50results about How to "Reduces levels of oxidative stress" patented technology

The invention discloses lactobacillus paracasei capable of relieving alcoholic intestinal injury and an application of the lactobacillus paracasei capable of relieving alcoholic intestinal injury, andbelongs to the technical field of microorganisms and medicines, The invention provides a medicine capable of preventing and/or treating alcoholic intestinal injury or alcoholic liver injury. Effective components of the medicine are lactobacillus paracasei CCFM1120, and the lactobacillus paracasei CCFM1120 can effectively relieve the alcoholic intestinal injury and the alcoholic liver injury. Thelactobacillus paracasei has the specific effects that the mRNA expression level of intestine tight junction proteins of alcohol modeled mice can be notably increased, the content of endotoxin in serumof the alcohol modeled mice can be notably reduced, the activity of alanine aminotransferase and aspartate aminotransferase in the serum of the alcohol modeled mice can be notably reduced, the oxidation stress level of the liver of the alcohol modeled mice can be notably reduced, and the pathology damage of liver tissue of the alcohol modeled mice can be notably improved.

The invention belongs to the technical field of biological materials and biological medicines, and discloses an oxidase-loaded microneedle for promoting wound healing of diabetics and a preparation method thereof.The preparation method comprises the steps that SilMA is dissolved in deionized water, and a photoinitiator HMPP is added under the dark condition to obtain a mixed solution A; adding PBZs and VEGF solution into the mixed solution A to obtain a mixed solution B; adding the mixed solution A into a polymyxin solution to obtain a mixed solution C; and respectively adding the mixed solution B and the mixed solution C into a microneedle mold, carrying out crosslinking under ultraviolet light, and separating the mold to obtain the composite microneedle. The PBZs and the VEGF are creatively loaded into the SilMA composite hydrogel microneedle to treat diabetic skin wounds, the oxidative stress level of diabetic skin wound tissues can be effectively relieved, a proper oxidation microenvironment is provided for the VEGF to play a role in promoting angiogenesis, and healing of the diabetic skin wounds can be better promoted.

The invention relates to a preparation method of a polycaprolactone nerve scaffold loaded with fullerol. The method comprises the following steps: uniformly mixing a polycaprolactone solution and a fullerol solution, and injecting the mixture into an electrostatic spinning device to prepare a fullerol-loaded polycaprolactone electrospun film; then preparing the polycaprolactone electrospun film loaded with fullerol into a hollow tubular stent with the wall thickness of 0.4-1.2 mm, and forming a plurality of through holes with the diameter of 10-30 [mu] m in the tube wall, thereby obtaining the polycaprolactone nerve stent loaded with fullerol. The inner diameter of the polycaprolactone nerve scaffold loaded with fullerol is 1.5 mm to 7 mm, and the length of the polycaprolactone nerve scaffold loaded with fullerol is 2 cm to 3 cm. The preparation method is simple, the size is controllable, and the material requirement is low; the polycaprolactone nerve scaffold disclosed by the invention can simulate an extracellular matrix structure, reduce the oxidative stress level in a peripheral nerve injury repair process and promote peripheral nerve regeneration; meanwhile, the mechanical strength can be increased, the degradation time can be prolonged, and nutrition exchange between defective peripheral nerves and peripheral tissues outside the tube wall is facilitated.

The invention discloses a repairing makeup remover containing vitamin B12. The makeup remover comprises: 61.2-95.08 parts of deionized water, 0.05-0.1 part of ethylenediamine tetraacetic acid disodiumsalt, 2-5 parts of glycerol, 0.1-3 parts of butanediol, 0.1-3 parts of propylene glycol, 1-5 parts of poloxamer, 0.5-5 parts of disodium cocoamphodiacetate, 0.3-3 parts of ethoxylated esters, 0.3-1.5parts of maltodextrin, 0.1-2 parts of trehalose, 0.1-1 part of perilla leaf extract, 0.1-1 part of kapok extract, 0.1-1 part of sweet marijoram leaf extract, 0.2-5 parts of C5-C6 glycols, 0.1-2 partsof capryl glycol, 0.1-0.3 part of cetyl pyridine chloride monohydrate, 0.005-0.15 part of citric acid, 0.005-0.3 part of sodium citrate and 0.001-0.5 part of vitamin B12.

