58 results about "Thiol functionalized" patented technology

Oligonucleotides and other biomolecules are immobilized in high density on solid substrates through covalent forces using either a permanent thioether bond, or a chemoselectively reversible disulfide bond to a surface thiol. Substrates which have hydroxyl groups on their surfaces can be first silanized with a trichlorosilane containing 2-20 carbon atoms in its hydrocarbon backbone, terminating in a protected thiol group. The oligonucleotides or other biomolecules are first connected to a tether consisting of a hydrocarbon or polyether chain of 2-20 units in length which terminates in a thiol group. This thiol may be further modified with a halobenzylic-bifunctional water soluble reagent which allows the conjugate to be immobilized onto the surface thiol group by a permanent thioether bond. Alternatively, the oligonucleotide-tether-thiol group can be converted to a pyridyldisulfide functionality which attaches to the surface thiol by a chemoselectively reversible disulfide bond. The permanently bound oligonucleotides are immobilized in high density compared to other types of thiol functionalized silane surface and to the avidin-biotin method.

The present invention relates to a method of preparing a carbon nanotube-quantum dot conjugate having a high density of quantum dots (QDs) on its surface. This method involves providing a plurality of semiconductor quantum dots and providing a thiol-functionalized carbon nanotube having a plurality of terminal thiol groups on its surface. The plurality of semiconductor quantum dots are attached to the surface of the carbon nanotube under conditions effective to yield a carbon nanotube-quantum dot conjugate having a high density of quantum dots on its surface. The present invention also relates to a carbon nanotube-quantum dot conjugate having a high density of quantum dots on its surface. The present invention further relates to a photodetector device. This device includes a substrate and a nanocomposite layer. The nanocomposite layer includes a plurality of the carbon nanotube-quantum dot conjugates previously described.

Provided according to some embodiments of the invention are methods of forming co-condensed silica particles. In some embodiments, the methods include reacting a thiol-containing silane and a backbone alkoxysilane in a reaction solution that comprises water to form thiol-functionalized co-condensed silica particles, wherein the thiol-functionalized co-condensed silica particles include a polysiloxane matrix and at least some of thiol groups are present within the polysiloxane matrix; and reacting the thiol-functionalized co-condensed silica particles with a nitrosating agent to provide the S-nitrosothiol-functionalized co-condensed silica particles. In some embodiments, provided are S-nitrosothiol-functionalized co-condensed silica particles.

The invention relates to a thiol functionalization method and application of a nano hole metal-organic framework material. Through the coordination of the nano hole metal-organic framework material containing a coordination unsaturated active site and a dithiol compound, a certain proportion of thiol in a dithiol compound molecule is connected with the coordination unsaturated active site of the nano hole metal-organic framework material through a coordination bond, and a thiol functional group is grafted to a metal-organic framework, so that the thiol-functionalized nano hole metal-organic framework material is generated. The thiol-functionalized nano hole metal-organic framework material can be used as an adsorption and separation material of heavy metal ions, and is applied to removal of heavy metal ions in a water body.

The invention pertains to a coating composition comprising a) a first compound comprising at least one bicyclo-orthoester group, p0 b) a second compound comprising at least two isocyanate groups, and c) a third compound comprising at least one thiol group. The invention also relates to a process for curing the present coating composition. More particularly, the latent hydroxyl groups of the bicyclo-orthoester groups have to be deblocked and reacted with the isocyanate-groups of the second compound if the present coating composition is to be cured.

The present invention describes a new synthetic strategy that permits to produce 2D 1D, e OD hybrid organic-inorganic nanocrystals of tungsten / molybdenum chalcogenides. The innovative chemical approach is based on the thermal decomposition of a molecular precursor containing both metal and sulphur, in a mixture of long chain amines and / or fatty acids and / or long chain thiols. By the control of reaction conditions is possible to address the synthesis can be driven towards the formation of nanosystems with different morphologies such as sheets, particles, rods, tubes.

