Compound traditional Chinese medicine preparation for targeting egg drop syndrome of duck and goose

Abstract

The application relates to the technical field of traditional Chinese medicine preparation, and particularly discloses a compound traditional Chinese medicine preparation for targeting egg duck and goose egg cytoplasmic disease, which comprises the following components: white head, Coptis chinensis, Huangqi, Phellodendron amurense, wine Danpi, bran-fried peach kernel, Chinese perilla, pomegranate peel, liquorice, honeysuckle, Andrographis, figwort, emblic, ginger, fried atractylodes, fried safflower, Xianhecao, spiny amaranth, and Poria cocos. Through the combination of monarch, minister, assistant and messenger, the core effects of heat-clearing and detoxifying, blood-cooling and dysentery-stopping, and dampness-drying and insect-killing of the medicines are synergistically exerted, the pathogenesis characteristics of the egg cytoplasmic disease are accurately targeted, blood stasis and blood circulation are promoted to eliminate the swelling of the lesion, and the intestinal mucosa damage is repaired to stop bleeding, the symptoms of hematochezia, diarrhea and oviduct inflammation of the egg duck and goose caused by the egg cytoplasmic disease are effectively relieved, the problems of the decreased antibiotic effect, drug residue, bacterial flora disorder and food safety risk are effectively solved, and the compound traditional Chinese medicine preparation has the remarkable progress of drug resistance, safety, no residue, intestinal protection and green environmental protection.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine preparations, and in particular to a compound traditional Chinese medicine preparation targeting egg drop disease in ducks and geese. Background Technology

[0002] Currently, egg drop syndrome in ducks and geese is an acute or subacute infectious disease of the reproductive system and abdominal cavity of laying ducks and geese caused by pathogens such as pathogenic Escherichia coli. The disease is characterized by oviduct inflammation, yolk rupture, peritonitis, and a large amount of caseous exudate in the abdominal cavity. Clinically, it manifests as a sharp decrease in egg production, a significant increase in mortality and culling rates, and causes serious economic losses to the waterfowl farming industry.

[0003] Prevention and control of egg disease in ducks and geese mainly rely on antibiotics and chemically synthesized antibacterial drugs. However, due to the complex serotypes of Escherichia coli and the increasingly serious drug resistance, the clinical efficacy of antibiotics is declining, and long-term or improper use can easily lead to drug residues, intestinal flora imbalance and food safety risks.

[0004] Therefore, there is an urgent need for a compound traditional Chinese medicine preparation that targets egg disease in ducks and geese to address the technical problems of declining efficacy of antibiotics, drug residues, intestinal flora imbalance, and food safety risks. Summary of the Invention

[0005] The purpose of this invention is to provide a compound traditional Chinese medicine preparation that targets egg disease in ducks and geese, aiming to solve the technical problems of declining efficacy of antibiotics, easy drug residues, intestinal flora imbalance and food safety risks in the prior art.

[0006] To achieve the above objectives, the present invention employs a compound traditional Chinese medicine preparation targeting egg drop disease in ducks and geese, comprising the following raw materials in parts by weight: 10-18 parts of Pulsatilla chinensis, 4-8 parts of Coptis chinensis, 5-10 parts of Scutellaria baicalensis, 4-8 parts of Phellodendron chinense, 4-8 parts of Paeonia suffruticosa (processed with wine), 4-8 parts of stir-fried Prunus persica (stir-fried with wheat bran), 8-15 parts of Euphorbia humifusa, 4-10 parts of Punica granatum peel, 5-8 parts of Glycyrrhiza uralensis, 8-15 parts of Lonicera japonica, 6-12 parts of Andrographis paniculata, 6-10 parts of Scrophularia ningpoensis, 6-12 parts of Phyllanthus emblica, 3-6 parts of prepared Zingiber officinale, 5-10 parts of stir-fried Atractylodes macrocephala, 4-8 parts of stir-fried Typha orientalis, 6-12 parts of Agrimonia pilosa, 8-15 parts of Portulaca oleracea, and 6-12 parts of Poria cocos.

[0007] The mass ratio of Pulsatilla chinensis to Coptis chinensis is (2~3):1.

[0008] The total mass fraction of Coptis chinensis, Scutellaria baicalensis, and Phellodendron chinense is in the ratio of the mass fraction of Pulsatilla chinensis to that of Coptis chinensis (1.2~1.8):1.

[0009] The total mass fraction of the three herbs, namely, *Euphorbia humifusa*, *Portulaca oleracea*, and *Andrographis paniculata*, is in the ratio of the mass fraction of *Pulsatilla chinensis* to that of *Pulsatilla chinensis* (2~3.5):1.

[0010] The total mass fraction of the four ingredients—peony bark, stir-fried peach kernel, stir-fried cattail pollen, and agrimony—is in a ratio of (3~5):1 to the mass fraction of pomegranate peel.

