489 results about "Disease causative agent" patented technology

The invention discloses a pathogen transmission rapid early warning and traceability analysis method based on multi-source data fusion. The method comprises the steps of S1, collecting multi-source data such as drug sales, network behaviors, social media, outpatient diagnosis and traffic time and space; s2, through cleaning and standardized preprocessing, social text disease features are extracted by adopting BERT; s3, mining a comprehensive weak signal through single-source anomaly detection and multi-source correlation analysis; s4, fusing the features by using an Attention-LSTM model, and outputting a regional risk index; s5, training an early warning model based on historical data, and setting a three-level threshold to trigger early warning; and S6, positioning a propagation starting point in combination with the spatio-temporal data, and constructing a propagation chain through a graph neural network. The early warning is advanced by 3-7 days, the traceability precision reaches the community level, and the prevention and control precision is improved.

Methods and compositions for identifying, selecting and / or producing a pathogen resistant plant, plant cell or seed (e. g,, a maize plant, plant cell or seed) are provided. Polynucleotides and polypeptides are provided, which when expressed in a plant increase disease and / or pathogen resistance (e.g., to Fusarium stalk rot) of the plant. Plants, plant cells and seed are provided comprising such polypeptides and polynucleotides, as are methods for their use.

The invention discloses antibacterial gel for female private part nursing and a preparation method of the antibacterial gel, and belongs to the technical field of female nursing gel. The gel provided by the invention has good biocompatibility and biological adhesion, is convenient to form a gel state under the action of body temperature, is tightly adhered to the surface of a mucous membrane to form a protective hydrated film, can physically isolate pathogens, and is used for preventing female genital tract infection and maintaining vagina health. The performance of the chitosan is improved through grafting modification, a plurality of carboxyl, guanidyl and siloxane structural units are introduced to the chitosan at the same time, guanidyl can effectively adsorb and destroy bacteria and fungi usually carrying negative charges, and the water solubility and biocompatibility of molecules are enhanced through the carboxyl and siloxane structure; the siloxane structure can improve the spreadability and adhesion of molecules on the mucous membrane surface and prolong the drug residence time, and the functional monomers are grafted to the chitosan skeleton through amido bonds to ensure the structural stability and function durability of the modified polymer.

A method for inactivating pathogens is described, comprising the steps of: partially deacylating a poly(2-alkyl-2-oxazoline) to yield a copolymer, an alkyl in the poly(2-alkyl-2-oxazoline) comprising a hydrocarbon chain, the copolymer comprising: first monomers, the first monomers comprising a -NH2 +CH2CH2- group; and second monomers, the second monomers comprising an acyl group, -C(=O)-R', attached to a nitrogen in a polymer backbone group comprising -NCH2CH2-, wherein R' comprises the hydrocarbon chain, the first monomers and the second monomers arranged in any order in the copolymer; preparing a formulation, the formulation comprising the copolymer and a total cationic charge in a range of 0.2 to 10 C / cm3, the total cationic charge at least 95% offset by counteranions in the formulation; contacting the pathogens with the formulation; and inactivating at least ninety percent of the pathogens within ninety minutes of the step of contacting.

An antifungal composition including a first essential oil, and a second essential oil, where the composition is configured to reduce disease onset, pathogen spread, or a combination thereof. Further, an antifungal compound including one or more aroma compounds selected from 4-(4-hydroxyphenyl)-2-butanone, furaneol, ethyl methylphenylglycidate, ethyl hexanoate, ethyl butanoate, beta-ionone, alpha-ionone, (R)-(+)-limonene, (S)-(-)-limonene, cis-3-Hexen-1-ol, nerol, linalool, 2-heptanone, alpha-terpineol, beta-damascenone, β-caryophyllene, ethyl 2-methylbutanoate, β-myrcene, gamma-octalactone, alpha-humulene, nerolidol, (E,E)-2,4-decadienal, (E,E)-α-farnesene, vanillin, phenylethyl acetate, citral, 3-methylbutan-1-ol, or a combination thereof.

Multi-modal, modular biosensing and sterilization systems and methods for detection and neutralization of pathogens, toxins, and contaminants, and integrating coordinated agents and dispensers therefor for decontamination. The systems and methods are operable as closed-loop or cloud-connected platforms, and can be configured for communication with health and authorities for reporting and tracking.