The invention provides a preparation method of a polyvinylidene fluoride oil-water emulsion separation membrane with characteristics of good surface hydrophilicity and underwater super oleophobicity.According to the method, hyperbranched polydimethylaminoethyl methacrylate with controlled molecular weight is prepared by using dimethylaminoethyl methacrylate containing a tertiary amine group as amonomer through a reversible addition-fragmentation chain transfer polymerization method; the hyperbranched polydimethylaminoethyl methacrylate with controlled molecular weight and 1,3-propane sultoneare subjected to a quaternization reaction to prepare a hyperbranched zwitterionic polymer; a thiol-functionalized hyperbranched zwitterionic polymer is obtained through an aminolysis reaction; and the hyperbranched zwitterionic polymer is introduced onto the surface of a polyvinylidene fluoride membrane by using a surface biomimetic chemical modification method so as to effectively improve the hydrophilicity of the polyvinylidene fluoride membrane, such that the separation membrane has efficient and stable oil-water emulsion separation ability. According to the present invention, the polyvinylidene fluoride membrane is subjected to surface modification, the used modifier has the controlled structure, and the prepared oil-water emulsion separation membrane has excellent anti-pollution performance, and has important practical application value in oil-water separation.

The invention discloses gold nanoparticles and a preparation method thereof. The method comprises the steps of enabling chloroauric acid hydrated to make contact with a reducing agent on the condition that a solvent and a stabilizer exist, wherein the stabilizer is thiol-functionalized methoxypolyethylene glycol amine. The preparation method of the gold nanoparticles is easy to achieve, the sizes of the obtained gold nanoparticles are small and uniform, the gold nanoparticles are good in dispersity in the solution and wide in application prospect, and a new simple and direct way is provided for preparation of the gold nanoparticles.

The invention discloses folic acid-functionalized drug-loaded mesoporous silica and a preparation method thereof. The folic acid-functionalized drug-loaded mesoporous silica of the present invention is prepared according to the following steps: 1) adopting orthosilicate as a silicon source, adopting an n-hexadecyl quaternary ammonium salt as a template agent, adopting mercaptopropyl trimethoxysilane as a functionalization reagent, and adopting a method of copolycondensation, synthesis and grafting to prepare thiol-functionalized mesoporous silica; 2) carrying out a reaction of the thiol-functionalized mesoporous silica and 2-(pyridindithio)ethyl ammonium chloride to obtain amino-functionalized mesoporous silica adopting a disulfide bond as a linker; 3) adopting a physical adsorption method to assemble a drug into pore channels of the mesoporous silica; and 4) linking folic acid to the mesoporous silica through the disulfide bond with a covalence effect to obtain the folic acid-functionalized drug-loaded mesoporous silica. The product of the present invention has characteristics of folic acid targeting effect, large specific surface area, high thermal stability, no toxicity, high drug loading rate, and effective prevention from drug leakage.

The invention discloses a method for preparing thiol-functionalized polyester with a micro-reaction unit. Delta-valerolactone (VL) or epsilon-caprolactone (CL) is used as a reaction monomer, tin trifluoromethanesulfonate (Sn(OTf)2) is used as a metal complex catalyst, fatty alcohol with an end thiol group is used as a functionalization initiator, and the thiol-functionalized polyester is prepared in the micro-reaction unit. Compared with the prior art, the adopted metal complex catalyst is simple and easy to obtain and high in catalytic activity, the technology is high in operability, and cost is low. Meanwhile, the whole polymerization process is short, reaction conversion rate is high, polymer thiol introduction rate is high, and high-precision control of polymerization reaction is achieved.

The invention discloses preparation of a thiol-ended polyvinyl alcohol quantum dot composite material. The preparation of the thiol-ended polyvinyl alcohol quantum dot composite material comprises the following steps: with acetic anhydride as an acetylation reagent and concentrated sulfuric acid as an esterification catalyst, under an acidic condition, carrying out an esterification reaction on polyvinyl alcohol and mercaptoacetic acid so as to obtain thiol-functionalized polyvinyl alcohol; complexing thiol-functionalized polyvinyl alcohol serving as a stabilizer with cadmium ion and sulfur ion, so as to obtain the thiol-ended polyvinyl alcohol quantum dot composite material with excellent stability, dispersity and optical property. Experiments show that with the addition of Cu<2+> with different concentrations (1-1000nM) in an aqueous solution of the thiol-ended polyvinyl alcohol quantum dot composite material, fluorescence of the solution shows certain linear extinction; therefore, the thiol-ended polyvinyl alcohol quantum dot composite material has the characteristics of high detection speed and ultra sensitiveness when used for detecting trace Cu<2+> in a water sample.

