24 results about "Vertebral endplate" patented technology

Described herein are various implementations of systems and methods for treating back pain (e.g., chronic low back pain) caused by different (e.g., independent) sources of pain, such as pain originating or stemming from intervertebral discs, from vertebral endplates, and / or from intraosseous locations within one or more vertebral bodies. For example, methods for treating back pain (e.g., chronic low back pain) may involve both vertebral fusion (e.g., arthrodesis or spondylodesis to fuse adjacent vertebrae) and neuromodulation (for example, ablation of nerves within or surrounding one or more of the adjacent vertebrae). The neuromodulation may facilitate treatment of pain that is generated by insertion of fusion hardware.

A biomimetic intervertebral fusion device with a piezoelectric multifunctional coating belongs to the field of implantable medical devices. It includes an upper piezoelectric multifunctional coating, a fusion device body, and a lower piezoelectric multifunctional coating. A bone graft window is located in the middle of the biomimetic intervertebral fusion device. The piezoelectric multifunctional coating is made of electrospun piezoelectric PVDF / HA fibers, which are conformally adhered to the upper and lower surfaces of the fusion device body through a polydopamine adhesive layer. The upper and lower surfaces of the fusion device body have a biomimetic curved surface configuration to match the morphology of the vertebral endplates, increasing the contact area and reducing stress concentration at the fusion interface. While maintaining an elastic modulus similar to natural bone and good radiation permeability, this fusion device, after implantation, can create a microenvironment conducive to cell adhesion and proliferation. Under the influence of cell traction, ultrasonic stimulation, and the physiological load of the human lumbar spine, it generates electrical stimulation signals, promoting bone fusion, improving the stability of the fusion interface, and reducing the risk of postoperative loosening and subsidence of the fusion device.

The present application relates to a kind of intervertebral fusion cage, including body, with the first surface and the second surface of facing away, the body is provided with the bone graft cavity through the first surface and the second surface;Rotary shaft, with the body relatively rotatable connection, the axial end of rotary shaft respectively extends the first surface and second surface.Surperior fusion cage is used when in the process of intervertebral fusion surgery, when doctor needs secondary adjustment fusion cage position, rotary shaft remains unmoved, body can rotate around rotary shaft, since the two ends of rotary shaft are slightly higher than the surface of body, the extrusion and friction between body and vertebral endplate during body rotation will reduce, reduce the probability of body escape;Also reduce the difficulty of doctor rotating and adjusting fusion cage during operation, reduce operation time.In addition, since reducing the secondary extrusion and friction to vertebral endplate, reduce the pain of patient.

The invention discloses application of vitamin K in preparation of a medicine for treating paravertebral muscle adiposis of obese patients. The core of the application is to reverse fat infiltration in paravertebral muscles (such as multifidus muscle, erector spine muscle and lumbar major muscle) of an obese patient, so that the structure and function of a vertebral endplate are improved, the stability of the spine is enhanced, and degeneration of the spine intervertebral disc of the obese patient is relieved. The method has the advantages of non-invasiveness, high safety and the like, and is suitable for treating lumbago diseases related to long-term obesity management and paravertebral muscle adiposis.

Described herein are various implementations of systems and methods for treating back pain (e.g., chronic low back pain) caused by different (e.g., independent) sources of pain, such as pain originating or stemming from intervertebral discs, from vertebral endplates, and / or from intraosseous locations within one or more vertebral bodies. For examples, methods for treating back pain (e.g., chronic low back pain) may involve both vertebral fusion (e.g., arthrodesis or spondylodesis to fuse adjacent vertebrae) and neuromodulation (for example, ablation of nerves within or surrounding one or more of the adjacent vertebrae). The neuromodulation may facilitate treatment of pain that is generated by insertion of fusion hardware.

Expandable spinal fusion devices, systems, and methods of using them are provided, and they can be inserted in a subject in a collapsed state through a small surgical corridor, and the expand cephalocaudal only, transverse only, or in both directions, in which direction of expansion can also be obtained independently, if desired, after the insertion. These inventions are valuable in reducing risk and surgical complexity, allowing for an on-the-fly selection of a desirable width footprint, a desired control of height expansion through a gradual cephalocaudal expansion, and a desired control of the alignment of the adjacent vertebral bodies. Devices, systems, and methods are also offered to provide a desired control of the contact area desired between the device and the upper and lower vertebral endplates achieved, for example, using an interdigitated endplate system.

