48 results about "Activating macrophage" patented technology

The invention provides an in-vitro skin blood vessel immune model as well as a preparation method and application thereof. THP-1 human monocyte leukemia cells are induced to be differentiated into M0 type macrophages, and then the M0 type macrophages are respectively induced into M1 type macrophages and / or M2 type macrophages; then co-culturing the M1 type and / or M2 type macrophages and vascular endothelial cells to form a vascular immune model; finally, the 3D skin model is placed on the blood vessel immune model, external stimulation is conducted, and the in-vitro skin blood vessel immune model is constructed. The in-vitro skin blood vessel immune model can be used for repairing skin barriers, inflammation pathways, blood vessel metabolism, the expression level of genes or proteins related to extracellular matrixes, vascular endothelial cells, the proliferation and migration ability of activated macrophages and the like. The seven feature dimensions of the physiological structure feature of the skin model are used for screening the to-be-tested sample and exploring the action mechanism, and the method has the characteristics of rapidness, multiple screening dimensions, high accuracy, low construction difficulty, low cost and high universality.

The invention relates to the technical field of microorganisms, in particular to bifidobacterium bifidum BGLP1 capable of regulating sugar digestion and producing GLP-1 at high yield and application of the bifidobacterium bifidum BGLP1. The preservation number of the bifidobacterium bifidum BGLP1 is CGMCC (China General Microbiological Culture Collection Center) No.35718, and the bifidobacterium bifidum BGLP1 can be used for preparing the feed additive. The strain has the capability of inhibiting alpha-glucosidase and alpha-amylase; sTC-1 cells are stimulated to secrete GLP-1, and the blood glucose reducing pathway capacity of the intestinal tract is activated; the activity of pancreatic lipase is obviously inhibited, and the dietary fat absorption capability can be effectively reduced; redundant cane sugar is converted into exopolysaccharide, so that the probiotic function capability is improved; the capability of converting white fat into brown fat is promoted; macrophages are activated, and the body immune function is improved. In addition, the bifidobacterium bifidum BGLP1 also has relatively strong intestinal colonization ability, has good tolerance in artificial gastric juice and artificial intestinal juice, and can smoothly reach the intestinal tract of a human body.

The present invention relates to alternatively activated macrophages (AAMs) for use in the treatment of liver injury and methods of treating and preventing liver injury using AAMs.

This invention belongs to the field of plant extract technology, specifically relating to a plant extract composition for enhancing immunity. By weight, it is composed of the following raw materials: 3-5 parts Astragalus membranaceus extract, 2.5-4 parts Echinacea purpurea extract, and 1.5-3.5 parts Rhodiola rosea extract. This plant extract composition, through the scientific formulation of Astragalus membranaceus, Echinacea purpurea, and Rhodiola rosea, and an enzymatic extraction process, enhances the immunomodulatory effect. The combination of the three extracts increases the secretion of TNF-α and IL-6 by macrophages. Furthermore, the spleen lymphocyte stimulation index (SI) of the three extracts reaches 5.57, and the lymphocyte transformation rate increases from 191% to 457%. These results indicate that this plant extract composition effectively enhances the body's non-specific and cellular immune functions by activating macrophages and promoting T lymphocyte proliferation through multiple pathways, providing more comprehensive immune protection.

The application discloses a kind of nanoclusters with golgi targeting and its preparation method and application, the nanocluster is zinc sulfide nanocluster, the surface of the zinc sulfide nanocluster is coupled with targeting ligand, the targeting ligand can actively target RA synovial activated macrophage, and can target golgi subcellular organelle, the nanocluster can release H2S gas in inflammatory weak acid microenvironment.The application can realize "inflammatory joint enrichment-> macrophage active uptake-> lysosome escape-> golgi deep anchoring" multi-level precise delivery, release H2S gas in inflammatory weak acid microenvironment, fundamentally reshape intracellular Ca 2+ Steady state, relieve endoplasmic reticulum, golgi and mitochondria triple stress, block inflammatory signal pathway, realize the efficient, safe treatment of RA.

