Method for cell-specific targeting

a cell-specific and targeting technology, applied in the field of cell-specific targeting, can solve the problems of limiting the use of currently known folate-mediated targeting methods in various medical applications, the risk of radiation injury in sensitive renal tissue, and the inability to exploit tumour-targeting for its use in radiotherapy, so as to reduce the burden of unwanted doses and precise localisation of malignant cell populations
US20070280880A1Active Publication Date: 2007-12-06MERCK & CIE KG
2 Cites 12 Cited by

Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
MERCK & CIE KG
Publication Date
2007-12-06

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

Method for selective targeting of one or more effector moiety such as diagnostic or a therapeutic agent to a cell or population of cells expressing a folate-receptor comprising simultaneous or sequential administration of an antifolate with a folate- or pteroate-conjugate comprising said one or more effector moiety.
Need to check novelty before this filing date? Find Prior Art

Description

FIELD OF THE INVENTION

[0001] The present invention relates to a method for selective protection of human healthy, normal tissue expressing folate receptors while enhancing targeting of a cell or populations of cells expressing folate-receptors of the type alpha, beta and gamma or activated (but not resting) synovial macrophages, and its use in diagnostic and therapeutic medical applications, for example diagnostic imaging, radiotherapy, boron neutron capture therapy, chemotherapy. In particular selective protecting is achieved by simultaneous or sequential administration of an antifolate with a folate- or pteroate-conjugate comprising one or more effector moieties.BACKGROUND OF THE INVENTION

[0002] Cell-specific targeting for delivery of effector moieties such as diagnostic or therapeutic agents is a widely researched field and has led to the development of non-invasive diagnostic and / or therapeutic medical applications. In particular in the field of nuclear medicine procedures and tre...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More