292 results about "Disease causative agent" patented technology

The invention discloses a pathogen transmission rapid early warning and traceability analysis method based on multi-source data fusion. The method comprises the steps of S1, collecting multi-source data such as drug sales, network behaviors, social media, outpatient diagnosis and traffic time and space; s2, through cleaning and standardized preprocessing, social text disease features are extracted by adopting BERT; s3, mining a comprehensive weak signal through single-source anomaly detection and multi-source correlation analysis; s4, fusing the features by using an Attention-LSTM model, and outputting a regional risk index; s5, training an early warning model based on historical data, and setting a three-level threshold to trigger early warning; and S6, positioning a propagation starting point in combination with the spatio-temporal data, and constructing a propagation chain through a graph neural network. The early warning is advanced by 3-7 days, the traceability precision reaches the community level, and the prevention and control precision is improved.

Multi-modal, modular biosensing and sterilization systems and methods for detection and neutralization of pathogens, toxins, and contaminants, and integrating coordinated agents and dispensers therefor for decontamination. The systems and methods are operable as closed-loop or cloud-connected platforms, and can be configured for communication with health and authorities for reporting and tracking.

The present specification discloses compositions, articles of manufacture, containers or kits comprising such compositions, and methods and uses to control a causal agent of a plant disease, increasing plant growth and / or food production and / or improving performance of an irrigation system(s).

Disclosed herein are apyrase inhibitors of Formula (I). Also disclosed herein are methods for using the disclosed inhibitors, including in methods for protecting crops from pests. In one aspect the apyrase inhibitors are useful for enhancing the activity of pesticides for the protection of crops from pathogens and to support crop yield.

A method for treating a pathogen, comprising the steps of: (1) providing a polyethylenimine in a solution, the polyethylenimine comprising a total cationic charge of protonated secondary amines of the polyethylenimine, the solution comprising anionic counterions associated with the protonated secondary amines; (2) tuning a protonated site of the polyethylenimine, in a formulation of the solution containing ions, to an activity coefficient (γ) in a range of 0.93 to 0.999; (3) forming from the formulation an antibacterial film, the antibacterial film comprising a mean thickness of less than 5 μm and the total cationic charge of the protonated secondary amines in a range of 0.1 to 1.8 C / in2; and (4) inactivating greater than 99% of first bacteria within less than five minutes of contact with the antibacterial film.

The present invention relates to the treatment of viral infections using photosensitizers in dairy cattle. The invention also relates to the prevention of transmission of viral infections from dairy cattle infected by virus to the same or other species. The invention is also directed to methods of controlling infectious agents on milking equipment for dairy cattle. The invention is further directed to milking processes including the treatment of viral infections and / or the prevention of transmission of viral infections from dairy cattle infected by virus to the same or other species and / or the methods for controlling infectious agents on milking equipment for dairy cattle.

The present application relates to the technical field of agricultural chemistry, in particular to butenolide compounds containing a thiazolidinone structure as well as a preparation method therefor and the use thereof. The butenolide compounds containing a thiazolidinone structure are characterized by having the following structural general formula (I). The compounds disclosed by the present application have excellent fungicidal activity on various pathogens in agriculture or other fields, and can favorably protect important crops and domestic animals in agriculture and horticulture industry, and the environment that the human beings rely on from invasion of pathogens.

A vaccine comprising effective amounts of i) E. coli colonization factor antigens comprising CFA / I, CS3, CS5 and CS6 antigens; ii) a heat labile enterotoxin B subunit antigen being an LCTBA protein; and iii) an adjuvant being double mutant (R192G / L211A) of E. coli heat-labile toxin (dmLT), for use in inducing protective immunity against diarrheal disease caused by Salmonella spp. and / or Shigella spp.

Vaccine compositions for protecting a subject against diseases caused by viral pathogens of the Picornaviridae family are disclosed. These vaccines comprise nucleic acids encoding the capsid polyprotein (P1 polyprotein) mixed with the viral 3C protease that processes the P1 polyprotein, and encapsulated within nanoparticle carriers. Methods of preventing, reducing, inhibiting, or delaying the symptoms of an infection caused by a viral pathogen, or of inducing an immune response against a viral pathogen in a subject are provided. Methods of making the vaccines are also described.

Disclosed herein are apyrase inhibitors of Formula (I):Also disclosed herein are methods for using the disclosed inhibitors, including in methods for protecting crops from pests. In one aspect the apyrase inhibitors are useful for enhancing the activity of pesticides for the protection of crops from pathogens and to support crop yield.