[0011] The total mass ratio of licorice to all other raw materials is 1:(18~25).

[0012] The mass ratio of prepared ginger to stir-fried Atractylodes macrocephala is 1:(1.5~2.5).

[0013] The mass ratio of honeysuckle to scrophularia is (1.2~1.8):1.

[0014] The mass ratio of Phyllanthus emblica to Poria cocos is (1~1.5):1.

[0015] The preparation is a powder, granule, or oral liquid.

[0016] This invention discloses a compound traditional Chinese medicine preparation targeting egg disease in ducks and geese. Through the combination of principal, assistant, and adjuvant herbs, the core effects of clearing heat and detoxifying, cooling blood and stopping dysentery, and drying dampness and killing parasites are synergistically exerted. It precisely targets the pathogenesis of egg disease, with a reasonable ratio of peony bark (processed with wine), stir-fried peach kernel, stir-fried cattail pollen, agrimony, and pomegranate peel. This combination can both promote blood circulation and remove blood stasis to eliminate swelling of lesions, and astringe and stop bleeding to repair intestinal mucosal damage. It effectively alleviates symptoms of bloody dysentery, diarrhea, and oviduct inflammation caused by egg disease in ducks and geese. The ratio of licorice to the other ingredients is also controlled. For example, it is combined with prepared ginger, stir-fried Atractylodes macrocephala, and Poria cocos, which can not only warm the middle and strengthen the spleen and stomach, protect the intestines and stomach, and prevent the spleen and stomach functions of ducks and geese from being damaged by a large amount of bitter and cold drugs, but also harmonize the various drugs to ensure that the medicinal properties are mild, reduce stress response, and are suitable for large-scale breeding. It has multi-target synergistic antibacterial effect, natural ingredients with no residue, regulates the balance of intestinal flora, and can be used throughout the egg-laying period. It effectively solves the problems of decreased efficacy of antibiotics, drug residues, flora imbalance and food safety risks. This compound Chinese medicine preparation has made significant progress in being less prone to drug resistance, safe and residue-free, protecting the intestines, and being green and environmentally friendly. Detailed Implementation

[0017] This invention provides a compound traditional Chinese medicine preparation targeting egg drop disease in ducks and geese, comprising the following raw materials in parts by weight: 10-18 parts of Pulsatilla chinensis, 4-8 parts of Coptis chinensis, 5-10 parts of Scutellaria baicalensis, 4-8 parts of Phellodendron chinense, 4-8 parts of Paeonia suffruticosa (processed with wine), 4-8 parts of stir-fried Prunus persica (stir-fried with wheat bran), 8-15 parts of Euphorbia humifusa, 4-10 parts of Punica granatum peel, 5-8 parts of Glycyrrhiza uralensis, 8-15 parts of Lonicera japonica, 6-12 parts of Andrographis paniculata, 6-10 parts of Scrophularia ningpoensis, 6-12 parts of Phyllanthus emblica, 3-6 parts of prepared Zingiber officinale, 5-10 parts of stir-fried Atractylodes macrocephala, 4-8 parts of stir-fried Typha orientalis, 6-12 parts of Agrimonia pilosa, 8-15 parts of Portulaca oleracea, and 6-12 parts of Poria cocos.

[0018] Furthermore, the mass ratio of Pulsatilla chinensis to Coptis chinensis is (2~3):1.

[0019] Furthermore, the total mass fraction of Coptis chinensis, Scutellaria baicalensis, and Phellodendron chinense is in the ratio of the mass fraction of Pulsatilla chinensis to (1.2~1.8):1.

[0020] Furthermore, the total mass fraction of the three herbs—Euphorbia humifusa, Portulaca oleracea, and Andrographis paniculata—is in a mass fraction of (2~3.5):1.

[0021] Furthermore, the total mass fraction of the four ingredients—peony bark, stir-fried peach kernel, stir-fried cattail pollen, and agrimony—is in a mass fraction of (3~5):1 with that of pomegranate peel.

[0022] Furthermore, the total mass ratio of the licorice to all other raw materials is 1:(18~25).

[0023] Furthermore, the mass ratio of the prepared ginger to the stir-fried Atractylodes macrocephala is 1:(1.5~2.5).

[0024] Furthermore, the mass ratio of honeysuckle to scrophularia is (1.2~1.8):1.

[0025] Furthermore, the mass ratio of Phyllanthus emblica to Poria cocos is (1~1.5):1.

[0026] Furthermore, the preparation is a powder, granules, or oral liquid.

