19 results about "Hyperbranched polyglycerol" patented technology

The application discloses a kind of eluent and its preparation method and application, preparation method includes: adding potassium methoxide methanol solution to the trimethylolpropane in molten state, after stirring, vacuumizing, then droping glycidol monomer, after reaction, add methanol, dry, obtain hyperbranched polyglycerol ether;Add carbonyl imidazole to the N,N-dimethylformamide solution of saturated fatty acid, after stirring and mixing, drop to the N,N-dimethylformamide solution of hyperbranched polyglycerol ether, reaction is heated in nitrogen atmosphere, after reaction, the product is treated, obtain temperature-sensitive hyperbranched polyglycidol ether eluent.The eluent prepared in the application can greatly reduce the treatment cost of elution waste liquid while efficiently removing heavy metals.

Bioadhesive and biodegradable polymeric nanoparticles can be administered intrathecally, for example, via the cisterna magna, into the spinal column to allow widespread distribution for the treatment of tumors such as leptomeningeal metastases. The nanoparticles rapidly spread to all cerebrospinal fluid (CSF) compartments, including the brain parenchyma and spinal column. The bioadhesive nanoparticles penetrate and are retained for long periods of time, during which time they can continue to release drugs. These nanoparticles can be loaded with different therapeutic, preventive, or diagnostic agents, most preferably DNA repair inhibitors, to enhance the killing of leptomeningeal tumors, such as leptomeningeal metastases, and disseminated tumors, such as medulloblastoma. In a preferred embodiment, patients are treated with a combination of a PARP inhibitor and temozolomide.

This invention belongs to the field of metallurgical separation technology and relates to a method for separating and recovering tungsten and vanadium from a high-concentration molybdenum solution. The method includes: adding hydrogen peroxide solution to the liquid to be treated, heating to 60-80°C and maintaining the temperature for 30-60 minutes, then adjusting the pH to 2.5-3.5, and then adding an extractant for extraction to obtain a tungsten-vanadium-containing organic phase. The extractant consists of an amine extractant, tributyl phosphate, an ionic liquid, hyperbranched polyglycerol, and a diluent. The concentration of molybdenum in the liquid to be treated is not less than 150 g / L, the concentration of tungsten is 1-10 g / L, and the concentration of vanadium is 1-10 g / L. This invention aims to solve the technical problems of low efficiency and easy emulsification in the separation of tungsten and vanadium from high-concentration molybdenum solutions.

The invention discloses a lithium battery polymer protective coating as well as a preparation method and application thereof, and belongs to the technical field of lithium batteries, the preparation method of the coating comprises the following steps: adding a macromolecular fluorine-containing polymer, boric acid ester-containing branched polyether and a lithiated mesoporous molecular sieve into a solvent, and stirring and dispersing to obtain a coating; coating the coating on the surface of a metal lithium negative electrode, and performing vacuum drying to form a lithium battery polymer protective coating; the boric acid ester-containing branched polyether is obtained by sequentially reacting hyperbranched polyglycidyl with long-chain alkyl succinic anhydride and trimethyl borate; according to the invention, a high-efficiency and stable lithium battery negative electrode protection system is constructed by introducing functional groups such as long-chain alkyl, carbonyl, borate group and the like on the structure of hyperbranched polyglycerol and utilizing the characteristics of the branched structure and the lithiated mesoporous molecular sieve. The system can effectively inhibit the growth of lithium dendrites, improve the safety of the battery and prolong the cycle life of the battery.

This invention discloses a low-VOC environmentally friendly interior wall coating composition and its preparation method in the field of architectural coatings technology. The method involves mixing deionized water, diethylenetriamine-terminated hyperbranched polyglycerol-grafted polypropylene glycol diglycidyl ether star copolymer, and polyether-modified polysiloxane. Titanium dioxide, calcined kaolin, heavy calcium carbonate, and talc are then added and ground to obtain a pigment and filler slurry. Next, styrene-acrylic emulsion, acrylic emulsion, and a mixture containing N-(diaminoethyl)-aminopropylmethyldimethoxysilane-modified glycidyl methacrylate-polyetheramine-epoxy soybean oil ring-opening copolymer and methyl isobutyl ketone are added. After stirring, the pH is adjusted to 8.0-9.5 using an associative polyurethane thickener and aminomethylpropanol. Polyether-modified polysiloxane and benzisothiazolinone are then added, followed by degassing to obtain the final product. This coating has extremely low volatile organic compound content and exhibits excellent formaldehyde removal, scrub resistance, and dispersion stability.

