a direct current construction module, which extracts the amplitude of the stimulation current of the first stimulation mode at a certain moment to construct a direct current stimulation result; and an effect simulation module, which is used to map the direct current stimulation result to the effect simulation result of alternating current stimulation at all times. The present invention can shorten the calculation time of the simulation result of tACS, improve the simulation efficiency, and can also be applied to the effect simulation of complex stimulation schemes.

This invention discloses a transcranial magnetic stimulation (TMS) system and method. The TMS system includes: a transcranial alternating current (TAC) stimulator for outputting a sinusoidal wave of a specific frequency, which outputs sinusoidal alternating current through stimulation electrodes; a first electroencephalogram (EEG) acquisition device for acquiring target EEG signals from a target brain region; a phase synchronization detection module for generating a detection start signal when the sinusoidal electrical stimulation signal from the TAC stimulator and the target EEG signal are phase-synchronized; a control module for reading the real-time phase of the sinusoidal electrical stimulation signal output from the TAC stimulator based on the detection start signal, and generating a control signal based on the real-time phase and preset conditions; and a TMS stimulator for outputting TMS pulses through a coil to stimulate the target brain region of the target subject based on the TMS pulses. The technical solution based on this invention improves the accuracy of TMS pulse control.

The invention relates to the technical field of transcranial alternating current stimulation for brain synchronization of two persons, and particularly discloses a transcranial alternating current stimulation device for enhancing brain synchronization of two persons and an application method of the transcranial alternating current stimulation device. The present invention relates to an emotional training system (100) suitable for situations such as co-emotional regulation, cooperative training, relation modeling, and the like, comprising: a first positive channel (110A) and a second positive channel (110B), which are respectively connected to forehead lobe region electrodes of a first individual and a second individual, for outputting an alternating current at a set frequency, the frequency being set as an intermediate frequency of an emotional-related alpha wave frequency band, i.e., a 10Hz alpha wave frequency band, and the frequency being set as an intermediate frequency of the emotional-related alpha wave frequency band; and the induction synchronization capability is relatively high. According to the transcranial alternating current stimulation device for enhancing brain synchronization of two persons and the application method thereof, the phase synchronization of alpha waves of the two prefrontal lobes can be remarkably enhanced in practical application, and the cross-brain emotion cooperation capability is improved.

The application discloses a deep learning-based electroencephalogram slow wave real-time feedback transcranial electrical stimulation method and system, relates to the cross technical field of neural regulation and deep learning, and comprises the following steps: collecting electroencephalogram signals of a target object and pre-processing the electroencephalogram signals to obtain pre-processed electroencephalogram signals; inputting the pre-processed electroencephalogram signals into a pre-constructed deep learning model for analysis to obtain a latent representation representing the dynamic state of electroencephalogram slow waves; wherein the deep learning model is obtained through the collaborative training of three types of self-supervised targets, namely self-predictive representation, unsupervised target conditional reinforcement learning and inverse dynamics modeling; transcranial electrical stimulation parameters are decided based on the latent representation, wherein the stimulation parameters at least include a stimulation type, a stimulation intensity and a stimulation frequency; and corresponding transcranial direct current stimulation or transcranial alternating current stimulation is output to specific brain regions of the target object according to the transcranial electrical stimulation parameters.

A method of transcranial alternating current stimulation (tACS) is provided. The method includes generating a current and transmitting the current to two electrodes contacting the patient's scalp to deliver a therapeutic dose of tACS for a predetermined treatment time. The current has a constant average amplitude of 2.2 mA and a bidirectional square waveform having a carrier wave at a frequency of 15 kHz, one modulation waveform frequency being 15 Hz and the other modulation waveform frequency being 500 Hz. The current includes a sub-burst within a burst duration including a burst on duration of 50 ms including the sub-burst followed by a burst off duration of 16.7 ms without the sub-burst. After each burst duration, the current switches polarity. Each sub-burst includes a pulse within a sub-burst duration that includes a sub-burst on duration of 1 ms including a pulse followed by a sub-burst off duration of 1 ms without a pulse. Each pulse extends about 33.33 ps, followed by a pause of 33.33 ps.

This invention provides a method for enhancing attention and executive function based on the synergy of transcranial alternating current stimulation (TCD) and white noise. The method includes: acquiring clinical and functional phenotypic vectors, behavioral vectors of attention and executive function, and neural oscillation and brain network vectors to obtain a comprehensive representation; defining target cognitive function, target brain region, target stimulation frequency, and stimulation parameters to obtain an individualized target brain network and oscillation frequency band scheme; designing a TCD stimulation scheme, a cognitive task training scheme, a white noise scheme, and an overall timetable to obtain a synergistic intervention scheme; recording behavioral process data, neural process data, and subjective experience data of the research subjects to obtain multimodal feedback data; and analyzing the multimodal feedback data to obtain an evaluation result of the intervention effect. This invention achieves synergistic intervention of individualized brain networks, frequency bands, tasks, noise, and time, which can not only address the symptoms and self-care abilities of individual patients but also promote the development of medicine and neuroscience.

