The present invention belongs to the technical field of hydrogels. Disclosed are
hydrogel microspheres, a preparation method therefor, and use thereof. According to the present invention,
epigallocatechin gallate and
vitamin E are self-assembled into a hydrophobic
polyphenol-based
micelle, wherein the hydrophobic
polyphenol-based
micelle, with EGCG as the core, forms a stable structure by means of non-covalent interactions (such as hydrophobic interactions,
hydrogen bonding, and π-π stacking), thereby enhancing the stability and functionality of the hydrophobic core. Then, the hydrophobic structure is mixed with hydrophilic
sodium alginate to form a gel, ultimately resulting in
hydrogel microspheres with a unique amphiphilic heterogeneous structure. The
hydrogel microspheres can exist stably in an aqueous environment, and actively capture dietary fats, thereby improving the ability to capture dietary fats, and improving the stability of the hydrogel microspheres in the
gastrointestinal tract.