The invention relates to the technical field of materials, in particular to a polysulfone composite material and a preparation method and application thereof, and the polysulfone composite material comprises modified polysulfone, modified rubber particles, an amphiphilic copolymer and hyperbranched polyglycerol. A hydroxyl sulfonate bond is generated through an epoxy group of the modified SEBS and a sulfonic group of the modified polysulfone in the modified rubber particles to reinforce the two-phase binding force, and micro holes are generated around the modified rubber particles under the action of external force to reinforce the anti-falling property of the reusable filtering device, so that the service life is prolonged. The hydrophilic segment of the amphiphilic polymer is compatible with the modified polysulfone, and the hydrophobic segment anchors the modified rubber particles, so that the dispersion of the modified rubber particles in the polysulfone composite material is promoted, the light scattering is reduced, and the transparency of the bottle body is improved. The hyperbranched polyglycerol and the amphiphilic copolymer generate a copolymer-hyperbranched polyglycerol complex, and the steric hindrance of a branched structure is utilized to prevent the modified rubber particles from getting close to each other, so that the dispersion efficiency of the amphiphilic copolymer is remarkably improved.

The present application belongs to the technical field of biomedical materials, and particularly relates to a Janus hydrogel coating agent, a preparation method and application thereof. The Janus hydrogel coating agent comprises hyperbranched polyglycerol and polyvinyl alcohol. The present application utilizes the differences in concentration, hydrophilicity and hydrophobicity and molecular chain movement of the two polymers to construct a Janus structure with different physical and chemical properties. The outer layer is a dense film structure, which can provide a physical barrier and mechanical strength, and at the same time resist external pathogenic bacteria. The internal skeleton is a porous network structure, which can realize partition loading and controlled release. In the treatment of skin diseases, the hydrogel coating agent can improve the skin environment and improve the treatment compliance, and has a good application prospect. At the same time, the preparation method is simple and does not need complex crosslinking.

The invention discloses a moisturizing microemulsion, a preparation method thereof and application of the moisturizing microemulsion in supercritical modification, and belongs to the technical field of dyeing and finishing. A modified small molecule oily moisturizing agent and hyperbranched polyglycerol fatty acid ester are compounded to prepare a compound emulsifier with a stable solubilizing effect; under the action of sugar alcohol, the moisturizing microemulsion which has a good solubilizing effect on a macromolecular water-based moisturizing agent in a supercritical system is obtained; the moisturizing microemulsion is used for carrying out supercritical modification treatment on fibers, and the obtained fibers are loaded with a micromolecular oily moisturizer and a macromolecular aqueous moisturizer at the same time, so that the moisturizing microemulsion has a very good moisturizing effect.

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses an icodextrin preparation for peritoneal dialysis and a preparation method of the icodextrin preparation. According to the icodextrin preparation for peritoneal dialysis provided by the invention, the first independent solution and the second independent solution are respectively prepared by adopting a double-chamber structure, and the taurine, the quercetin and the hyperbranched polyglycerol are added into the first independent solution; the icodextrin peritoneal dialysis solution effectively solves the risks of metabolic disorder and peritoneal injury caused by a traditional glucose dialysis solution and peritoneal fibrosis and pipeline blockage existing in an existing icodextrin dialysis solution, the stability of the icodextrin peritoneal dialysis solution is remarkably improved, the probability of adverse reactions is reduced, and the icodextrin peritoneal dialysis solution is excellent in viscosity resistance and osmotic pressure stability and can be used for preparing peritoneal dialysis solutions. The peritoneal dialysis solution can well replace the existing peritoneal dialysis solution, is simple in preparation process and good in repeatability, is easy to realize industrial mass production, and has relatively high popularization and application values in peritoneal dialysis treatment of patients with end-stage nephropathy.