The present invention relates to a non-invasive stimulation device and method, the device comprising: a helmet in which a plurality of electrodes each including a patch configured to come into close contact with the head of a subject are disposed; at least one sensor module for sensing biometric information of a subject wearing the helmet; and a control unit for applying a direct current stimulation signal to at least one selected electrode in a transcranial direct current stimulation (tDCS) step, providing an alternating current stimulation signal to at least one selected electrode in a transcranial alternating current stimulation (tACS) step, and automatically switching from the tDCS step to the tACS step when an abnormal state in which a resistance value of the electrode exceeds a reference value or the biometric information exceeds a normal range is detected.

The application discloses an individualized cognitive function adjusting device based on cross-frequency coupling, which comprises a peak frequency automatic extraction module, a spectrum analysis and automatic frequency extraction are used to obtain the peak frequency of the frontal lobe theta oscillation and the parietal lobe gamma oscillation of an individual baseline as the stimulation frequency of transcranial alternating current stimulation; a target site determination module is used to automatically output the stimulation site of tACS by determining the positive and negative power values corresponding to the peak frequency between the left and right brain regions, and the stimulation equipment outputs current to the corresponding brain region according to the output stimulation site; a signal-to-noise ratio calculation module is used to adaptively output the stimulation current intensity of tACS according to the signal-to-noise ratio value at the peak frequency; and a multi-mode regulation model is used to set the peak nesting and valley nesting modes according to the cross-frequency tACS, so that the targeted regulation of cognitive function disorders such as memory, attention and emotion processing is realized.

The present application relates to the technical field of neuromodulation, and particularly relates to a closed-loop controlled transcranial alternating current stimulation method and system, comprising calculating a global brain network efficiency value at the current time according to a blood oxygen level dependent signal in real time; predicting a global brain network efficiency prediction value at the next sampling time through a nonlinear prediction model according to a time sequence of historical global brain network efficiency values and current and historical stimulation parameters; comparing the global brain network efficiency prediction value with a preset individualized target brain network efficiency, and calculating a prediction efficiency deviation; and obtaining a group of advanced stimulation parameters according to the prediction efficiency deviation mapping, the present application realizes advanced closed-loop control of generating and issuing stimulation instructions in advance for the predicted future brain network state deviation, thereby overcoming the mismatch problem between the control instructions and the real-time state of the brain caused by the inherent hemodynamic delay of functional magnetic resonance signals.

The present application provides a neuroregulatory device and system for performing transcranial alternating current stimulation on the hippocampus. The neuroregulatory device is used to stimulate the hippocampus on the first side to treat related brain diseases, including a first electrode sheet arranged at the scalp corresponding to the temporal lobe on the first side, and at least a group of second electrode sheets arranged at the scalp corresponding to the temporal lobe on the second side, one of the first electrode sheet and the group of second electrode sheets is grounded and used as a cathode, and the other of the first electrode sheet and the group of second electrode sheets is connected to an alternating current source and used as an anode, so that the alternating current flows into the first electrode sheet, or flows from the first electrode sheet to a group of second electrode sheets. In this way, the stimulation intensity of the hippocampus on the first side can be increased, and the treatment effect of related brain diseases can be improved.

The invention discloses a closed-loop nerve regulation and control system for hypertension intervention, and belongs to the technical field of medical electronic equipment. The system comprises a blood pressure monitoring module, a transcranial alternating current stimulation module, a trigeminal nerve activation monitoring module and a control unit, and is configured to continuously obtain blood pressure data of a user through the blood pressure monitoring module and run an intervention program when the blood pressure data is judged to be hypertension data; the intervention procedure comprises: instructing the transcranial alternating current stimulation module to apply therapeutic transcranial alternating current stimulation to the user; during the period of applying the therapeutic transcranial alternating current stimulation, instructing the trigeminal nerve activation monitoring module to obtain a nerve activation signal, and taking the nerve activation signal as nerve feedback; instructing the blood pressure monitoring module to continuously obtain the blood pressure data of the user, and taking the blood pressure data as physiological feedback; and adjusting stimulation parameters of the transcranial alternating current stimulation module according to the neural feedback and the physiological feedback. And closed-loop nerve regulation for hypertension intervention is realized.

A method and system is provided for administering a Repetitive Transcranial Magnetic Stimulation (rTMS) or Transcranial Alternating Current Stimulation (tACS) at a pulse interval of is set equal to the period of a curve that best fits a section of a person's electroencephalogram (EEG) recorded before the pulse train.

Embodiments may provide the capability to provide Transcranial Photobiomodulation (tPBM), Transcranial Direct Current Stimulation (tDCS), and Transcranial Alternating Current Stimulation (tACS) with dynamic closed loop feedback, such as may be provided by an Electro Encephalogram (EEG), as well as local and network-based processing to analyze and generate such signals. For example, in an embodiment, a device may comprise apparatus configured to apply Transcranial Photobiomodulation (tPBM) to a person, apparatus configured to apply Transcranial Direct Current Stimulation (tDCS) to the person, apparatus configured to obtain Electro Encephalogram (EEG) signals from the person, and apparatus configured to perform dynamic closed loop feedback of the tPBM and the tDCS based on the obtained EEG signals.