The present application relates to the technical field of microorganisms, and particularly relates to a bifidobacterium BGLP1 capable of regulating sugar digestion and high GLP-1 production and application thereof. Bifidobacterium bifidum The bifidobacterium BGLP1 (CGMCC No. 35718) has the abilities of inhibiting alpha-glucosidase and alpha-amylase, stimulating STC-1 cells to secrete GLP-1 and activating the intestinal glucose-lowering pathway, significantly inhibiting pancreatic lipase activity and effectively reducing dietary fat absorption, converting excess sucrose into extracellular polysaccharides to increase the probiotic function, promoting the conversion of white fat into brown fat, and activating macrophages and improving the immune function of the body. In addition, the bifidobacterium BGLP1 has strong intestinal colonization ability, has good tolerance in artificial gastric juice and artificial intestinal juice, and can successfully reach the human intestinal tract.

The invention discloses an application of an RGS1 gene inhibitor in preparation of a medicine for treating obesity-related metabolic diseases, relates to the technical field of biological medicines, and particularly relates to an application of the RGS1 gene inhibitor in preparation of a medicine for treating obesity-related metabolic diseases. The inhibitor of the RGS1 gene is used for preparing a medicine for treating obesity-related metabolic inflammatory diseases, and the medicine is used for activating a PINK1 / Parkin mediated mitochondrial autophagy pathway in macrophages; the inhibitor of the RGS1 gene is a shRNA (short hairpin Ribonucleic Acid) lentiviral expression vector capable of realizing targeted silencing of RGS1 gene expression; the application of the RGS1 gene inhibitor in preparation of drugs for treating obesity-related metabolic diseases has significant beneficial effects; the drug can accurately activate a PINK1 / Parkin mediated mitochondrial autophagy pathway in macrophages, has high targeting property, and improves the safety and effectiveness of the drug.

The present application relates to the field of microbial technology, and particularly relates to bifidobacterium BB36 with improved antigen presentation ability and enriched calcium, iron and selenium, probiotics and application thereof. Bifidobacterium bifidum The present application provides bifidobacterium BB36 with activated macrophages, up-regulated immune factor expression level, and activated dendritic cells, enhanced antigen presentation ability in immune process, and enriched calcium, iron and selenium, and can be used as a biological carrier of mineral elements, in addition, can inhibit the growth of escherichia coli and staphylococcus aureus, and protect intestinal health of the body.

This invention relates to the field of pharmaceutical technology, specifically to the novel use of avenanthramide A in the preparation of drugs for repairing liver damage. Experiments have demonstrated that the addition of avenanthramide A to activated macrophages significantly promotes the expression of tumor necrosis factor-α (TNF-α). Furthermore, co-culturing macrophages stimulated with avenanthramide A with hepatocytes effectively promotes hepatocyte proliferation. The addition of a TNF-α neutralizing antibody reverses this proliferative effect. This experiment confirms that avenanthramide A can promote hepatocyte proliferation and liver damage repair by increasing TNF-α expression in macrophages. This invention provides a novel drug target for enhancing hepatocyte proliferation.

The present invention relates to a composition for preventing, improving and treating an inflammatory macrophage-mediated autoimmune disease, including a stem cell-derived exosome surface-modified with a sugar compound to target an activated macrophage, and the composition according to the present invention may specifically target an activated macrophage to increase the therapeutic efficiency for various types of autoimmune diseases including rheumatoid arthritis. In addition, the composition according to the present invention has a more excellent therapeutic effect and minimizes side effects compared with conventional antiinflammatory agents, stem cell therapeutic agents or exosomes because it contains a gene, protein or growth factor related to the proliferation, differentiation and regeneration of stem cells, and does not include an antibiotic or serum, or harmful factors of the cell culture.

The invention discloses application of triptolide ketone in preparation of a medicine for treating sepsis lung injury, and belongs to the technical field of biological medicine. Aiming at the problems that traditional chemical synthetic drugs may cause a large amount of sequelae and antibiotic abuse, and triptolide may cause liver and kidney injury when treating sepsis, research finds that triptolide can be used for treating sepsis lung injury, and can be used for treating sepsis lung injury. According to the application, the protein expression level of HIF-1alpha in proinflammatory activated macrophages is lowered, so that aerobic glycolysis is inhibited, and the effect of treating sepsis lung injury is achieved. Compared with the triptolide alcohol, the triptolide ketone does not cause liver and kidney injury while playing a role in treating the sepsis lung injury, and the curative effect of the triptolide ketone is equivalent to that of the existing medicine 2ME2 for treating the sepsis lung injury, so that the triptolide ketone has important application potential clinically, and can be used for preparing medicines for treating the sepsis lung injury. And a theoretical basis is provided for clinically developing medicines for treating sepsis lung injury.

