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Multifunctional nuclear shell structure drug carrier material and preparation method thereof

A technology of core-shell structure and carrier material, which is applied in the direction of pharmaceutical formulations, preparations for in vivo tests, medical preparations of non-active ingredients, etc., can solve the problems of limiting the application of rare earth luminescent materials, achieve good crystal form, and avoid components The effect of volatilization and uniform particle size distribution

Inactive Publication Date: 2010-03-17
如皋市生产力促进中心
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Problems solved by technology

However, the fluorescence quenching effect of inorganic rare earth luminescent materials in contact with magneti

Method used

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  • Multifunctional nuclear shell structure drug carrier material and preparation method thereof
  • Multifunctional nuclear shell structure drug carrier material and preparation method thereof
  • Multifunctional nuclear shell structure drug carrier material and preparation method thereof

Examples

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Embodiment Construction

[0023] The following examples describe the present invention in more detail:

[0024] Implementation Process 1: Fe 3 o 4 @nSiO 2 @mSiO 2 @NaYF 4 : Synthesis of Yb, Er Microspheres

[0025] ① Fe 3 o 4 Preparation of nanoparticles

[0026] Using solvothermal method, firstly 1g FeCl 3 ·6H 2 O, 20mL ethylene glycol, 3g anhydrous sodium acetate and 10mL ethylenediamine were mixed and vigorously stirred for 30min to form a transparent solution. Then the obtained solution was transferred to a closed polytetrafluoroethylene-lined stainless steel reactor, and reacted at 200° C. for 12 h. After the reaction, it was naturally cooled to room temperature. The reaction product was washed several times with water and absolute ethanol, and finally dried at 80 °C for 12 h and ground into powder to obtain Fe 3 o 4 Nanoparticles.

[0027] ② Fe 3 o 4 @nSiO 2 Preparation of magnetic microspheres

[0028] core-shell Fe 3 o 4 @nSiO 2 Modified Prepared by sol-gel method. A typ...

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Abstract

The invention provides a multifunctional nuclear shell structure drug carrier material and a preparation method thereof; the preparation method comprises the following steps: step one, adopting a solvent-thermal method for preparing monodispersed ferroferric oxide magnetic nanoparticles with grain diameter of about 60nm as ferromagnetic nuclear material of the nuclear shell structure; step two, adopting a sol-gel method for cladding an imporous silicon dioxide layer and a meso-porous layer outside ferromagnetic nucleus in sequence; step three, adopting the sol-gel method for loading a layer ofup-conversion fluorescent material NaYF4: Yb, Er on the material obtained in the step two, wherein the molar concentration of Yb occupies 17% of Y concentration, and the molar concentration of Er occupies 3% of Y concentration. In the invention, an inertia SiO2 layer is designed between the magnetic nucleus and post-functionalized rare earth luminescent material for separating magnetic material from a rare earth luminescent layer so as to prevent fluorescent quenching; up-conversion fluorescent powder with higher fluorescent efficiency is used as fluorescent material; and the sol-gel method with mild reaction condition and uniform dispersion is adopted for forming the nuclear shell structure.

Description

(1) Technical field [0001] The invention relates to a drug carrier material with a core-shell structure. The invention also relates to a preparation method of a drug carrier material with a core-shell structure. (2) Background technology [0002] The core-shell structure materials can give full play to the respective maximum advantages of the shell material and the core material. After the core material is coated with an additional shell layer, it still retains its inherent characteristics, and its surface characteristics such as surface charge density, functionality, reactivity, biocompatibility, stability, and dispersion are adjusted and optimized by the shell material Therefore, core-shell nanoparticles have great development potential and application value in various aspects such as catalysts, optics, electromagnetism, biology, medicine and high-performance mechanical materials. The ordered mesoporous materials with a shell-core structure combined with magnetism and fl...

Claims

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Application Information

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IPC IPC(8): A61K47/04A61K47/02A61K49/00A61K9/16
Inventor 杨飘萍盖世丽王文鑫牛娜贺飞
Owner 如皋市生产力促进中心
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