36results about How to "Low molecular weight" patented technology

A conjugate that includes a drug covalently linked to a polymer. Upon administration, the conjugate is digested by an enzyme that is present at the site of administration thereby releasing a therapeutic agent. The conjugate may demonstrate substantially the same pharmacokinetic and pharmacodynamic behavior as the drug itself. A material for controllably releasing a conjugate in response to the local concentration of a molecular indicator. The material includes a plurality of conjugates and a plurality of multivalent cross-linking agents. The polymers of the conjugates include an analog of the indicator within their covalent structure. The multivalent cross-linking agents include cross-link receptors that interact with the indicator analog and thereby cross-link the conjugates. These non-covalent interactions are competitively disrupted when an amount of the molecular indicator is present thereby causing the material to release the conjugate in a manner that is dependent on the local concentration of indicator.

The invention relates to chewing gum comprising at least one biodegradable polyester copolymer obtained by the polymerization of two or more cyclic esters by ring-opening said at least one biodegradable polyester copolymer having a molecular weight of less than 150000 g/mol and said chewing gum further comprising chewing gum ingredients. According to the invention, an improved release of chewing gum ingredients has been obtained when a texture acceptable biodegradable polyester copolymer are applied as a chewing gum polymer.

A low molecular weight polyphenylene ether having a reduced viscosity of 0.04 to 0.18 dl/g as measured at 30° C. in a 0.5 g/dl chloroform solution, and a molecular weight distribution of 1.5 to 2.5; or a low molecular weight polyphenylene ether powder comprising the low molecular weight polyphenylene ether exhibits high thermal resistance and excellent electric properties, and thus is useful as electric materials such as printed circuit board and as modifiers of other resins.

The present invention relates to conjugate comprising a carrier substituted with one or more occurrences of a moiety having the structure (I): wherein each occurrence of M is independently a modifier having a molecular weight≦10 kDa; denotes direct of indirect attachment of M to linker L^M; and each occurrence of L^M is independently an optionally substituted succinamide-containing linker, whereby the modifier M is directly or indirectly attached to the succinamide linker through an amide bond, and the carrier is linked directly or indirectly to each occurrence of the succinamide linker through an ester bond. In another aspect, the invention provides compositions comprising the conjugates, methods for their preparation, and methods of use thereof in the treatment of various disorder, including, but not limited to cancer.

It is an object of the present invention to provide a cosmetic or external skin preparation that has an improved feel in use, e.g., excellent stretching on the skin surface, excellent permeation into the skin, and no stickiness, or crinkles. A cosmetic or an external skin preparation, and a medical instrument, comprising at least one lipid peptide-based gelator that contains a low-molecular lipid peptide of Formula (1):

(where R¹ to R³ are independently an organic group) or a pharmaceutically usable salt thereof.

The present invention provides isolated homogeneous polyfunctionalized proteins (e.g., erythropoietin), isolated glycopeptides, and a method for preparing polyfunctionalized peptides and/or proteins via cysteine-free native chemical ligation. In certain embodiments, the invention provides an isolated homogeneous polyfunctionalized protein having the structure (I). In certain other embodiments, the invention provides an isolated glycopeptide having Formula (II). In certain other embodiments, the inventive method is a method for preparing a polyfunctionalized peptide comprising a peptidic backbone made up of four or more amino acids, wherein two or more non-adjacent amino acids are independently substituted with a moiety having the structure (III)-LH. wherein A and L1 are as defined herein.

A display member for use at a temperature greater than at least about 40° C. The display member includes an arrangement of a plurality of optically anisotropic rotatable elements comprising a purified polymer. The plurality of rotatable elements have a surface in contact with an enabling fluid, the rotatable elements being electrically dipolar in the presence of the enabling fluid and being subject to rotation upon application of an electric field.

The present invention provides purified immunoglobulin compositions derived from the colostrum of a bovine immunized with a target antigen. The immunoglobulin composition comprises polyclonal antibodies specific for the target antigen and is depleted of non-immunoglobulin factors. The invention includes methods of manufacturing the compositions of the invention. The invention further includes pharmaceutical formulations comprising a purified immunoglobulin composition of the invention and an optional pharmaceutically acceptable excipient.