The present invention relates to a dual function catalyst and a preparation method thereof, wherein a sulfonic acid function group is grafted on the surface of the catalyst, and is adopted as an acid to provide acidity for cellulose hydrolysis so as to produce glucose, and the glucose obtained through hydrolysis is subjected to further hydrogenation under a hydrogen gas condition with the supported metal nanoparticles so as to produce sorbitol, such that one step conversion of cellulose into sorbitol under mild reaction conditions is achieved. The catalyst preparation method comprises: 1) preparing a thiol functionalized silica gel: grafting a thiol function group on the surface of a silica gel; 2) preparing a sulfonic acid functionalized silica gel: oxidizing the thiol grafted on the surface into sulfonic acid; and 3) adopting an equal volume impregnation method to prepare the metal nanoparticle-supported sulfonic acid functionalized silica catalyst, wherein the obtained catalyst can be used for conversion of cellulose to prepare sorbitol. The catalyst has characteristics of simple preparation method, low raw material cost, high activity and good stability, and is suitable for cellulose conversion reactions.

There is provided a nanocomplex having a core-shell structure. The shell of the nanocomplex comprises a functionalized hyaluronic acid while the core of the nanocomplex comprises a flavonoid encapsulating a metal-containing compound. Preferably, the flavonoid is epigallocatechin gallate (EGCG) and the hyaluronic acid is thiol-functionalized and subsequently conjugated to the flavonoid. There is also provided a method of forming the nanocomplex, a pharmaceutical composition comprising the nanocomplex, medical uses of the nanocomplex and a method of treating a patient, preferably with cancer using the nanocomplex.

The invention relates to a coating composition comprising:A) at least one thiol-functional compound having at least one thiol group,B) at least one polyisocyanate cross-linking agent with at least one free isocyanate group andC) at least one catalyst compound, said catalyst compound comprising at least one catalyst for the curing reaction between the thiol groups of component A and the free isocyanate groups of component B, and at least one cyclodextrine.

An amino or thiol linker building block for the synthesis of amino or thiol functionalized amino acids and generally of the following structure: is provided. Such building block may be introduced in the 5′ end position of an amino acid under standard coupling conditions. Such building block allows in-line coupling control, “trityl-on” purification, and solid support functionalization / derivatization. Such building block is a stable, solid compound and can therefore be easily handled. With the building block of the present invention, deprotection may be carried out under standard detritylation conditions.

The invention relates to a novel polyphosphorus polymer that is thiol-functionalised at the chain ends, of which the polymer chain comprises units bearing at least one phosphonate pendant functional group and / or at least one phosphonic pendant functional group along the length of the chain. This novel polymer is particularly suitable for use in a thiol-ene coupling reaction. This provides the possibility of grafting the polyphosphorus polymers to diene polymers for example.

The invention discloses a PVDF (Polyvinylidene Fluoride) / SiO2 composite membrane and a preparation method thereof, and belongs to the field of preparation of membrane materials. The preparation method comprises the following steps: (1) preparing thiol-functionalized mesoporous SiO2 microspheres; (2) preparing the thiol-functionalized mesoporous SiO2 microspheres obtained in the step (1) and PVDF into a casting solution; (3) preparing the casting solution obtained in the step (2) into a PVDF / SiO2 composite membrane through a solution precipitation phase inversion method. By adopting the preparation method, agglomeration of mesoporous silica nanoparticles is avoided, and effective fixation of mesoporous silica in membrane pores and penetration of the membrane pores and mesopores are realized, so that the obtained membrane has high stability and high heavy metal lead ion adsorption-desorption performance, and can be widely applied in the field of lead ion wastewater treatment.