Described herein are various implementations of systems and methods for accessing and modulating tissue (for example, systems and methods for accessing and ablating nerves or other tissue within or surrounding a vertebral body to treat chronic lower back pain). Assessment of vertebral endplate degeneration or defects (e.g., pre-Modic changes) to facilitate identification of treatment sites and protocols are also provided in several embodiments. Several embodiments comprise the use of biomarkers to confirm or otherwise assess ablation, pain relief, efficacy of treatment, etc. Some embodiments include robotic elements for, as an example, facilitating robotically-controlled access, navigation, imaging, and / or treatment.

Described herein are various implementations of systems and methods for accessing and modulating tissue (for example, systems and methods for accessing and ablating nerves or other tissue within or surrounding a vertebral body to treat chronic lower back pain). Assessment of vertebral endplate degeneration or defects (e.g., pre-Modic changes) to facilitate identification of treatment sites and protocols are also provided in several embodiments. Several embodiments comprise the use of biomarkers to confirm or otherwise assess ablation, pain relief, efficacy of treatment, etc. Some embodiments include robotic elements for, as an example, facilitating robotically controlled access, navigation, imaging, and / or treatment.

The present application belongs to the field of medical devices, and specifically relates to a fusion device system, comprising: a fusion device mechanism having a first end and a second end, the fusion device mechanism being curved and annular, the fusion device mechanism comprising an upper contact member and a lower contact member arranged opposite to each other, and a first connector elastically connecting the upper contact member and the lower contact member; an implant mechanism comprising a main body and a second connector, the second connector passing through the main body and connected to the fusion device mechanism; an adjustment structure comprising a connected driver and a third connector, the third connector being connected to the implant mechanism, and adjusting the relative position of the first and second ends of the fusion device mechanism by changing the driver to adjust the torsion angle of the fusion device mechanism until it fits with the surfaces of the upper and lower vertebral endplates. The above-mentioned configuration is used to adapt the fusion device system to the implantation environment.

One embodiment of the present invention is an interbody fixation device to be inserted into an intervertebral space between an upper vertebral body and a lower vertebral body. The interbody fixation device includes a plurality of independent elastic members each having a pair of upper and lower contact surfaces configured to be in contact with the endplates of the upper and lower vertebral bodies. Each of the plurality of elastic members has elasticity between the pair of upper and lower contact surfaces. When the vertebral endplates above and below an intervertebral disc space in which the interbody fixation device is implanted are partially fractured (damaged), an elastic member in contact with the fractured part sinks, while propagation of sinking to the other elastic members is suppressed, thereby ensuring stable retention. This makes it possible to provide an interbody fixation device that can be stably retained after implantation, even in cases in which vertebral body bones constituting the intervertebral disc space are fragile due to osteoporosis or the like.

Described herein are various implementations of systems and methods for determining likelihood of a patient favorably responding to a neuromodulation procedure based on a quantitative or objective score or determination based on a plurality of indicators of pain (e.g., chronic low back pain stemming from one or more vertebral bodies or vertebral endplates of a patient). The systems and methods may involve application of artificial intelligence techniques (e.g., trained algorithms, machine learning or deep learning algorithms, and / or trained neural networks).

A variety of expandable cage improvements are provided. The cages can have a width expansion assembly that operates independently of a height expansion assembly and the wedges and ramps do not need to make contact with each other. Wedges, or movable spacers with pivotal link connections, can be used, and any portion of the cage can be expanded in width or in height in an amount that differs from other portions of the cage to provide any of a multitude of desired cage shapes. Interdigitating fingers, slidable and / or pivoting, are provided to distribute stresses over a vertebral endplate as desired.

