Treating conditions associated with increased eotaxin with 25-hydroxyvitamin d3

a technology of eotaxin and eotaxin, which is applied in the direction of antiparasitic agents, drug compositions, immunological disorders, etc., can solve the problems of toxicity, rickets in children, osteomalacia in adults, etc., and achieve the effect of reducing the symptoms of conditions, and reducing the level of eotaxin

Inactive Publication Date: 2013-09-26
DSM IP ASSETS BV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0044]Normally, eosinophils are not found in the esophageal mucosa, but it esinophilic esophagitis, they can accumulate there, having a pro-inflammatory effect. Symptoms include dysphagia, chest pain and food impaction. In children, it can include nausea and vomiting, weight loss, anemia and failure to thrive. Often patients have a history of allergies, including food allergies to high protein foods such as milk, eggs, soybean, wheat, chicken and nuts. The eosinophils in the esophageal mucosa release major basic protein, which induces smooth muscle contractions, that are thought to be mechanistically similar to the broncho-constriction observed in asthma. Thus, reducing the amount of eotaxins would ameliorate the symptoms of eosinophilic esophagitis.

Problems solved by technology

A deficiency of vitamin D causes rickets in children and osteomalacia in adults.
But toxicity can occur after chronic intake of more than 100 times the recommended daily allowance (i.e., 5-15 μg or 200-600 IU vitamin D) for several months.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

Clinical Trial

Clinical Trial

[0076]Subjects

[0077]Healthy, postmenopausal women (50 to 70 years of age) were recruited using informed consent and screened using the following criteria: serum 25-hydroxy vitamin D3 between 20 nmol / L and 50 nmol / L, body mass index between 18 kg / m2 and 27 kg / m2, blood pressure less than 146 / 95 mm Hg, serum calcium less than 2.6 nmol / L, fasting glucose less than 100 mg / dl, no high-intensity exercise more than three times per week, no treatment for hypertension, no use of high-dose vitamin D or calcium supplement or drug affecting bone metabolism (e.g., biphosphonate, calcitonin, estrogen receptor modulator, hormone replacement therapy, parathyroid hormone), and not visiting a “sunny” location during the study.

[0078]Subjects were randomly assigned to one of seven treatment groups (i.e., daily, weekly, bolus as single dose, and bolus as combination dose). Each group included five subjects. They were followed for four months in Zürich, Switzerland during the ...

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PUM

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Abstract

The present invention relates to treating / preventing conditions associated with an increased level of eotaxin in a human with 25-hydroxyvitamin D3 (calcifediol). Optionally, vitamin D3 may be used together with 25-hydroxyvitamin D3.

Description

FIELD OF THE INVENTION[0001]The present invention relates to treating / preventing conditions associated with an increased level of eotaxin in a human with 25-hydroxyvitamin D3 (calcifediol). Optionally, vitamin D3 may be used together with 25-hydroxyvitamin D3.BACKGROUND OF THE INVENTION[0002]Vitamin D (e.g., ergocalciferol and cholecalciferol) is a group of fat-soluble compounds defined by their biological activity. A deficiency of vitamin D causes rickets in children and osteomalacia in adults. But toxicity can occur after chronic intake of more than 100 times the recommended daily allowance (i.e., 5-15 μg or 200-600 IU vitamin D) for several months. For vitamin D, “The threshold for toxicity is 500 to 600 mcg / kg body weight per day. In general, adults should not consume more than three times the RDA for extended period of time” (Garrison & Somer, The Nutrition Desk Reference, Third Ed., McGraw-Hill, pg. 82, 1997). Hypercalcemia may occur at a blood concentration of 25-hydroxyvitam...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/593A23L1/303A23L33/155
CPCA61K31/593A23L1/303A61K2300/00A23V2002/00A23V2200/30A23V2200/314A23V2200/32A23V2250/7106A23L33/155A61P1/00A61P1/04A61P11/00A61P11/02A61P11/06A61P29/00A61P33/00A61P35/00A61P37/08A61P43/00A61K9/0053A61K9/48
Inventor KRAMMER-LUKAS, STEPHANIESTOECKLIN, ELISABETHSCHWAGER, JOSEPHWOLFRAM, SWEN
Owner DSM IP ASSETS BV
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