87results about How to "Reduce translation" patented technology

A medical imaging recording and viewing system adapted for use interchangably with a variety of endoscopes. The system includes a portable hand-held device that may be removably placed within a cradle affixed to the endoscope. An interface between an image acquisition device of the endoscope and the portable device permits images to be transmitted to and stored within the portable device. The portable device also may include a viewing screen to permit a user to view the images. A docking station may receive the portable device for transferring images to a separate viewing device and for recharging the battery of the portable device.

A portable hand-held endoscopy system adapted for interchangeable use with a variety of endoscopes. The system includes an endoscope having a first end and a second end, the first end having an eyepiece and the second end having a viewing end, the endoscope further having a coupler for coupling to a light source; and a battery operated unitary digital camera having an optical input, viewing screen, digital signal processor, memory with embedded software for processing data from the processor and for displaying an image on the viewing screen, and a coupler having a first end and a second end, wherein the first end includes a connector for removably connecting to the eyepiece, and the second end is coupled to the optical input of the digital camera. The video display is rotatable and pivotable about several different axes of rotation and a pivot point spaced distally from the main camera body. An ergonomic camera housing is provided, including a bulbous gripping region and two opposing forefinger accepting regions, facilitating a trigger-like grip and use of the camera by a physician. Redundant controls for moving video and still image capture facilitate ease of use by the physician as the camera and associated endoscope are held in a variety of orientations.

Disclosed are methods for suppressing the induction of inducible nitric oxide synthase in a cell comprising contacting said cell with an effective amount of at least one induction suppressor of inducible nitric oxide synthase or a cytokine are disclosed. The induction suppressor can be an inhibitor of mevalonate synthesis, an inhibitor of the farnesylation of Ras, an antioxidant, an enhancer of intracellular cAMP, an enhancer of protein kinase A (PKA), an inhibitor of NF-kβ activation, an inhibitor of Ras / Raf / MAP kinase pathway, an inhibitor of mevalonate pyrophosphate decarboxylase or an inhibitor of farnesyl pyrophosphate.

A submicron structure having a silica body defining a plurality of pores is described. The submicron body may be spherical or non-spherical, and may include a cationic polymer or co-polymer on the surface of said silica body. The submicron structure may further include an oligonucleotide and be used to deliver the oligonucleotide to a cell. The submicron structure may further include a therapeutic agent and be used to deliver the therapeutic agent to a cell. An oligonucleotide and therapeutic agent may be used together. For example, when the oligonucleotide is an siRNA, the composition may be used to decrease cellular resistance to the therapeutic agent by decreasing translation of a resistance gene.

Antisense oligonucleotides specific for mammalian ACE mRNA have been identified. Administration of these oligonucleotides to animals resulted in a decrease in blood pressure, but no significant change in heart rate. Methods for discovering other oligonucleotides with the same activity are taught, as are uses of the antisense molecules for treatment of human and animal diseases.

Genes encoding an apoptosis-induced eukaryotic initiation Factor-5A (eIF-5A) and an apoptosis-induced deoxyhypusine synthase (DHS), whose expressions are induced by the onset of apoptosis, are identified. The DHS gene and the eIF-5A gene, alone or in combination, as well as inhibitors of the DHS reaction, are used to modulate apoptosis in animals and humans. For example, modulation of apoptosis in cells of animals and humans is achieved by introduction of a gene or gene fragment encoding apoptosis-induced eIF-5A, apoptosis-induced DHS, or both into the animal or human cell in antisense orientation.

A directional backlight apparatus includes a directional waveguide and a light source array, for providing large area directed illumination from localized light sources. Interfaces are provided between the directional waveguide and optical components adjacent the directional waveguide such that the coefficient of friction at the waveguide interfaces is greater than the coefficient of friction at least one outer interface on each side of the waveguide in the stack. Damage from compressive forces on the optical stack may be reduced, achieving improved optical performance and lifetime. Privacy display, low stray light display and autostereoscopic display may be provided with high uniformity, long lifetime and reduced cost mechanical components.

