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Veterinary interferon inducer and preparation method thereof

An interferon-induced, aqueous solution technology, applied in the directions of non-active ingredients medical preparations, antidote, pharmaceutical formulations, etc., can solve the problems of sodium metabisulfite being too toxic to be swallowed, unfavorable to the production and operation of workshop personnel, and side reactions, etc. Avoid antibiotic and toxic residues, no food safety issues, avoid degradation effects

Active Publication Date: 2015-06-17
SOUTH CHINA AGRI UNIV +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Substances such as sodium pyrosulfite and excipients are likely to irritate the body to varying degrees, especially sodium pyrosulfite is highly toxic and should not be swallowed. It will cause serious damage to the eyes of humans and animals, and it is not conducive to the production and operation of workshop personnel.
The polymuscular cell product prepared by the above-mentioned prior art has the risk of side effects and environmental pollution when it is injected into animals, dipped in a dip, or mixed with bait. If it is used for meat economic animals, it will also involve food safety issues and it is difficult to promote it.

Method used

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  • Veterinary interferon inducer and preparation method thereof
  • Veterinary interferon inducer and preparation method thereof
  • Veterinary interferon inducer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A veterinary interferon inducer, which is made of the following components: a volume of 500mL of sodium chloride-phosphate buffer solution with a pH value of 7.2, a volume of 1mL of calcium chloride aqueous solution with a concentration of 44.4g / L , a volume of 499mL chitosan hydrochloride aqueous solution with a concentration of 0.65g / L, 0.5g of polyinosinic acid, and 0.5g of polycytidylic acid.

[0027] The preparation method of the veterinary interferon inducer comprises the following steps:

[0028] a. Take 0.5g of polyinosinic acid, then dissolve it with 250mL of sodium chloride-phosphate buffer, and then heat it at 45°C for 5 minutes;

[0029] b. Take 0.5g of polycytidylic acid, then dissolve it with 250mL of sodium chloride-phosphate buffer, and then heat at 45°C for 5 minutes;

[0030] c. Mix the liquids obtained in steps a and b, and then stir at a speed of 30 rpm for 3 minutes; then react at a temperature of 45°C for 30 minutes, and keep stirring at a speed o...

Embodiment 2

[0056] A veterinary interferon inducer, which is made of the following components: a sodium chloride-phosphate buffer solution with a pH value of 7.2, a calcium chloride aqueous solution with a concentration of 10g / L, and a shell with a concentration of 0.1g / L Polysaccharide hydrochloride aqueous solution, polyinosinic acid, polycytidylic acid, the volume ratio of described polyinosinic acid quality and sodium chloride-phosphate buffer solution is 0.5g / L, described polycytidylic acid quality and The volume ratio of sodium chloride-phosphate buffer solution is 0.5g / L, and the volume ratio of described calcium chloride aqueous solution and sodium chloride-phosphate buffer solution is 16:1000, and described chitosan hydrochloride aqueous solution and The volume ratio of the sodium chloride-phosphate buffer solution is 984:1000; the volume ratio of the total volume of the calcium chloride aqueous solution and the chitosan hydrochloride aqueous solution to the sodium chloride-phosph...

Embodiment 3

[0086] A veterinary interferon inducer, which is made of the following components: a sodium chloride-phosphate buffer solution with a pH value of 7.2, a calcium chloride aqueous solution with a concentration of 80g / L, and chitosan with a concentration of 5g / L Sugar hydrochloride aqueous solution, polyinosinic acid, polycytidylic acid, the volume ratio of described polyinosinic acid quality and sodium chloride-phosphate buffer solution is 10g / L, described polycytidylic acid quality and chloride The volume ratio of sodium-phosphate buffer saline is 10g / L, and the volume ratio of described calcium chloride aqueous solution and sodium chloride-phosphate buffer saline is 2:1000, and described chitosan hydrochloride aqueous solution and sodium chloride -The volume ratio of the phosphate buffer solution is 998:1000; the volume ratio of the total volume of the calcium chloride aqueous solution and the chitosan hydrochloride aqueous solution to the sodium chloride-phosphate buffer solut...

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Abstract

The invention relates to a veterinary interferon inducer. The veterinary interferon inducer is prepared from the following components: a sodium chloride-phosphate buffer solution with the pH value of 7.2, a 10-80g / L calcium chloride aqueous solution, a 0.1-5g / L chitosan hydrochloride solution, polyinosinic acid and polycytidysic acid. The invention further provides a preparation method of the veterinary interferon inducer. The veterinary interferon inducer provided by the invention is few in side reaction, low in irritation and high in safety, and the preparation method can avoid precipitates generated by calcium chloride and other components.

Description

technical field [0001] The invention relates to an interferon inducer, in particular to a veterinary interferon inducer base and a preparation method thereof. Background technique [0002] Interferon (Interferon, IFN) is a kind of cytokine, which has multiple functions such as inhibiting cell division, regulating immunity, anti-virus, and anti-tumor. As a broad-spectrum antiviral agent, interferon does not directly kill or inhibit viruses, mainly through the action of cell surface receptors to make cells produce antiviral proteins, thereby inhibiting virus replication; at the same time, it can also enhance natural killer cells (NK cells) ), the vitality of macrophages and T lymphocytes, thereby playing an immune regulatory role and enhancing the antiviral ability. They have broad-spectrum anti-virus, affect cell growth, differentiation, regulation of immune function and other biological activities on the same kind of cells. [0003] Polyinosinic acid, also known as polyino...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/80A61K47/36A61K33/04A61P31/12A61P31/04A61P35/00A61P33/02A61P39/00A61P37/02
Inventor 陈瑞爱赖汉漳刘玉鹏
Owner SOUTH CHINA AGRI UNIV
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