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Hollow mesoporous silica microsphere, preparation method and application thereof

A technology of mesoporous silica and microspheres, applied in the direction of silica, silicon oxide, pharmaceutical formulations, etc., can solve the problems of limiting the application range and application value of materials, and achieve the expansion of application value, simple preparation method and high yield high effect

Inactive Publication Date: 2013-06-26
广州万泽医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Mesopores are too small to limit the entry and exit of large guest molecules and affect the rate of entry and exit of guest molecules, which objectively limits the practical application range and application value of materials

Method used

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  • Hollow mesoporous silica microsphere, preparation method and application thereof
  • Hollow mesoporous silica microsphere, preparation method and application thereof
  • Hollow mesoporous silica microsphere, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The specific preparation process of the hollow mesoporous silica microspheres of this embodiment is as follows:

[0033] (1) Preparation of pH is 60ml of aqueous ammonia solution of 12;

[0034] (2) in the aqueous ammonia solution of step (1), cetyltrimethylammonium bromide is added, and the mass percentage concentration of the cetyltrimethylammonium bromide in the solution is 0.5% (w / w), Stir to make the solution clear and then add n-heptane, the volume ratio of the added n-heptane to ammonia water is 0.1;

[0035] (3) Heating the mixed solution in step (2) at a temperature of 40° C., while stirring and emulsifying, the stirring speed is 500 rpm, and the emulsification time is 1 hour;

[0036] (4) Add ethyl orthosilicate to the mixed solution of step (3) under stirring, the mass ratio of ethyl orthosilicate added and cetyltrimethylammonium bromide is 1;

[0037] (5) Collect the solid by filtration after 2 hours, wash to neutrality and then dry;

[0038] (6) The drie...

Embodiment 2

[0042] The specific preparation process of the hollow mesoporous silica microspheres of this embodiment is as follows:

[0043] (1) preparing pH is 60ml of aqueous ammonia solution of 10;

[0044] (2) add cetyltrimethylammonium bromide in the aqueous ammonia solution of step (1), the mass percentage concentration of the cetyltrimethylammonium bromide in the solution is 0.1% (w / w), Stir to make the solution clear, then add the mixed solution of isooctane and n-decane, the volume ratio of the added mixed solution to ammonia water is 0.2;

[0045] (3) Heating the mixed solution in step (2) at a temperature of 30° C., while stirring and emulsifying, the stirring speed is 700 rpm, and the emulsification time is 2 hours;

[0046] (4) Add ethyl orthosilicate to the mixed solution of step (3) while stirring, and the mass ratio of ethyl orthosilicate added to cetyltrimethylammonium bromide is 0.05;

[0047] (5) Collect the solid by filtration after 2 hours, wash to neutrality and then ...

Embodiment 3

[0051] The specific preparation process of the hollow mesoporous silica microspheres of this embodiment is as follows:

[0052] (1) 60ml of hydrochloric acid solution of preparation 0.5M;

[0053] (2) Add PEO-PPO-PEO triblock copolymer P123 in the hydrochloric acid solution of step (1), the mass percent concentration of the PEO-PPO-PEO triblock copolymer P123 in the solution is 5.0% (w / w ), stir to make the solution clear, then add the mixed solution of 1,3,5-trimethylbenzene and isooctane, the volume ratio of the added mixed solution to ammonia is 0.01;

[0054] (3) Heating the mixed solution in step (2) at a temperature of 80° C., while stirring and emulsifying, the stirring speed is 200 rpm, and the emulsification time is 0.5 hour;

[0055] (4) Add tetraethyl orthosilicate to the mixed solution of step (3) while stirring, and the mass ratio of the added tetraethyl orthosilicate to P123 is 0.05;

[0056] (5) Collect the solid by filtration after 2 hours, wash to neutrality...

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Abstract

The invention discloses a hollow mesoporous silica microsphere with hollow core and adjustable mesopore and penetrating through a shell, preparation method and application thereof. The hollow mesoporous silica microsphere is obtained by the following steps: under the condition of acid or alkaline solution, taking hexadecyl trimethyl ammonium bromide or PEO-PPO-PEO triblock copolymer as template, adding non-polar solvent, stirring at a certain temperature, emulsifying, then adding silica source, after hydrolysis and condensation, filtering, drying, and roasting to remove the template. The preparation method has simple technique and short time, easy operation and low cost, the prepared microsphere comprises both macropore and mesopore structures, the mesopore penetrates through the shell, the aperture thereof is larger than 5nm and is adjustable within the range of 5-20nm, and by relatively large mesopore channel, internal and external transmissions of large guest molecules can be realized. The microsphere can be used as drug carrier, the drug loading amount can exceed 50% (mass percentage), and the drug release can be controlled by adjusting aperture of the mesopore and dissolutionrate of indissolvable drug can be improved.

Description

technical field [0001] The invention belongs to the fields of preparation of inorganic materials and application of medicines, and in particular relates to a hollow mesoporous silicon dioxide microsphere with a mesoporous shell and a hollow core, a preparation method thereof, and an application as a drug carrier. Background technique [0002] Due to their low density, large specific surface area and high pore volume, porous materials are widely used in various fields such as construction, chemical industry, and medicine. According to the definition of the International Union of Pure and Applied Chemistry (IUPAC), the pore size of porous materials is divided into three categories: pores smaller than 2 nanometers are micropores (micropores), pores larger than 50 nanometers are macropores (macropores), between 2 Pores to 50 nm are mesopores. The size of the pores determines the purpose of the porous material. Hollow mesoporous microspheres have both mesoporous and macroporous...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B33/12A61K47/04
Inventor 吴传斌陈宝王周华权桂兰
Owner 广州万泽医药科技有限公司
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