The invention belongs to the technical field of medicine, and particularly relates to novel application of oat alkaloid A in preparation of medicine for repairing liver injury. Experiments prove that the expression of a tumor necrosis factor TNF-alpha can be remarkably promoted by adding the avenanthramide A into the activated macrophages, the proliferation of the hepatocytes can be effectively promoted after the macrophages stimulated by the avenanthramide A and the hepatocytes establish a co-culture system, and the proliferation effect of the hepatocytes is reversed after a TNF-alpha neutralizing antibody is added. The experiment proves that the oat alkaloid A can promote liver cell proliferation and liver injury repair by improving TNFa expression of macrophages. The invention can provide a new drug target for improving hepatocyte proliferation.

The invention discloses a radix fici simplicissimae polysaccharide extract and a preparation method and application thereof.The radix fici simplicissimae polysaccharide extract is radix fici simplicissimae crude polysaccharide or purified polysaccharide, and the radix fici simplicissimae crude polysaccharide is obtained by conducting primary alcohol precipitation, Sevage method protein removal and secondary alcohol precipitation on a radix fici simplicissimae water extract and then conducting drying; the purified polysaccharide is obtained by performing DEAE-52 fiber column chromatography on RFH, eluting by taking a sodium chloride solution as an eluent, respectively collecting elution parts of 0.3 mol / L sodium chloride solution, 0.4 mol / L sodium chloride solution and 0.5 mol / L sodium chloride solution, and respectively performing dialysis and drying. The radix fici simplicissimae polysaccharide extract prepared through a limited method can effectively activate macrophages to generate immunocompetence and is expected to be used for preparing immunomodulators or related drugs or food for enhancing the immunologic function.

The invention provides a plant polysaccharide with an immunomodulatory function, an extraction method thereof and an immunomodulator, and relates to the technical field of plant polysaccharides. The extraction method provided by the invention comprises the following steps: carrying out alcohol extraction on plant raw materials, and then separating alcohol extraction residues; carrying out water extraction on the alcohol extraction residues, and separating to obtain a water extract; carrying out concentration and alcohol precipitation on the water extract, and centrifuging to obtain a polysaccharide mixture; deproteinizing, dialyzing and freeze-drying the polysaccharide mixture to obtain plant polysaccharide; the plant raw material is one of clover leaves, fairy leaves and banana flowers. According to the extraction method provided by the invention, the plant polysaccharide with relatively high immunocompetence can be obtained, and the plant polysaccharide effectively activates immune effector cells such as macrophages and promotes secretion of cytokines through a bidirectional immunoregulation effect, so that safe raw materials can be provided for developing products for enhancing body defense and maintaining immune balance.

The application discloses a kind of nucleic acid nano vesicles based on sulfonium copolymerization peptide and its preparation method and application.The vesicle is formed by the electrostatic self-assembly of a kind of sulfonium copolymerization peptide and polynucleotide, and is stable nano vesicle with hollow structure.The vesicle is different from conventional solid nanoparticles, and its unique hollow structure provides space for co-loading other therapeutic agents (such as enzymes, chemotherapeutic drugs).The application also provides a preparation method of the nano vesicle, and its application as a carrier for simultaneously loading nucleic acid drugs and other active ingredients for synergistic treatment.The nano vesicle has extraordinary long-term storage stability, and can deliver siRNA and catalase to tumor sites, block CD47 "don't eat me" signal through gene silencing, and enzymatically degrade immunosuppressive factor H2O2 in tumor microenvironment, thereby remodeling tumor immune microenvironment, efficiently activating macrophages, dendritic cells and T cells, and producing strong synergistic anti-tumor immune effect.

The application belongs to the field of tea polysaccharide research, and discloses a Zijuan tea polysaccharide ZTPW with immunoregulatory activity, and a preparation method and application thereof. The ZTPW is a uniform polysaccharide obtained by hot water extraction and alcohol precipitation of Zijuan tea leaves, and separation and purification through an ion exchange column and a gel column, the main repeating unit structure of which is shown in the following, and the weight average molecular weight thereof is 7.73 kDa. Through in vitro immunoregulatory activity research, the ZTPW can be recognized by pattern recognition receptors TLR2 and TLR4 to activate macrophages, significantly enhance the activity of mouse monocyte macrophage RAW264.7 cells, and mediate the production of NO and cytokines of mouse monocyte macrophage RAW264.7 through MAPKs and NF-kappa B signal pathway, so as to play an immunoregulatory role. The polysaccharide can be used as a potential immunoregulator for the development of functional food or medicine.

