Compositions comprising a bisphosphonate and an antifolate

A technology of anti-folate and bisphosphonates, which can be applied in the direction of anti-inflammatory agents, drug combinations, and resistance to vector-borne diseases, etc., and can solve problems such as side effects

Inactive Publication Date: 2009-04-08
CYPRESS BIOSCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] All current RA treatments have drawbacks and side effects, and not all treatments are effective for all individuals

Method used

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Examples

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Embodiment 1

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Abstract

Compositions and methods for the treatment of arthritis, particularly rheumatoid arthritis and osteoarthritis. These compositions include at least one antifolate and at least one bisphosphonate, or pharmaceutically acceptable salts thereof.

Description

technical field [0001] The present invention relates to compositions comprising at least one bisphosphonate and at least one antifolate. More particularly, the invention relates to the use of these compositions in the treatment of arthritis, including osteoarthritis and rheumatoid arthritis. Background technique [0002] Arthritis ("arth" means joint, "itis" means inflammation) actually includes more than 100 different conditions, which can range from relatively mild forms of tendonitis and bursitis to osteoarthritis ("wear and tear" ( wear and tear arthritis) to crippling systemic forms such as rheumatoid arthritis. The term "arthritis" also includes pain syndromes involving all parts of the body such as fibromyalgia syndrome and disorders involving arthritis such as lupus. Also, because it affects the joints, gout is also considered a type of arthritis. [0003] The major forms of arthritis are osteoarthritis and rheumatoid arthritis (RA). Osteoarthritis is the result ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/675A61K33/06A61K9/20
CPCA61K31/675A61K31/525A61K31/519A61K45/06A61P19/02A61P19/06A61P25/04A61P29/00A61P43/00Y02A50/30A61K2300/00
Inventor M·J·沃尔什
Owner CYPRESS BIOSCI
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