The invention discloses a nano reinforced impact modifier for polyvinyl chloride and a preparation method thereof, and relates to the technical field of impact modifiers. The nano reinforced impact modifier is prepared from the following raw materials: a CNC (at) ACM compound, hyperbranched polyglycerol, amino-terminated hyperbranched polyamide, organic montmorillonite, maleic anhydride grafted POE, a silane coupling agent and nano zinc oxide; the CNC (at) ACM compound is prepared from acrylate rubber, silanized nano cellulose and p-toluenesulfonic acid; the preparation method of the nano-reinforced impact modifier comprises the following steps: pretreating nano-cellulose, synthesizing a CNC-coated ACM compound, pretreating auxiliary components, preparing a base material, and preparing the nano-reinforced impact modifier. The nano-enhanced impact modifier prepared by the invention can effectively enhance the mechanical properties and thermal properties of polyvinyl chloride.

Core-shell particles and methods of making and using thereof are described herein. The core is formed of or contains one or more hydrophobic materials or more hydrophobic materials. The shell is formed of or contains hyperbranched polyglycerol (HPG). The HPG coating can be modified to adjust the properties of the particles. Unmodified HPG coatings impart stealth properties to the particles which resist non-specific protein absorption and increase circulation in the blood. The hydroxyl groups on the HPG coating can be chemically modified to form functional groups that react with functional groups and adhere the particles to tissue, cells, or extracellular materials, such as proteins.

The present invention relates to hyperbranched polyglycerol polyglycidyl ethers having a molecular weight of 750 to 15,000 Da and an epoxy equivalent weight of 183 to 7,000 g / eq. The present invention also relates to crosslinked polysaccharides obtained by crosslinking polysaccharides with the hyperbranched polyglycerol polyglycidyl ethers. The present invention also relates to methods for their preparation and their use in therapeutic, cosmetic, agricultural, and food applications.

The invention discloses a far infrared radiation technology-based heating type high-speed rail bullet train bedding and a preparation method thereof, and relates to the technical field of high-speed rail bedding fabrics, the preparation method comprises the following steps: selecting raw materials, and mixing according to a weight ratio; raw materials comprise far infrared ceramic powder, graphene quantum dots, pumice powder, a silane coupling agent, aliphatic hyperbranched polyurethane and hyperbranched polyglycerol, and a mixed raw material system is formed; carrying out solution composite spinning on the mixed raw material to obtain far infrared heat storage filaments; the heat storage fabric is obtained by interweaving and weaving the far infrared heat storage filaments. The technical problem that in the prior art, a high-speed train bedding is poor in heat storage performance is solved.

The application provides a drug-loaded bottle-brush polymer of hyperbranched polyglycerol and a preparation method thereof, and relates to the technical field of bottle-brush polymers.The application utilizes Grubbs-III catalyst to perform water-phase ring-opening metathesis polymerization on a hyperbranched macromonomer to obtain a bottle-brush polymer; an excessive amount of the bottle-brush polymer is reacted to convert the hydroxyl groups in the bottle-brush polymer into carboxyl groups; and then, a grafting reaction is performed with paclitaxel to obtain the drug-loaded bottle-brush polymer of hyperbranched polyglycerol.The bottle-brush hPG synthesized by the application is a safe and efficient nanodrug carrier, and has great potential to replace expensive albumin.In addition, the bottle-brush hPG has a large number of -OH groups and excellent hydrophilicity, so that it becomes a multifunctional polymer platform coupled with other drugs or targeting molecules.

The invention belongs to the technical field of automobile chemicals, and particularly relates to bio-based environment-friendly windshield cleaning fluid. Comprising 10%-35% of hyperbranched polyglycerol functionalized by a hydrophobic group, 5%-25% of a bio-based eutectic solvent, 0.5%-5% of a composite bio-based surfactant, 0.1%-1.0% of a bio-based chelating agent, 0.05%-0.5% of a proteolytic enzyme preparation, 0.1%-0.5% of a pH buffer agent, 0.05%-0.2% of a preservative and the balance of deionized water. By the adoption of the technical scheme, efficient cleaning and low-temperature anti-freezing performance on complex dirt can be achieved, meanwhile, damage to materials such as rubber and paint surfaces is avoided, a complete bio-based source and high biodegradability are achieved, and environmental friendliness and material safety are remarkably improved.