[0027] In this embodiment, The herbs mentioned above are Pulsatilla chinensis, Coptis chinensis, Scutellaria baicalensis, and Phellodendron chinense. Among them, Pulsatilla chinensis is the core chief herb, which is cold in nature and enters the large intestine and liver meridians. It is specifically used to clear damp-heat in the large intestine, cool the blood and detoxify. It is an essential medicine for treating dysentery caused by heat toxins and directly targets the core pathogenesis of dysentery. Coptis chinensis, Scutellaria baicalensis, and Phellodendron chinense are auxiliary chief herbs. Coptis chinensis is bitter and cold and clears damp-heat in the heart and stomach, assisting Pulsatilla chinensis in enhancing its heat-clearing and dampness-drying power. Scutellaria baicalensis is bitter and cold and clears damp-heat in the upper burner. Phellodendron chinense is bitter and cold and clears damp-heat in the lower burner. The four herbs work together to form a powerful core of "one chief herb and three auxiliary herbs" for clearing heat and drying dampness. The herbs mentioned above are *Euphorbia humifusa*, *Portulaca oleracea*, and *Andrographis paniculata*. *Euphorbia humifusa* has the functions of clearing heat and detoxifying, cooling blood and stopping bleeding, and assisting the principal herb in enhancing its detoxifying and dysentery-relieving effects. *Portulaca oleracea* has the functions of clearing heat and detoxifying, cooling blood and stopping dysentery, and it works synergistically with *Euphorbia humifusa*. *Andrographis paniculata* has the functions of clearing heat and detoxifying, drying dampness and reducing swelling, broadening the antibacterial spectrum, and enhancing anti-inflammatory effects. *Euphorbia humifusa*, *Portulaca oleracea*, and *Andrographis paniculata* all have the functions of clearing heat and detoxifying, cooling blood and stopping dysentery. Together with the principal herb, they form a heat-clearing synergistic group, significantly enhancing the ability to clear damp-heat epidemic toxins and inhibiting pathogens at multiple targets. The ingredients, namely, peony bark (processed with wine), stir-fried peach kernel, stir-fried cattail pollen, agrimony, prepared ginger, stir-fried atractylodes macrocephala, poria cocos, amla fruit, and pomegranate peel, are divided into three groups of adjuvant herbs. Adjuvant drug group 1: Promotes blood circulation and stops bleeding, targeting bloody dysentery, fallopian tube bruising, and mucosal damage. The wine-processed peony bark is used as an adjuvant to cool the blood, remove blood stasis, and clear heat and toxins from the blood. The wheat bran-fried peach kernel is used as an adjuvant to break up blood stasis and promote the absorption of inflammatory exudates. The fried cattail pollen is used as an adjuvant to remove blood stasis and stop bleeding, and to astringe and stop bleeding without leaving blood stasis. The agrimony is used as an adjuvant to astringe and stop bleeding while also tonifying deficiency and repairing damaged mucous membranes. Adjuvant Group 2: Strengthens the spleen and protects the body's vital energy, counteracts the stomach-damaging effects of bitter and cold medicines, and supports the body's overall health. Prepared ginger acts as a counteracting herb, warming the middle and dispelling cold, thus restraining the bitter and cold nature of the entire formula; stir-fried atractylodes macrocephala acts as an adjuvant, strengthening the spleen and drying dampness, enhancing digestive function; poria cocos acts as an adjuvant, promoting diuresis and strengthening the spleen, assisting atractylodes macrocephala in supporting the body's vital energy; emblica acts as an adjuvant, clearing heat and generating fluids while supporting the body's vital energy, promoting diuresis without harming yin. Adjuvant group three: assists in astringency Pomegranate peel is used as an adjuvant medicine to astringe the intestines and stop diarrhea, astringe and stop bleeding, strengthen the intestines and prevent loss of body fluids; The adjuvant group works together to resolve blood-related diseases, the spleen-strengthening and blood-protecting group prevents the bitter and cold herbs from harming the body's vital energy, and the astringent group consolidates and stops diarrhea. The three groups work together to achieve "eliminating pathogens while supporting the body's vital energy, treating the symptoms while not forgetting to strengthen the root cause".

[0028] The licorice, honeysuckle, and scrophularia are used as adjuvant herbs; licorice also acts as a guiding herb, harmonizing the various herbs, tonifying qi and regulating the middle jiao, and moderating the medicinal properties; honeysuckle also acts as an adjuvant herb, clearing heat and detoxifying, guiding the medicine into the blood, and having both adjuvant and guiding functions; scrophularia also acts as an adjuvant herb, nourishing yin and cooling blood, clearing heat and detoxifying, and assisting honeysuckle in guiding the medicine into the blood; licorice harmonizes the properties of the entire formula, and honeysuckle and scrophularia work together to guide the medicine into the blood, so that the medicinal properties can accurately act on the disease location where heat has entered the blood.

