Application of pharmaceutical combined preparation and traditional Chinese medicine composition in preparation of chemotherapeutic drug synergistic attenuated agent

A technology of chemotherapy drugs and compositions, applied in the field of medicine, to reduce oxidative stress levels, protect the digestive tract mucosa, and improve appetite suppression

Active Publication Date: 2019-03-29
津药达仁堂集团股份有限公司乐仁堂制药厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no completely effective drug or method for the prevention and treatment of mucosal injury and inflammation caused by chemotherapy.

Method used

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  • Application of pharmaceutical combined preparation and traditional Chinese medicine composition in preparation of chemotherapeutic drug synergistic attenuated agent
  • Application of pharmaceutical combined preparation and traditional Chinese medicine composition in preparation of chemotherapeutic drug synergistic attenuated agent
  • Application of pharmaceutical combined preparation and traditional Chinese medicine composition in preparation of chemotherapeutic drug synergistic attenuated agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0098] 1.1, the pretreatment of traditional Chinese medicine composition

[0099] The traditional Chinese medicine composition according to the present invention is used to measure and crush each raw material according to the formula, pass through a 160-mesh sieve, weigh 100 g of the traditional Chinese medicine composition powder, add 10 times the amount of methanol, heat and reflux for extraction twice, each time for 1 hour, and concentrate the filtrate under reduced pressure Afterwards, the methanol extract of the traditional Chinese medicine composition was obtained by heating on a water bath at 60° C., and the extraction recovery rate was 44.5% (w / w), and the extract of the Chinese medicinal composition was stored for future use.

[0100] 1.2. Preparation of neutral formalin fixative and phosphate buffered saline (PBS)

[0101] Neutral formalin: 40% formaldehyde 100mL, KH 2 PO 4 4.0g, Na 2 HPO 4 12H 2 O 6.5g, distilled water to 1000mL, sealed.

[0102] PBS: Na 2 H...

Embodiment 2

[0105] Embodiment 2 Oxaliplatin combined with traditional Chinese medicine composition

[0106] 2.1. Dosing regimen

[0107] Balc / c mice were divided into 6 groups, labeled with picric acid:

[0108] group

Dosage

Blank group (Control healthy mice)

-

Model group (Model tumor-bearing mice)

-

Traditional Chinese Medicine Composition Group (WCA)

0.4g / kg

Oxaliplatin group (OLP)

5mg / kg

Oxaliplatin + traditional Chinese medicine composition group (OLP + WCA)

5mg / kg+0.4g / kg

Oxaliplatin + positive drug loperamide (OLP+LOP)

5mg / kg+8mg / kg

[0109] Each administration group was administered 8 times according to body weight 0.2mL / 20g, and the blank group and model group were given the same amount of distilled water. Fasting for 24 hours before the last administration, mice were collected to observe the synergistic and attenuating effect of the traditional Chinese medicine composition combined with the chemot...

Embodiment 3

[0129] Embodiment 3 Irinotecan is combined with traditional Chinese medicine composition

[0130] 3.1. Dosing regimen

[0131] Balc / c mice were divided into 6 groups, labeled with picric acid:

[0132] group

Dosage

Blank group (Control healthy mice)

-

Model group (Model tumor-bearing mice)

-

Traditional Chinese Medicine Composition Group (WCA)

0.4g / kg

Irinotecan group (CPT)

75mg / kg

Irinotecan + traditional Chinese medicine composition group (CPT + WCA)

75mg / kg+0.4g / kg

Irinotecan + positive drug loperamide (CPT + LOP)

75mg / kg+8mg / kg

[0133] Each administration group was administered 8 times according to body weight 0.2mL / 20g, and the blank group and model group were given the same amount of distilled water. Fasting for 24 hours before the last administration, the mice were collected to observe the synergistic and attenuating effect of the traditional Chinese medicine composition combined with th...

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Abstract

The invention provides application of a pharmaceutical combined preparation and traditional Chinese medicine composition in preparation of a chemotherapeutic drug synergistic attenuated agent, and relates to the technical field of medicine. The pharmaceutical combined preparation provided by the invention comprises a chemotherapeutic medicine and a traditional Chinese medicine composition. Compared with single usage of chemotherapeutic drugs, the pharmaceutical combined preparation can effectively improve the appetite suppression, mental state difference and weight loss which are easy to occurin cancer patients during a chemotherapy process, without significant influence on tumor inhibition rate. At the same time, the pharmaceutical combined preparation can effectively enhance the body'soxidative free radical scavenging power and avoid the intensification of the body cell damage. Moreover, the pharmaceutical combined preparation can also improve the stimulation and damage of the gastrointestinal tracts by the chemotherapeutic drug, and has the function of protecting the mucosa of the digestive tracts.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of a drug combination preparation and a traditional Chinese medicine composition in the preparation of chemotherapeutic drug synergists and detoxifiers. Background technique [0002] Cancer is a disease caused by the loss of normal regulation and excessive proliferation of body cells. Excessively proliferating cells are called cancer cells. Cancer cells can often invade surrounding tissues and even transfer to other parts of the body through the circulatory system and / or lymphatic system. There are many types of cancer, and the severity of the disease depends on where the cancer cells are located, how malignant they are, and whether they have metastasized. [0003] At present, malignant tumors seriously endanger people's health, and the number of cases is increasing. With the development and clinical application of new anticancer drugs, cancer chemotherapy has ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K36/835A61P35/00A61K31/4745A61K31/555A61K33/28A61K35/55
CPCA61K31/4745A61K31/555A61K33/28A61K35/55A61K36/185A61K36/236A61K36/285A61K36/47A61K36/575A61K36/708A61K36/725A61K36/752A61K36/835A61K45/06A61P35/00A61K2300/00
Inventor 金兆祥王琳张宇王玉晶范迪郭琳
Owner 津药达仁堂集团股份有限公司乐仁堂制药厂
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