6 results about "Static light scattering" patented technology

The present invention provides an apparatus, method, and system for measuring the attributes of a viral gene delivery vehicle sample through isolation. [Solution] In one embodiment, the method, system, and computer program product perform a series of logical operations to analyze a viral gene delivery vehicle sample in a set of analytical instruments including at least one separation instrument, at least one static light scattering instrument, and at least two concentration detectors, thereby determining the capsid protein mass of the sample m A And the sample modification factor mass m B And the molar mass M of the modifying factor in the sample B This results in the molar mass of the capsid protein in the sample M A The data source receives the molar mass of the capsid protein, the injection volume v of the sample from the injection volume data source, and the total VGDV particle concentration C of the sample. A This includes performing a series of logical operations to calculate [something].

A method, system, and apparatus for combining DLS and SLS for number density estimation is disclosed. An example measurement device includes a sample holder containing at least a first sample, a set of optics, and a scanning mechanism to scan the sample holder relative to the set of optics. The example set of optics includes illumination optics. The example set of optics further includes a first detector beam configured for standard dynamic light scattering (DLS). The example set of optics further includes a second detector beam configured for enhancing DLS regularization with static light scattering (SLS) information.

This invention discloses a dynamic and static light scattering synergistic analysis laser particle size analyzer, relating to the field of laser particle size analyzer technology. It includes a bubble suppression component housed inside the main unit. The bubble suppression component comprises a progressive cone, a first honeycomb rectifier plate, a second honeycomb rectifier plate, and multiple turbine blades. The first and second honeycomb rectifier plates are respectively located at both ends of the progressive cone, used to disperse turbulent incoming water into multiple parallel fine streams, thereby reducing the number of bubbles and eliminating dead zones and eddies caused by bubbles. The water flow impact drives multiple turbine blades to rotate on one side of the second honeycomb rectifier plate, preventing a large number of bubbles from adhering to the edges of the holes in the second honeycomb rectifier plate. The fluid pressure is converted into mechanical rotation to eliminate the impact force of the water flow, allowing the water flow to be introduced into the sample cell in a parallel state for laser detection. This reduces the risk of the first inlet pipe being affected by vibration during laser particle size detection.

A method, system, and apparatus for combining DLS and SLS for number density estimation is disclosed. An example measurement device includes a sample holder containing at least a first sample, a set of optics, and a scanning mechanism to scan the sample holder relative to the set of optics. The example set of optics includes illumination optics. The example set of optics further includes a first detector beam configured for standard dynamic light scattering (DLS). The example set of optics further includes a second detector beam configured for enhancing DLS regularization with static light scattering (SLS) information.

The application discloses a flow mode nanoparticle size analyzer based on dynamic and static light scattering technology and a detection method thereof. The technology and method are suitable for being connected with a complete front-end separation equipment-field flow separation system or gel permeation chromatography, wherein the front-end separation equipment can separate each component according to the size of the sample components and flow out in sequence. The nanoparticle size analyzer comprises a flow-through sample cell, an APD detector for dynamic light scattering technology, a PD detector for static light scattering technology, a laser, a lens group, first and second data acquisition cards and a control unit. The laser emitted by the laser irradiates on the sample in the flow-through sample cell through the lens group, the two detectors simultaneously receive the scattered light of the sample, and the signals are transmitted to the control unit through the first and second data acquisition cards respectively. The application realizes accurate and high-resolution detection of the size and molecular weight of the sample, and meanwhile, the intrinsic viscosity information can also be obtained.

A microfluidic cartridge and associated apparatus for performing exchange of buffers or concentrating biologics in liquid are disclosed. The cartridge may include a liquid transport mechanism, a sample container, a series of concentration measurement chambers, and air pressure driven valves for flow control. The cartridge may have a port through which the sample is transported to viscosity, static light scattering, and / or dynamic light scattering measuring devices in sequence for measurement of interaction parameter, molecular weight, hydrodynamic radius, opalescence, viscosity, and / or osmolality.