[0029] Active ingredients such as Pulsatilla saponins, berberine, baicalin, and phellodendron chinense exert multi-target inhibition on pathogens such as Riemerella anatipestifer and Escherichia coli through multiple mechanisms including inhibiting bacterial cell wall synthesis, interfering with protein synthesis, and disrupting bacterial biofilms, significantly reducing the risk of single-component drug resistance. Honeysuckle and Andrographis paniculata work synergistically to fight bacteria and inflammation. Both have broad-spectrum antibacterial effects and downregulate the expression of inflammatory factors (TNF-α, IL-6, IL-1β), achieving both antibacterial and anti-inflammatory effects. Pulsatilla chinensis and Paeonia suffruticosa work synergistically to reduce inflammation. Pulsatilla chinensis saponins inhibit inflammatory signaling pathways, while Paeonia suffruticosa phenol reduces the release of inflammatory mediators. Together, they alleviate congestion and edema of the intestinal and fallopian tube mucosa. Scrophularia assists honeysuckle in achieving the clearing of both qi and blood. Honeysuckle clears heat and toxins from the qi and blood, while Scrophularia nourishes yin and cools the blood. The two work together to clear heat and detoxify, while also preventing heat and toxins from consuming yin and blood, which is in line with the pathogenesis of egg disease where heat enters the blood.

[0030] The wine-processed peony bark and the bran-fried peach kernel work together to remove blood stasis. The wine-processed peony bark cools the blood and removes blood stasis, while the peach kernel breaks up blood stasis. Together, they promote the absorption of inflammatory exudates from the fallopian tubes and intestinal mucosa, eliminate stagnation, and restore local blood circulation. Fried cattail pollen and agrimony work together to stop bleeding. Fried cattail pollen removes blood stasis and stops bleeding, while agrimony astringes and stops bleeding while also replenishing deficiency. The two work together to achieve precise regulation of stopping bleeding without leaving blood stasis and removing blood stasis without causing bleeding, effectively relieving symptoms such as bloody dysentery, bloody eggs, and fallopian tube bleeding caused by egg disease. The combination of Euphorbia humifusa and pomegranate peel works synergistically to repair the skin. Euphorbia humifusa clears heat and detoxifies, cools the blood and stops bleeding, while pomegranate peel astringes the intestines and stops diarrhea, and has astringent and consolidating properties. Together, they clear damp heat, astringe the damaged intestinal mucosa, reduce exudation, and promote the healing of ulcers. Purslane and Poria cocos work together to promote urination. Purslane clears heat and detoxifies while also promoting diuresis, while Poria cocos promotes urination, eliminates dampness, and strengthens the spleen. Together, they guide the elimination of damp-heat pathogens through urination, while avoiding the damage to the body's vital energy caused by bitter and cold diuretics. This achieves the therapeutic goal of eliminating dampness without retaining pathogens and removing pathogens without harming the body's vital energy.

[0031] Phyllanthus emblica's dual antioxidant synergy: Quercetin, kaempferol, and vitamin C work together to fight oxidation. All three are potent antioxidants that work together to eliminate free radicals and reduce the damage of oxidative stress to the intestinal and reproductive tract mucosa. Gallic acid and ellagic acid enhance antioxidant and anti-inflammatory effects. The two work synergistically to enhance the ability to scavenge free radicals, while inhibiting the release of inflammatory mediators, thus blocking the vicious cycle of "inflammation-damage-re-inflammation" from the perspective of oxidative stress. Atractylodes macrocephala polysaccharide and Poria cocos polysaccharide can enhance the phagocytic function of macrophages, promote lymphocyte transformation, and improve the overall disease resistance of laying ducks and geese. Licorice harmonizes the effects of various herbs, and also has the functions of invigorating qi and regulating the middle jiao, and enhancing immunity. Together with Phyllanthus emblica, it can both eliminate pathogens and strengthen the body's resistance. Prepared ginger and stir-fried atractylodes macrocephala work together to strengthen the spleen and protect the stomach. Prepared ginger warms the middle and dispels cold, while stir-fried atractylodes macrocephala strengthens the spleen and dries dampness. Together, they effectively restrain the damage to the spleen and stomach yang qi of ducks and geese caused by bitter and cold herbs such as coptis chinensis, scutellaria baicalensis, and pulsatilla chinensis, preventing side effects such as decreased feed intake and worsened diarrhea, and ensuring the safety of the whole formula in eliminating pathogens without harming the body's vital energy.

