The invention relates to a plaster for treating rheumatism, hyperostosis and internal medicine miscellaneous diseases and a preparation method thereof. The plaster is prepared from the following raw materials of musk, squama manis, rhizoma paridis, corn cervi pantotrichum, ossific antler, ligamentum cervi, yak bone, hippocampus, donkey-hide glue, tortoise plastron, snow lotus herba, aquilariae lignum resinatum, rhizoma gastrodiae, herba hedyotidis diffusae, scolopendra, scorpion, bombyx batryticatus, hirudo, dragon's blood, cortex daphnes, rhizoma drynariae, radix notoginseng, safflower, eucommia bark, radix dipsaci, caulis sargentodoxae, fructus mume and wooly datchmanspipe herb. The plaster disclosed by the invention can effectively prevent and treat acute and chronic rheumatism, rheumatoid arthritis, scapulohumeral periarthritis, sciatica, lumbar muscle strain, prolapsed intervertebral disc and the like caused by wind-cold-damp arthralgia, as well as pain, heavy and numb limbs, inconvenience in movement, neck rigidity and the like caused by hyperostosis. The plaster also has superior effects of preventing and treating gout, prosopalgia, facial paralysis, dysmenorrhea, irregularmenstruation, breast hyperplasia, prostatitis, bronchitis, cold, rhinitis, insufficiency of cerebral blood supply, nerve headache, chronic gastritis, chronic enteritis and spleen-stomach deficiency, and the like.