Described are immunogenic compositions comprising a non-naturally occurring pan-fungal Kex peptide, and methods of using such compositions for the treatment or prevention of infection and / or diseases associated with fungal pathogens (e.g., Pneumocystis, Aspergillus, Candida, or Cryptococcus) in the subject. Also provided are compositions and kits for detecting or quantifying the presence of antibodies directed against a non-naturally occurring pan-fungal Kex peptide in a subject.

Provided are compositions containing a conjugate containing a phthalocyanine dye, including compositions containing stabilizing agents, such as non-ionic surfactants and / or protectants. In some aspects, the compositions result reduced aggregation of the conjugate due to agitation, temperature exposure, and / or pH. Also provided are articles of manufacture containing the compositions containing the conjugates, and methods for their administration to subjects for photoimmunotherapy. In some embodiments, the phthalocyanine dye conjugates are conjugated to a targeting molecule, such as an antibody, that targets the conjugate to a cell or pathogen, such as by binding to a cell surface protein.

A portable airborne pathogen control apparatus and system. Aspects of the present disclosure provide for a portable airborne pathogen control apparatus configured to be selectively positioned within an interior room and configured to enable a floor-to-ceiling flow of air within the interior room. The portable airborne pathogen control apparatus may comprise a housing with an air intake disposed at a lower area of a base housing and an air outlet disposed at an upper area of an elongated duct extending from the base housing. A blower fan housed within an interior chamber of the housing may be configured to direct a floor-to-ceiling flow of air through the interior chamber from the air intake to the air outlet. A volume of air directed through the interior chamber of the housing may be disinfected using one or more UV-C emitters and / or cold plasma generator(s) housing in the interior chamber of the housing.

Provided are methods for manufacturing a conjugate containing a phthalocyanine dye, including methods that include one or more steps of preparing or producing the conjugate, formulating the conjugate and packaging the conjugate. In some aspects, the manufacturing methods result in the generation of a stable conjugate. Also provided are stable phthalocyanine dye conjugates, compositions and articles of manufacture containing the stable conjugates, and methods for their administration to subjects for photoimmunotherapy. In some embodiments, the phthalocyanine dye conjugates are conjugated to a targeting molecule, such as an antibody, that targets the conjugate to a cell or pathogen, such as by binding to a cell surface protein.

The present invention relates to means and methods comprising a bacterial heme peroxidase and / or a functional fragment thereof for medical and non-medical use in preventing and / or controlling a pathogen on food, plants, or in or on the human or animal body. The present invention thus relates to novel medical and non-medical uses of a bacterial heme peroxidase and / or a functional fragment thereof for preventing and / or controlling a pathogen on food, plants, or on the human or animal body. Furthermore, the present invention relates to corresponding methods comprising a bacterial heme peroxidase and / or a functional fragment thereof for preventing and / or controlling a pathogen on food, plants or on or in the human or animal body comprising applying a sufficient amount of the bacterial heme peroxidase and / or a functional fragment thereof on said food, plants, or on mucosae, skin, in particular epidermal skin like scalp or facial skin and / or teeth to reduce the number of cells of said pathogen. In addition, the invention relates to specific heme peroxidases that have been identified to have desired properties. The invention also relates to fragments of or small heme peroxidases that have particularly advantageous properties. Moreover, the present invention further relates to corresponding compositions comprising a bacterial heme peroxidase and / or a functional fragment thereof for preventing and / or controlling a pathogen on food, plants, or in or on the human or animal body. Kits comprising components used in the methods and compositions of the invention are also provided herein. Furthermore, provided is the use of a bacterial heme peroxidase and / or of a functional fragment thereof for the preparation of the compositions of the present invention. The present invention finally also relates to a method for producing a bacterial heme peroxidase protein and / or a functional fragment thereof in an engineered Bacillus subtilis strain. The inventive use of the bacterial heme peroxidase of the present invention and / or a functional fragment thereof for preventing and / or controlling a pathogen is, without being limiting, particularly useful in ecologically compatible commercial plant / crop protection campaigns as well as in daily personal care products such as toothpaste for example.

The disclosure relates to methods and compositions for altering the production of one or more secondary plant metabolites comprising applying an effective amount of at least one elicitor, wherein the elicitor is a jasmonate or a salicylate, and combinations thereof. The disclosure further teaches compositions comprising effective amounts of the elicitors disclosed here. The disclosure further relates to methods and compositions for controlling plant pathogens, such as fungal pathogens.