The invention discloses a polarimetric SAR classification method based on a semi-supervised convolutional neural network. According to the method, first, image data is input, and super pixel segmentation is performed; training samples and test samples are extracted; a neighborhood preserving and sparse filtering deep learning network (NDSFN) is adopted to perform unsupervised pre-training on parameters of the convolutional neural network, and a needed filter set is obtained; a feature map is obtained through convolution operation; fuzzy processing is performed on the feature map through downsampling; parameter settings of the NDSFN are adjusted according to the filter size in a second convolution layer to obtain a new feature map; a Softmax classifier is utilized to perform image classification on the training samples; and a small quantity of marked samples are adopted for slight adjustment to obtain a polarimetric SAR terrain classification. Through the method, by constructing a novelsemi-supervised convolutional neural network (SNCNN) model, the problem that a traditional supervised convolutional neural network has a high requirement for marked samples is effectively solved.

Search time is reduced with a search engine that includes a bi-directional inverted index facility which can be accessed with a keyword search in one of a number of languages and provide a listing of documents contained in all of those languages. The keywords in all supported languages are preferably stored in an inverted index lookup table cross referenced to documents in those language containing the keywords. Keywords with the same meaning in different languages are accessible together when that keyword in one of the languages is queried. The search engine containing the table can identify pertinent documents either in a selected language, a second language or in all supported languages, as determined by the user. Information about each document can include not only the identity of the document but also information used in ranking the documents such as the number of times that a keyword appears in that document, and the keywords proximity to other keywords. The use of the inverted index table therefore reduces search time by eliminating the need for translation of keywords, their identification in documents and accumulating of ranking information at search runtime and avoids inaccuracies which may result from full text translations of documents.

The invention provides a DNA molecule comprising a multicistronic transcription unit coding for i) a selectable marker polypeptide functional in a eukaryotic host cell, and for ii) a polypeptide of interest, the polypeptide of interest having a translation initiation sequence separate from that of the selectable marker polypeptide, characterized in that the coding sequence for the polypeptide of interest is downstream from the coding sequence for the selectable marker in said multicistronic transcription unit, and the nucleic acid sequence coding for the selectable marker polypeptide comprises a mutation that decreases the translation efficiency of the selectable marker in a eukaryotic host cell. The invention also provides methods for obtaining host cells expressing a polypeptide of interest, said host cells comprising the DNA molecules of the invention. The invention further provides the production of polypeptides of interest, comprising culturing host cells comprising the DNA molecules according to the invention.

Described are methods for identifying targets in RNA molecules based on differences in RNA secondary structure related to sequence variances between different allelic forms. Also described are methods for identifying or developing small molecules which can be used to modulate a target RNA by creation of protein-small-molecule-RNA complexes, as well as compositions which include such small molecules and methods of using those small molecules and compositions.

The current invention provides for methods and medicaments that apply an oligonucleotide comprising aninosine and / or an uracile and / or a nucleotide containing a base able to form a wobble base pair, said oligonucleotide being preferably RNAse H substantially independent and being complementary only to a repetitive sequence in a human gene transcript, for the manufacture of a medicament for the diagnosis, treatment or prevention of a cis-element repeat instability associated genetic disorders in humans. The invention hence provides a method of treatment for cis-element repeat instability associated genetic disorders. The invention also pertains to a modified oligonucleotide which can be applied in a method of the invention to prevent the accumulation and / or translation of repeat expanded transcripts in cells.

The invention discloses an automatic boxing system for a second generation of tetra brik milk bag gift box. The automatic boxing system comprises a separation mechanism (1), wherein the separation mechanism (1) comprises a primary separation mechanism (11) and two secondary separation mechanisms (12); an integration device (2) is correspondingly arranged at the tail end of each secondary separation mechanism (12), and two groups of partition board feeding mechanisms (3) and a milk box conveying line (5) which are corresponding are arranged beside each integration device (2) successively, the two groups of partition board feeding mechanisms (3) are respectively sleeved with lower partition boards, and a milk bag unit inbox mechanism (4) corresponds to an upper partition board straight-line module (6). A milk box sleeved with the partition board is conveyed to a corresponding lid buckling and box sealing machine (8) for lid buckling and box sealing through the milk box conveying line (5), and a two-in-one conveying mechanism (9) on the rear side of the lid buckling and box sealing machine (8) continues to convey the milk box. The automatic boxing system carries out automatic boxing in a two-in-one way, therefore reducing the speed, reducing links and increasing the output.

