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Composition for preventing and treating hyperuricemia and application thereof

A technology of hyperuricemia and composition, applied in the fields of pharmacy, medicine, and immunology, to protect the kidneys and relieve kidney damage

Inactive Publication Date: 2019-11-22
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This aspect of research has not been reported, and it is innovative

Method used

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  • Composition for preventing and treating hyperuricemia and application thereof
  • Composition for preventing and treating hyperuricemia and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1: Composition 1

[0019] Take 70 mg of olive oil and 37.6 mg of oregano oil, put them in a stainless steel tank, mix them and stir evenly, and the mixed oils are colloidally ground for 2-3 times to obtain the product. Each milligram of the composition contains approximately 0.24 mg of carvacrol.

Embodiment 2

[0020] Example 2: Composition 2

[0021] Take 32.4 mg of olive oil and 75.2 mg of oregano oil, put them in a stainless steel tank, mix them and stir them evenly, and the mixed oils are colloidally ground for 2-3 times to obtain the product. Each milligram of the composition contains approximately 0.48 mg of carvacrol.

Embodiment 3

[0022] Embodiment 3: Composition to prevent and treat hyperuric acid mouse model experiment

[0023] 3.1 Experimental instruments and reagents

[0024] Experimental gavage needle (Beijing Jiandaer Technology Co., Ltd.), TG16-W micro high-speed centrifuge (Changsha Xiangyi Centrifuge Instrument Co., Ltd.), ST-360 microplate reader (Shanghai Kehua Experimental System Co., Ltd.), -86 ℃ Refrigerator (Zhongke Meiling Equipment Co., Ltd.), Mannitol (Sinopharm Chemical Reagent Co., Ltd.), Libao Fatty Ning (Braun Medical (Suzhou) Co., Ltd.).

[0025] 3.2 Experimental animals

[0026] Twenty-four SPF grade Kunming mice, 4 weeks old, male, weighing 18-22 g, were provided by Beijing Speifu Co., Ltd., animal certificate number: SCXK (Beijing) 2016-0011. Environmental conditions for animal feeding: humidity 50% to 70%, temperature 23±2°C.

[0027] 3.3 Grouping and administration

[0028] Male Kunming mice were randomly divided into four groups, 6 in each group, which were normal group,...

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Abstract

The invention discloses a composition for preventing and treating hyperuricemia and application thereof. The composition comprises an effective amount of carvacrol and an excipient or an additive. Thecomposition can be used for preparing medicines or health products for preventing or treating hyperuricemia and gout. Experiments of control model mice prove that indexes, such as uric acid and creatinine, in hyperuricemia can be remarkably reduced by using the composition. Besides, the composition can protect the kidney functions, prevent kidney tissue lesions and improve the survival rate, andhas good application prospects.

Description

technical field [0001] The invention relates to the related fields of immunology, pharmacy and medicine, in particular to a composition for preventing and treating hyperuricemia and its application. Background technique [0002] Uric acid is the terminal metabolite of human purine compounds. The serum uric acid value of healthy people is generally: male 238-375 μmol / L, female 178-297 μmol / L, usually measured 2-3 times within 1-2 weeks, if the male continues to exceed 380 μmol / L, and the female continuously exceeds 300 μmol / L, It can be called hyperuricemia (Hyperuricemia, HU). The increase of serum uric acid level is related to the disorder of purine metabolism. For example, intake of high-purine food, fatigue or strenuous exercise can also lead to increase of serum uric acid level. [0003] In the past, people knew little about the role and significance of purine metabolites, and HU has been regarded as a rare disease in my country. In recent years, due to the improvemen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A61P13/12A61K31/05A61P19/06
CPCA61K31/05A61K36/32A61K36/53A61P19/06A61K2300/00
Inventor 李泰明曹慧敏杨菁
Owner CHINA PHARM UNIV
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