[0032] Example 1: Ingredient ratio: 18 parts Pulsatilla chinensis, 6 parts Coptis chinensis, 10 parts Scutellaria baicalensis, 6 parts Phellodendron chinense, 5 parts Paeonia suffruticosa (processed with wine), 5 parts stir-fried Prunus persica (stir-fried with wheat bran), 15 parts Euphorbia humifusa, 6 parts Punica granatum peel, 5 parts Glycyrrhiza uralensis, 15 parts Lonicera japonica, 12 parts Andrographis paniculata, 8 parts Scrophularia ningpoensis, 8 parts Phyllanthus emblica, 3 parts prepared Zingiber officinale, 6 parts stir-fried Atractylodes macrocephala, 5 parts stir-fried Typha orientalis, 8 parts Agrimonia pilosa, 15 parts Portulaca oleracea, 8 parts

[0033] The dosage of Pulsatilla chinensis reached 18 parts, with a ratio of 3:1 to Coptis chinensis (6 parts), which enhanced the direct inhibition against Escherichia coli and Riemerella anatipestifer. Pulsatilla chinensis saponins, by disrupting the integrity of bacterial cell membranes and interfering with bacterial metabolism, synergistically blocked bacterial protein synthesis with berberine in Coptis chinensis. The dosages of Scutellaria baicalensis and Phellodendron chinense were also increased accordingly. The ratio of the total mass of the three herbs to Pulsatilla chinensis was 1.22:1, ensuring that the heat-clearing effect was maximized without losing balance. The upper limits of the concentrations of Euphorbia humifusa, Portulaca oleracea, and Andrographis paniculata were all used. The ratio of the total amount of the three to Pulsatilla chinensis was approximately 2.33:1, which significantly enhanced the ability to clear damp-heat epidemic toxins. Andrographolide can downregulate inflammatory factors such as TNF-α and quickly relieve systemic inflammatory response. The ratio of Lonicera japonica to Scrophularia ningpoensis was 1.875:1, which was slightly higher than (1.2~1.8):1, but still within a reasonable range, which enhanced the effect of clearing both qi and blood. The chlorogenic acid of Lonicera japonica and the harpagoside of Scrophularia ningpoensis worked synergistically to clear heat toxins from the blood and prevent heat toxins from consuming yin fluids. The ratio of prepared ginger to stir-fried Atractylodes macrocephala is 1:2, which effectively warms the middle and strengthens the spleen, preventing diarrhea from worsening. The ratio of Phyllanthus emblica to Poria cocos is 1:1, which allows the antioxidant components of quercetin and gallic acid to be utilized, reducing the damage of oxidative stress to the intestinal mucosa. Clinical efficacy: After 3-5 days of continuous medication during the acute phase, ducks and geese showed decreased fever, improved spirit, bloody diarrhea turned into loose stools, increased feed intake, reduced oviduct congestion, and decreased peritoneal exudate. This example is not suitable for long-term use.

[0034] Example 2: Ingredient ratio: 15 parts Pulsatilla chinensis, 5 parts Coptis chinensis, 8 parts Scutellaria baicalensis, 5 parts Phellodendron chinense, 8 parts Paeonia suffruticosa (processed with wine), 8 parts stir-fried Prunus persica (stir-fried with wheat bran), 12 parts Euphorbia humifusa, 5 parts Punica granatum peel, 6 parts Glycyrrhiza uralensis, 12 parts Lonicera japonica, 10 parts Andrographis paniculata, 8 parts Scrophularia ningpoensis, 8 parts Phyllanthus emblica, 4 parts prepared Zingiber officinale, 8 parts stir-fried Atractylodes macrocephala, 8 parts stir-fried Typha orientalis, 10 parts Agrimonia pilosa, 12 parts Portulaca oleracea, 8 parts

[0035] This embodiment focuses on promoting blood circulation, removing blood stasis, clearing the channels, and reducing swelling. It targets the stage of egg plague in the middle and late stages, with the main pathological features being stagnation in the oviduct and abdominal cavity. The clinical manifestations include decreased egg production, hemorrhagic eggs, and deformed eggs. Autopsy reveals congestion and edema of the oviduct mucosa, accumulation of caseous exudate in the lumen, and peritonitis caused by yolk rupture. The total weight of the four ingredients—peony bark (wine-processed), peach kernel (wheat bran-fried), cattail pollen (fried), and agrimony—was 34 parts, with pomegranate peel accounting for 5 parts. The ratio of the two ingredients was 6.8:1, far exceeding the upper limit of (3~5):1. However, this embodiment focuses on promoting blood circulation and removing blood stasis, with astringency as a secondary function. Therefore, the proportion of the blood-activating drugs was appropriately increased. Paeonol in peony bark can inhibit platelet aggregation and improve microcirculation. Amygdalin in peach kernel (wheat bran-fried) can promote the absorption of inflammatory exudates. Flavonoids in cattail pollen have both blood-activating and hemostatic bidirectional regulatory effects. Agrimonia pilosa in agrimony can repair damaged vascular endothelium. The four drugs work synergistically to eliminate fallopian tube stasis and prevent excessive blood activation leading to bleeding. The dosage of Pulsatilla chinensis was reduced to 15 parts, and the response of Coptis chinensis, Scutellaria baicalensis, and Phellodendron chinense was reduced to avoid excessive damage to Yang Qi from bitter and cold herbs. The ratio of the total amount of the three herbs to Pulsatilla chinensis was 1.2:1, which preserved sufficient heat-clearing ability to control residual infection. The pomegranate peel is reduced to 5 parts to avoid premature astringency leading to internal blockage of blood stasis and heat. The ratio of roasted ginger to stir-fried atractylodes macrocephala is 1:2 to warm the middle and strengthen the spleen, preventing the blood-activating drugs from damaging the stomach and intestines. Poria cocos and amla fruit promote diuresis without harming yin. Clinical efficacy: After 5-7 days of continuous medication, a decrease in blood egg production, gradual absorption of exudate from the fallopian tube lumen, slow recovery of egg production rate, reduction of caseous material in the abdominal cavity, and restoration of the gloss of the fallopian tube mucosa can be observed. This embodiment is suitable for use when the symptoms of stasis are prominent after the acute phase has been controlled.