The present specification discloses compositions, articles of manufacture, containers or kits comprising such compositions, and methods and uses to control a causal agent of a plant disease, increasing plant growth and / or food production and / or improving performance of an irrigation system(s).

A biocontrol agent of the present invention, comprising one or more of the selected, isolated bacteria disclosed herein, is useful in methods of protecting plants against disease or damage by plant pathogens. A method comprises applying a biocontrol agent to plants, plant seeds, or media or soil surrounding plants provide disease protection to plants or plants produced from the contacted plant seeds. Biocontrol agents of the present invention are useful in horticulture, aquaculture, aeroculture, hydroponic culture, agriculture and all types of plant growing conditions to protect plants from a variety of plant bacterial, fungal, and viral diseases. The compositions and methods of the present invention are effective against plant pathogens.

The present disclosure relates generally to agricultural compositions comprising an anti-pathogenic compound and a chemical activator, wherein the fungicides and chemical activators provide a synergistic effect on the control of pathogens typically found in plant crops, trees, fruits, vegetables, leaves, stems, roots, seeds, flowers, animals, equipment, stockyard, farm, barn, animal housing units, farm tools, farm buildings, storage areas or food contact areas.

Disclosed herein are apyrase inhibitors of Formula (I). Also disclosed herein are methods for using the disclosed inhibitors, including in methods for protecting crops from pests. In one aspect the apyrase inhibitors are useful for enhancing the activity of pesticides for the protection of crops from pathogens and to support crop yield.

A method for treating a pathogen, comprising the steps of: (1) providing a polyethylenimine in a solution, the polyethylenimine comprising a total cationic charge of protonated secondary amines of the polyethylenimine, the solution comprising anionic counterions associated with the protonated secondary amines; (2) tuning a protonated site of the polyethylenimine, in a formulation of the solution containing ions, to an activity coefficient (γ) in a range of 0.93 to 0.999; (3) forming from the formulation an antibacterial film, the antibacterial film comprising a mean thickness of less than 5 μm and the total cationic charge of the protonated secondary amines in a range of 0.1 to 1.8 C / in2; and (4) inactivating greater than 99% of first bacteria within less than five minutes of contact with the antibacterial film.

A galley monument for a cabin area of an aircraft including a first monument stack, a second monument stack adjacent to the first monument stack, a tray within the second monument stack to secure a rapid pathogen tester, a slidably moveable support located below the tray to secure a plurality of tools to use along with the rapid pathogen tester, and at least one light within the tray to irradiate the tools placed within the support.

The application relates to a dual sterilization-anti-adhesion composite crosslinking coating as well as a preparation method and application thereof, and belongs to the technical field of functional polymer materials. The raw materials of the coating include 5-30 parts of crosslinkable release type multifunctional branched polymer and 30-95 parts of crosslinkable functional polymer. The above-mentioned dual sterilization-anti-adhesion composite crosslinking coating can combine the advantages of contact sterilization, release of antibacterial factors and anti-adhesion together. On one hand, the super-hydrophilic component can effectively prevent the initial adhesion of bacteria and proteins. Even if a small amount of bacteria falls into the coating surface, the contact sterilization component can effectively kill the small amount of adhered bacteria, thereby avoiding the formation of bacteria and biofilms. In addition, the introduction of the releaseable antibacterial molecules can effectively enhance the antibacterial effect, so that the purpose of killing pathogenic bacteria in a deep level is achieved.

The present invention relates to the treatment of viral infections using photosensitizers in dairy cattle. The invention also relates to the prevention of transmission of viral infections from dairy cattle infected by virus to the same or other species. The invention is also directed to methods of controlling infectious agents on milking equipment for dairy cattle. The invention is further directed to milking processes including the treatment of viral infections and / or the prevention of transmission of viral infections from dairy cattle infected by virus to the same or other species and / or the methods for controlling infectious agents on milking equipment for dairy cattle.

The present application relates to the technical field of agricultural chemistry, in particular to butenolide compounds containing a thiazolidinone structure as well as a preparation method therefor and the use thereof. The butenolide compounds containing a thiazolidinone structure are characterized by having the following structural general formula (I). The compounds disclosed by the present application have excellent fungicidal activity on various pathogens in agriculture or other fields, and can favorably protect important crops and domestic animals in agriculture and horticulture industry, and the environment that the human beings rely on from invasion of pathogens.

