31 results about "Calciferols" patented technology

An oral composition, suitable as a hypoglycemic agent, includes an isolate from the leaves of Gymnema sylvestre, having a specified molecular weight. The isolate has a molecular weight at least about 3000 Daltons as determined by molecular weight cut-off filtration. Glucose metabolism in a human patient can be regulated by dosage forms that contain the aforesaid isolate from the leaves of Gymnema sylvestre, in combination with a non-metabolizable, water-swellable polysaccharide such as the exudate of Sterculia urens, and a water-soluble polysaccharide such as guar gum. Optionally, the present oral compositions can include a physiologically acceptable calcium source, a physiologically acceptable metal carbonate salt, a physiologically acceptable chromium salt, and / or a physiologically acceptable vanadium compound. In addition, antioxidants such as ascorbic acid, cholecalciferol, d-α-tocopherol, the carotenoids, lycopene, lutein, and the like, can be included as well. The present compositions are useful for amelioration of cholesterolemia, obesity, chronic complications of diabetes and prophylaxis for patients predisposed to the foregoing.

The present invention discloses methods of using of compounds for the enhancement of the innate immune system of a patient. In particular, the active compounds of the present invention include at least one calcineurin inhibitor, mTOR inhibitor or non-immunosuppresive derivative, or a derivative, isomer, or pharmaceutically acceptable salt thereof; and optionally, at least one calciferol or LMW inhibitor, or a derivative, isomer, or pharmaceutically acceptable salt thereof. Pharmaceutical formulations comprising same are also disclosed.

We disclose treating hyperglycemia in a human with 25-hydroxyvitamin D3 (calcifediol). Blood glucose is reduced to a level which is closer to normal than baseline. Vitamin D3 (cholecalciferol) may optionally be used together with 25-hydroxy vitamin D3. Forms and dosages of a pharmaceutical composition, as well as processes for manufacturing medicaments, are also disclosed.

An implant to be used as medical or dental implant, comprising a metallic or polymeric base which is covered by the vitamin D precursor cholecalciferol. The implant can be obtained by direct covering of the polymeric or metallic base with a solution comprising cholecalciferol or also covering the base with the 7-dehydrocholesterol (7-DHC), and subsequently irradiated with UV light to induce the formation of cholecalciferol. Optionally, the coating of the implant may include an antioxidant such as vitamin E. This implant enhances osseointegration in compromised patients by means of the endogenous synthesis and activity of vitamin D in hard and mineralized tissue regeneration. Furthermore, a method to obtain these implants which comprises coating the surface of the implant directly with cholecalciferol or with a specific concentration of 7-DHC and irradiated with UV light to induce the formation of cholecalciferol.

The invention discloses an Eyer calciferol soft capsule preparation method which includes the steps: preparing capsule shells; preparing contents; pressing soft capsules. A preparation method of the contents includes the steps: taking Eyer calciferol, adding absolute ethyl alcohol, and stirring and dissolving mixture by the aid of a glass bar; adding median chain triglyceride oil and vitamin E, and electrically stirring mixture for 1-2 hours; transferring solution to a rotary evaporator, rotatably evaporating the solution at the temperature of 40-60 DEG C and at the pressure of 0.08-0.1Mpa, and enabling residue content to be lower than 0.5% according to detection; transferring solution to a stirring tank, and adding and stirring the median chain triglyceride oil; adjusting filled volume and pressing pills. A lot of experimental researches are implemented, temperature, pressure and time of rotary evaporation are controlled, residue of the absolute ethyl alcohol is controlled, and the absolute ethyl alcohol is removed. The Eyer calciferol soft capsule without ethyl alcohol can have effect on more patients, and particularly, alcoholic allergy people can be more effectively treated.

The invention provides a composite nutrient balancing flour which is prepared through combining vitamins, minerals, dietary fiber, natural nutrients, grease emulsification, it also comprises flour, folic acid, nicotinic acid, retinol acetic ester, calciferol, sulfur ammonium, lactoflavin, chlorhydric pyridoxol, L-ascorbic acid, L-lysine hydrochlorate, calcium salts, ferric salts, zinc salts, selenium salts, cereal germ powder, defatted soybean powder, composite cereal and potatoes, dietary fabric, composite biological enzymes. The preparation comprises the steps of weighing, blending, diluting, mixing masterbatch and carrier flour homogeneously by a predetermined proportion, and loading into beading machine through auger delivery.

