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Polymer micro-needle array chip, and preparation method and application thereof

A microneedle array and polymer technology, applied in the field of biomedical materials and micro-processing, can solve the problems of loss of activity and insufficient mechanical strength to pierce the skin

Inactive Publication Date: 2013-09-18
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The disadvantage of current polymer microneedles is that on the one hand, their mechanical strength is generally not enough to pierce the skin. On the other hand, most of the polymer materials used to prepare microneedles cannot be dissolved in water, and need to be poured and molded in a molten state. High temperature treatment can easily inactivate drugs that are sensitive to high temperature, such as protein and peptide drugs

Method used

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  • Polymer micro-needle array chip, and preparation method and application thereof
  • Polymer micro-needle array chip, and preparation method and application thereof
  • Polymer micro-needle array chip, and preparation method and application thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0191] The invention provides a synthetic method for preparing the above-mentioned polyacrylamide polymer, which mainly includes the following steps:

[0192] S-1, in the reactor equipped with stirring device, add organic solvent, water and acrylamide monomer according to the set value;

[0193] The organic solvent of the present invention is mainly based on alcohols, supplemented by ketones. Alcohols are selected from at least one or a mixture of two or more of components such as methanol, ethanol, n-propanol, isopropanol, n-butanol; preferably, the volume percentage of the alcohol solvent in the reaction system is ≥ 60%; The ketones are selected from one of acetone, butanone, methyl isobutyl ketone and cyclohexanone, or a mixture of two or more of them. Preferably, the volume percentage of the ketone solvent in the reaction system is ≤25%; the present invention can control the molecular weight of the polymer by changing the volume percentage of the organic solvent in the re...

Embodiment 1

[0312] In a 250ml three-neck round-bottomed flask equipped with a mixed-flow condenser, a thermometer, and a nitrogen-equaling device, add water, ethanol, acetone, and isopropanol in sequence in a volume ratio of 2:5:10:83, and a total of 100ml is added through a magnetic stirrer. Mix it evenly; continue to add 10.66g of acrylamide monomer to the system, continue to stir to dissolve it; pass nitrogen gas, heat the reaction system through a water bath, and set the target temperature to 60°C; dissolve 107mg of azobisisobutyronitrile in In 10ml of isopropanol, mix evenly to make it fully dissolve. After the temperature of the reaction system reaches the target temperature of 60°C, add 1ml of isopropanol dissolved in azobisisobutyronitrile to the system, and keep it warm for 15 hours. Keep stirring during the reaction, and ensure the uninterrupted feeding of high-purity nitrogen;

[0313] After the reaction, the system was cooled, and the solid-liquid of the reaction system was se...

Embodiment 2

[0316] Same as Example 1, the proportioning of water, ethanol, acetone and isopropanol in changing solvents is 5:5:10:80. The content of residual acrylamide monomer in the polymer was detected by the Daofeng liquid chromatograph (LC-20A / SPD-20AV), and the measured value was ≤0.5ppm. Measure its molecular weight according to the GB 17514-2008 method in conjunction with the static light scattering method (Wyatt DAWN HELEOS-II), and the molecular weight of the obtained polymer is about 1.35×10 5 . The Vickers hardness of the corresponding block material is about 300HV measured according to the GB / T4340.2 standard. According to the D-256 standard of American ATSM, the impact strength is about 25J / m.

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Abstract

The invention discloses a polymer micro-needle array chip. The chip comprises a micro-needle array and a substrate used for the standing of the micro-needle array; and the matrix material of the micro-needle array is a polyacrylamide polymer. The invention also discloses a preparation method of the polymer micro-needle array chip, a micro-needle transdermal drug delivery patch prepared through utilizing the polymer micro-needle array chip, and a preparation method of the patch. The micro-needle of the polymer micro-needle array chip has a high mechanical strength and a sharp needle point, so the skin cuticle can be easily pierced; the preparation method avoids a high-temperature processing treatment step, and is in favor of maintaining the activities of biomacromolecules comprising polypeptides, proteins and the like; the polyacrylamide polymer can easily dissolve or swell after meeting with the water-containing environment, and is in favor the sustained release of drugs in skins; and the preparation method of the polymer micro-needle array chip based transdermal drug delivery patch is simple, so the batch produced can be realized through utilizing present manure processing technologies.

Description

technical field [0001] The invention relates to a polymer microneedle array chip, a preparation method and an application thereof, and belongs to the field of biomedical materials and microprocessing. Background technique [0002] Transdermal drug delivery refers to the drug delivery method in which drugs penetrate the skin at a certain rate and are absorbed into the blood circulation system of the whole body through capillaries to produce drug effects. Due to the barrier function of the stratum corneum, which is about 30-50 microns thick in the outermost layer of human skin, the traditional transdermal drug delivery method is only suitable for drugs with a molecular weight of less than 500 Daltons and high fat-soluble properties. In order to improve the transdermal permeability of macromolecular drugs such as peptides, proteins and vaccines, in the 1970s, researchers proposed the concept of "microneedle patch" drug delivery, that is, microneedles or microneedle arrays made ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/32A61K47/34A61M37/00C08F120/56
CPCA61K9/0021A61K47/32A61M37/0015A61M2037/0046A61M2037/0053C08L33/26C08F120/56A61K38/28A61K38/385A61K39/145A61M2037/0023B29C39/026B29K2033/26B29K2901/00C12N7/00C12N2760/16034
Inventor 吴飞鹏苗元华
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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