38 results about "Calcifediol" patented technology

We disclose the use of 25-OH D3 (calcifediol) to increase muscle strength, muscle function, or both. Vitamin D3 (cholecalciferol) may optionally be used together with 25-OH D3. Forms and dosages of a pharmaceutical composition, as well as processes for manufacturing medicaments, are also disclosed.

We disclose treating hyperglycemia in a human with 25-hydroxyvitamin D3 (calcifediol). Blood glucose is reduced to a level which is closer to normal than baseline. Vitamin D3 (cholecalciferol) may optionally be used together with 25-hydroxy vitamin D3. Forms and dosages of a pharmaceutical composition, as well as processes for manufacturing medicaments, are also disclosed.

We disclose compositions comprising Vitamin D (cholecalciferol and/or ergocalciferol) and 25-OH D3 (calcifediol), and use of those compositions to affect at least concentration, bioavailability, metabolism, or efficacy of vitamin D in a human. Forms and dosages of the composition, as well as processes for manufacturing a spray-dried formulation, are also disclosed.

The invention relates to a preparation method of calcitriol which is a compound material, belonging to the technical field of preparation of drug synthesis and organic compound synthesis. In the invention, the calcifediol is taken as raw material, a majority of produced impurities in the chemical reaction process are removed through medium-pressure liquid phase chromatography, wherein calcifediol carried out sulfonylation and ring closing on toluene, and the medium-pressure liquid phase chromatography is used for removing the impurities; products carry out oxidation reaction, medium-pressure chromatographic column separates and removes the impurities, ring opening is carried out, medium-pressure liquid phase is added for coarsely separating stereoisomeride, and at last the products separated by high-pressure liquid phase chromatography is hydrolyzed and refined to obtain the calcitriol. The invention is reasonably selected, comprehensively applies the advantages of the medium and high pressure liquid phase chromatography, has simple detaching method, can effectively remove the impurities, thoroughly separates the stereoisomeride, has high purity of the calcitriol obtained from separation, has a productive rate of 40 percent, high yield and low cost, shortens production period, is suitable for industrial scale, has application prospect, and provides a time-saving, economic and efficient method for the separation and the preparation of chiral compounds.

The invention relates to a eutectic crystal of calcifediol and vitamin D3 as well as a preparation method and application thereof. In the eutectic crystal, the mole ratio of the calcifediol to the vitamin D3 is 1 to 1. The eutectic crystal of the calcifediol and the vitamin D3 is subjected to comprehensive characterization by applying measures such as X-ray single crystal diffraction, X-ray powderdiffraction, thermogravimetric analysis, differential scanning calorimetry and infrared spectroscopic analysis, thereby finding that the chemical stability of the vitamin D3 of the eutectic crystal can be obviously improved under an illumination condition. The preparation method of the eutectic crystal of the calcifediol and the vitamin D3 is simple, and the eutectic crystal can be repeatedly prepared.

The present invention relates to calcifediol soft capsules, to their use in the treatment or prevention of diseases related to vitamin D deficiency, such as vitamin D deficiency, demineralization such as hypocalcemia and hypophosphatemia, renal osteodystrophy, rickets, osteoporosis, osteopenia, osteoarthritis, osteoarthrosis, osteomalacia, hypoparathyroidism, and inflammatory bowel disease, and to their process of manufacture.

The invention discloses a feeding culture medium by fermenting calcifediol, a feeding method for fermentation and a fermentation method of the calcifediol. The feeding culture medium comprises, by concentration, 0.2-3.0g/100ml of an organic nitrogen source, 0.2-3.0g/100ml of an inorganic nitrogen source, 0.5-3.0g/100ml of a carbon source, 0.1-1.0g/100ml of inorganic salt A, 0.1-1.0g/100ml of inorganic salt B and 0.0002-0.0006g/100ml of a microelement. The feeding method and the fermentation method comprise the steps that the feeding culture medium and water are added into fermentation broth, therefore the requirements for nutrient ingredients of fermentation of the calcifediol are satisfied, the requirements for oxygen dissolution of fermentation of the calcifediol are satisfied, the power cost is lowered, and the fermentation efficiency is improved.

The invention relates to autotrophic pseudonocardia and application thereof, and belongs to the technical field of microorganisms. The pseudonocardia autotrophicus can be used for preparing calcifediol and/or calcitriol, compared with an original strain, the yield is remarkably improved.

A medicine composition contains vitamin D and metformin, wherein vitamin D comprises vitamin D2, vitamin D3, alphacalcidol, calcifediol, calcitriol, and dihydrotachysterol. The composition can be used in the preparation of a medicine for treating and/or preventing a polyp and cancer in large intestine.

Disclosed herein is an improved and efficient process for synthesis of vitamin D3 and its analogue Calcifediol from Ergosterol. Particularly, the present invention discloses the synthesis of key intermediate 3β-tert-Butyldimethylsilyloxy-22-hydroxy-23,24-bisnorchola-5,7-diene (5), and novel intermediate β-tert-Butyldimethylsilyloxy-22-iodo-23,24-bisnorchola-5,7-diene (9) by a simple and cost effective process. The industrially viable processes for preparation of said intermediate(s) results in providing provitamins with various side chains and the desired products in high yield.

We disclose compositions comprising Vitamin D (cholecalciferol and/or ergocalciferol) and 25-OH D3 (calcifediol), and use of those compositions to affect at least concentration, bioavailability, metabolism, or efficacy of vitamin D in a human. Forms and dosages of the composition, as well as processes for manufacturing a spray-dried formulation, are also disclosed.

The invention discloses a preparation method of a calcifediol intermediate ring A, and belongs to the technical field of organic chemistry. A compound III, a compound IV and a compound V are respectively obtained by taking a compound I as an initial raw material according to a synthesis route through a process shown in a reaction formula, and a key intermediate VII is finally obtained. The synthesis process adopts conventional organic chemical reactions, the raw materials are low in cost and easy to obtain, the process is simple, the synthesis route is short, the yield is high, the product quality is stable, large-scale production is easily achieved, and the method has good economic benefits and wide application prospects.

The present invention is inter alia concerned with a combination (i) a first compound selected from the group consisting of a norepinephrine-dopamine reuptake inhibitor (NDRI), a catecholamine and pharmaceutically acceptable salts thereof, (ii) a second compound selected from the group consisting of vitamin D3, calcifediol, calcitriol, vitamin D2, ercalcidiol and ercalcitriol, and (iii) a third compound selected from the group consisting of vitamin K1, vitamin K2 and vitamin K3, for use in the treatment of an inflammatory disease, preferably multiple sclerosis.

Methods and compositions for controlling hyperparathyroidism are disclosed.