Described herein are various implementations of systems and methods for determining likelihood of a patient favorably responding to a neuromodulation procedure based on a quantitative or objective score or determination based on a plurality of indicators of pain (e.g., chronic low back pain stemming from one or more vertebral bodies or vertebral endplates of a patient). The systems and methods may involve application of artificial intelligence techniques (e.g., trained algorithms, machine learning or deep learning algorithms, and / or trained neural networks).

In accordance with at least one aspect of this disclosure, a disc replacement implant includes, a first endplate configured to engage a vertebral endplate of a first vertebra adjacent an intervertebral space, a second endplate configured to engage a vertebral endplate of a second vertebra opposite the first end plate in the intervertebral space, a core between the first and second endplates, and an annulus surrounding the core and connecting a perimeter of the first endplate to a perimeter of the second end plate. In embodiments, the annulus can include a portion that extends inwardly between the first and second core plates to the spacer.

A method for decorticating a vertebral endplate material from spinal vertebrae using a decorticating tool having height adjustable blades at a distal end of a shaft assembly, translates axial movement of a control rod of a shaft assembly of the vertebral endplate preparation tool with height adjustable blades into radial blade height change (extension and retraction) through a controller of a handle assembly. The blades may also be configured for collecting and removing shaven vertebral endplate material. The blades controllably move outward radially from the distal end of the shaft assembly and controllably move inward radially into the distal end of the shaft assembly upon manipulation of the controller. Radial blade extension and retraction from the distal end is accomplished via mutual angled dovetail features of the blades and the distal end, or via pins of the distal end of the shaft assembly situated in angled slots of the blades.

Described herein are various implementations of systems and methods for treating back pain (e.g., chronic low back pain) caused by different (e.g., independent) sources of pain, such as pain originating or stemming from intervertebral discs, from vertebral endplates, and / or from intraosseous locations within one or more vertebral bodies. For example, methods for treating back pain (e.g., chronic low back pain) may involve both vertebral fusion (e.g., arthrodesis or spondylodesis to fuse adjacent vertebrae) and neuromodulation (for example, ablation of nerves within or surrounding one or more of the adjacent vertebrae). The neuromodulation may facilitate treatment of pain that is generated by insertion of fusion hardware.

A spinal implant and a delivery system for spinal surgery. The delivery device may be configured to deliver, articulate, and deploy the spinal implant in a disc space between a pair of vertebrae, and to deliver or inject a bone void filler to the spinal implant for deployment of the expandable mesh component. A mesh component may provide a reservoir for larger volumes of bone void filler and greater surface area for load distribution of the spinal cage. The mesh component may include pores through which bone void filler may interdigitate against the vertebral endplates. The delivery device may include a handle having components operable to attach the spinal implant for insertion, position and orient the spinal implant in a desired location and orientation and detach the spinal implant in place. A syringe, syringe gun, and / or packing rod may be utilized to deliver bone void filler through the delivery device.

An instrument includes a distraction mechanism having a proximal end and an opposed distal end. The distal end includes opposed first and second end members. A first vertebral endplate spreader includes a proximal spreader section mounted to the first end member of the distraction mechanism. The first spreader also includes a distal spreader section operatively connected to the proximal spreader section for lateral movement relative to the proximal spreader section. A second vertebral endplate spreader is mounted to the second end member of the distraction mechanism. The distraction mechanism is configured and adapted to distract the spreaders apart and to retract the spreaders together along a distraction axis. The distal spreader section of the first spreader is configured to move relative to the second spreader in a lateral direction relative to the distraction axis for correction of vertebral alignment, as in treatment of spondylolisthesis, scoliosis, and the like.

This invention discloses a silk warp-knitted biomimetic hook-and-loop artificial vertebral endplate assembly and its preparation method, relating to orthopedic implants. The artificial vertebral endplate comprises a sheet-like fabric endplate body, with a bonding surface for connecting the artificial intervertebral disc core or intervertebral device on its opposite sides, and a functional surface formed by a loop array. The bonding surface is formed by a warp-knitted base structure with a mesh-like base structure, while the functional surface is formed by a loop array with adjustable height, density, and end curvature from silk fibers, modified silk protein fibers, or their composite fibers. The endplate body is integrally woven using a warp-knitting process, with at least two ground combs forming the base structure and at least one yarn comb forming the loop array. The roots of the loops are integrally looped and anchored to the base structure, and the endplate body has three-dimensional interconnected pores. The hook structure surface of the bone-side hooking structure or matching hooking component cooperates with the loop array to form a mechanical interlock, and the bone integration surface is used to form a contact interface with the bone side.