The present invention relates to the discovery that salt inducible kinases (SIKs) suppress the formation of anti-inflammatory molecules such as IL-10, which are important for the resolution of inflammation and identifies SIK inhibitors that may be used to treat disorders associated with undesirable inflammation, such as inflammatory bowel disease and / or autoimmune disorders.

A portable hand-held endoscopy system adapted for interchangeable use with a variety of endoscopes. The system includes an endoscope having a first end and a second end, the first end having an eyepiece and the second end having a viewing end, the endoscope further having a coupler for coupling to a light source; and a battery operated unitary digital camera having an optical input, viewing screen, digital signal processor, memory with embedded software for processing data from the processor and for displaying an image on the viewing screen, and a coupler having a first end and a second end, wherein the first end includes a connector for removably connecting to the eyepiece, and the second end is coupled to the optical input of the digital camera. The video display is rotatable and pivotable about several different axes of rotation and a pivot point spaced distally from the main camera body. An ergonomic camera housing is provided, including a bulbous gripping region and two opposing forefinger accepting regions, facilitating a trigger-like grip and use of the camera by a physician. Redundant controls for moving video and still image capture facilitate ease of use by the physician as the camera and associated endoscope are held in a variety of orientations.

The present invention relates to novel methods for modulating the activity of p53 tumor suppressor protein by affecting p53 translational regulation. More specifically, the invention relates to novel methods for modulating p53 mRNA translation in a cell by affecting a function of a p53 5′-untranslated region (5′UTR), including its interaction with proteins such as Ribosomal Protein L26 (RPL26), nucleolin, and p53. The invention also relates to the use of these methods for treating cancer, neurodegenerative disorders and minimizing the negative effects of cellular stresses.

A microstructured reconfigurable or morphing composite material with controlled anisotropic deformation properties. The composite material provides highly controlled deformation and stiffness properties. Microscopic three dimensional structures are included in the composite material to control its deformation kinematics and stiffness properties. The composite material has highly segregated in-plane and out-of-plane stiffness properties.

The present invention relates to compositions and methods of treating a cognitive disorder in a subject by administering an effective amount of a phenserine compound or a pharmaceutically acceptable salt or ester thereof and an effective amount of a HMG CoA reductase inhibitor or a pharmaceutically acceptable salt thereof to a subject, thereby treating a cognitive disorder in the subject.

The current invention provides for methods and medicaments that apply an oligonucleotide comprising aninosine and / or an uracile and / or a nucleotide containing a base able to form a wobble base pair, said oligonucleotide being preferably RNAse H substantially independent and being complementary only to a repetitive sequence in a human gene transcript, for the manufacture of a medicament for the diagnosis, treatment or prevention of a cis-element repeat instability associated genetic disorders in humans. The invention hence provides a method of treatment for cis-element repeat instability associated genetic disorders. The invention also pertains to a modified oligonucleotide which can be applied in a method of the invention to prevent the accumulation and / or translation of repeat expanded transcripts in cells.

A translation information providing apparatus includes a forward translator that generates a first translation by translating a first original sentence in a first language into a second language, a back translator that generates a first back translation by back-translating the first translation into the first language, and a translation result outputter that outputs at least either the first original sentence or the first translation and, as the first back translation, a back translation that semantically matches or is semantically similar to the first original sentence.

The present invention relates to the discovery that salt inducible kinases (SIKs) suppress the formation of anti-inflammatory molecules such as IL-10, which are important for the resolution of inflammation and identifies SIK inhibitors that may be used to treat disorders associated with undesirable inflammation, such as inflammatory bowel disease and / or autoimmune disorders.

Compositions and uses of mGluR5 antagonists for the treatment and inhibition of amyloid precursor protein (APP), Aβ protein, and APP proteolytic products in Alzheimer's disease, Fragile X Syndrome, autism, and Down's Syndrome are provided. The invention provides methods for diagnosing Fragile X Syndrome via the assessment of Aβ1-42 levels in blood plasma.

This invention provides an isolated nucleic acid encoding a human MCH1 receptor, a purified human MCH1 receptor, vectors comprising isolated nucleic acid encoding a human MCH1 receptor, cells comprising such vectors, antibodies directed to a human MCH1 receptor, nucleic acid probes useful for detecting nucleic acid encoding human MCH1 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding human MCH1 receptors, transgenic, nonhuman animals which express DNA encoding a normal or mutant human MCH1 receptor, methods of isolating a human MCH1 receptor, methods of treating an abnormality that is linked to the activity of a human MCH1 receptor, as well as methods of determining binding of compounds to mammalian MCH1 receptors.