A vaccine comprising effective amounts of i) E. coli colonization factor antigens comprising CFA / I, CS3, CS5 and CS6 antigens; ii) a heat labile enterotoxin B subunit antigen being an LCTBA protein; and iii) an adjuvant being double mutant (R192G / L211A) of E. coli heat-labile toxin (dmLT), for use in inducing protective immunity against diarrheal disease caused by Salmonella spp. and / or Shigella spp.

Vaccine compositions for protecting a subject against diseases caused by viral pathogens of the Picornaviridae family are disclosed. These vaccines comprise nucleic acids encoding the capsid polyprotein (P1 polyprotein) mixed with the viral 3C protease that processes the P1 polyprotein, and encapsulated within nanoparticle carriers. Methods of preventing, reducing, inhibiting, or delaying the symptoms of an infection caused by a viral pathogen, or of inducing an immune response against a viral pathogen in a subject are provided. Methods of making the vaccines are also described.

The invention provides a microorganism-loaded silicon-calcium-potassium-magnesium-phosphorus soil conditioner based on double-tailing synergistic activation and a preparation method thereof, and relates to the field of solid waste recycling. The soil conditioner comprises a porous carrier, and a protective layer, an adsorption layer, a fungicide layer and a fixing layer which are sequentially arranged on the surface of the porous carrier, the porous carrier comprises the following raw materials: phosphate tailings, silicate tailings, a pore-forming agent and a binder solution; the raw materials of the protective layer comprise a first coating solution and a first cross-linking solution; the first coating solution comprises an aqueous solution consisting of sodium alginate, chitosan, glycerol and sodium dihydrogen phosphate; the raw material of the adsorption layer comprises a second coating solution which specifically comprises an aqueous solution consisting of chitosan, humic acid and acetic acid; the raw materials of the microbial agent layer comprise a microbial agent, a pH buffer agent, a cell protective agent, a nutrition activator and water; the fixed layer is prepared from a third coating solution and a second cross-linking solution. The soil conditioner has the effects of providing valuable components, inhibiting pathogen growth, promoting plant growth and the like.

Disclosed herein are apyrase inhibitors of Formula (I):Also disclosed herein are methods for using the disclosed inhibitors, including in methods for protecting crops from pests. In one aspect the apyrase inhibitors are useful for enhancing the activity of pesticides for the protection of crops from pathogens and to support crop yield.

The present disclosure relates to a phosphor compound for diagnosing fire blight in fruit trees based on fluorescence and use thereof. The compound is capable of selectively detecting Erwinia amylovora, the causal pathogen of fire blight in fruit trees, and emits red fluorescence in response. Due to its rapid diagnostic response and high sensitivity, the compound can be effectively used for diagnosing fire blight in fruit trees through various simple methods such as spraying or swabbing, without the need for specialized equipment.

The present invention is directed to phage therapy for the treatment and control of bacterial infections, in particular urinary tract infections caused by Escherichia coli. More specifically, the present invention is directed to novel bacteriophage strains, cocktails thereof and variants thereof; and to methods using the same in the treatment, reduction or prevention of bacterial infections. The cocktail is used as a first line treatment against urinary tract infections, in particular in cancer patients, diabetic patients, or patients with a weakened immune system. Disclosed herein is a pharmaceutical composition comprising one or more purified strains of bacteriophage, each purified strain having a genome with at least 98% sequence identity to a nucleotide sequence selected from SEQ. ID No. 1, SEQ ID NO. 4, SEQ ID NO. 5 and SEQ ID NO. 6 and / or variants thereof. The pharmaceutical composition may also be used in combination with other therapies for urinary tract infections such as antibiotics. The pharmaceutical composition may also be used in a method of diagnosis of the causative agent of a bacterial infection. A bacteriophage comprising at least 95% sequence identity with SEQ. ID No. 1, SEQ ID NO. 5 or SEQ ID NO. 6 is also disclosed.

Provided are methods for inducing immune responses against pathogens in a mammal. The methods comprise administering a single cycle adenovirus (SC-Ad) comprising a nucleic acid sequence encoding an immunogen of said pathogen to said mammal. The SC-Ad is administered by inhalation and infects a cell of said mammal, thereby causing expression of said immunogen leading to the induction of said immune response. New infectious virions are not produced. The methods may be of particular utility in vaccination for respiratory pathogens. Corresponding medical uses of the SC-Ads are also provided.