The invention discloses an application of dracocephalum moldavica total flavonoids to preparation of a drug for preventing and treating the AD (Alzheimer's disease). An AD mouse model is established through hypodermic injection of sodium nitrite/D-galactose, the learning and memory capacity and biochemical indexes are scientifically assessed through mouse positioned navigation tests and space exploration tests, it proves that the dracocephalum moldavica total flavonoids can improve the space learning and memory capacity of AD model mice, dose dependence is formed, escape incubation of the AD mice is shortened, and platform crossing times in the space exploration tests are significantly increased; meanwhile, the content of MDA in cortical tissue in the AD mice can be significantly decreased, the content of SOD can be significantly increased, and the oxidative stress level in brain tissue can be reduced; also, through reduction of expression of pro-inflammatory factors IL-1beta and TNF-alpha, inflammatory injuries to the brain tissue can be relieved, the neuron protection role can be played, and the learning and memory capacity of the AD mice can be improved finally. Thus, a reference basis can be provided for clinic application of the dracocephalum moldavica total flavonoids in the future.

The invention discloses application of a nucleotide mixture in preparation of a preparation for preventing or relieving senile sarcopenia, and belongs to the field of medicine and health care. The nucleotide mixture consists of five kinds of 5'-mononucleotides or sodium salts thereof, and the mass ratios of CMP, AMP, UMP, GMP and IMP acid types converted by each kind of nucleotide are respectively as follows: 23-78% of CMP, 6-44% of AMP, 7-40% of UMP and 7-51% of GMP, and IMP is 0 or is greater than 0 but not greater than 2.5%. Nucleotide molecular weight is small, absorption is fast after the nucleotide mixture is taken by the human body, and bioavailability is high. The invention discovers that the intake nucleotide can improve the skeletal muscle function of the old body and increase the muscle mass by eliminating the mitochondrial dysfunction and reducing the oxidative stress so as to perform the functions of sarcopenia prevention and treatment, and a new way for preparing medicines or functional foods for preventing and treating the sarcopenia is provided.

The invention belongs to the technical fields of biology and medicine, and particularly relates to application of Nano-MitoPBN in preparing medicines for resisting oxidation and treating diabetes. Dueto the micro-compartmentalization effect, Nano-MitoPBN can remove mitochondrion superoxide/hydrogen peroxide generated by single electron leakage of a liver mitochondrion electron transport chain, increase the respiration rate of a mitochondrion state 3 and the respiration control ratio, improve synthesis of ATP, and promote the function of mitochondria. In addition, by reducing ROS, Nano-MitoPBNreduces gluconeogenesis, increases glycolysis, reverses ROS-mediated liver glycometabolism reprogramming in diabetic animals, then reduces the peripheral blood glucose level of the diabetic animals and restores the glucose tolerance of the diabetic animals. Nano-MitoPBN serves as a material for preparing the medicines for treating diabetes, can be used for targeting liver prevention and relievingand treating diabetes, and can obtain a remarkable curative effect with a very small dosage.

The invention relates to the field of health-care food, in particular to a bifidobacterium longum dietary composition for intervening chronic nephritis and uremia and the application thereof. The bifidobacterium longum dietary composition comprises 100mL of bifidobacterium longum BLG301 probiotic milk and 40g of cereal powder tablets. The preparation method comprises the following steps: taking out probiotic powder frozen and preserved at -80 DEG C, cooling to room temperature, adding the probiotic powder into the pasteurized cow milk; the product prepared by the preparation method of the bifidobacterium longum BLG301 probiotic cow milk and cereal powder tablets are jointly used as diet collocation, so that oxidative stress in intestinal tracts of human bodies is improved, and the levels of inflammatory factors and urotoxin in the human bodies are reduced. Compared with the prior art, the probiotics are adopted to intervene chronic nephritis, so that the oxidative stress level of patients with chronic nephritis can be reduced; the inflammatory factor level and the uremic toxin level of a chronic nephritis patient are improved; the pH value of the excrement is improved, the organic acid content of the excrement is increased, intestinal flora is healthier, beneficial bacteria are increased, harmful bacteria are reduced, and the flora structure is more beneficial to intestinal health.

The invention discloses an application of FUNDC1 in treating acute respiratory distress syndrome and belongs to the technical field of biology. The present invention provides the application of the FUNDC1 in preparing products for preventing and/or treating inflammatory diseases. The mechanism of the FUNDC1 in preventing and/or treating inflammatory diseases is mainly to reduce lung injury by mediating mitochondrial autophagy to inhibit activation and expansion of inflammatory reactions induced by an ROS-NLRP3 signaling pathway. The invention provides the application of the FUNDC1 in preparingproduct for preventing and/or treating acute respiratory distress syndrome. The product provided by the invention can reduce lung injury by inhibiting inflammatory reactions by promoting autophagy during ARDS period. The FUNDC1 is expected to become a new target for ARDS treatment and has a wide application prospect.

