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Artificial tissue engineeing biological cornea

A technology of tissue engineering, cornea, applied in the field of constructing vector

Inactive Publication Date: 2004-02-11
ZHONGSHAN OPHTHALMIC CENT SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The present invention provides an artificial tissue engineered biocornea with a good carrier to solve the above-mentioned problems of the artificial cornea

Method used

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Embodiment Construction

[0013] The inventors conducted systematic research on the immunogenicity of heterogeneous corneal stroma and the recovery of corneal nerves after transplantation, histological changes in the implant bed, and the changes in corneal transparency, diopter and thickness in different periods after transplantation. Among them, human→monkey, monkey→human, Pig→rabbit, human→rabbit have all carried out preservation and fresh corneal stroma transplantation experiments, and the results show that the immunogenicity of corneal stroma is very low and can be used for xenotransplantation. After transplantation, the thickness and diopter of corneal stroma remain unchanged, and the Nerves can grow in, corneal sensation is mostly restored, epithelial cells are firmly attached, and the physiological connections between cells and between cells and the basement membrane are normal. The inventors believe that the heterogeneous corneal stroma has the potential to be a carrier of cultured cells for the...

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Abstract

The present invention discloses a kind of artificial tissue engineering biological cornea. The present invention utilizes homogeneous and xenogenous or heterogeneous cornea substrate as carrier, which may be preprocessed, and plants and cultures cells on it to constitute engineering biological cornea. The cornea constituted with the carrier has very low immunogenicity, unchanged thickness and diopter after transplantation, grown autogenous nerve, mostly restored cornea aesthesia, firmly adhered epithelium and normal connection between the cells and between the cell and the substrate membrane.

Description

technical field [0001] The invention relates to a construction carrier for constructing tissue engineered biological cornea. Background technique [0002] Corneal blindness ranks first in the world's blinding eye diseases. Fortunately, corneal blindness is curable blindness. Successful corneal transplantation can help patients with corneal blindness recover their vision. However, the lack of donor material sources and immune rejection after transplantation seriously This restricts the extensive development and curative effect of this operation. [0003] Tissue engineering is the principle and method of applying engineering and life sciences. It combines cells and carriers through different tissue construction methods to form artificial tissues or organs with specific three-dimensional structures and biological activities for replacement or repair. Damaged organs and tissues of the human body to achieve the purpose of restoring tissue shape and function. It marks that medic...

Claims

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Application Information

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IPC IPC(8): A61F2/14A61L27/00
Inventor 王智崇葛坚陈冬
Owner ZHONGSHAN OPHTHALMIC CENT SUN YAT SEN UNIV
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