Application of polydatin in preparation of testis ischemia-reperfusion injury protective drugs

A technology of ischemia-reperfusion and polydatin, which is applied in drug combinations, pharmaceutical formulas, cardiovascular system diseases, etc., can solve problems such as the unclear effect and mechanism of polydatin, protect the testis from ischemia-reperfusion injury, and reduce interstitial hyperemia and bleeding, easy to obtain results

Inactive Publication Date: 2016-08-17
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, the anti-oxidative stress activity of polydatin in ischemia-reperfusion injury has been widely studied, especially in tissues such as heart, brain and lung, but the effect and mechanism of polydatin in testicular ischemia-reperfusion injury are still unclear. unclear

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  • Application of polydatin in preparation of testis ischemia-reperfusion injury protective drugs
  • Application of polydatin in preparation of testis ischemia-reperfusion injury protective drugs
  • Application of polydatin in preparation of testis ischemia-reperfusion injury protective drugs

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Embodiment Construction

[0023] The present invention will be described in detail below in combination with specific embodiments.

[0024] The invention relates to the application of polydatin in the preparation of a drug for protecting testicular ischemia-reperfusion injury, including two aspects of prevention and treatment. Specific functions include:

[0025] (1) The role of polydatin in improving tissue damage during testicular ischemia-reperfusion.

[0026] (2) The role of polydatin in regulating lipid peroxidation and enzymatic antioxidant defense system during testicular ischemia-reperfusion.

[0027] (3) The role of polydatin in preventing germ cell apoptosis caused by testicular ischemia-reperfusion, which was detected by TdT-mediated dUTP nick end labeling (TUNEL).

[0028] (4) Polydatin alleviated the effect of apoptosis-related proteins in ischemia-reperfusion testis, including caspase-3, caspase-8, caspase-9, PARP, Bcl-2 and Bax.

[0029] The specific verification effect of the applica...

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Abstract

The invention relates to the application of polydatin in protecting testicular ischemia-reperfusion injury. Repositioning after testicular torsion is a process of ischemia-reperfusion injury, which will affect male reproductive function and even lead to infertility, and there is a lack of effective clinical adjuvant treatment. The anti-oxidative stress activity of polydatin in ischemia-reperfusion injury has been widely studied, especially in tissues such as heart, brain and lung, but the effect and mechanism in testicular ischemia-reperfusion injury have not been reported yet. The invention discloses the application of polydatin as a medicine for treating testicular ischemia-reperfusion injury, which can improve testicular tissue damage, regulate lipid peroxidation and enzymatic antioxidant defense system in the process of testicular ischemia-reperfusion, and relieve testicular ischemia Germ cell apoptosis induced by reperfusion regulates apoptosis-associated proteins in ischemia-reperfused testes. Polydatin has the function of protecting testicular ischemia-reperfusion injury, broadens the research and application of polydatin, and provides new ideas for the treatment of testicular torsion.

Description

technical field [0001] The invention relates to a drug application, in particular to the application of polydatin in the preparation of a drug for protecting testicular ischemia-reperfusion injury. Background technique [0002] Testicular torsion is a urological emergency that most commonly occurs in neonates, children, and adolescent males, with an incidence of 1 in 4,000 young males under the age of 25, and 61% of patients under the age of 21. Testicular torsion, also known as spermatic cord torsion, is usually accompanied by sudden scrotal pain, nausea, vomiting and other symptoms. Due to compression and blockage of testicular blood vessels, testicular tissue ischemia or even necrosis results, which in turn leads to decreased reproductive function or even infertility. After symptoms appear, surgical reduction must be performed as soon as possible to avoid further damage. Generally, detwisting within 6 hours can avoid complete loss of testicular function, but if the torsi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7034A61P9/10A61P15/00
CPCA61K31/7034
Inventor 李臻乔慧莲陈浩曹碗君
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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