[0036] Example 3: Ingredient ratio: 12 parts Pulsatilla chinensis, 4 parts Coptis chinensis, 6 parts Scutellaria baicalensis, 4 parts Phellodendron chinense, 4 parts Paeonia suffruticosa (processed with wine), 4 parts stir-fried Prunus persica (stir-fried with wheat bran), 10 parts Euphorbia humifusa, 8 parts Punica granatum peel, 8 parts Glycyrrhiza uralensis, 10 parts Lonicera japonica, 8 parts Andrographis paniculata, 8 parts Scrophularia ningpoensis, 10 parts Phyllanthus emblica, 6 parts prepared Zingiber officinale, 10 parts stir-fried Atractylodes macrocephala, 5 parts stir-fried Typha orientalis, 8 parts Agrimonia pilosa, 10 parts Portulaca oleracea, 12

[0037] This embodiment focuses on strengthening the spleen and warming the middle jiao, supporting the body's resistance and consolidating its foundation. It is suitable for poultry with prolonged disease course, repeated use of antibiotics or bitter and cold Chinese medicines, resulting in spleen and stomach deficiency and cold. The clinical manifestations include low feed intake, loose or undigested feces, lethargy, and long-term failure to recover egg production, with a pale tongue and white coating. The ratio of prepared ginger to stir-fried atractylodes macrocephala is 1:1.67, close to the lower limit of 1:1.5, which strengthens the warming and dispelling cold effects. The gingerone in prepared ginger can promote gastrointestinal motility and improve digestion and absorption. The atractylodes macrocephala lactone in stir-fried atractylodes macrocephala can repair the intestinal mucosal barrier and enhance the spleen's immune function. The dosage of Poria cocos is 12 parts, and the ratio with Phyllanthus emblica is 1.2:1, which can both eliminate dampness and strengthen the body, preventing dampness from trapping the spleen. The dosage of Pulsatilla chinensis was reduced to 12 parts, Coptis chinensis to 4 parts, Scutellaria baicalensis to 6 parts, and Phellodendron chinense to 4 parts, which significantly reduced the overall cold nature of the formula. The ratio of the total amount of the three herbs to Pulsatilla chinensis was 1.17:1, which is slightly lower than the lower limit of 1.2:1. However, this embodiment focuses on supporting the body's resistance and is acceptable. The dosage of Glycyrrhiza uralensis was 8 parts, which is 1:16.6 of the total mass of the other raw materials, which is lower than the range of 1: (18~25). This enhances the purpose of invigorating qi and harmonizing the middle jiao, and harmonizing the properties of the herbs, and prevents the bitter and cold herbs from damaging the stomach. The ratio of pomegranate peel to the blood-activating and hemostatic group (peony bark, stir-fried peach kernel, stir-fried cattail pollen, and agrimony) was 2.625:·, which is lower than (3~5):1, reflecting the idea of ​​less blood-activating and more astringent, which is suitable for chronic diarrhea due to deficiency. Agrimony also has the effect of tonifying deficiency, and works synergistically with atractylodes macrocephala and poria cocos to enhance immunity. Clinical effects: After 7-10 days of medication, a significant increase in feed intake, formed feces, improved mental state, and reddening of the comb and wattles can be observed. Egg production gradually recovers in the following 2 weeks. This example is suitable for use in the later stages of an epidemic or during the cold winter and spring seasons. It can be used as a preventive health care method, administered 2-3 days a week to improve the disease resistance of duck and goose flocks.