The invention relates to a fusion polypeptide for diabetes wound repair and a pharmaceutical composition thereof, and discloses a sequence design and a preparation method of the fusion polypeptide FP-DW01-Chol, and a temperature-sensitive hydrogel composition containing the polypeptide and MitoQ. The fusion polypeptide contains a TREM2 agonist domain, an AGE-RAGE blocking domain, an MMP9 recognition cleavage site, an Angiopoietin-2 mimic peptide fragment and a cholesterol modification terminal, and can activate anti-inflammatory polarization of macrophages, block a chronic inflammation pathway and respond to a wound enzyme environment to release an angiogenesis promoting fragment. The pharmaceutical composition takes poloxamer 407 / 188 as a temperature-sensitive carrier, realizes cooperative delivery of polypeptide and MitoQ, and has the advantages of slow release, skin retention and stability. In-vitro and db / db mouse model experiments prove that the composition can remarkably promote high-glucose damaged cell activity recovery, inhibit inflammatory factor release, accelerate wound closure, promote angiogenesis and tissue remodeling, provides a multi-mechanism synergistic and local long-acting treatment scheme for diabetic refractory wounds, and has important clinical transformation value.

The present application relates to the technical field of biological medicine, in particular to a new application of a BTK PROTAC compound NX-5948, especially to a new application of a Bruton's tyrosine kinase protein degradation targeting chimera BTK PROTAC compound NX-5948 in a drug for treating secondary hemophagocytic syndrome (HLH). In the present application, the BTK PROTAC compound NX-5948 inhibits the activation of the macrophage BTK / NF-κB axis signaling pathway through targeting, on the one hand, reduces the number of activated macrophages by inhibiting the proliferation and survival of macrophages, on the other hand, induces the polarization of macrophages from pro-inflammatory M1 macrophages to anti-inflammatory M2 macrophages through the immunoregulatory effect on macrophages, and then inhibits the release of cytokines and the occurrence and development of HLH, so that the effect of the new application of the present application is that it can inhibit the abnormal activation of macrophages and improve the clinical symptoms or laboratory indexes existing in patients with secondary hemophagocytic syndrome.

The present disclosure provides methods and compositions related to the combination therapy of a macrophage-directed immunotherapy and a cytokine (e.g., IL-10). The combination of the macrophage-directed immunotherapy and a cytokine is useful in treating and / or preventing cancer (e.g., lung cancer) in a subject. Therapies that activate macrophages are emerging in cancer immunotherapy. One potential therapeutic target is the CD47-SIRPa, interaction, which acts as a myeloid immune checkpoint. Cluster of Differentiation 47 (CD47) is highly expressed on many different types of cancer cells, including lung cancer cells. CD47 binds to an inhibitory receptor, signal regulatory protein alpha (SIRPa,), that is expressed on the surface of macrophages and other myeloid immune cells.

The invention discloses sea cucumber glycoprotein MYP with immunocompetence and application of the sea cucumber glycoprotein MYP, and belongs to the technical field of marine biological activity. The immunocompetence protein MYP derived from the sea cucumber water extract is obtained, the MYP is obtained from the sea cucumber water extract through anion exchange chromatographic column purification, the immunomodulatory activity of the obtained protein is researched, and the result shows that the obtained sea cucumber glycoprotein can activate RAW264.7 macrophages to be converted from an M0 type to an M1 type, the phagocytic ability of the macrophages is improved, and the immunocompetence of the macrophages is improved. And the secretion of cell factors such as NO, ROS, IL-6, IL-1beta, TNF-alpha and the like can be effectively promoted. Meanwhile, the simulated digestion product of the MYP can also effectively promote the secretion of NO, ROS and cell factors of cells. And practical verification shows that the active protein MYP and the digestion product thereof have good immunomodulatory activity, and can provide technical basis and data support for subsequent industrial development.

