The invention belongs to the technical field of medicines for preventing and treating acute
lung injury, and discloses application of a
fritillaria heterosteroid
alkaloid monomer, namely application of the
fritillaria heterosteroid
alkaloid monomer in preparation of medicines for treating, relieving or preventing
lung injury.
Lung injury is acute
lung injury induced by LPS. The
lung injury can also be caused by influenza
virus infection, bacterial infection and / or fungal infection. The
fritillaria heterosteroid
alkaloid monomer comprises dehydroobberidine and peimisine. The invention further discloses a preparation method of the fritillaria heterosteroid. According to the invention, corresponding representative compounds, namely dehydroobberidine and peimisine, are selected for an activity experiment for preventing and treating the acute
lung injury, and the two natural small-molecule alkaloid monomers, namely dehydroobberidine and peimisine, are determined to have good activity for preventing and treating the acute
lung injury, and can obviously relieve lung
inflammation and
pulmonary edema conditions; the new application
disease range of fritillaria plants is widened, and a reliable direction and basis are provided for development of safe and effective new drugs for acute lung injury.