[0038] Example 4: Ingredient ratio: 14 parts Pulsatilla chinensis, 5 parts Coptis chinensis, 7 parts Scutellaria baicalensis, 5 parts Phellodendron chinense, 6 parts Paeonia suffruticosa (processed with wine), 6 parts stir-fried Prunus persica (stir-fried with wheat bran), 14 parts Euphorbia humifusa, 10 parts Punica granatum peel, 6 parts Glycyrrhiza uralensis, 12 parts Lonicera japonica, 10 parts Andrographis paniculata, 8 parts Scrophularia ningpoensis, 8 parts Phyllanthus emblica, 4 parts prepared Zingiber officinale, 8 parts stir-fried Atractylodes macrocephala, 7 parts stir-fried Typha orientalis, 12 parts Agrimonia pilosa, 14 parts Portulaca oleracea, 8

[0039] This embodiment emphasizes astringent hemostasis and mucosal repair. It targets the subtype of egg plague, which is characterized by intestinal damage and bloody diarrhea. The toxins produced by pathogenic Escherichia coli can cause extensive bleeding and erosion of the intestinal mucosa. Clinically, it is seen as bright red or dark red bloody stools, frequent diarrhea, and rapid dehydration. Autopsy reveals intestinal mucosal congestion, bleeding points, and ulcers. The dosage of pomegranate peel reached 10 parts, and the ratio of the total mass of the four herbs in the blood-activating and hemostatic group (peony bark, bran-fried peach kernel, fried cattail pollen, and agrimony) was 3.1:1, achieving a balance between blood-activating and astringent effects. The tannins in pomegranate peel can form a protective film on the surface of the intestinal mucosa, reducing exudation and bleeding. Agrimonia pilosa can promote platelet aggregation and accelerate hemostasis. The flavonoids in fried cattail pollen enhance capillary density. 14 parts of Euphorbia humifusa and 14 parts of Portulaca oleracea are both rich in flavonoids, tannins and organic acids. They can clear heat and detoxify, as well as cool the blood and stop bleeding. Euphorbia humifusa and pomegranate peel work together to clear damp heat while astringing damaged mucous membranes and promoting ulcer healing. 10 parts of Andrographis paniculata have anti-inflammatory effects and reduce intestinal edema. The ratio of prepared ginger to stir-fried Atractylodes macrocephala is 1:2 to ensure warming the middle and strengthening the spleen, and to prevent qi stagnation caused by astringent drugs. The ratio of Phyllanthus emblica to Poria cocos is 1:1, which has antioxidant and diuretic effects. Clinical results: After 3-5 days of medication, bloody dysentery was significantly reduced, stool color changed from red to yellow and gradually became formed, dehydration was corrected, and the patient's mental state recovered. Autopsy showed a reduction in intestinal bleeding points and the mucosal ulcers began to heal.

[0040] Example 5: Ingredient ratio: 12 parts Pulsatilla chinensis, 4 parts Coptis chinensis, 6 parts Scutellaria baicalensis, 4 parts Phellodendron chinense, 5 parts Paeonia suffruticosa (processed with wine), 5 parts stir-fried Prunus persica (stir-fried with wheat bran), 10 parts Euphorbia humifusa, 6 parts Punica granatum peel, 7 parts Glycyrrhiza uralensis, 10 parts Lonicera japonica, 8 parts Andrographis paniculata, 10 parts Scrophularia ningpoensis, 12 parts Phyllanthus emblica, 5 parts prepared Zingiber officinale, 8 parts stir-fried Atractylodes macrocephala, 5 parts stir-fried Typha orientalis, 8 parts Agrimonia pilosa, 10 parts Portulaca oleracea, 10

[0041] This embodiment aims to balance clearing heat and strengthening the body's resistance, and enhance immunity. It is suitable for the recovery period of egg plague, chronic latent infection, or as a whole-process health care during the egg-laying period. At this stage, most of the pathogenic factors have been eliminated, but the body's resistance has not been restored. Residual damp heat can lead to unstable egg production rate, poor eggshell quality, and easy recurrence. The formula consists of 12 parts Pulsatilla chinensis, 14 parts Coptis chinensis, Scutellaria baicalensis, and Phellodendron chinense, with a ratio of 1.17:1 between the three herbs and Pulsatilla chinensis, preserving basic antibacterial capabilities. The formula also includes 10 parts Lonicera japonica and 10 parts Scrophularia ningpoensis, with a ratio of 1:1, which is lower than (1.2~1.8):1. This formula focuses more on nourishing yin and cooling blood rather than strongly clearing heat, making it suitable for long-term use. The dosage of Phyllanthus emblica is 12 parts, and the ratio of Phyllanthus emblica to Poria cocos is 1.2:1, which conforms to (1~1.5):1. Phyllanthus emblica is rich in vitamin C, quercetin, and gallic acid, and has a strong antioxidant effect. It can eliminate free radical damage caused by egg disease and promote lymphocyte transformation. Poria cocos polysaccharide can enhance the phagocytic function of macrophages. The ratio of Atractylodes macrocephala to Zingiber officinale is 1.6:1, which strengthens the spleen and warms the middle. Glycyrrhiza uralensis is 7 parts, and the ratio of its mass to the total mass of the other raw materials is 1:20.7, which harmonizes the various herbs and benefits qi and the middle. The total weight of the wine-processed peony bark, bran-fried peach kernel, stir-fried cattail pollen, and agrimony was 23 parts, with 6 parts of pomegranate peel, in a ratio of 3.83:1. It has a moderate effect of promoting blood circulation and removing blood stasis, promoting the recovery of microcirculation in the fallopian tubes and intestines without causing bleeding. Agrimony nourishes deficiency and stops bleeding, making it suitable for chronic exudation. Clinical efficacy: As a treatment, after 7-10 consecutive days, the egg production rate steadily increases, eggshell color improves, and deformed eggs decrease. As a preventive and health care treatment, administering the medication 2-3 days a week during the egg production period can significantly reduce the recurrence rate of egg plague and improve the uniformity of the flock. This embodiment is safe and residue-free, meets the requirements of green farming, and can be used throughout the egg production period.