A pharmaceutical composition or kit of parts comprising at least three ingredients from a HMG-CoA reductase inhibitor, a leukotriene antagonist, a proton pump inhibitor, melatonin or a melatonin receptor agonist, a bioavailable preparation of a curcuminoid, a calciferol derivative, a compound from the group consisting of metformin and phenformin, valproate, minocycline and chloroquine and one or more pharmaceutically acceptable carriers or excipients.

The present invention relates to a process for purifying Doxercalciferol, a synthetic vitamin D analog, also known as 1α-hydroxy vitamin D2, to the purity greater than 99.5% by crystallization from a mixed solvent of methanol and acetonitrile. Each of the individual impurities can be controlled no more than 0.1% which meets the individual unknown impurities specification requirement of International Conference on Harmonisation (ICH) guideline. The crystallization yield is more than 75% which is suitable for employed as a commercial process.

The invention relates to an anti-stress compound premix feed for laying fowls as well as a preparation method and application of the anti-stress compound premix feed. The premix feed is composed of the following raw materials in parts by weight: 160-240 parts of citric acid, 80-160 parts of fumaric acid, 8-15 parts of a plant essential oil compound, 2-5 parts of 25-hydroxy cholecalciferol, 0.15-0.75 part of ammonium sulfate nitrate, 6-15 parts of nicotinamide, 0.2-0.5 part of riboflavin, 0.2-0.5 part of D-calcium pantothenate, 1-2 parts of pyridoxine hydrochloride, 20-36 parts of DL-alpha-tocopheryl acetate, 0.4-0.7 part of menadione sodium bisulfite, 1-4 parts of biotin, 0.3-0.9 part of vitamin B12, 10-30 parts of phytase, 1-5 parts of protease, 2-10 parts of DL-methionine, 20-60 parts ofselenium yeast, 50-150 parts of calcium hydrophosphate and 200-600 parts of a carrier. The premix feed provided by the invention can significantly improve the stress intestinal injury of the laying fowls and improve the digestive absorption capacity, and finally achieves the effects of relieving the stress of the laying fowls, reducing the dirty egg rate, improving the egg laying rate in a stressstate, improving the egg quality and the breeding performance of breeding fowls, reducing the dirty egg rate, improving the fertilization rate and the hatching rate and increasing the economic benefits of farmers.

The invention discloses a new preparation method of a derivative A of a key Ayr calciferol intermediate (Z)-2-((3R,4R,5R)-3,5-dihydroxy-4-(3-hydroxy-propoxy)-2-methylene cyclohexyl) ethanol. The method comprises the following steps: performing 3,5-hydroxy protection on a compound 1 serving as a starting material, then reacting the protected compound 1 with R2O(CH2)3X to protect 4-hydroxy, oxidizing with a permanganate to obtain 1,2-hydroxy, performing further oxidation and wittig reaction to obtain 2-methylene, reducing, oxidizing, reacting the oxidized product with trimethyl silicon-based ethyl acetate, and performing DiBAL-H reduction to obtain a compound A. Compared with the prior art, illumination reaction is not used in the new route, so that the operation is simple and amplification is facilitated; and the used raw materials are cheap and readily available natural products, and all chiral centers are introduced from the raw materials, so the cost is low and the quality of the compound A is easy to control.

The invention discloses milk powder for females and a manufacturing method thereof. The milk powder for females is prepared from skim goat milk powder, lactose, inulin, corn syrup solid, full cream goat milk powder, cod collagen protein peptide powder, cranberry powder, beetroot juice powder, L-sodium ascorbate, dl-a-tocopheryl acetate, bifidobacterium animalis, ferric pyrophosphate, vitamin A acetate, and cholecalciferol. A pure dry method process is adopted; a process of a product is simplified; the energy is saved; the environment pollution is little; New Zealand grass-fed goat milk powderis used as a main raw material; collagen protein powder from deep sea cod, cranberry powder, inulin and bifidobacterium animalis are added; vitamin C and vitamin E are enhanced; the nutrition is supplemented; meanwhile, the effects of maintaining beauty, keeping young and promoting digestion can also be achieved; through the added cranberry powder, the whole color and luster of the product is light pink; through the added beetroot juice powder containing folic acid and iron elements, after the brewing, the liquid product is also light pink; the anemia is prevented; the mouth feel is unique; meanwhile, the drinking desire of customers is increased; and wide market prospects are realized.

