805 results about "Disease causative agent" patented technology

[Problem] To provide: a control agent having an antagonistic action on a pathogen Foc TR4 of Panama disease of Cavendish bananas; and a method for controlling the pathogen using the control agent. [Solution] The pathogen Foc TR4 of Panama disease of Cavendish bananas is controlled by using a mycelium fertilizer that is derived from a bacterium of the genus Bacillus, a heat-resistant actinomycete, or both and that is obtained by kneading 20-30 parts by weight of an organic substance having a carbon ratio of 15% or less and a water content of 25-30 parts by weight into a porous carrier having a pH of 7.5-9.5 and a particle size of 4-100 mesh.

The invention discloses a tropical pathogen spectrum multiple detection primer group based on a tNGS technology and application thereof. The multiple detection primer group comprises primers as shown in SEQ NO.: 1 to SEQ NO.: 260 in a sequence table. By utilizing the multiple detection primer group, 100 common pathogens in the tropical region can be efficiently and accurately detected in the same reaction system.

The present disclosure describes, in part, compositions and methods for safeguarding plant immunity to pathogens in response to environmental changes.

The invention discloses a double-sterilization-anti-sticking composite cross-linked coating as well as a preparation method and application thereof, and belongs to the technical field of functional polymer materials. The coating comprises the following raw materials in parts by weight: 5-30 parts of a cross-linkable release type multifunctional branched polymer and 30-95 parts of a cross-linkable functional polymer. According to the double-sterilization-anti-adhesion composite cross-linked coating, the advantages of contact sterilization, antibacterial factor release and adhesion resistance can be combined together, on one hand, the super-hydrophilic component can effectively prevent initial adhesion of bacteria and protein, and even if a small amount of bacteria fall into the surface of the coating, the contact sterilization component can effectively kill a small amount of adhesion bacteria; the formation of bacteria and biological membranes is avoided; in addition, the introduction of releasable antibacterial molecules can effectively enhance the antibacterial effect, and the purpose of deeply killing pathogens is achieved.

Burkholderia, and a composition, use and usage method thereof. Provided are the Burkholderia, and a composition comprising the strain and / or a metabolite, culture, fermentation broth and / or extract thereof. The Burkholderia or the composition thereof can generate a siderophore, induce plants or seeds thereof to generate systemic resistance to plant pathogens, and reduce the chemotaxis of plant pathogens to plants, so that prevention and treatment of plant diseases and insect pests are achieved. In addition, plant root system development can be promoted, a nitrogen fixation effect is provided, a phosphate solubilization effect is provided, indoleacetic acid is generated, and weeds are removed, thereby promoting plant growth.

The present invention relates to a composition comprising a) a Bacillus cell expressing a recombinant spore-producing outer wall of a fusion protein comprising (i) at least one plant growth stimulating protein or peptide and (ii) a targeting sequence localizing the fusion protein onto the spore outer wall of the Bacillus cell in a synergistically effective amount; and b) at least one other biological control agent selected from a mutant of a particular microorganism disclosed herein and / or a particular strain of a microorganism disclosed herein having all identifying characteristics of the respective strain, and / or at least one metabolite produced by the respective strain, and / or at least one metabolite produced by the respective strain that exhibits activity against insects, mites, nematodes and / or phytopathogens. Furthermore, the present invention relates to the use of this composition and methods for enhancing plant growth, promoting plant health and / or reducing overall damage of plants and plant parts.

A robust nasal organoid culture system and fully characterized 2D and 3D in vitro produced organoids are provided, as well as methods of using the organoids. The nasal organoids comprise a population of differentiated nasal epithelial cells having cellular heterogeneity and molecular markers similar to mature nasal epithelial tissue. Improved methods for producing two-dimensional and three-dimensional nasal organoids are also provided. These methods generally require a two-phase culture system, i.e., amplification and differentiation culture. The provided nasal organoids are suitable for reproducing nasal tissue complexity, for mimicking respiratory diseases, studying barrier function and drug delivery, high throughput drug screening, and assessing the effects of pathogens and environmental toxins on nasal respiratory epithelium.

The invention discloses a quaternary ammonium salt modified linalool derivative as well as preparation and application thereof. The structure of the quaternary ammonium salt modified linalool derivative is shown as a formula (I). The quaternary ammonium salt modified linalool derivative is prepared by carrying out nucleophilic substitution reaction on linalool and benzyltrimethylammonium chloride. The derivative can be applied to water-based disinfectants or antibacterial daily necessities. The derivative has good water solubility and bactericidal activity. Through the synergistic interaction of the quaternary ammonium salt group and the linalool mother nucleus, the disinfection and sterilization capacity of the linalool derivative is remarkably improved compared with that of independent quaternary ammonium salt or linalool, and the linalool derivative particularly has a better disinfection and killing effect on pathogens of a quaternary ammonium salt-resistant disinfectant. # imgabs0 #

The present disclosure relates to a fungicidal composition. More particularly, the present disclosure relates to a granular fungicidal composition comprising a copper compound and a benzamide fungicide. The present disclosure also relates to a process for preparing the fungicidal composition and a method for controlling growth of fungal phytopathogens using the same.