Custom patient-specific interbody implants, systems, and methods of generating custom implants. The implants may include upper and lower surfaces with an irregular surface topography, which are custom contoured to match the adjacent vertebral endplates of a specific patient. The method may include uploading images of the spine for the patient and processing the images into a virtual three-dimensional model of the spine including topography of individual vertebral bodies. The user may automatically and / or manually manipulate the virtual three-dimensional model to pre-operatively simulate a desired correction to the spine. The virtual implant model may be generated based on the desired correction and the topography of adjacent vertebral bodies.

Embodiments disclosed herein include devices, systems, and methods for spinal disc removal and vertebral endplate preparation for spinal fusion. In an embodiment, a surgical device includes a sleeve including a proximal end and a distal end, a cutting head, and a handpiece secured to the sleeve. The cutting head is selectively movable between a retracted position in which the cutting head is disposed within the sleeve and a deployed position in which the cutting head is disposed outside the sleeve. The cutting head includes a drill member and multiple cutting blades that automatically adjust between a collapsed configuration in the retracted position within the sleeve and an expanded configuration in the deployed position outside the sleeve. A distance between the multiple cutting blades in the expanded configuration is greater than a diameter of the sleeve. The multiple blades are configured to cut spinal discs when rotated.

A variety of expandable cage improvements are provided. The cages can have a width expansion assembly that operates independently of a height expansion assembly and the wedges and ramps do not need to make contact with each other. Wedges, or movable spacers with pivotal link connections, can be used, and any portion of the cage can be expanded in width or in height in an amount that differs from other portions of the cage to provide any of a multitude of desired cage shapes. Interdigitating fingers, slidable and / or pivoting, are provided to distribute stresses over a vertebral endplate as desired.

A method of detecting a vertebral endplate rim according to embodiments of the present disclosure includes receiving, at a processor, a binary mask of a vertebra; applying a Laplacian filter to the binary mask to yield a processed image; identifying, in the processed image, a set of edges having a sharpness that exceeds a predetermined threshold; deformably registering a template to a plurality of points corresponding to at least some of the edges in the set of edges; excluding some of the plurality of points based on at least one predetermined criterion; and generating additional points by interpolating among a remaining subset of the plurality of points to yield a set of points defining an endplate rim of the vertebra.

Instrument that allows the retrieval of metallic foreign bodies lost in the disc space (Figure 1). This instrument has two jaws (Figure 2) which open like those of scissors but whose particularity is that one of the jaws is magnetized so that the metallic foreign body adheres to it (Figure 3), the second jaw then catches it by means of a conical clamping (Figure 4), which allows a capture on the spot of the foreign body while preventing it from escaping deep into the disc space. We propose a second configuration of the surgical instrument (Figure 6), which increases the functional clearance between the two jaws to allow for the retrieval of foreign bodies of varying thicknesses. This solution is equipped with three springs of different stiffnesses, positioned coaxially with the jaws' axis of rotation, with transverse displacement to accommodate different thicknesses of foreign body to be retrieved. The central spring maintains a minimal initial play, which gradually increases as the jaws close. Conversely, the two outer springs apply a clamping force that ensures the captured foreign object is immobilized. This instrument is very easy to use. With the jaws open, the instrument is inserted into the disc space parallel to the vertebral endplates. The foreign object will be attracted to the magnetic jaw. Once in place, and under fluoroscopic guidance, the surgeon closes the jaws of the forceps, allowing for safe retrieval of the foreign body. We propose that this instrument be included in the standard equipment of all spinal surgery operating rooms. Indeed, although rare, the loss of a metallic foreign body at the surgical site, particularly within the disc space (e.g., a broken instrument or scalpel blade), is potentially serious. The invented instrument represents a "life-saving tool" that helps to avoid further complications, including life-threatening situations.