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Application of all-cannabinoid in preparation of drug for treating Parkinson's disease

A technology for Parkinson's disease and cannabinoids, which is applied in the field of industrial hemp utilization, can solve the problems of hindering the influence of THC on the nervous system and unsatisfactory treatment effect, and achieve the effects of clearly treating Parkinson's disease, improving the mobility of the rotating rod, and scavenging free radicals Effect

Inactive Publication Date: 2016-09-28
云南瑞酚生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CBD is a non-addictive ingredient in marijuana, which can hinder the influence of THC on the human nervous system, and has pharmacological activities such as anti-spasmodic, anti-rheumatic arthritis, and anti-anxiety. It has also been reported in the treatment of Parkinson's disease, but it is alone Treatments with Cannabidiol (CBD) Are Not Effective

Method used

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  • Application of all-cannabinoid in preparation of drug for treating Parkinson's disease
  • Application of all-cannabinoid in preparation of drug for treating Parkinson's disease
  • Application of all-cannabinoid in preparation of drug for treating Parkinson's disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The flowers, leaves, hemp bran and hemp seeds of "Yunma No. 1", an industrial hemp variety grown in Yunnan, are used as raw materials. Take mature industrial hemp hemp seeds, dry, remove impurities, and crush them for later use; use ethanol to extract the crushed hemp seeds (at 60-85°C, heat and extract twice, each time for 1-3 hours ), the ethanol concentration is 95% to 100% (V / V), and the ratio of solid to liquid is 1:5 to 1:20; the extract is filtered out and concentrated under reduced pressure to obtain the industrial hemp hemp seed extract.

[0028] Take the mixture of industrial hemp flowers, leaves and hemp bran in a mass ratio of 1:3:2, dry, remove impurities, and pulverize to 10-60 mesh; supercritical carbon dioxide extraction: put the above-mentioned pulverized industrial hemp raw materials into supercritical In the carbon dioxide extraction device, the extraction temperature is controlled at 40-50°C, the extraction time is 30-90min, the extraction pressure i...

Embodiment 2

[0031] Repeat Example 1, with the following differences: when extracting industrial hemp hemp seeds with ethanol, extract at room temperature, and extract 2 times for each batch of materials, each for 7 to 10 days. A 1:1:1 mass ratio mixture of flowers, leaves, and hemp bran of industrial hemp is used as a raw material for extracting hemp cannabinoids.

[0032] Take 0.3 part of industrial hemp hemp seed extract and 99.7 parts of industrial hemp cannabinoid, and mix well to obtain the required pancannabinoid A.

Embodiment 3

[0034] Repeat Example 1, the following difference is arranged: when extracting industrial hemp hemp seed with ethanol, adopt ultrasonic assisted extraction, ultrasonic frequency 30~60kHz, power 100~1000W, extraction time 30~60min, leaching temperature 25~ 50°C. A 3:2:1 mass ratio mixture of flowers, leaves, and hemp bran of industrial hemp is used as the raw material for extracting hemp cannabinoids.

[0035] Take 99.7 parts of industrial hemp hemp seed extract and 0.3 part of industrial hemp cannabinoid, and mix well to obtain the required pancannabinoid C.

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Abstract

The invention discloses application of all-cannabinoid in preparation of a drug for treating a Parkinson's disease (PD). The all-cannabinoid is prepared by uniformly mixing, by weight, 0.3-99.7 parts of an industrial hemp seed extract with 99.7-0.3 parts of industrial cannabinoids. Experiments prove that the prepared all-cannabinoid has the effects of removing free radicals, inhibiting lipid peroxidation and enabling generation and removal of oxygen radicals to be in dynamic balance to slow disease progress of the PD. The all-cannabinoid has a good application prospect on preparation of the drug for treating the Parkinson's disease.

Description

technical field [0001] The invention belongs to the technical field of industrial hemp utilization, and in particular relates to the application of a pharmaceutical composition prepared from industrial hemp as a main raw material in the preparation of a drug for treating Parkinson's disease. Background technique [0002] The cultivation of hemp has a long history. In ancient times, hemp was mainly used to make and process ropes, fishing nets, clothing and paper-making raw materials, as well as oil and food. With the development and progress of society, people found that a toxic ingredient (tetrahydrocannabinol) in marijuana can make people addicted to hallucinations. Many countries in Europe and the United States have banned the cultivation of marijuana for a long time. Due to the high economic value of cannabis, by the 1980s, some European countries had researched and bred low-toxic cannabis varieties and promoted their cultivation. In 1990, the European Community took the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/60A61P25/16
CPCA61K36/60A61K2236/333A61K2236/37A61K2300/00
Inventor 陈天睿胡瀞月
Owner 云南瑞酚生物科技有限公司
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