A packet transfer apparatus having a plurality of protocol processing units 10 and a switch 20 for switching IP packets among the protocol processing units, wherein a protocol processing unit connected to an IPv4 network includes: input-side address translator CNv6 (I) for translating the address of an input packet to an IPv6 address; output-side address translator CNv4 (O) for translating, when an IPv6 packet is received from the switch, the address to an IPv4 address and transferring the resultant packet to the IPv4 network; and an operation mode controller for omitting address translation by the input-side address translator.

A backlight includes a directional waveguide and a light source array, for providing large area directed illumination from localized light sources. Interfaces are provided between the directional waveguide and optical components adjacent the directional waveguide such that the coefficient of friction at the waveguide interfaces is greater than the coefficient of friction at least one outer interface on each side of the waveguide in the stack. Damage from compressive forces on the optical stack may be reduced, achieving improved optical performance and lifetime. Privacy display, low stray light display and autostereoscopic display may be provided with high uniformity, long lifetime and reduced cost mechanical components.

The present invention relates to the discovery that salt inducible kinases (SIKs) suppress the formation of anti-inflammatory molecules such as IL-10, which are important for the resolution of inflammation and identifies SIK inhibitors that may be used to treat disorders associated with undesirable inflammation, such as inflammatory bowel disease and / or autoimmune disorders.

The current invention discloses novel methods for the inhibition of inducible nitric oxide synthesis (iNOS) and the production of NO. Methods of inhibiting the induction of proinflammatory cytokines are also described. Methods of treating various disease states, such as X-linked adrenoleukodystrophy, multiple sclerosis, Alzheimer's and septic shock using inhibitors of iNOS and cytokine induction are disclosed. The inhibitors include the exemplary compounds lovastatin, a sodium salt of phenylacetic acid (NaPA), FPT inhibitor II, N-acetyl cysteine (NAC), and cAMP.

The invention relates to a floating multifunctional signal tower for transmitting open sea information and a working method of the floating multifunctional signal tower. The floating multifunctional signal tower is provided with a lifting platform, wherein the lifting platform comprises a manned platform, a plurality of small pulleys, a large pulley, an out-of-tower rope and an in-tower rope; the plurality of small pulleys are divided into two groups, each group of small pulleys are fixed on the left and right sides of the signal tower through supports, one end of the out-of-tower rope is fixed on a control room and winds around one group of small pulleys, the large pulley and other group of small pulleys, the other end of the out-of-tower rope is fixed in the control room, and the large pulley is located on the part, connected between the two groups of small pulleys, of the out-of-tower rope; the lifting platform is fixed on the part winding around the two groups of small pulleys, of the out-of-tower rope, a position, supporting the large pulley, of the out-of-tower rope is vertically connected with one end of the in-tower rope, and the other end of the in-tower rope is connected with a first roller. The floating multifunctional signal tower is provided with the lifting platform, a worker can arrive at any height of the signal tower by the aid of the lifting platform, working of the worker is facilitated, and the safety is guaranteed.

The invention discloses an achieving method for automatically publishing a road construction quality information map based on a GeoServer. The map storing, generating and publishing functions provided by a GeoServer service are utilized to automatically publish the road construction quality information map. Firstly the GeoServer service is deployed, and the functions of a work space, a storage, a WMS service and the like are configured; a timing task is set to obtain construction quality data, and the construction quality data is processed according to predefined data to generate a file of an an shp format; a map layer publishing method in a GeoServer tool package is called to publish the generated file of the shp format into the WMS service; finally, according to a WMS service norm, OpenLayers are utilized to dynamically display the road construction quality map.

A system for guiding a gun-fired or mortared round towards an intended target, the system including a round having: a forward facing image pick-up device for capturing image data; a first transceiver; guidance device for varying a flight path of the round; and a first processor. The system further including a control platform remotely located from the round, the control platform having: a second transceiver; a second processor; an input device; and a display. Where the first processor transmits image data from the image pick-up device through the first transceiver to the second processor through the second transceiver, the second processor transmits guidance information from the second transceiver to the first processor through the first transceiver and the first processor controls the guidance device based on the guidance information to guide the round towards the intended target.