The present disclosure relates to a phosphor compound for diagnosing fire blight in fruit trees based on fluorescence and use thereof. The compound is capable of selectively detecting Erwinia amylovora, the causal pathogen of fire blight in fruit trees, and emits red fluorescence in response. Due to its rapid diagnostic response and high sensitivity, the compound can be effectively used for diagnosing fire blight in fruit trees through various simple methods such as spraying or swabbing, without the need for specialized equipment.

The present disclosure relates generally to compositions, systems, and methods for lysing blood samples comprising an infectious agent, for example a bacteria, or a fungus, while maintaining viability of the infectious agent for subsequent characterization, for example phenotyping or genotyping. A lysing composition may include one or more surfactants, such as one or more detergents. A lysing composition may include lysing agent including one or more salts. A lysing composition may include one or more enzymes to break down one or more lyses byproducts, such as nucleic acids and / or protein aggregates.

The invention provides a bacillus velezensis QT1 and an application of the bacillus velezensis QT1. The classification name of the bacillus velezensis is bacillus velezensis QT1, and the bacillus velezensis is preserved in the China Center for Type Culture Collection on November 12, 2025, the preservation address is Wuhan University, Wuhan, China, and the preservation number is CCTCC NO: M 20252531. The strain shows remarkable biological control efficiency, realizes effective control on various plant pathogens, and can prevent and treat tomato bacterial wilt and tea tree anthracnose. In addition, the bacillus velezensis QT1 can also effectively kill root-knot nematodes (especially meloidogyne incognita). When the strain is applied to plant cultivation, the growth of various pathogens can be remarkably inhibited, the health and yield of crops are improved, the strain is environment-friendly, the use of chemical pesticides is reduced, soil pollution is avoided, and the development requirement of sustainable agriculture is met.

The invention relates to the technical field of biomedical detection, and discloses a treponema pallidum constant-temperature nucleic acid detection sample pretreatment device which comprises a treatment box and an integrated support carrier serving as the whole device, and a placement groove for positioning a detection test tube and a storage tube for storing a standby magnetic bar are arranged in the treatment box. Regular layout and protection of parts are realized; the synergistic cracking assembly is integrally mounted on the left side in the treatment box and is used for cracking the tough outer membrane of the treponema pallidum through the synergistic effect of mechanical oscillation and ultrasound so as to ensure full release of nucleic acid; the constant-temperature treatment assembly is in linkage installation with the collaborative cracking assembly and is used for providing a precise constant-temperature environment for sample cracking and a subsequent nucleic acid binding process. A synergistic system of treponema pallidum nucleic acid pretreatment is constructed by additionally arranging the synergistic lysis assembly and matching with the constant-temperature treatment assembly, and the synergistic system and the constant-temperature treatment assembly form a multi-dimensional lysis acting force, so that the technical problems that the treatment efficiency of stubborn pathogens is low and nucleic acid release is incomplete in a traditional single lysis mode are effectively solved.

Metallic nanoparticle agglomerates can deliver biocidal activity to surfaces on which they are deposited and adhered, such as various air filtration media. Air filtration media can include a plurality of fibers to which a plurality of metallic nanoparticle agglomerates are adhered. The metallic nanoparticle agglomerates can include a plurality of fused, partially fused, or unfused metallic nanoparticles associated with one another on the surface of the plurality of fibers. Suitable metallic nanoparticles for facilitating biocidal activity against various pathogens, such as viruses and bacteria, can include copper nanoparticles and / or silver nanoparticles. Face masks, inline filters, and air filtration systems can integrate the air filtration media.

A formula, APSW (Anti Pathogen Seawater), for preparing seawater for fish farms and aquariums that contains some or all the normal ingredients of sea salt with the exception of having low or no sulfates. Testing by the applicant has revealed that sea water without sulfates eliminates amyloodiniosis (Amyloodinium ocellatum), one of the most serious diseases of warm water marine fish.

The nose mask is intended to be used during an airborne pandemic. The nose mask is a single triangle / cone shaped that covers only the nose, that comes with two ear elastic bands or a single head elastic band for support. The nose mask is designed to be disposable with a filter for better protection and to minimize the passage of aerosols, fluids and airborne pathogen agents or to be made with washable material allowing users to re-use it.

To provide a reagent and a methyl salicylate sensor for detecting methyl salicylate which is a plant hormone released when a plant is infected with a pathogenic fungus in the cultivation of the plant including a field crop, to provide a method for sensing methyl salicylate using the same, and to provide a method for detecting the pathogenic fungus infection of the plant.SOLUTION: A reagent for detecting methyl salicylate, comprising a terbium compound and an amine. A methyl salicylate sensor includes a methyl salicylate capture part having the reagent, and a detection part for detecting that methyl salicylate is captured by the capture part.SELECTED DRAWING: None

A pathogen detection system and method are disclosed. The pathogen detection system includes a pathogen sensor comprising a plasmonically active pathogen sensing area that comprises a hybrid structure of electrically conductive surface and metal nanofractals, forming a surface enhanced Raman spectroscopic (SERS) substrate and a controller comprising a memory storing one or more trained machine learning algorithms, that perform label-free identification and differentiation of a pathogen or the pathogen and a pathogen mutation based on acquired Raman spectra.