The invention discloses a composite peptide premix feed capable of improving immunity of livestock and poultry aquatic products and a preparation method thereof, and relates to the technical field of feeds. In order to reduce the use amount of antibiotics in the livestock breeding process, a composite peptide component is added into the premix feed, and the use amount of the antibiotics is reduced by adding bovine lactoferrin peptide in the premix feed. Macrophages and natural killer cells are activated, immune globulin secretion is promoted, and the mucosal immune barrier function is enhanced, so that the autoimmunity of livestock is improved, and the disease resistance of the livestock is improved; and in order to avoid the defect that the feed is easy to mildew to generate mildew toxins, mildew-proof modified attapulgite clay is also prepared and added, so that the mildew speed after the premixed feed and the feed are mixed and watered is effectively slowed down, and the diarrhea rate of livestock is reduced.

Provided is a method for preventing and alleviating inflammatory bowel disease by administering a composition including puer tea extract as an active ingredient to a subject in need thereof. Puer tea extract of the present disclosure showed an effect of improving damaged colonic tissue in a mouse model of acute ulcerative colitis induced by dextran sulfate sodium (DSS), and showed an inhibitory effect on clinical symptoms of the disease activity index (DAT) of weight loss, diarrhea, and rectal bleeding. In addition, puer tea extract inhibited the expression of inflammatory cytokines TNF-α and IL-6 in the colonic tissue and inhibited the inflammatory response through inhibition of the activity of NF-κB, an anti-inflammatory mechanism. In addition, the DPPH free radical and ABTS free radical scavenging ability increased proportionally as the concentration of puer tea extract increased at the cellular level, and COX-2 expression was inhibited in LPS-activated macrophages.

The invention belongs to the technical field of medicines, health-care products and foods, and discloses a clam polysaccharide as well as a preparation method and application thereof. The invention discloses a polysaccharide. The polysaccharide is a homopolysaccharide composed of glucose only. The polysaccharide provided by the invention can be used for effectively activating RAW264.7 macrophages, remarkably improving the phagocytic activity of RAW264.7 cells and promoting secretion of tumor necrosis factors, interleukin and nitric oxide, so that an immunological enhancement function is exerted. The polysaccharide can be used for preparing medicines and health-care products for treating diseases related to low immunity or functional foods for improving the life quality of tumor patients.

This specification relates to compositions comprising novel amide compounds derived from amino acid structures such as valine, leucine, phenylalanine, proline, or pipecolic acid. [Solution] The composition can exert an immune-enhancing effect by activating the phagocytic activity of macrophages, which are important components of the human immune system and help eliminate pathogens.

The invention provides difunctional tremella polysaccharide as well as a preparation method and application thereof, the tremella polysaccharide is prepared by adopting a water extraction method, and the steps of crushing and sieving, hot water extraction, centrifugal separation, vacuum concentration, alcohol precipitation, Sevag deproteinization, dialysis, acidolysis, dialysis and freeze drying are performed. The trifluoroacetic acid degradation method has the characteristics of rapidness, high efficiency, simplicity and easiness in operation, the neutral sugar content of the prepared tremella polysaccharide is greater than or equal to 74%, the uronic acid content is greater than or equal to 21%, and the purity is greater than or equal to 96%. The difunctional tremella polysaccharide can significantly promote proliferation and secretion of nitric oxide NO of RAW264.7 macrophages, and significantly promote proliferation of bacteroides multiforme, bacteroides simplex, bacteroides ovale, bacteroides fragilis, bifidobacterium longum subsp. Longum, bifidobacterium breve, bacteroides bacteria, bifidobacterium bacteria and mixed bacteria. The compound has the advantages of being high in purity, activating macrophages and promoting probiotic proliferation, and can be applied to food and health care products.

The invention relates to the technical field of microorganisms, in particular to bifidobacterium bifidum BB36 capable of improving antigen presentation capacity and enriching calcium, iron and selenium, a metagen and application of the bifidobacterium bifidum BB36. The bifidobacterium bifidum BB36 disclosed by the invention is preserved in the China General Microbiological Culture Collection Center (CGMCC) on February 2, 2026, the preservation address is No.3, No.1 yard, Beichen West Road, Chaoyang District, Beijing, and the preservation number is CGMCC No.37593. The invention further discloses a preparation method of the bifidobacterium bifidum BB36. The bifidobacterium bifidum BB36 provided by the invention has the effects of activating macrophages, up-regulating the expression level of immune factors, directly activating dendritic cells and enhancing the antigen presentation capacity in the immune process, has the capacity of enriching calcium, iron and selenium, and can be used as a biological carrier of mineral elements; the growth of escherichia coli and staphylococcus aureus can be inhibited, and the intestinal health of a body is protected.

