The invention provides a bottom water reservoir horizontal well water flooding numerical simulation method based on a quasi-streamline method, which comprises the following steps: step 1, collecting basic static and dynamic information of a reservoir, and providing parameters for numerical simulation calculation; step 2, calculating parameter tables such as Kro, Krw, fw, fw 'and PV under each water saturation according to the relative permeability experiment data; 3, determining quasi-streamline distribution according to the form of the bottom water ridge, and performing isovolumetric mesh generation along the streamline; 4, initializing a model, and setting initial saturation, a pressure boundary and the like of a grid according to the actual condition of an oil reservoir; step 5, calculating simulation parameters such as saturation field distribution, seepage resistance and the like according to a water drive leading edge displacement theory. Aiming at the understanding problem of the water displacement rule of the bottom water reservoir, a bottom water displacement theoretical model is established by adopting a quasi-streamline method, the development dynamics of a horizontal well of the bottom water reservoir are simulated, and theoretical and technical support is provided for making a bottom water reservoir development technical policy.