Preparation method of chitosan gel bead

A chitosan gel, chitosan technology, applied in the direction of organic dyes, etc., can solve the problems of poor mechanical strength of drugs, uncertain gel shape, damage to the encapsulation structure, etc., achieving less leakage, reducing manufacturing difficulty, Good package stability

Inactive Publication Date: 2017-05-31
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 1. The shape of the gel is uncertain
[0007] 2. Due to the unsealed nature of the gel, small molecules such as drug dyes entrapped inside the gel may detach from the gel during delivery
[0008] 3. The mechanical strength of a single gel-loaded drug is very poor, and the structure of the drug is easily damaged

Method used

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  • Preparation method of chitosan gel bead
  • Preparation method of chitosan gel bead
  • Preparation method of chitosan gel bead

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Dissolve 1.4g of β-glycerophosphate sodium pentahydrate in 2mL of water, and dissolve 0.4g of medium-viscosity chitosan with a viscosity of 200-400mPa.s in 0.1mol / L acetic acid solution. Stirring is accelerated for rapid dissolution. After dissolving, let stand to make the air bubbles in the chitosan solution disperse completely. Weigh 25g of disodium hydrogen phosphate solid and dissolve it in 100ml of water to obtain a saturated disodium hydrogen phosphate solution. Under the ice-water bath, slowly add β-glycerophosphate sodium pentahydrate solution dropwise to the dissolved chitosan solution, after the dropwise addition is completed, adjust the pH value to between 6.9-7.1 with saturated disodium hydrogen phosphate solution, A chitosan / β-sodium glycerophosphate mixed solution (CS / β-GP mixed solution) was obtained. Weigh 0.2g-0.8g of sodium lauryl sulfate solid and dissolve it in 20mL of water to prepare a 2% sodium lauryl sulfate solution as a receiving solution. U...

Embodiment 2

[0040] According to embodiment 1 formula, change curing time is 50min, and its condition is constant. Prepare the capsule-shaped chitosan gel beads that this case implements according to the step of Example 1. The dosage of β-glycerophosphate sodium pentahydrate is 1.4g, the dosage of medium viscosity chitosan is 0.4g, the concentration of acetic acid is 0.1mol / L, the pH value is adjusted between 6.9-7.1, the dosage of sodium lauryl sulfate 0.2g, the water bath temperature is 42°C, and the water bath time is 5min. Chitosan gel beads with excellent gel effect can also be obtained.

Embodiment 3

[0042] According to the formula of Example 1, changing the aging time is 60min, and its condition is constant. Prepare the capsule-shaped chitosan gel beads that this case implements according to the step of Example 1. The dosage of β-glycerophosphate sodium pentahydrate is 1.4g, the dosage of medium viscosity chitosan is 0.4g, the concentration of acetic acid is 0.1mol / L, the pH value is adjusted between 6.9-7.1, the dosage of sodium lauryl sulfate 0.2g, the water bath temperature is 42°C, and the water bath time is 5min. Chitosan gel beads with excellent gel effect can also be obtained.

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Abstract

The invention discloses a preparation method of a capsule-shaped chitosan gel bead capable of entrapping small-molecule dyes, belonging to the technical field of preparation processes of chitosan gel beads. The preparation method comprises the following steps: dissolving chitosan into an acetic acid solution, and slowly and drowise adding a beta-sodium glycerophosphate pentahydrate solution into an ice-water bath; regulating the pH value of the mixed solution to be neutral; drowise adding the prepared chitosan / beta-sodium glycerophosphate pentahydrate mixed solution (CS / beta-GP solution) into SDS receiving liquid, and carrying out curing, so as to form a chitosan drop packaging the CS / beta-GP solution; and heating in a water bath to generate internal gelatinization under the action of hydrogen bonds, so as to finally obtain the chitosan gel bead. The chitosan gel bead prepared by virtue of the preparation method has an excellent entrapment property to the small-molecule dyes with the molecular weights of 300-800, the leakage amount of the dyes is low, the entrapment stability is good, and the dyes are not obviously leaked after 12 hours.

Description

technical field [0001] The invention belongs to the technical field of chitosan gel beads preparation, in particular to a preparation method of chitosan gel beads which are capsule-shaped and can carry small molecular dyes. [0002] technical background [0003] Chitosan (chitosan, CS) is white or off-white, slightly pearly, translucent sheet-like solid, also known as deacetylated chitin, soluble chitin, polyglucosamine, is the product of chitin deacetylation. The relative molecular mass of chitosan ranges from hundreds of thousands to millions, and the molecular formula is (C 6 h ll o 4 N)n, most of its monomers are 2-amino-D-glucose. The solubility of chitosan is better than that of chitin, soluble in dilute organic acids and some inorganic acids, such as lactic acid, hydrochloric acid and acetic acid, etc., but insoluble in dilute sulfuric acid, dilute nitric acid, dilute phosphoric acid, oxalic acid, insoluble in water and alkaline solutions , low viscosity chitosan c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J3/12C08B37/08C09B67/00C08L5/08
CPCC08B37/003C08J3/075C08J3/12C08J2305/08C09B67/0001
Inventor 陈艳军赵光宇张超灿丁妮
Owner WUHAN UNIV OF TECH
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