The invention relates to a hirsutella sinensis strain as well as a fermentation method and application thereof, and belongs to the technical field of microorganisms. The strain is separated from a natural cordyceps sinensis sample, and green, high-yield, stable and sustainable Hirsutella sinensis mycelia are obtained through a liquid fermentation process. The strain disclosed by the invention shows excellent growth and proliferation rates in fermentation culture, and the adenosine content of the strain is surprisingly high. In addition, the strain disclosed by the invention shows an excellent bidirectional immunoregulation effect, not only can effectively improve the immune function of macrophages in a resting state, but also has an inhibition effect on excessively activated macrophages.

The invention discloses a ganoderma lucidum spore oil composite fungal polysaccharide anti-tumor oral preparation and application thereof. The ganoderma lucidum spore oil composite fungal polysaccharide anti-tumor oral preparation comprises the following components in percentage by weight: 15-25% of ganoderma lucidum spore oil; 10%-15% of composite fungal polysaccharide; 1%-3% of coenzyme Q10; 1%-2% of a nano encapsulation carrier; the auxiliary materials comprise 3%-6% of phospholipid and 0.3%-0.8% of vitamin E; the balance is sterile water; the grifola frondosa polysaccharide activates macrophages, the schizophyllum commune polysaccharide enhances NK cytotoxicity, the agaricus blazei murill polysaccharide inhibits angiogenesis, and the cordyceps sinensis polysaccharide regulates immune balance, so that a triple synergistic network of direct killing, immune activation and blood vessel blocking is formed; by adopting a membrane emulsification technology of a sodium caseinate-chitosan composite carrier, the problem of co-delivery of fat-soluble and water-soluble components is solved; the positive charge characteristic of chitosan realizes targeted delivery; by means of component innovation, process optimization and mechanism breakthrough, inherent defects of existing fungus anti-tumor preparations are overcome, and a brand new solution is provided for efficient and low-toxicity tumor adjuvant therapy.

The present disclosure belongs to the technical field of biological medicine, and particularly relates to the application of finerenone in the preparation of a drug for treating hypertensive renal injury. The present disclosure provides the application of finerenone in the preparation of a drug for preventing and / or treating hypertensive renal injury, specifically, by using a deoxycorticosterone acetate-salt-induced hypertensive mouse model and a primary mouse renal tubular epithelial cell-bone marrow-derived macrophage co-culture model, it is first revealed that aldosterone and salt corticosteroid receptor signals mediate cell-to-cell communication by promoting PANX1-dependent ATP release in renal tubular epithelial cells, and then activate macrophage P2X7, activate NLRP3-mediated macrophage pyroptosis, and aggravate the molecular mechanism of aldosterone-driven renal inflammation and fibrosis. The present disclosure also provides the application of a substance targeting a PANX1 / extracellular ATP / P2X7 signal axis in the preparation of a drug for preventing and / or treating hypertensive renal injury.

The invention discloses a formula design and a processing technology of functional mushroom curry sauce, and belongs to the technical field of curry sauce processing, agaricus blazei murill is rich in polysaccharide and has the characteristics of enhancing immunity, resisting tumors and resisting oxidation, active ingredients of the agaricus blazei murill can activate macrophages and natural killer cells, the defense capacity of the organism is improved, and the functional mushroom curry sauce is prepared. Agaricus blazei murill can be combined with lentinan to amplify the immune regulation effect, curcumin has the anti-inflammatory effect to assist the agaricus blazei murill to relieve oxidative stress, hericium erinaceus can improve gastrointestinal health, polyphenols have the effects of protecting the liver and resisting ulcers, quercetin in onion powder and antioxidant components of hericium erinaceus cooperate to enhance the nerve protection effect, and the anti-inflammatory effect of curcumin is improved. Furthermore, the agaricus blazei murill, the shiitake mushrooms and the hericium erinaceus cooperate with one another to enhance the antiviral, immunoregulation and antioxidant functions of the body, and the turmeric powder, the garlic powder and the onion powder cooperate with one another to enhance the antibacterial and anti-inflammatory effects and promote digestion, so that the effects of the agaricus blazei murill, the shiitake mushrooms and the hericium erinaceus supplement one another.