The disclosure provides an extracorporeal devices, systems and methods for removing a pathogen or a toxin from a biological fluid of a subject comprising contacting a biological fluid from the subject with a loosely packed bed of adsorption media, such as a fluidized bed, wherein the adsorption media comprises heparin, to remove the pathogen or the toxin to form a treated biological fluid; and infusing the treated fluid into the subject.

A method for treating a pathogen, comprising the steps of: removing, with an acid, less than 99% of —COR1 acyl groups from nitrogen sites of a poly(2-alkyl-2-oxazoline) in a solution to form a partially protonated and partially acylated poly(2-alkyl-2-oxazoline), where R1 comprises an alkyl group; adjusting a pH of the solution to greater than 2.5; forming a film from the solution, the film comprising a total cationic charge in a range of 0.001 to 10.0 coulombs per square inch, the total cationic charge countered with counteranions; and reducing activity of the pathogen contacting the film by: greater than 9% and less than 99.99995% in less than one minute, greater than 99.999% in less than four days, and greater than 99.99995% in less than seven days.

A disposable basin for extremity procedures, irrigation and lavage in the operating room, treatment clinic or ward allows the extremity to rest comfortably, safely, and securely inside the basin, allowing the surgeon, physician, clinician, and or provider ease of access within a contained protective barrier. Contaminated fluid safely and efficiently drains into an integrated suction trough via the intrinsic design of the basin, resulting in decreased exposure to pathogens, containment of contamination, ease of execution and disposal, and cost savings.

The invention discloses an application of a small peptide PEP914 or PEP890 in preparation of a biopesticide, and belongs to the technical field of biology. The biopesticide comprises a small peptide PEP914 or PEP890 and is a biopesticide for resisting bacterial leaf spot, rust disease or phytophthora root rot, the amino acid sequence of the small peptide PEP914 is shown as SEQ ID No.1, and the amino acid sequence of the small peptide PEP890 is shown as SEQ ID No.2. The small peptide PEP914 or PEP890 is applied to preparation of the biopesticide, a novel biopesticide thought is provided, and the problems that in the prior art, chemical pesticides are prone to remaining, environment problems are prone to being caused, and pathogens generate drug resistance are solved.

A sensor comprising one or more metal oxides as sensor material is used to detect pathogen-derived VOCs, such as those released from an infected wound. The metal oxides can comprise one or more metal elements selected from aluminum, antimony, bismuth, boron, cerium, chromium, cobalt, copper, gold, indium, iridium, iron, lanthanum, lead, manganese, molybdenum, nickel, niobium, osmium, palladium, platinum, rhodium, ruthenium, selenium, silicon, silver, tantalum, tellurium, terbium, tin, titanium, tungsten, vanadium, ytterbium, yttrium, zinc, and zirconium. The sensor device can have one or more sensors that detect and record various VOCs indicative of the presence of pathogens, which are associated with mortality and / or infection.

The present invention is in the field of agricultural pathogen control. Methods and compositions are described for controlling plant diseases caused by pathogens, including fungi and oomycete phytopathogens. Chemicals were screened for activity as autophagy inhibitors. The screening method used a bioluminescence resonance energy transfer (BRET)-based high-throughput screening strategy to identify compounds that inhibit fungal ATG4 cysteine protease-mediated cleavage of ATG8 for autophagosome formation. Ebselen and ebselen analogs were identified as inhibitors of fungal pathogens ATG4-mediated ATG8 processing. Identified chemicals inhibit spore germination, hyphal development, and appressorium formation. The autophagy inhibitors significantly reduced the virulence of pathogens in their corresponding plant hosts. The invention also provides for compositions comprising the same, methods of making the same, and methods of controlling plant disease.

Devices, systems, and methods of facilitating airway management with reduced risk of release of droplets and aerosolized pathogens from the lungs of a patient are disclosed, including a bronchoscope adapter for an endotracheal tube, an endotracheal tube with integral bronchoscope adapter, an endotracheal intubation mask system, a laryngeal mask airway-specific mask system, and a quick-seal laryngeal mask airway-specific mask system.

The present invention relates to novel tomato plants having improved resistance to lesion-forming pathogens caused by a reduced level, activity, or expression of Pub17 protein. The level, activity, or expression of a Pub17 protein can be reduced by modification of the Pub17 allele to contain an SNP identified to associate with increased resistance to lesion-forming pathogens. The present invention further relates to plant parts and seeds derived from said tomato plants, and to methods of making said tomato plants or increasing resistance to lesion-forming pathogens in a tomato plant, as well as use of the SNP as a marker and associated kits.