The invention discloses a composition of a health care product for auxiliary treatment of pelvic effusion. The composition is prepared from the following components in parts by mass: 0.1-1 part of biological complex enzyme, 3-7 parts of red alga extract, 2-5 parts of brown alga extract, 1-4 parts of bee glue, 2-5 parts of calciferol, 5-12 parts of lemon extract and 30-35 parts of additive. By adopting the technical scheme disclosed by the invention, the composition of the health care product for auxiliary treatment of pelvic effusion can be synergistic with other drugs to obtain very obvious treatment effects.

The invention discloses formula sheep milk powder for promoting sleep and a preparation method of the formula sheep milk powder, and relates to the technical field of formula sheep milk powder. The formula sheep milk powder consists of raw sheep milk, demineralized whey powder, full cream sheep milk powder, isomaltooligosacharide, concentrated whey protein powder, mixed vegetable oil, milk mineral salt, collagen peptide, tea leaf theanine, potassium hydroxide and a compound nutrition enhancer. The compound nutrition enhancer consists of taurine, L-ascorbic acid, dl-alpha-tocopheryl acetate, pyridoxine hydrochloride, retinyl acetate, cholecalciferol, folic acid, calcium carbonate, ferrous sulfate, zinc sulfate, sodium selenite and lactose. According to the formula sheep milk powder disclosed by the invention, the tea leaf theanine is added into the formula milk powder, and the formula milk which can be used for children over 3 years old is formed through reasonable compatibility of substances such as milk mineral salt, the collagen peptide and the taurine, so that the height problem of the children caused by sleep quality is solved.

The invention relates to high protein containing nutritive cereal based food composition comprising appropriate amount of wheat flour, defatted soya flour, sugar, fat, other conventional additives, characterized in that enzymes, vitamins and antioxidant based on per 100gm of wheat flour and defatted soya flour blend are present in order of Enzymes: Papain (mg): 0.20 to 0.30 (tyrosine unit / g powder), Alkaline protease (mg): 0.10 to 0.15 (tyrosine unit / g powder). Vitamins: Thiamine hydrochloride (mg): 4.00 to 4.20, Riboflavin (mg): 1.40 to 1.60, Nicotinic acid (mg): 18.00 to 22.00, Vitamin A (acetate or palminate) (mg): 4.00 to 6.50, Vitamin D (Calciferol) (ug): 0.25 to 0.35. Antioxidant: Butylated Hydroxy Anisole: 0.40 to 0.55 (BHA) (mg); and a process for producing the composition.

The invention discloses bone-strengthening probiotic formula milk powder for preventing senile osteoporosis, and every 100 g of the formula milk powder comprises the following components: desalted whey powder, inulin, calcium carbonate, 3.8-6.2 g of fructo-oligosaccharide, xylooligosaccharide, vitamin A (retinyl acetate), vitamin D (cholecalciferol), vitamin E (dl-alpha-tocopheryl acetate), ferrous sulfate, sodium selenite and the balance of water. The milk powder is prepared from the following raw materials by weight: 5g of yak bone marrow collagen peptide powder, 0.4-0.6 g of phospholipid, L-carnitine, sodium hyaluronate, milk mineral salt, hydrolyzed yolk powder, bifidobacterium lactis HN019 and the balance of skim milk powder. On the basis of the prior art, in addition to reasonable matching of calcium, phosphorus and vitamins, probiotics, angiopoietin and cysteine-inhibiting protease protein are particularly added, the bone tissue density is further improved and strengthened, and therefore the occurrence rate of osteoporosis is more effectively reduced.

The invention belongs to the field of medicinal chemistry, and in particular relates to a new crystal form A of docalciferol and a preparation method thereof. The invention also relates to a pharmaceutical composition containing the new crystal form A of docalciferol and its role in the treatment of osteoporosis Hyperparathyroidism or secondary hyperparathyroidism. The new crystal form A of docalciferol, using Cu-Kα radiation, X-ray powder diffraction at 2θ angles at 7.82, 8.51, 12.06, 13.01, 15.60, 17.05, 17.82, 18.71, 19.35, 20.06, There are diffraction peaks at 20.37, 20.62, 21.98, 22.68, 22.90, 23.81, and 24.79. At the same time, the invention also discloses a process improvement scheme for preparing high-purity doxercalciferol, which has simple steps, easy operation, short time consumption and low cost, and is very beneficial to large-scale industrial production.

