3 results about "Antifolate" patented technology

Antibody constructs that bind human folate receptor alpha (FRα or FOLR1) and antibody-drug conjugates (ADCs) comprising an anti-FRα antibody construct conjugated to a drug, such as a cytotoxin or an immune modulator, and their use as therapeutics or diagnostics, for example, in the treatment or diagnosis of cancer.

The invention relates to the technical field of biological medicines, and particularly discloses application of a composition in preparation of anti-colorectal cancer medicines. The composition comprises an anti-folic acid drug and a pharmaceutically acceptable salt thereof, and an anti-creatine transport drug and a pharmaceutically acceptable salt thereof. Wherein the anti-folic acid medicine is used for inhibiting a folic acid-dependent nucleotide synthesis process and limiting DNA synthesis and replication of tumor cells, so that abnormal proliferation of the tumor cells is inhibited; the anti-creatine transport drug is used for inhibiting creatine uptake mediated by creatine transporter, reducing the level of phosphocreatine in cells and further weakening the energy buffering capacity and stress recovery capacity of tumor cells. According to the composition provided by the invention, two key metabolic pathways of nucleotide synthesis and energy homeostasis maintenance in colorectal cancer cells can be intervened at the same time, and dual inhibition and synergistic intervention are formed on the metabolism level, so that the inhibition effect on tumor cell proliferation and survival is enhanced; and the possibility of drug resistance of tumor cells to a single therapy through metabolic reprogramming can be reduced.