The invention discloses a sugar juice decoloring method. The method comprises the following steps: during a sugar making process, ClO2 is used for decoloring a sugar juice; the sugar juice refers to any one, two, three or four of a clear juice coming out of a clarification section, crude syrup or re-dissolution syrup coming out of an evaporation section, or massecuite coming out of a crystallization section; CIO2 is respectively added to any one, two, three, or four of the clear juice, the syrup or the messecuite; any one, two, three or four of the four sugar juices are respectively or simultaneously oxidized and declored; the amount of CIO2 added into the sugar juice is 0.0005 percent to 0.3 percent of the weight of the sugar juice; and the adding method is that CIO2 is directly added to a corresponding sugar juice, and the sugar juice is fully mixed and reacted with CIO2 during a flow and pumping process, so as to achieve the aim of oxidation and decoloration. The sugar juice decoloring method of the invention can effectively reduce the color value of the sugar juice, reduce the color value of a product sugar and the residue of sulfur, and simultaneously improve the purity and the quality of the sugar.

The present invention provides novel low molecular weight, high functionality number, polymers. The polymers may be made, for example, by heating (preferably, to a temperature of between about 130° C. and 180° C.) one or more ethylenically unsaturated monomers in the presence of a substantially aprotic solvent system; and maintaining the temperature for a time sufficient to polymerize the monomers to a preferred monomer to polymer conversion percentage of at least about 95 percent by weight. In a presently preferred embodiment, the polymer has a weight average molecular weight between about 900 and 7,000 Dalton and a functionality number of at least 100. The process is also preferably substantially free of chain transfer agents.

The invention provides a medium-high-temperature oil well cement retarding agent as well as a preparation method and application thereof. The method comprises the following steps of under the condition of existence of organo-phosphonate and an initiator, itaconic acid, acrylic acid and 2-acrylamido-2-methylpropanesulfonic acid take polyreaction in water to obtain the medium-high-temperature oil well cement retarding agent. The obtained retarding agent product is the medium-high-temperature oil well cement retarding agent with the application temperature range being 65 to 135 DEG C; meanwhile,the addition sensitivity of small molecular compounds, high initial thickness of carboxylic acid polymers and abnormal gelling phenomenon are overcome; during application, no reversal phenomenon occurs. The raw materials used by the oil well cement retarding agent are proper; the preparation process is simple; the application temperature range of the retarding agent is wide; the influence on the cement rock intensity is small; the thickening time and the retarding agent addition are in linear relationship.

The invention discloses a preparation method of an inorganic-organic composite inkjet printing paste. In the method, specially modified bentonite is adopted as a printing stock paste to completely or partially replace an organic stock paste in a traditional inkjet printing paste to prepare an environment-friendly inkjet printing paste. Compared with traditional organic inkjet printing pastes including sodium alginate and the like, printing wastewater generated by adopting the paste provided by the invention is greatly reduced in pollution degree because an organic paste is replaced by inorganic substances; and moreover, compared with an inorganic-organic composite paste of non-modified bentonite, a printed fabric produced by adopting the paste provided by the invention is higher in color yield and better in line sharpness. Therefore, the inorganic-organic composite inkjet printing paste is a low-pollution environment-friendly composite printing paste. The inorganic-organic composite inkjet printing paste disclosed by the invention not only is suitable for inkjet printing of natural fiber fabrics of silk, cotton, flax and the like, but also can be applied to flat and rotary screen printing of the natural fiber fabrics.

A linker for a unimolecular FRET biosensor based on a principle of fluorescence resonance energy transfer, the linker including: a polypeptide containing 52 to 400 amino acids residues, wherein at least 45% of a total number of the amino acid residues are glycine, alanine, or both thereof, and at least 10% of the total number of the amino acid residues are alanine.

The invention discloses a low-VOC halogen-free flame-retarding polyolefin cable material used for locomotives, which is composed of: 55-95 parts of an ethylene-vinyl acetate copolymer, 0.2-0.4 parts of an ethylene-maleic anhydride copolymer, 5-45 parts of polyethylene, 0.7-2 parts of ZnO, 120-165 parts of a halogen-free flame-retardant, 0.7-1.8 parts of a coupling agent, 1.5-3 parts of a crosslinking sensitizer, 1.4-2.4 parts of an antioxidant, 2-5 parts of a silicone master batch, and 0.5-1.2 parts of a lubricant. The cable material is low in TVOC value, has excellent anti-scraping white exposure effect and anti-oil effect, is excellent in direct current stability, is low-smoke and toxic-free, is environment-friendly and safe, and can be extruded rapidly. The cable material can be used for producing locomotive cables satisfying the standard EN50264 in requirement of CRRC.