The invention relates to a preparation method of tendon and bone strengthening yak donkey collagen calcium. The method comprises the steps of mixing a yak donkey bone, cornu cervi degelatinatum, a donkey bone, a mother-of-pearl, a prepared rehmannia root, sealwort, fructus lycii and semen sesami nigrum, extracting for twice with 10 and 8 times of 70% alcohol respectively for 1.5h each time, merging extracts for concentration, drying to form dry cream, mixing with colla corii asini, grinding into fine powder, and adding milk powder, sucrose, dextrin, calcium lactate, calcium gluconate, calciferol and starch to form particles for bagging, or form tablets, oral liquid and the like.

The invention discloses a feed additive for health care of sows. The formula of the feed additive consists of the following components in parts by weight: 3-5 parts of calcium formate powder, 4-6 parts of amino acid powder, 2-4 parts of sodium diacetate, 6-8 parts of sodium glutamate, 4-6 parts of maltose, 6-8 parts of L-carnitine hydrochloride, 2-4 parts of 25-hydroxycholecalciferol, 3-5 parts oflight weight calcium carbonate powder and 6-8 parts of vitamin powder. The formula of the feed disclosed by the invention is reasonable, the richness of the nutrition of the feed is greatly increased, healthy growth of the sows is facilitated, promotion of calcium absorption is facilitated, the disease resistance of the sows is improved, and the feed has good health-care effects.

The present invention provides for a composition to be applied in the treatment of borreliosis and a kit. The composition includes four groups of components with which group A) the components 1000-5000 mgs Cat's Claw, 1000-3000 mgs Krill Oil or Kalamarine Oil or combinations of it, 200-600 mgs Magnesium Malate, 3000-5000 mgs ester C, 100-300 mgs Alpha-Lipoic Acid, 25-75 mgs Pyridoxyl-5-Phosphate (vitamin B6), 6000-14000 IU Cholecalciferol (vitamin D3), 2000-4000 mgs He Shou Wu, 1200-2500 mgs Purple Clovers Tea, 10-50 mls parsley juice, the group B) 2000-4000 mgs Monolaurine, 400-800 mgs N-Acetylcysteine, 100-300 mgs Hyaluronic acid with BioCell collagens II, 1-5 drops Teasel Root, the group C) 10-70 drops Spilanthes Acmella and the group D) 500-1500 μg Cyancobalamin (vitamin B12). The composition and the kit is suitable to be applied in the treatment of borreliosis with which the components of the group A) are administered once daily, those of the group B) twice daily, those of the group C) three times daily and that of the group D) every 14 days.

The invention provides a device and method for stimulating photobiochemical synthesis of vitamin D3-cholecalciferol. The device includes a housing (1), a power section (2) located in the housing, a section (3) for parameter setting and for narrow-band UVB radiation regulation, a screen or touch screen (4) for visualization, a source (5) for narrow-band UVB radiation, and a module (6) for uniform distribution of the narrow-band UVB radiation, which can be in direct contact with the skin. The technical result of the claimed invention is to provide stimulation of the synthesis of the required daily dose of vitamin D3-cholecalciferol using low intensity narrow-band radiation in the UVB range, which makes it possible to increase the concentration of vitamin D3-cholecalciferol to the required daily norm.

Disclosed herein are devices for stimulating the photo biochemical synthesis of vitamin D3-cholecalciferol in the body. The device includes a housing (1), a power section (2) located in the housing, a section (3) for parameter-setting and for narrowband UVB radiation regulation, a screen or touch screen (4) for visualization, a source (5) for narrow-band UVB radiation, and a module (6) for uniform distribution of the narrow-band UVB radiation, which can be in direct contact with the skin. The technical result of the claimed invention is to provide stimulation of the synthesis of the required daily dose of vitamin D3-cholecalciferol using low intensity narrow-band radiation in the UVB range, which makes it possible to increase the concentration of vitamin D3-cholecalciferol to the required daily norm.

The invention discloses a new preparation method of a derivative A of a key Ayr calciferol intermediate (Z)-2-((3R,4R,5R)-3,5-dihydroxy-4-(3-hydroxy-propoxy)-2-methylene cyclohexyl) ethanol. The method comprises the following steps: performing 3,5-hydroxy protection on a compound 1 serving as a starting material, then reacting the protected compound 1 with R2O(CH2)3X to protect 4-hydroxy, oxidizing with a permanganate to obtain 1,2-hydroxy, performing further oxidation and wittig reaction to obtain 2-methylene, reducing, oxidizing, reacting the oxidized product with trimethyl silicon-based ethyl acetate, and performing DiBAL-H reduction to obtain a compound A. Compared with the prior art, illumination reaction is not used in the new route, so that the operation is simple and amplification is facilitated; and the used raw materials are cheap and readily available natural products, and all chiral centers are introduced from the raw materials, so the cost is low and the quality of the compound A is easy to control.