The application discloses a preparation method of isotropic graphite material paste for a thorium-based molten salt reactor and belongs to the technical field of materials. The method comprises the following steps: S1, raw material selection: the additives comprise modified hyperbranched polyglycerol, bismaleimide-pyridine diamide bridging agent, zinc acetylacetonate and polyethylene glycol diacrylate; S2, dry powder preheating: the aggregate is preheated to 180 DEG C under nitrogen protection, the prepolymer and polyethylene glycol diacrylate are added, and dry mixing is carried out for 15 minutes; S3, first-time kneading: 70% of the total mass of bitumen is added, and kneading is carried out at a temperature of 110-130 DEG C for 30 minutes; S4, second-time kneading: the remaining 30% of the bitumen and the zinc acetylacetonate are added, the temperature is increased to 150-160 DEG C, and kneading is carried out for 40 minutes; and S5, paste cooling, crushing and collecting: the paste is transferred into a cooling and crushing pot, is ground into powder, is selected, and is batched. The application solves the problem of uneven mixing of the aggregate and the binder in the prior art.

The invention discloses a preparation method of isotropic graphite material paste for a thorium-based molten salt reactor, and belongs to the technical field of materials, the preparation method comprises the following steps: S1, raw material selection: additives comprise modified hyperbranched polyglycerol, a bismaleimide-pyridine diamide bridging agent, zinc acetylacetonate and polyethylene glycol diacrylate; s2, preheating dry powder: preheating the aggregate to 180 DEG C under the protection of nitrogen, adding the prepolymer and polyethylene glycol diacrylate, and carrying out dry mixing for 15 minutes; s3, mixing and kneading for the first time: adding asphalt accounting for 70% of the total mass, and mixing and kneading for 30 minutes at the temperature of 110-130 DEG C; s4, mixing and kneading for the second time: adding the rest 30% of asphalt and zinc acetylacetonate, raising the temperature to 150-160 DEG C, and mixing and kneading for 40 minutes; and S5, cooling, crushing and collecting the paste: transferring the paste into a cooling and crushing pot, grinding, selecting powder and blending. The problem that in the prior art, aggregate and a binder are not evenly mixed is solved.

The invention discloses a long-acting anti-pollution polyamide reverse osmosis membrane as well as a preparation method and application thereof, and belongs to the technical field of membrane separation. Comprising a porous supporting layer and a polyamide selection layer located on the surface of the porous supporting layer, monoamino terminal hyperbranched polyglycerol is covalently grafted in the polyamide selection layer, and the monoamino terminal hyperbranched polyglycerol reacts with acyl chloride monomers in the interfacial polymerization process through terminal primary amine groups of the monoamino terminal hyperbranched polyglycerol to be grafted in a polyamide network. The polyhydroxy branched structure of the hyperbranched polyglycerol is enriched towards the surface of the membrane, and a stable hydrophilic anti-pollution structure is formed on the surface of the membrane. According to the long-acting anti-pollution polyamide reverse osmosis membrane as well as the preparation method and the application thereof, the prepared membrane is long-acting and stable in anti-pollution performance, strong in hydrophilicity, simple in preparation process and easy to industrialize.

The invention relates to the field of coating preparation, in particular to adaptive environment-friendly putty-free coating and a preparation method thereof. The coating comprises a film-forming agent, nano silicon dioxide, a functional additive and deionized water, the film-forming agent comprises a hybrid emulsion and a supramolecular quadruple hydrogen bond monomer; the hybrid emulsion is formed by copolymerization of acrylate containing disulfide bonds and organic silicon; the functional additive comprises any one or more of hyperbranched polyglycerol ester, phosphorylated modified bamboo fiber nanocrystals and polyether modified silicone oil. A double-network interpenetrating structure is formed by the acrylic acid-organic silicon hybrid emulsion containing the disulfide bond and the supramolecular quadruple hydrogen bond monomer, the disulfide bond endows the coating with self-repairing ability, and the quadruple hydrogen bond improves the film-forming property and adhesive force of the coating. And nano silicon dioxide enhances hardness and alkali resistance. In the functional additive, hyperbranched polyglycerol ester improves the rheological property, phosphorylated bamboo fiber nanocrystals and silicon dioxide form multi-stage filling to improve the environmental protection property of the coating, and a defoaming system improves the uniformity of the coating.