The invention discloses a coating system applied to the surface of a plastic substrate. The coating system comprises a UV curing primer and a wear-resistant protective PVD coating, wherein the UV curing primer comprises: 30-60 parts of organosilicone-modified urethane acrylate, 20-40 parts of epoxy acrylate, 5-20 parts of a reactive diluent, 5-20 parts of a thiol functional compound, 2-5 parts ofa photoinitiator, and 0.5-2 parts of an addition agent; the wear-resistant protective PVD coating is a TiaX(1-a)CrNsOt coating, wherein X represents Si or / and Al; a is greater than or equal to 0.5 andsmaller than 1; the sum of r, s and t is 1; and the thickness of the coating is between 0.5 microns to 5 microns. The surface of a plastic product prepared by the coating system has metallic luster,and the coating is good in adhesive force, excellent in durability, excellent in wear resistance and scratch resistance, and suitable for packaging products, craft decorations, electronics, home appliances and automobile industries and the like.

An amino or thiol linker building block for the synthesis of amino or thiol functionalized amino acids and generally of the following structure:is provided. Such building block may be introduced in the 5′ end position of an amino acid under standard coupling conditions. Such building block allows in-line coupling control, “trityl-on” purification, and solid support functionalization / derivatization. Such building block is a stable, solid compound and can therefore be easily handled. With the building block of the present invention, deprotection may be carried out under standard detritylation conditions.

The invention relates to a novel polyphosphorus-based chain-end thiol-functionalized polymer, the polymer chain of which comprises units bearing at least one pendant phosphonate function and / or at least one pendant phosphonic function along the chain. This novel polymer is quite particularly suited to participating in a thiol-ene coupling reaction, which affords the possibility of grafting the polyphosphorus-based polymers onto diene polymers, for example.

A new, facile, general one-phase method of generating thiol-functionalized transition metal nanoparticles and surfaces modified by (co)polymers synthesized by the RAFT method is described. The method includes the steps of forming a (co)polymer in aqueous solution using the RAFT methodology, forming a colloidal transition metal precursor solution from an appropriate transition metal; adding the metal precursor solution or surface to the (co)polymer solution, adding a reducing agent into the solution to reduce the metal colloid in situ to produce the stabilized nanoparticles or surface, and isolating the stabilized nanoparticles or surface in a manner such that aggregation is minimized. The functionalized surfaces generated using these methods can further undergo planar surface modifications, such as functionalization with a variety of different chemical groups, expanding their utility and application.

A new, facile, general one-phase method of generating thiol-functionalized transition metal nanoparticles and surface modified by (co)polymers synthesized by the RAFT method is described. The method includes the steps of forming a (co)polymer in aqueous solution using the RAFT methodology, forming a collidal transition metal precursor solution from an appropriate transition metal; adding the metal precursor solution or surface to the (co)polymer solution, adding a reducing agent into the solution to reduce the metal colloid in situ to produce the stabilized nanoparticles or surface, and isolating the stabilized nanoparticles or surface in a manner such that aggregation is minimized. The functionalized surfaces generated using these methods can further undergo planar surface modifications, such as fuctionalization with a variety of different chemical groups, expanding their utility and application.

The invention discloses a preparation method of a high-sensitivity functionalized silver nanoparticle-doped aniracetam MIECS (Molecular Imprinting Electrochemical Sensor). The preparation method is characterized by taking aniracetam as a template molecule, dihydromyrcenol as a functional monomer, hydrocortisone acetate as a coupling agent and decyl mercaptan functionalized silver nanoparticles as a doping agent, thus preparing the high-sensitivity decyl mercaptan functionalized silver nanoparticle-doped aniracetam MIECS. An analysis method is simple and practical, and the disadvantages of complexity, expensive price of equipment and low sensitivity of a previous analysis method are overcome.

The invention discloses a PVDF (Polyvinylidene Fluoride)-SiO2 composite membrane for synthesizing thiol-functionalized mesoporous silica microspheres in membrane pores and a preparation method thereof, and belongs to the field of preparation of membrane materials. The preparation method comprises the following steps: (1) modifying a PVDF polymer with MAA (Methacrylic Acid); (2) preparing the modified polymer obtained in the step (1) into a casting solution; (3) preparing the casting solution obtained in the step (2) into a membrane through a solution phase inversion method; (4) synthesizing thiol-functionalized mesoporous silica microspheres in the membrane pores and on the membrane surface of the membrane obtained in the step (3) to obtain the PVDF-SiO2 composite membrane. The uniformly-dispersed thiol-functionalized mesoporous silica microspheres are synthesized in the membrane pores and on the membrane surface of a large-pore base membrane in one step, and effective fixation of mesoporous silica in the membrane pores and on the membrane surface and penetration of the membrane pores and mesopores are realized, so that the obtained membrane has high stability and high heavy metal ion adsorption-desorption performance, and can be widely applied in the field of wastewater treatment.

