The invention discloses a large-field-of-view survey telescope wavefront curvature sensing method, device and equipment, and a medium. The large-field-of-view survey telescope wavefront curvature sensing method comprises the steps of: carrying out coarse alignment on a large-caliber main focus assembly, and carrying out imaging through using staggered curvature sensors located at two sides of a focal plane to obtain an out-of-focus star point graph; acquiring the boundary of the out-of-focus star point graph, and segmenting the out-of-focus star point graph into a plurality of sub-aperture regions, wherein each sub-aperture region is divided into a pure internal region without a boundary and a boundary-containing region; in the pure internal regions, solving wavefront curvatures corresponding to the pure internal regions; in the boundary-containing regions, solving the wavefront curvatures and the wavefront slopes corresponding to the boundary-containing regions, and estimating the parameters of the constrained wavefront slopes by using the maximum likelihood; and carrying out comprehensive arrangement and analysis on the solved wavefront curvatures and the constrained wavefront slopes to obtain wavefront phase information of the telescope. In this way, the finally solved wavefront sensing result is more accurate, the correction time is shortened, and the correction precision is improved.