The invention provides for the use of Vitamin D compounds such as 1-alpha-fluoro-25-hydroxy-16,23E-diene-26,27-bishomo-20-epi-chole-calciferol, in the prevention or treatment of prostate cancer.

The invention discloses a content calculation method of a doxercalciferol injection. The method comprises: destroying doxercalciferol by means of a sodium hydroxide water solution to generate a doxercalciferol precursor and 5,6-trans-doxercalciferol, and doxercalciferol and 5,6-trans-doxercalciferol response factors under given chromatographic conditions; calculating the concentration of a doxercalciferol standard substance before destroying, the concentration of the 5,6-trans-doxercalciferol generated after destroying, and the concentration of the non-destroyed doxercalciferol, so as to obtain the concentration of the doxercalciferol precursor after destroying; calculating a precursor response factor according to the peak area of the doxercalciferol precursor after destroying, so that the precursor response factor can be converted into a correction factor of the doxercalciferol, and the correction factor can be directly substituted for calculation when the content of the injection is tested. The method has operability through practice test, the degree of transforming the doxercalciferol into the precursor is not required, the accuracy is high, the method is simple and convenient, and the content of the doxercalciferol in the injection can be effectively controlled.

The invention belongs to the technical field of food processing, and discloses milk pudding added with AD calcium. The milk pudding is prepared from the following raw materials, according to the formula per ton: 43 kg of milk powder, 40 kg of white sugar, 6 kg of an emulsifier, 1.5 kg of DL-malic acid, 1.5 kg of lactic acid, 1 kg of honey, 0.5-0.6 kg of beta-carotene, 0.5-0.6 kg of calcium lactate, 0.5-0.6 kg of food grade vitamin A, 0.5-0.6 kg of cholecalciferol, 0.3-0.4 kg of lactobacillus bulgaricus, and 0.3-0.4 kg of streptococcus thermophilus, with the balance being purified water for drinking. The milk pudding is reasonable in component formula, unique in preparation technology, high in nutrition and good in taste, so that the milk pudding is popular among consumers.

The invention discloses slimming cereal nutrition powder with a weight losing function, and relates to the technical field of food processing. The slimming cereal nutrition powder comprises the following components: oatmeal, dried skim milk, puffed corn flour, inulin, crystalline fructose, peony seed oil powder, quinoa flour, buckwheat flour, guar gum, freeze-dried strawberry particles, freeze-dried blueberry particles, edible essence, sodium, vitamin A acetate, cholecalciferol, dl-alpha-tocopherol acetate, thiamine hydrochloride, riboflavin, pyridoxine hydrochloride, L-sodium ascorbate, nicotinic acid, D-calcium pantothenate, calcium carbonate, ferric pyrophosphate and zinc gluconate. The oatmeal, the quinoa flour, the buckwheat flour, the skimmed milk powder and the like are taken as main materials, and the peony seed oil powder, the freeze-dried fruit particles, the puffed corn flour, the inulin and various vitamins and minerals are added, so that the slimming cereal nutrition powder has the characteristics of balanced nutrition, low calorie, blood fat regulation and cholesterol reduction, and meets the requirements of modern people on management of own figures and comprehensive nutrition. The application prospect is wide.

We disclose treating hyperglycemia in a human with 25-hydroxyyitamin D3 (calcifediol). Blood glucose is reduced to a level which is closer to normal than baseline. Vitamin D3 (cholecalciferol) may optionally be used together with 25-hydroxy vitamin D3. Forms and dosages of a pharmaceutical composition, as well as processes for manufacturing medicaments, are also disclosed.

The invention discloses a nutrient capable of favorably improving cough and asthma. The nutrient comprises glucose, white granulated sugar, loquat leaf, bitter almond, radix glycyrrhizae, platycodon grandiflorum, honeysuckle, snow pear, fructose-oligosaccharide, galacto-oligosaccharide, zinc gluconate, ferric pyrophosphate, vitamin A acetate, cholecalciferol thiamine hydrochloride, riboflavin andL-ascorbic acid. The nutrient is good in absorption effect, easy in raw material obtaining, refreshing in taste, capable of improving the cough and asthma and widely applicable to medical and healthcare product industry.