The present invention relates to a method of preparing a carbon nanotube-quantum dot conjugate having a high density of quantum dots (QDs) on its surface. This method involves providing a plurality of semiconductor quantum dots and providing a thiol-functionalized carbon nanotube having a plurality of terminal thiol groups on its surface. The plurality of semiconductor quantum dots are attached to the surface of the carbon nanotube under conditions effective to yield a carbon nanotube-quantum dot conjugate having a high density of quantum dots on its surface. The present invention also relates to a carbon nanotube-quantum dot conjugate having a high density of quantum dots on its surface. The present invention further relates to a photodetector device. This device includes a substrate and a nanocomposite layer. The nanocomposite layer includes a plurality of the carbon nanotube-quantum dot conjugates previously described.

An adsorbent suitable for heavy metal absorption is described, comprising a thiol-functionalised support containing a stabilising amount of an alkaline metal reacted with said thiol functionality. The adsorbent may be used to remove heavy metals e.g. mercury and / or arsenic, from wastewater streams such as produced water or flue gas scrubber waters.

The invention belongs to the technical field of functionalized magnetic nano-materials, and especially relates to a preparation method of a thiol-functionalized magnetic silica nano-material. The preparation method comprises the following steps: carrying out a co-precipitation method of raw materials comprising a ferric salt and a ferrous salt to prepare super-paramagnetic ferriferrous oxide particles; wrapping the bare ferriferrous oxide nano-particles by treating a silane cross-linking agent as a silicon source through an improved sol-gel method to obtain a magnetic silica carrier; and carrying out functional modification of the surface of the carrier by a silane coupling agent to obtain the thiol-functionalized magnetic silica nano-material. The preparation method has the advantages of less consumption of organic solvents, mild reaction conditions, short reaction time, simple preparation process, less energy consumption, low cost and the like, and the finally obtained product has an average particle size of 20-30nm, and has a good selectivity and a high adsorption capacity when the product is used in the absorption of Hg (II) in wastewater.

The invention discloses a method for preparing thiol functionalized mesoporous bamboo charcoal materials. The method has the advantages that preliminary activating treatment is carried out on bamboo powder by the aid of activating solution with surfactants and alkali metal salt, accordingly, the surface performance of the bamboo powder can be improved, the dispersity of the bamboo powder in organosilicon sol can be enhanced, follow-up bamboo powder carbonization effects can be improved by the introduced metal salt, and the carbon immobilizing rate is high; bamboo charcoal powder obtained after the bamboo powder already subjected to dipping treatment by the aid of organosilicon sol systems is carbonized is fine and uniform in pore diameter distribution and is high in strength; the bamboo charcoal powder is functionally modified by the aid of thiol siloxane sol, thiol can be effectively set by the aid of sol-gel processes, and the thiol functionalized mesoporous bamboo charcoal materials prepared by the aid of the method can be obviously functionalized.

The invention belongs to the technical field of heavy metal passivation, discloses thiol functionalized attapulgite and a preparation method thereof. The preparation method comprises: placing pre-treated attapulgite into a mixed solvent, and ultrasonically treating by using an ultrasonic wave system to uniformly disperse the attapulgite in the mixed solvent; carrying out pretreatment impurity removal on the raw attapulgite; dissolving gamma-trimethoxysilylpropanethiol (MTS) in absolute ethanol, and adding water and PEG400 to obtain a mixed solvent; carrying out a stirring reaction for 7-8 h ina stirrer, and carrying out centrifugal separation on the sample after the reaction to remove the upper layer aqueous solution and retain the solid-state substance; and washing the solid-state substance with distilled water to achieve a neutral state, and carrying out vacuum drying for 10-12 h at a temperature of 60-80 DEG C to obtain the thiol functionalized attapulgite. According to the presentinvention, the thiol is grafted by using the silane coupling method, such that the new approach is provided for the research and development of heavy metal contaminated soil passivating agents with advantages of large adsorption capacity, environmental friendliness and good adsorption selectivity.