The invention discloses a pathogen transmission rapid early warning and traceability analysis method based on multi-source data fusion. The method comprises the steps of S1, collecting multi-source data such as drug sales, network behaviors, social media, outpatient diagnosis and traffic time and space; s2, through cleaning and standardized preprocessing, social text disease features are extracted by adopting BERT; s3, mining a comprehensive weak signal through single-source anomaly detection and multi-source correlation analysis; s4, fusing the features by using an Attention-LSTM model, and outputting a regional risk index; s5, training an early warning model based on historical data, and setting a three-level threshold to trigger early warning; and S6, positioning a propagation starting point in combination with the spatio-temporal data, and constructing a propagation chain through a graph neural network. The early warning is advanced by 3-7 days, the traceability precision reaches the community level, and the prevention and control precision is improved.

The present invention relates to a method of conferring or increasing resistance against fungal pathogens in plants and / or plant material. To this end the invention focuses on facilitating or increasing the production and / or accumulation of a membrane steroid binding protein 1 (MSBP1), fragment or homolog thereof in a plant or plant material compared to corresponding wild type plant or plant material. The invention also relates to plant and plant material having an increased resistance against fungal pathogens and to material and methods to create or use such plants plant parts or to produce products therefrom.

The gynecological medicine applying device comprises a medicine storage part, the bottom end of the medicine storage part is rotationally connected with a sealing device, a medicine outlet barrel is connected to the bottom end of the sealing device in an inserted mode, a feeding part is rotationally arranged in the medicine storage part, the feeding part penetrates through the sealing device and the medicine outlet barrel, and the medicine outlet barrel is connected with the sealing device in an inserted mode. A medicine applying device is arranged on the medicine outlet cylinder; through the structural design of the medicine storage piece and the feeding piece, after medicine in the first barrel body is used up, the whole device does not need to be taken out of the body of a patient for filling, medicine filling can be conducted only by splitting the medicine storage piece and the feeding piece, unnecessary interference to the patient is greatly reduced in the process, and the medicine filling efficiency is improved. The device is simple in structure and convenient to use, physical discomfort and psychological burden caused by repeated taking and placing of the device to a patient are avoided, meanwhile, the number of times of contact between the device and the external environment is reduced, the risk that bacteria or pathogens invade the body of the patient is effectively reduced, and safety of the patient in the treatment process is guaranteed to the maximum extent.

The present invention relates to pathogen cleaning and simulation of pathogen spreading. More particularly, some implementations of the described invention relate to systems and methods for spraying materials in a manner that mimics the spreading of pathogens from coughing or sneezing. Some implementations further relate to using a non-aerosol sprayer that produces both a mist and droplets of a mixture containing water, a fluorescent marker, a surfactant, and an antifoaming agent. In some cases, the pump sprayer defines an internal compartment that includes the mixture. In some cases, the sprayer further includes a pump mechanism that is configured to be pumped to compress a gas within the compartment and a release valve that is configured to release pressure within the compartment through a spray nozzle of the sprayer such that droplets and mist of the mixture are sprayed from the nozzle. Other implementations are also described.

The invention provides a low-temperature-resistant inactivated guanidine salt virus preservation solution and a preparation method thereof, and relates to the field of virus preservation solutions. Comprising the following raw materials: NaCl, KCl, glucose, KH2PO4, Na2HPO4, guanidine hydrochloride, penicillin, streptomycin, amphotericin B and glycerol. The raw materials are mixed and uniformly stirred. The preserving fluid is suitable for being used in a low-temperature environment, can preserve a liquid state within several hours in the low-temperature environment, can significantly inactivate pathogens, can also maintain completeness of subsequent nucleic acid extraction, and has no significant influence on amplification and the like.

The invention relates to a super-multiplex digital PCR (polymerase chain reaction) detection method for simultaneously detecting multiple pathogens of shrimps and application of the super-multiplex digital PCR detection method. According to the digital PCR primer, the probe, the kit and the detection method for shrimp pathogen detection, pathogens aiming at 18 shrimp pathogens can be rapidly, accurately and ultrasensitively detected. By detecting pathogens in the prawns, the health condition of the prawns in intensive prawn culture can be evaluated in time, disease transmission can be prevented, intervention measures can be taken in time, the risk of disease transmission to prawn groups in intensive culture can be reduced, serious economic loss can be avoided, and the application value is extremely high. Accurate identification of specific pathogens in a shrimp sample is very important for designing a proper control strategy, because each pathogen may require different prevention and management methods, drug use conditions can be effectively reduced. The shrimp pathogen detection can improve the culture benefit, and is also beneficial for developing the epidemic disease prevention and control work of aquatic animals and the inspection and quarantine monitoring plan of main aquaculture variety offspring seeds.