The present invention provides a method for the treatment of chemical substance abuse by selectively inhibiting ghrelin activity in humans comprising administering to a human in need thereof a therapeutically-effective amount of a ghrelin receptor ligand (GHS-RL). The ghrelin receptor ligand (GHS-RL) can be selected from the group consisting of a ghrelin receptor antagonist (GHS-RA), a ghrelin receptor inverse agonist (GHS-RIA), and a ghrelin receptor partial agonist (GHS-RPA). More specifically, the invention provides a method for treating alcohol related disorders in humans comprising administering to a human in need thereof a therapeutically-effective amount of a compound which is a ghrelin receptor ligand (GHS-RL), such as a ghrelin receptor antagonist (GHS-RA), a ghrelin receptor inverse agonist (GHS-RIA) and a ghrelin receptor partial agonist (GHS-RPA).

Provided is an aliphatic polycarbonate macropolyol including —OAO— and Z(O—)_a as repeating units. In the aliphatic polycarbonate macropolyol, the repeating units —OAO— and Z(O—)_a are linked to each other via carbonyl (—C(O)—) linkers or are bonded to hydrogen to form terminal —OH groups. The number of moles of the terminal —OH groups is from aZ to aZ+0.2Z (where Z represents the number of moles of the repeating unit Z(O—)_a). Further provided is an aliphatic polycarbonate-co-aromatic polyester macropolyol including —OAO— and Z(O—)_a as repeating units. In the aliphatic polycarbonate-co-aromatic polyester macropolyol, the repeating units —OAO— and Z(O—)_a are linked via carbonyl (—C(O)—) and —C(O)YC(O)— as linkers or are bonded to hydrogen to form terminal —OH groups.

The present disclosure provides, in some aspects, macromonomers of Formula (I), and salts thereof; methods of preparing the macromonomers, and salts thereof; Brush prodrugs (polymers); methods of preparing the Brush prodrugs; compounds of Formula (II); conjugates of Formula (III), and salts thereof; pharmaceutical compositions comprising a Brush prodrug, or a conjugate or a salt thereof; kits comprising: a macromonomer or a salt thereof, a Brush prodrug, a compound, a conjugate or a salt thereof, or a pharmaceutical composition; methods of using the Brush prodrugs, or conjugates or salts thereof; and uses of the Brush prodrugs, and conjugates or salts thereof. These chemical entities may be useful in delivering pharmaceutical agents to a subject or cell.

The system and method for conversion of molecular weights of fluids includes an elongate metallic pipe. A liquid, e.g., a hydrocarbon liquid, is caused to flow through the pipe. A center electrode is mounted within the pipe coaxially with the pipe axis and the flow direction, the electrode being insulated from the pipe wall. The center electrode and the pipe wall are connected to the terminals of a voltage source to create an electric field extending radially between the center electrode and the pipe wall. A source of gamma radiation positioned either within the center electrode or external to the pipe directs gamma rays transverse to the direction of fluid flow. The combined radiation and electric field disrupts carbon-sulfur, carbon-hydrogen, and carbon-carbon bonds, creating ionization zones and resulting in the formation of lower molecular weight compounds. Optionally, a magnetic field may be superimposed in the direction of fluid flow.

The present invention provides a modified rubber containing silicon and phosphorus, and a composition and manufacturing method thereof. The present invention provides the modified rubber structured as formula (1),

The purified nerve growth factor consisting of 116 amino acids from the venom of Naja kaouthia snake was fragmented by trypsin digestion. The fragments were isolated individually by high pressure liquid chromatography (HPLC). Thus separated fragments were tested for the biological activity of neurite growth on rat adrenal pheochromocytoma (PC12) cells. The fragment which showed the most activity was named ADESH. Subsequently, ADESH was sequenced. Synthetic ADESH was constructed using ten amino acids N L G E H P V C D S (SEQ. ID. NO: 3) of the fragment from its N-terminal is designated as AD-10. Different versions of synthetic ADESH such as AD-15 and AD-5 consisting of 15 and 5 amino acids respectively were constructed; having the sequence: N L G E H P V C D S T D T W V (SEQ. ID. NO: 2) for AD-15 and N L G E H (SEQ. ID. NO: 4) for AD-5. The synthetic AD-15 and AD-5 mimic the biological activity of the natural NGF.