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Method and equipment for preparing tissue engineering scaffold with anisotropic pore structure

A tissue engineering scaffold and anisotropic technology, applied in medical science, prosthesis, etc., can solve problems such as difficulty in meeting application requirements, and achieve the effect of easy implementation, simple equipment structure, and promotion of tissue repair

Active Publication Date: 2011-02-23
GUANGZHOU SUN SHING BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the process of implementing tissue engineering technology, considering the particularity and complexity of the application environment, it is difficult to meet the application requirements with uniform and isotropic scaffolds or implants

Method used

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  • Method and equipment for preparing tissue engineering scaffold with anisotropic pore structure
  • Method and equipment for preparing tissue engineering scaffold with anisotropic pore structure
  • Method and equipment for preparing tissue engineering scaffold with anisotropic pore structure

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Embodiment Construction

[0029] refer to Figure 1 to Figure 4 , a method for preparing a tissue engineering scaffold with anisotropic pore structure of the present invention, comprising the following steps:

[0030] (a), the polymer is made into a solution, mixed with a porogen, and placed in the cavity of the equipment core;

[0031] (b), according to actual needs, divide the outside of the core into at least two temperature zones, and feed heat exchangers of various temperatures into these temperature zones, so that the temperature of the material in the core changes and the polymer solution produces phase separation;

[0032] (c) Fixing the polymer during phase separation as required, removing the porogen added in step (b), and drying to obtain a porous scaffold.

[0033] In the method, the polymer solution and the porogen are subjected to zoned heat exchange, so that the precise and anisotropic distribution of the pores and pore diameters on the obtained scaffold can be realized, and the tissue...

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Abstract

The invention discloses a method for preparing a tissue engineering scaffold with an anisotropic pore structure. The method comprises the following steps of: placing polymer solution and porogen into specific equipment; performing heat exchange of subzones by using a plurality of temperature zones and the polymer solution, and precisely controlling the temperature change curves and the heat exchange directions of the polymer solution and the porogen; and fixing the phase separation degree, removing the porogen and solvent and drying. The method can realize precise and controllable anisotropism of the pore structure inside the scaffold by performing the precise and controllable heat exchange of the subzones on the prepared polymer scaffold so as to meet the requirements of tissue engineering application and improve the repairing effect. In addition, the invention also discloses equipment for implementing the method.

Description

technical field [0001] The invention relates to a method for preparing a tissue engineering scaffold with anisotropic pore structure, and also relates to a device using the method. Background technique [0002] Implants or cell scaffolds used in tissue engineering techniques are generally porous materials. Tissue engineering applications place stringent requirements on these porous materials, requiring scaffolds or implants with precise levels of structure. Furthermore, the industrialization of tissue engineering porous implants and scaffolds requires that the products obtained through various processing techniques have the basic property of small batch differences. Therefore, in order to obtain products with precise and regular structures, conforming to the design requirements, and small batch differences, the improvement of processing technology and equipment is particularly important. [0003] In the process of implementing tissue engineering technology, considering the...

Claims

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Application Information

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IPC IPC(8): A61L27/56A61L27/14
Inventor 全大萍曾晨光
Owner GUANGZHOU SUN SHING BIOTECH CO LTD
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