[0042] The above description discloses only one preferred embodiment of the present invention, and should not be construed as limiting the scope of the present invention. Those skilled in the art will understand that all or part of the processes of the above embodiments can be implemented, and equivalent changes made in accordance with the claims of the present invention are still within the scope of the invention.

Claims

1. A compound traditional Chinese medicine preparation targeting egg drop disease in ducks and geese, characterized in that, Includes the following parts by weight of raw materials: 10-18 parts of Pulsatilla chinensis, 4-8 parts of Coptis chinensis, 5-10 parts of Scutellaria baicalensis, 4-8 parts of Phellodendron chinense, 4-8 parts of Paeonia suffruticosa (processed with wine), 4-8 parts of stir-fried Prunus persica (stir-fried with wheat bran), 8-15 parts of Euphorbia humifusa, 4-10 parts of Punica granatum peel, 5-8 parts of Glycyrrhiza uralensis, 8-15 parts of Lonicera japonica, 6-12 parts of Andrographis paniculata, 6-10 parts of Scrophularia ningpoensis, 6-12 parts of Phyllanthus emblica, 3-6 parts of prepared Zingiber officinale, 5-10 parts of stir-fried Atractylodes macrocephala, 4-8 parts of stir-fried Typha orientalis, 6-12 parts of Agrimonia pilosa, 8-15 parts of Portulaca oleracea, and 6-12 parts of Poria cocos.

2. The compound traditional Chinese medicine preparation targeting egg plague in ducks and geese as described in claim 1, characterized in that, The mass ratio of Pulsatilla chinensis to Coptis chinensis is (2~3):

1.

3. The compound traditional Chinese medicine preparation targeting egg plague in ducks and geese as described in claim 1, characterized in that, The ratio of the total mass fraction of Coptis chinensis, Scutellaria baicalensis, and Phellodendron chinense to the mass fraction of Pulsatilla chinensis is (1.2~1.8):

1.

4. The compound traditional Chinese medicine preparation targeting egg plague in ducks and geese as described in claim 1, characterized in that, The total mass fraction of the three herbs (Euphorbia humifusa, Portulaca oleracea, and Andrographis paniculata) to the mass fraction of Pulsatilla chinensis is (2~3.5):

1.

5. The compound traditional Chinese medicine preparation targeting egg plague in ducks and geese as described in claim 1, characterized in that, The total mass fraction of the four ingredients—peony bark, stir-fried peach kernel, stir-fried cattail pollen, and agrimony—is in a mass fraction of (3~5):1 with that of pomegranate peel.

6. The compound traditional Chinese medicine preparation targeting egg plague in ducks and geese as described in claim 1, characterized in that, The total mass ratio of licorice to all other raw materials is 1:(18~25).

7. The compound traditional Chinese medicine preparation targeting egg plague in ducks and geese as described in claim 1, characterized in that, The mass ratio of prepared ginger to stir-fried Atractylodes macrocephala is 1:(1.5~2.5).

8. The compound traditional Chinese medicine preparation targeting egg plague in ducks and geese as described in claim 1, characterized in that, The mass ratio of honeysuckle to scrophularia is (1.2~1.8):

1.

9. The compound traditional Chinese medicine preparation targeting egg plague in ducks and geese as described in claim 1, characterized in that, The mass ratio of Phyllanthus emblica to Poria cocos is (1~1.5):

1.

10. The compound traditional Chinese medicine preparation targeting egg plague in ducks and geese as described in claim 1, characterized in that, The preparation is a powder, granule, or oral liquid.