The present invention relates to the field of animal health. Particularly, the present invention relates to a composition, comprising a modified Duck Enteritis Virus (DEV) which comprises and is capable of expressing a heterologous polynucleotide coding for an antigen of a chicken pathogen. Furthermore, the present invention relates to a composition, comprising the modified DEV as vector-vaccine for chicken, and the use thereof. More particularly, the present invention relates to a vaccine composition against a chicken pathogen, comprising a modified DEV that shows no or reduced pathogenicity in chicken.

The invention discloses a method for enhancing co-metabolism degradation of antibiotics in ammoxidation sludge, and belongs to the technical field of sewage treatment. According to the method, ammonia oxidation sludge is enriched firstly, artificially synthesized sewage is used as inlet water of an ammonia oxidation sludge enrichment reactor, the reactor is operated by adjusting the pH value to be acidic, sulfamethoxazole with different concentrations in the inlet water is treated in stages, co-metabolism of the ammonia oxidation sludge is enhanced, and sulfamethoxazole degradation is enhanced under the long-term operation condition; the ammonia nitrogen removal rate is not obviously inhibited. The method provided by the invention not only can remove ammonia nitrogen in sewage, but also can efficiently and stably degrade antibiotics, and can reduce propagation and invasion of pathogens in nature, thereby protecting biodiversity and stability of an ecological system.

Methods and compositions for identifying, selecting and / or producing a pathogen resistant plant, plant cell or seed (e. g,, a maize plant, plant cell or seed) are provided. Polynucleotides and polypeptides are provided, which when expressed in a plant increase disease and / or pathogen resistance (e.g., to Fusarium stalk rot) of the plant. Plants, plant cells and seed are provided comprising such polypeptides and polynucleotides, as are methods for their use.

The invention discloses antibacterial gel for female private part nursing and a preparation method of the antibacterial gel, and belongs to the technical field of female nursing gel. The gel provided by the invention has good biocompatibility and biological adhesion, is convenient to form a gel state under the action of body temperature, is tightly adhered to the surface of a mucous membrane to form a protective hydrated film, can physically isolate pathogens, and is used for preventing female genital tract infection and maintaining vagina health. The performance of the chitosan is improved through grafting modification, a plurality of carboxyl, guanidyl and siloxane structural units are introduced to the chitosan at the same time, guanidyl can effectively adsorb and destroy bacteria and fungi usually carrying negative charges, and the water solubility and biocompatibility of molecules are enhanced through the carboxyl and siloxane structure; the siloxane structure can improve the spreadability and adhesion of molecules on the mucous membrane surface and prolong the drug residence time, and the functional monomers are grafted to the chitosan skeleton through amido bonds to ensure the structural stability and function durability of the modified polymer.

A method for inactivating pathogens is described, comprising the steps of: partially deacylating a poly(2-alkyl-2-oxazoline) to yield a copolymer, an alkyl in the poly(2-alkyl-2-oxazoline) comprising a hydrocarbon chain, the copolymer comprising: first monomers, the first monomers comprising a -NH2 +CH2CH2- group; and second monomers, the second monomers comprising an acyl group, -C(=O)-R', attached to a nitrogen in a polymer backbone group comprising -NCH2CH2-, wherein R' comprises the hydrocarbon chain, the first monomers and the second monomers arranged in any order in the copolymer; preparing a formulation, the formulation comprising the copolymer and a total cationic charge in a range of 0.2 to 10 C / cm3, the total cationic charge at least 95% offset by counteranions in the formulation; contacting the pathogens with the formulation; and inactivating at least ninety percent of the pathogens within ninety minutes of the step of contacting.

An electrostatic air cleaner may be operated according to a manner designed to achieve acceptable air quality while balancing power usage and corona electrode degradation levels. The voltage applied to the corona electrode(s) may be controlled as well as the voltage applied to repelling electrodes and air flow velocity. The air cleaner may also be operated to achieve desired particle separation.

An antifungal composition including a first essential oil, and a second essential oil, where the composition is configured to reduce disease onset, pathogen spread, or a combination thereof. Further, an antifungal compound including one or more aroma compounds selected from 4-(4-hydroxyphenyl)-2-butanone, furaneol, ethyl methylphenylglycidate, ethyl hexanoate, ethyl butanoate, beta-ionone, alpha-ionone, (R)-(+)-limonene, (S)-(-)-limonene, cis-3-Hexen-1-ol, nerol, linalool, 2-heptanone, alpha-terpineol, beta-damascenone, β-caryophyllene, ethyl 2-methylbutanoate, β-myrcene, gamma-octalactone, alpha-humulene, nerolidol, (E,E)-2,4-decadienal, (E,E)-α-farnesene, vanillin, phenylethyl acetate, citral, 3-methylbutan-1-ol, or a combination thereof.