The invention discloses a new use of sodium pyruvate, namely application in the preparation of a storage liquid for improving stored erythrocyte quality and/or post-infusion tissue damage.The sodium pyruvate is used as an active ingredient to prepare the storage liquid for improving stored erythrocyte quality and/or post-infusion tissue damage, it is possible to improve the stored erythrocyte quality and/or post-infusion tissue damage, the therapeutic effect is significant, no side effect occurs, safety is good, and the sodium pyruvate plays an important role in studying and developing this storage liquid and has promising application prospect and great social significance.

The invention belongs to the field of food processing, and relates to the technical field of health-caring nutrition products; and the invention specifically relates to konjac nutrition powder and konjac capsules containing the konjac nutrition powder with a nutrient-enriching function. The konjac nutrition powder comprises the following raw-material ingredients: konjac powder and a nutrition fortifier; content of konjac glucomannan in the konjac powder is 50-70%; and the nutrition fortifier comprises vitamin A acetate, vitamin D3, riboflavin, pyridoxine hydrochloride, cobalamin, nicotinamide, calcium carbonate, ferrous fumarate, vitamin E acetate, and ascorbic acid. After entering the intestines and the stomach, the konjac powder is capable of expanding by absorbing water so as to increase satiety. The nutrition fortifier solves the problem of liable nutrient deficiency caused by long-term intake of the konjac powder. The konjac nutrition powder and the konjac capsules containing the konjac nutrition powder with the nutrient-enriching function are especially suitable for people with the demand of losing weight.

The invention discloses application of all-cannabinoid in preparation of a drug for treating a Parkinson's disease (PD). The all-cannabinoid is prepared by uniformly mixing, by weight, 0.3-99.7 parts of an industrial hemp seed extract with 99.7-0.3 parts of industrial cannabinoids. Experiments prove that the prepared all-cannabinoid has the effects of removing free radicals, inhibiting lipid peroxidation and enabling generation and removal of oxygen radicals to be in dynamic balance to slow disease progress of the PD. The all-cannabinoid has a good application prospect on preparation of the drug for treating the Parkinson's disease.

Synthetic ionophores for the active carry and transport of free ions across biological membranes in vivo, comprising coordination complexes of molecules with polarized hexa-aqua and/or tetra-aqua systems of free ionic metals and ionic salts as the ionophores, useful in transporting pharmaceutical, nutrient, and personal healthcare compounds. Also described are methods of their administration, methods of their synthesis and manufacture, and the ionophore products of such synthesis and manufacturing methods.

The invention belongs to the technical field of Chinese patent medicines, and relates to pharmaceutical use of a hirudo and rhizoma ligustici capsule in treatment of non-alcoholic fatty liver disease(NAFLD). The hirudo and rhizoma ligustici capsule is prepared from hirudo, rhizoma ligustici, radix puerariae, herba leonuri and radix salviae miltiorrhizae at the ratio of 1 to 1 to 1 to 1 to 1. According to the pharmaceutical use, high fat diet (HFD) induced rat NAFLD model is adopted for studying the treatment effect of ZXC on rat NAFLD, it is found that ZXC can significantly reduce the blood lipid level of the model rat, significantly relieve liver fat caused by HFD, alleviate liver injury, reduce oxidative stress level of liver, and have high medicinal value.

The invention relates to the technical field of probiotics, and particularly discloses a novel application of a composite probiotic preparation to the field of oxidation resistance. The composite probiotic preparation can be used for preparing antioxidant products. The composite probiotic preparation disclosed by the invention consists of streptococcus thermophilus S709, lactobacillus paracasei L578 and lactobacillus helveticus L551, can effectively remove oxygen free radicals (DPPH, ABTS, superoxide anion free radicals and hydroxyl free radicals) in vivo and in vitro, effectively reduces the oxidative stress level of cells, improves the activity of SOD and GSH-PX and increases the antioxidant capacity of a matrix, is free from any toxic and side effects, and establishes a foundation for exploring the action mechanism of the probiotics in antioxidation and sleep regulation.

The invention discloses a composition for preventing and treating hyperuricemia and application thereof. The composition comprises an effective amount of carvacrol and an excipient or an additive. Thecomposition can be used for preparing medicines or health products for preventing or treating hyperuricemia and gout. Experiments of control model mice prove that indexes, such as uric acid and creatinine, in hyperuricemia can be remarkably reduced by using the composition. Besides, the composition can protect the kidney functions, prevent kidney tissue lesions and improve the survival rate, andhas good application prospects.