Application of dimethyldiguanide in drugs taking protective effect on chemoradiotherapy injury

A metformin and protective technology, applied in the field of metformin, can solve problems such as lack of treatment methods, achieve the effect of promoting research and reducing the level of oxidative stress in hematopoietic stem cells

Inactive Publication Date: 2014-06-18
INST OF RADIATION MEDICINE CHINESE ACADEMY OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The molecular mechanism of irradiation-induced aging of HSCs has not yet been elucidated, and there is currently a lack of effective treatments

Method used

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  • Application of dimethyldiguanide in drugs taking protective effect on chemoradiotherapy injury
  • Application of dimethyldiguanide in drugs taking protective effect on chemoradiotherapy injury
  • Application of dimethyldiguanide in drugs taking protective effect on chemoradiotherapy injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A method for constructing a mouse model that reduces radiotherapy damage, comprising the steps of:

[0021] 24 hours before irradiation, the C57BL / 6 mice were administered by intragastric administration, and the dosage: Metformin 250mg / kg, given once to the mice 137 Cs source gamma ray whole body irradiation, dose 4Gy, dose rate 0.76Gy / min, continue to gavage administration after irradiation, dosage: Metformin 250mg / kg, once a day, continue to gavage administration for 7 days after irradiation, different time The peripheral blood cell count and lymphocyte typing, immune organ index, spleen nodule formation count, bone marrow hematopoietic progenitor cell and stem cell function and other indicators were detected.

Embodiment 2

[0023] A method for constructing a mouse model that reduces chemotherapy damage, comprising the steps of:

[0024] Metformin 250mg / kg was administered orally to ICR mice, once a day, 10 times in total; cisplatin was injected intraperitoneally to ICR mice, cisplatin 1mg / kg, once a day, and the administration was started from the next day for a total of 10 times. Administration was administered 7 times; peripheral blood cell count and lymphocyte typing, immune organ index, spleen nodule formation count, bone marrow hematopoietic progenitor cell and stem cell function and other indicators were detected at different times.

Embodiment 3

[0026] A method for constructing a mouse model that reduces chemotherapy damage, comprising the steps of:

[0027] Metformin 250mg / kg was intragastrically administered to ICR mice, once a day, a total of 10 times, intraperitoneal injection of cyclophosphamide to ICR mice, cyclophosphamide 50mg / kg, intraperitoneal injection on the 2nd, 5th, and 8th days After administration, peripheral blood cell count and lymphocyte typing, immune organ index, spleen nodule formation count, bone marrow hematopoietic progenitor cell and stem cell function and other indicators were detected at different times.

[0028] The following specific experiments will verify the protective effect of metformin on hematopoietic immune injury caused by radiotherapy and chemotherapy.

[0029] 1), experimental animals

[0030] C57BL / 6 male mice (SPF grade) were provided by the Institute of Experimental Animals, Chinese Academy of Medical Sciences, certificate number [SCXK (Beijing) 2005-0013], body weight 20....

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Abstract

The invention relates to an application of dimethyldiguanide in drugs taking protective effect on chemoradiotherapy injury. As an optimal implementation scheme, the invention relates to the application of the dimethyldiguanide in preparing drugs taking protective effect on long-term bone marrow suppression caused by radiotherapy. As an optimal implementation scheme, the invention relates to the application of the dimethyldiguanide in preparing drugs taking protective effect on the long-term bone marrow suppression caused by chemotherapeutics. Proved by the invention, the dimethyldiguanide has a certain protective effect on hematopoietic immune cell injury caused by irradiation and / or the chemotherapeutics.

Description

technical field [0001] The invention relates to a new application of metformin, in particular to an application of metformin in a drug that protects hematopoietic immune cell damage caused by radiotherapy and / or chemotherapy drugs. Background technique [0002] Many tumor patients suffer from severe side effects during radiotherapy and chemotherapy, which make them unable to adhere to treatment and lead to poor prognosis. Among them, acute and chronic myelosuppression are common side effects of treatment. Acute myelosuppression is mainly the apoptotic reaction of hematopoietic progenitor cells (HPCs) caused by radiotherapy and chemotherapy, and has a slight effect on hematopoietic stem cells (HSCs) in the quiescent phase. Take treatment. However, there are also some patients with long-term bone marrow suppression due to long-term injury, which is manifested by the reduction of HSCs reserve and the decline of HSCs self-renewal ability after recovery from acute bone marrow s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/155A61P37/04A61P7/06
Inventor 孟爱民许国顺吴红英王月英李德冠王小春张恒路璐李程程王营营
Owner INST OF RADIATION MEDICINE CHINESE ACADEMY OF MEDICAL SCI
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