Provided herein are systems and methods for animal health assessment, surveillance, and enhancement. For example, provided here are systems, devices, and processes that collect and analyze, in an efficient and high-throughput manner, biological information, environmental information, and demographic information about animal subjects to detect, identify, predict, and / or surveil adverse-health-causative or-associated agents, such as pathogens, and to select and identify suitable interventions.

The invention provides a linear or cyclic polypeptide and a derivative or analogue thereof, wherein the linear or cyclic polypeptide is used for mobilizing a stress-inducing protein (sestrin) from GATOR / mTOR to sMAC in a non-aging cell; the polypeptide comprises or consists of an amino acid sequence derived from a stress-inducing protein or a truncated sequence thereof. These polypeptides are useful in the treatment of conditions requiring immediate intervention, such as acute diseases, sepsis caused by pathogen infection, or anaphylaxis, such as allergic shock, as immunotherapeutic agents for the treatment of cancer, and for autoimmune diseases.

The present invention relates to a method of combating, preventing or controlling Diaporthe species, which comprises applying to a crop of soybean, the locus thereof, or propagation material thereof, a compound of formula (I) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts or N-oxides of those compounds, or a composition comprising the compound of formula (I).

The invention relates to a device for automatically extracting, purifying and amplifying (PCR) regions of Mycobacterium tuberculosis DNA and recording results in real time. The device consists of a single-use cartridge, an ultrasonic generator, an emitter, and an analyzer in the form of a device capable of interacting with the single-use cartridge and managing the processes of DNA extraction and subsequent PCR and detecting a fluorescent signal in real time inside the enclosed space of the cartridge. The device further comprises a filter element for keeping a pathogen in a ventilation well of a cell of the single-use cartridge into which a sample to be analyzed is placed, as well as at least one source of UV light arranged inside and providing for the disinfection of the inner cavities of the device. The technical result is that of protecting an inner cavity between a lid and the surrounding environment against contamination of the analyzer and of the surrounding space by a pathogenic agent.

A biocontrol formulation for plant pathogens includes a Trichoderma viride filtrate and an inert substance selected from the group consisting of a viscosity reducer, a surfactant, flour, clay, and combinations thereof. In an embodiment, the filtrate includes conidia of the Trichoderma viride. In an embodiment, the filtrate includes byproducts obtained from the fermentation of Trichoderma viride. In an embodiment, the byproducts include at least one of the organic acids, growth regulators, and amino acids.

The present invention relates to a method for eradicating pathogens, in particular to a method for eradicating bacteria in a closed space. The method comprises the use of germicidal UV light of a wavelength of 220 nm, wherein the UV light is emitted by a UV lamp having a lamp cover made of 220 nm-UV transmissive glass. The invention comprises a 220 nm-UV transmissive glass, the use of such UV transmissive glass and a method for its preparation.

A portable airborne pathogen control apparatus and system. Aspects of the present disclosure provide for a portable airborne pathogen control apparatus configured to be selectively positioned within an interior room and configured to enable a floor-to-ceiling flow of air within the interior room. The portable airborne pathogen control apparatus may comprise a housing with an air intake disposed at a lower area of a base housing and an air outlet disposed at an upper area of an elongated duct extending from the base housing. A blower fan housed within an interior chamber of the housing may be configured to direct a floor-to-ceiling flow of air through the interior chamber from the air intake to the air outlet. A volume of air directed through the interior chamber of the housing may be disinfected using one or more UV-C emitters and / or cold plasma generator(s) housing in the interior chamber of the housing.

The application discloses a method for synthesizing an antifungal pathogen reagent N-methyl-3-[(4-methylphenyl)thio]quinolinium iodide by realizing quinoline C3-H heteroatomization under nickel catalysis and mild conditions. The method comprises two steps, first, 3-(p-tolylthio)quinoline is synthesized under room temperature conditions, and then quinoline is N-methylated, so as to prepare the antifungal pathogen reagent N-methyl-3-[(4-methylphenyl)thio]quinolinium iodide. Compared with the past reports, the starting material is more cheap and easy to obtain, the steps are more simple, the atom utilization rate is higher, and the conditions are more mild, so the method is more suitable for kilogram scale amplification production.